This page provides the summaries of the CAF Third Round matches for the 2010 FIFA World Cup qualification. The 20 qualifiers (the 12 group winners and the best 8 runners-up from the second round) were split into 5 groups of four, in the draw held on 22 October 2008 in Zürich, Switzerland. Teams in each group will play a home-and-away round-robin in 2009, with the 5 groups winners advancing to the World Cup Finals in South Africa (together with hosts South Africa).[note 1]
^South Africa also entered World Cup qualifying in order to qualify for the 2010 African Cup of Nations. Had they made it to this round, their matches would not have been counted in determining who would advance to the World Cup finals in their group.
^Had Angola made it to this round, all the other three teams in their group would advance to the African Cup of Nations finals.