In molecular biology, exonuclease VII (EC3.1.11.6, Escherichia coli exonuclease VII, E. coli exonuclease VII, endodeoxyribonuclease VII, Exodeoxyribonuclease VII) is a bacterialexonucleaseenzyme.[1][2] It is composed of two nonidentical subunits; one large subunit and 4 small ones.[3] Exonuclease VII catalyses exonucleolytic cleavage in either 5'-3' or 3'-5' direction to yield 5'-phosphomononucleotides. The large subunit also contains an N-terminalOB-folddomain that binds to nucleic acids.
References
^Chase, J.W.; Richardson, C.C. (1974). "Ribonuclease VII of Escherichia coli". J. Biol. Chem. 249 (14): 4545–4552. PMID4602029.
^Chase, J.W.; Richardson, C.C. (1974). "Exonuclease VII of Escherichia coli". J. Biol. Chem. 249 (14): 4553–4561. PMID4602030.