Deoxyribonuclease IV

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Deoxyribonuclease IV (phage-T4-induced)
EC number3.1.21.2
CAS number63363-78-0
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum

Deoxyribonuclease IV (phage-T4-induced) (EC, endodeoxyribonuclease IV (phage T4-induced), E. coli endonuclease IV, endodeoxyribonuclease, redoxyendonuclease, deoxriboendonuclease, Escherichia coli endonuclease II, endonuclease II, DNA-adenine-transferase) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction

Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products

Deoxyribonuclease IV is a type of deoxyribonuclease that functions at AP-sites.


  1. ^ Friedberg, E.C.; Goldthwait, D.A. (1969). "Endonuclease II of E. coli. I. Isolation and purification". Proc. Natl. Acad. Sci. USA. 62 (3): 934–940. doi:10.1073/pnas.62.3.934. PMC 223688. PMID 4895219.
  2. ^ Friedberg, E.C.; Hadi, S.-M.; Goldthwait, D.A. (1969). "Endonuclease II of Escherichia coli. II. Enzyme properties and studies on the degradation of alkylated and native deoxyribonucleic acid". J. Biol. Chem. 244 (21): 5879–5889. PMID 4981786.
  3. ^ Hadi, S.M.; Goldthwait, D.A. (1971). "Endonuclease II of Escherichia coli. Degradation of partially depurinated deoxyribonucleic acid". Biochemistry. 10 (26): 4986–4993. doi:10.1021/bi00802a024. PMID 4944066.
  4. ^ Sadowski, P.D.; Hurwitz, J. (1969). "Enzymatic breakage of deoxyribonucleic acid. I. Purification and properties of endonuclease II from T4 phage-infected Escherichia coli". J. Biol. Chem. 244 (22): 6182–6191. PMID 4310836.

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