The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Recently, it has been shown through the use of PDE4A knock out mice that PDE4A may play a role in the regulation of anxiety and emotional memory.
^Milatovich A, Bolger G, Michaeli T, Francke U (1994). "Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse". Somatic Cell and Molecular Genetics20 (2): 75–86. doi:10.1007/BF02290677. PMID8009369.
^Wallace DA, Johnston LA, Huston E, MacMaster D, Houslay TM, Cheung YF, Campbell L, Millen JE, Smith RA, Gall I, Knowles RG, Sullivan M, Houslay MD (June 2005). "Identification and characterization of PDE4A11, a novel, widely expressed long isoform encoded by the human PDE4A cAMP phosphodiesterase gene". Molecular Pharmacology67 (6): 1920–34. doi:10.1124/mol.104.009423. PMID15738310.
^Mackenzie KF, Topping EC, Bugaj-Gaweda B, Deng C, Cheung YF, Olsen AE, Stockard CR, High Mitchell L, Baillie GS, Grizzle WE, De Vivo M, Houslay MD, Wang D, Bolger GB (April 2008). "Human PDE4A8, a novel brain-expressed PDE4 cAMP-specific phosphodiesterase that has undergone rapid evolutionary change". The Biochemical Journal411 (2): 361–9. doi:10.1042/BJ20071251. PMID18095939.
Sullivan M, Egerton M, Shakur Y, Marquardsen A, Houslay MD (1995). "Molecular Cloning and Expression, in both COS-1 Cells and S. cerevisiae, of a Human Cytosolic Type-IVA, Cyclic AMP Specific Phosphodiesterase (hPDE-IVA-h6.1)". Cellular Signaling6 (7): 793–812. doi:10.1016/0898-6568(94)00039-5. PMID7888306.
Lario PI, Bobechko B, Bateman K, Kelly J, Vrielink A, Huang Z (2001). "Purification and characterization of the human PDE4A catalytic domain (PDE4A330–723) expressed in Sf9 cells". Archives of Biochemistry and Biophysics394 (1): 54–60. doi:10.1006/abbi.2001.2513. PMID11566027.
Pryzwansky KB, Madden VJ (2004). "Type 4A cAMP-specific phosphodiesterase is stored in granules of human neutrophils and eosinophils". Cellular and Tissue Research312 (3): 301–311. doi:10.1007/s00441-003-0728-y. PMID12764607.