PDE4A

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PDE4A
Protein PDE4A PDB 1loi.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PDE4A, DPDE2, PDE4, PDE46, phosphodiesterase 4A
External IDs MGI: 99558 HomoloGene: 4520 GeneCards: 5141
RNA expression pattern
PBB GE PDE4A 204735 at tn.png

PBB GE PDE4A 211447 s at tn.png

PBB GE PDE4A 211591 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001111307
NM_001111308
NM_001111309
NM_001243121
NM_006202

NM_019798
NM_183408
NM_001310750

RefSeq (protein)

NP_001104777.1
NP_001104778.1
NP_001104779.1
NP_001230050.1
NP_006193.1

NP_062772.3
NP_899668.1

Location (UCSC) Chr 19: 10.42 – 10.47 Mb Chr 9: 21.17 – 21.21 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

cAMP-specific 3',5'-cyclic phosphodiesterase 4A is an enzyme that in humans is encoded by the PDE4A gene.[3][4]

Function[edit]

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes.[4] Recently, it has been shown through the use of PDE4A knock out mice that PDE4A may play a role in the regulation of anxiety and emotional memory.[5]

Clinical significance[edit]

PDE4A is a target of a number of drugs including:[6][7][8]

  • rolipram (antidepressant and antiinflammatory) and cilomilast (antiinflammatory) – inhibits PDE4A isoforms 1, 2, 6, and 7
  • roflumilast (antiinflammatory) – inhibits PDE4A isoforms 1, 2, and 6

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Milatovich A, Bolger G, Michaeli T, Francke U (Mar 1994). "Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse". Somatic Cell and Molecular Genetics. 20 (2): 75–86. doi:10.1007/BF02290677. PMID 8009369. 
  4. ^ a b "PDE4A phosphodiesterase 4A, cAMP-specific ( Homo sapiens )". Entrez Gene. NCBI. 2012-03-04. Retrieved 2012-04-02. 
  5. ^ Hansen RT, Conti M, Zhang H-T (2014). "Mice deficient in phosphodiesterase-4A display anxiogenic-like behavior". Psychopharmacology. 231: 2941–2954. doi:10.1007/s00213-014-3480-y. 
  6. ^ Rena G, Begg F, Ross A, MacKenzie C, McPhee I, Campbell L, Huston E, Sullivan M, Houslay MD (May 2001). "Molecular cloning, genomic positioning, promoter identification, and characterization of the novel cyclic amp-specific phosphodiesterase PDE4A10" (pdf). Molecular Pharmacology. 59 (5): 996–1011. PMID 11306681. 
  7. ^ Wallace DA, Johnston LA, Huston E, MacMaster D, Houslay TM, Cheung YF, Campbell L, Millen JE, Smith RA, Gall I, Knowles RG, Sullivan M, Houslay MD (Jun 2005). "Identification and characterization of PDE4A11, a novel, widely expressed long isoform encoded by the human PDE4A cAMP phosphodiesterase gene". Molecular Pharmacology. 67 (6): 1920–34. doi:10.1124/mol.104.009423. PMID 15738310. 
  8. ^ Mackenzie KF, Topping EC, Bugaj-Gaweda B, Deng C, Cheung YF, Olsen AE, Stockard CR, High Mitchell L, Baillie GS, Grizzle WE, De Vivo M, Houslay MD, Wang D, Bolger GB (Apr 2008). "Human PDE4A8, a novel brain-expressed PDE4 cAMP-specific phosphodiesterase that has undergone rapid evolutionary change". The Biochemical Journal. 411 (2): 361–9. doi:10.1042/BJ20071251. PMID 18095939. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.