RNASEH1

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RNASEH1
PDB 2qk9 EBI.png
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases RNASEH1, H1RNA, RNH1, PEOB2, ribonuclease H1
External IDs MGI: 1335073 HomoloGene: 2202 GeneCards: 246243
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001286834
NM_001286837
NM_002936

NM_001286865
NM_011275

RefSeq (protein)

NP_001273763.1
NP_001273766.1
NP_002927.2

n/a

Location (UCSC) Chr 2: 3.54 – 3.56 Mb Chr 12: 28.65 – 28.66 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Ribonuclease H1 also known as RNase H1 is an enzyme that in humans is encoded by the RNASEH1 gene.[1][2][3] The RNase H1 is a non-specific endonuclease and catalyzes the cleavage of RNA via a hydrolytic mechanism.

References[edit]

  1. ^ "Entrez Gene: ribonuclease H1". 
  2. ^ ten Asbroek AL, van Groenigen M, Jakobs ME, Koevoets C, Janssen B, Baas F (June 2002). "Ribonuclease H1 maps to chromosome 2 and has at least three pseudogene loci in the human genome". Genomics 79 (6): 818–23. doi:10.1006/geno.2002.6776. PMID 12036296. 
  3. ^ Nowotny M, Gaidamakov SA, Ghirlando R, Cerritelli SM, Crouch RJ, Yang W (October 2007). "Structure of human RNase H1 complexed with an RNA/DNA hybrid: insight into HIV reverse transcription". Mol. Cell 28 (2): 264–76. doi:10.1016/j.molcel.2007.08.015. PMID 17964265. 

Further reading[edit]