List of U.S. Highways in South Carolina

U.S. Highways of South Carolina
U.S. Highways of South Carolina
	Highway marker for U.S. Highways in South Carolina
System information
	Maintained by SCDOT
Formed	November 11, 1926
Highway names
US Highways	U.S. Highway nn (US nn)
System links
	South Carolina State Highway System; Interstate; US; State; Scenic;

There are 23 U.S. Highways that exist entirely or partially in the U.S. state of South Carolina. In South Carolina, all U.S. Highways are maintained by the South Carolina Department of Transportation (SCDOT).

Mainline highways


Number	Length (mi)	Length (km)	Southern or western terminus	Northern or eastern terminus	Formed	Removed	Notes
US 1	170.1	273.7	Georgia state line at North Augusta	North Carolina state line near Wallace	01926-01-011926	current	Travels north-south along the sandhills region; connecting the cities of North Augusta, Aiken, Columbia, and Camden. South of Camden, it parallels with I-20.
US 15	158.6	255.2	Walterboro	North Carolina state line at McColl	01935-01-011935	current	Travels north-south, connecting the cities of Walterboro, Sumter, and Bennettsville.
US 17	221.0	355.7	Georgia state line near Limehouse	North Carolina state line near Little River	01927-01-011927	current	Travels north-south along the coastal plain area, connecting the cities of Hardeeville, Charleston, Georgetown, and Myrtle Beach.
US 21	232.2	373.7	Hunting Island State Park	North Carolina state line near Little River	01926-01-011926	current	Travels north-south, connecting the cities of Beaufort, Orangeburg, Columbia, and Rock Hill. North of Columbia, it parallels with I-77.
US 25	140.3	225.8	Georgia state line in North Augusta	North Carolina state line near Travelers Rest	01926-01-011926	current	Travels north-south in the western part of the state, connecting the cities of North Augusta, Greenwood, and Greenville.
US 29	109.1	175.6	Georgia state line near Holland Store	North Carolina state line at Blacksburg	01927-01-011927	current	Travels north-south in the Upstate area, parallel to I-85. It connects the cities of Anderson, Greenville, and Spartanburg.
US 52	161.0	259.1	Charleston	North Carolina state line near Cheraw	01980-06-101980	current	Travels north-south, connecting the cities of Charleston, Lake City, Florence, and Darlington.
US 76	297.9	479.4	Georgia state line near Westminster	North Carolina state line near Nichols	01926-01-011926	current	Longest US Highway in the state, going east-west; it connects the cities Anderson, Columbia, Sumter, and Florence.
US 78	141.0	226.9	Georgia state line near North Augusta	Charleston	01926-01-011926	current	Travels east-west, connecting the cities of North Augusta, Aiken, Bamberg, and Charleston.
US 117	45.0	72.4	Conway	North Carolina state line near Little River	01932-01-011932	01935-01-011935	Replaced by US 501 and US 17.
US 123	57.4	92.4	Georgia state line near Westminster	Greenville	01968-01-011968	current	Travels north-south in the Upstate area, connecting the cities of Westminster and Greenville.
US 176	218.7	352.0	North Carolina state line near Landrum	Goose Creek	01926-01-011926	current	Travels east-west, parallel to I-26. It connects the cities of Spartanburg, Union, and Columbia.
US 178	232.7	374.5	Ridgeville	North Carolina state line near Rocky Bottom	01932-01-011932	current	Travels east-west, connecting the cities of Anderson, Greenwood, and Orangeburg.
US 217	24.4	39.3	Pee Dee	North Carolina state line near Dillon	01927-01-011927	01932-01-011932	Replaced by US 301.
US 221	125.9	202.6	Georgia state line near Clarks Hill	North Carolina state line at Chesnee	01932-01-011932	current	Travels north-south within the Piedmont area, connecting the cities of Greenwood and Spartanburg.
US 276	34.2	55.0	North Carolina state line near Cleveland	Mauldin	01932-01-011932	current	Shortest US Highway in the state, going east-west; it goes through the city of Greenville.
US 278	146.0	235.0	Georgia state line near North Augusta	Hilton Head Island	01965-01-011965	current	Travels east-west, connecting the cities of North Augusta and Hilton Head Island.
US 301	190.3	306.3	Georgia state line near Allendale	North Carolina state line near Dillon	01932-01-011932	current	Travels north-south, loosely parallel to I-95. It connects the cities of Orangeburg, Florence, and Dillon.
US 321	227.4	366.0	Hardeeville	North Carolina state line near Clover	01930-01-011930	current	Travels north-south, connecting the cities of Hardeeville, Columbia, and York.
US 378	210.9	339.4	Georgia state line near McCormick	Conway	01952-01-011952	current	Travels east-west, connecting the cities of Columbia, Sumter, and Conway.
US 401	77.2	124.2	Sumter	North Carolina state line near McColl	01957-01-011957	current	Travels north-south, connecting the cities of Sumter, Darlington, and Bennettsville.
US 501	74.0	119.1	Myrtle Beach	North Carolina state line near Dillon	01935-01-011935	current	Travels north-south through the Grand Strand area, connecting the cities of Myrtle Beach, Conway, and Dillon.
US 521	173.5	279.2	Georgetown	North Carolina state line at Indian Land	01932-01-011932	current	Travels north-south, connecting the cities of Georgetown, Sumter, Camden, and Lexington.
US 601	181.4	291.9	Tarboro	North Carolina state line at Pageland	01927-01-011927	current	Travels north-south,connecting the cities of Bamberg, Orangeburg, Camden, and Pageland.
US 701	61.5	99.0	Georgetown	North Carolina state line near Loris	01932-01-011932	current	Travels north-south through the Grand Strand area, connecting the cities of Georgetown and Conway.
Former

Special routes


Number	Length (mi)	Length (km)	Southern or western terminus	Northern or eastern terminus	Formed	Removed	Notes
US 15 Alt.	—	—	Walterboro	North Carolina state line near McColl	01937-01-011937	01946-01-011946	The entire route was in concurrency with US 15 in South Carolina.
US 15 Alt.	—	—	Sumter	Society Hill	01955-01-011955	01957-01-011957	Replaced by US 401.
US 15 Bus.	6.6	10.6	Hartsville		01969-01-011969	current	Routed along Fifth Street.
US 15 Bus.	—	—	Bennettsville		01952-01-011952	01990-01-011990	Was routed along Main Street and Tyson Avenue, in concurrency with US 401 Bus. It was replaced by SC 385.
US 17 Alt.	6.7	10.8	Georgia state line near Savannah, Georgia	Limehouse	01955-01-011955	01994-01-011994	Provided an alternate route from Savannah, via the Talmadge Memorial Bridge. Was reassigned as mainline US 17.
US 17 Alt.	123.4	198.6	Pocotaligo	Georgetown	01952-01-011952	current	Travels north-south,connecting the cities of Walterboro, Summerville, Moncks Corner and Georgetown.
US 17 Bus.	4.2	6.8	Mount Pleasant		01967-01-011967	01992-01-011992	Was routed along Coleman Boulevard and Georgetown Highway (Chuck Dawley Boulevard) in concurrency with US 701 Bus. It was replaced by SC 703 and BS 526.
US 17 Bus.	22.8	36.7	Murrells Inlet	Myrtle Beach	01967-01-011967	current	Connects the downtown areas of Murrells Inlet, Garden City, Surfside Beach and Myrtle Beach.
US 21 Bus.	3.2	5.1	Beaufort		01967-01-011967	current	Routed along Sea Island Parkway, Carteret Street and Boundary Street.
US 21 Bus.	3.3	5.3	Orangeburg		01950-01-011950	01967-01-011967	Was routed along Broughton Street (in concurrency with US 178 Bus.) and Columbia Road.
US 21 Bus.	2.9	4.7	Orangeburg		01967-01-011967	current	Routed along Rowesville Road, Charleston Highway and Magnolia Street.
US 21 Bus.	6.7	10.8	Rock Hill		01950-01-011950	02013-01-012013	Was routed along Main Street, Albright Road, Black Street, Oakland Avenue, and Cherry Road, through downtown Rock Hill. It was decommissioned at the request of Rock Hill to gain ownership and maintenance oversight.^[2]^[3]
US 21 Bus.	6.1	9.8	Fort Mill		01948-01-011948	current	It is routed along Spratt Street, White Street, Old Nations Road, and Springfield Parkway, through downtown Fort Mill.
US 25 Bus.	2.8	4.5	Georgia state line in North Augusta		01961-01-011961	current	Only business loop that crosses the Georgia–South Carolina state line.
US 25 Bus.	2.8	4.5	Greenwood		01969-01-011969	current
US 25 Bus.	4.5	7.2	Ware Shoals		01963-01-011963	current
US 25 Bus.	—	—	Greenville		01969-01-011969	01995-01-011995	Former business loop through downtown Greenville; replaced in parts by US 123, US 276, SC 20 and SC 291.
US 29 Alt.	—	—	Greenville		01938-01-011938	01948-01-011948	Was an alternate route through downtown Greenville, was downgraded to secondary roads.
US 29 Alt.	—	—	Spartanburg	Blacksburg	01955-01-011955	01962-01-011962	Was a redesignation of mainline US 29 between Spartanburg and Blacksburg; after I-85 was established, it was reverted to US 29.
US 29 Bus.	6.4	10.3	Anderson		01947-01-011947	current
US 29 Bus.	—	—	Greenville		01958-01-011958	01962-01-011962
US 52 Bus.	4.0	6.4	Darlington		01974-01-011974	current
US 76 Bus.	—	—	Seneca		01958-01-011958	02000-01-012000
US 76 Bus.	3.8	6.1	Laurens		01982-01-011982	current
US 76 Bus.	—	—	Newberry		01952-01-011952	02001-01-012001
US 76 Bus.	5.9	9.5	Sumter		01959-01-011959	current
US 78 Bus.	0.7	1.1	Blackville		01981-01-011981	current
US 123 Alt.	—	—	Greenville		01950-01-011950	01972-01-011972	Replaced by SC 124.
US 123 Bus.	—	—	Seneca		01958-01-011958	02000-01-012000	Was routed along North First Street.
US 123 Bus.	—	—	Easley		01958-01-011958	01964-01-011964	Was routed along Main Street and Liberty Drive. It was replaced by SC 93.
US 176 Alt.	—	—	Spartanburg		01938-01-011938	01948-01-011948	Traversed in downtown Spartanburg, along Magnolia and Howard streets. Some map inserts of the time list it as "Optional US 176;" was downgraded to secondary roads.
US 176 Bus.	—	—	Union		01958-01-011958	01990-01-011990	Was routed along Pinckney Street and Thompson Boulevard. It was replaced by SC 18.
US 178 Bus.	3.9	6.3	Greenwood		01949-01-011949	current
US 178 Bus.	4.9	7.9	Orangeburg		01970-01-011970	current
US 221 Alt.	5.3	8.5	Chesnee	North Carolina state line near Cowpens National Battlefield	01941-01-011941	current	Provides an alternate route from Chesnee to Forest City, NC.
US 276 Bus.	—	—	Greenville		01948-01-011948	01970-01-011970
US 278 Bus.	8.8	14.2	Hilton Head		01998-01-011998	current
US 321 Bus.	4.3	6.9	Winnsboro		01952-01-011952	current
US 321 Bus.	3.0	4.8	Chester		01964-01-011964	current
US 321 Bus.	2.6	4.2	York		01958-01-011958	current
US 378 Bus.	6.6	10.6	Sumter		01961-01-011961	—	Was routed along Broad Street, Liberty Street and Myrtle Beach Boulevard.
US 378 Bus.	2.6	4.2	Lake City		01958-01-011958	current	Routed along Main Street (with SC 341) and Church Street/Myrtle Beach Highway.
US 401 Bus.	—	—	Bennettsville		01958-01-011958	01990-01-011990	Was routed along Main Street and Tyson Avenue, in concurrency with US 15 Bus. It was replaced by SC 385.
US 501 Bus.	4.4	7.1	Conway		01964-01-011964	current
US 501 Bus.	6.6	10.6	Marion		01964-01-011964	current
US 521 Bus.	1.4	2.3	Kershaw		—	—
US 521 Bus.	3.8	6.1	Lancaster		01965-01-011965	current
US 701 Bus.	4.2	6.8	Mount Pleasant		01967-01-011967	01992-01-011992	Was routed along Coleman Boulevard and Georgetown Highway (Chuck Dawley Boulevard) in concurrency with US 17 Bus. It was replaced by SC 703 and BS 526.
US 701 Bus.	0.1	0.16	North Carolina state line near Tabor City, North Carolina		01960-01-011960	current	Only business loop that crosses the North Carolina–South Carolina state line
Former