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S. Murty Srinivasula

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Prof. S. Murty Srinivasula
Prof. S. Murty Srinivasula
Born1963 (age 60–61)
NationalityIndian
Alma mater
Known forStudies on novel regulators of Apoptosis and Autophagy
Scientific career
FieldsBiology, cell biology, apoptosis, autophagy
Institutions

Srinivasa Murty Srinivasula is an Indian cell biologist whose research mainly focus on apoptosis, autophagy and cancer. He has published around 100 papers and reviews in international journals and has over 43,000 citation and an H-Index of 66.[1][2] His current occupation is Professor at school of biology, IISER Thiruvananthapuram. He has additional charge as Professor-in-charge Administration at the IISER Thiruvananthapuram at Kerala, India.[3][4]

Life and career

Murty received his B.Sc and M.Sc degree from Andhra University and PhD from Banaras Hindu University, Varanasi in India. Later he moved to Thomas Jefferson University as a research associate and he became an instructor at Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia. During 2003–2012, he was a principle investigator at National Cancer Institute, NIH, Bethesda.[5][6] Currently he is Professor at IISER Thiruvananthapuram. He is also part of IISER TVM senate[7] and few other institute committees.[8][9][10][11]

Key awards and distinctions

Murty has received the following awards:

Research

Murty's research focuses on identification and characterization of diverse signaling pathways in cell, including apoptosis, autophagy, organelle homeostasis, ubiquitin signalling and host-pathogen interaction. Most of his earlier work involved caspases and other proteins involved in cell death. He is known for his work involving characterization of Apaf-1 and Caspase-9 interaction and its role as an upstream regulator of apoptotic protease cascade.

Publications

Key publications

  1. Gan X, Wang J, Wang C, Sommer E, Kozasa T, Srinivasula S, Alessi D, Offermanns S, Simon MI, Wu D. (2012). PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα (12). Nat. Cell Biol[13]
  2. Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S. M., Ahmad, M., Alnemri, E. S., & Wang, X. (1997). Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade. Cell, 91(4), 479–489.[14]
  3. Fujita K and Srinivasula SM. (2011). TLR4-mediated autophagy in macrophages is a p62-dependent type of selective autophagy of aggresome-like induced structures (ALIS). Autophagy, 7: 29–31.[15]
  4. Fujita K, Xiao Q, Maeda D and Srinivasula SM. (2011). Nrf2-mediated induction of p62 controls TLR4-driven ALIS formation and autophagic degradation, Proc Nat Acad Sci, USA, 108: 1427–32.[16]
  5. Shukla S, Fujita K, Xiao Q, and Srinivasula SM. (2011). A shear stress responsive gene product PP1201 protects against Fas-mediated apoptosis by reducing Fas expression on the cell surface. Apoptosis, 16: 162–173.[17]
  6. Liao, W, Fujita K, Xiao Q, Tchikov V, Yang W, Gunsor, M, Garfield S, Goldsmith, P. El-Deiry WS, Schutze S, and Srinivasula SM. (2009). CARP1 Regulates Induction of NF-κB by TNF-a. Current Biology. 19: R17-R19[18]
  7. Liao, W, Xiao Q, Tchikov V, Fujita K, Yang W, Wincovitch S, Garfield S, Schutze S, El-Deiry WS, and Srinivasula SM. (2008). CARP-2 is an endosome-associated ubiquitin ligase for RIP and regulates TNF-induced NF-?B activation. Current Biology (article). 18: 641–9.[19]
  8. Srinivasula SM, Jones JM., Datta P., Ji W., Gupta S., Zhang Z., Davies E., Hajnóczky G., Saunders TL., Van Keuren ML., Alnemri T., Meisler ML and Alnemri ES. (2003). Loss of Omi/HtrA2 protease activity causes the neuromuscular disorder of mnd2 mutant mice. Nature. 425: 721–727.[20]
  9. Srinivasula SM, Datta P, Kobayashi M, Wu J-W, Fujioka M, Hegde R, Zhang Z, Mukattash, Fernandes-Alnemri T, Shi Y, Jaynes JB, Alnemri ES. (2002). Sickle, a novel Drosophila death gene in the reaper/hid/grim region encodes an IAP-inhibitory protein. Curr Biol. 12: 125–30.[21]
  10. Srinivasula SM, Hegde R, Saleh A, Datta P, Shiozaki E, Chai J, Lee RA., Robbins PD, Fernandes-Alnemri T, Shi Y., Alnemri ES. (2001). A conserved XIAP-interaction motif in caspase-9 and Smac/Diablo regulates caspase activity and apoptosis. Nature. 410: 112–16.[22]
  11. Srinivasula SM, Saleh A, Balkir L, Robbins PD, and Alnemri ES. (2000). Negative regulation of the Apaf-1 apoptosome by Hsp70. Nature Cell Biol 2: 476–483.[23]

Book chapters

  1. Fujita, K and Srinivasula SM. (2009). Ubiquitination and Death-receptor signaling. Death Receptors and Cognate Ligands in Cancer. Results Probl Cell Differ, SpringerLinks Publisher. 49: 87-114.[24]
  2. Srinivasula SM, Saleh A, Ahmad M, Fernandes-Alnemri T, Alnemri ES. (2001). Isolation and Assay of Caspases. Ch. 1. Methods in Cell Biol. 66:1-27.[25]

References

  1. ^ "IRINS Profile page".{{cite web}}: CS1 maint: url-status (link)
  2. ^ "Google Scholar profile".{{cite web}}: CS1 maint: url-status (link)
  3. ^ "IISER Faculty".{{cite web}}: CS1 maint: url-status (link)
  4. ^ "The HINDU news paper". The Hindu. 14 March 2020.{{cite news}}: CS1 maint: url-status (link)
  5. ^ "NIH PI".{{cite web}}: CS1 maint: url-status (link)
  6. ^ "Linkedin profile".{{cite web}}: CS1 maint: url-status (link)
  7. ^ "Senate committee".{{cite web}}: CS1 maint: url-status (link)
  8. ^ "Building and work committee IISER TVM".{{cite web}}: CS1 maint: url-status (link)
  9. ^ "students_grievance_committee".{{cite web}}: CS1 maint: url-status (link)
  10. ^ "students_grievance_committee" (PDF).{{cite web}}: CS1 maint: url-status (link)
  11. ^ "SC/ST cell" (PDF).{{cite web}}: CS1 maint: url-status (link)
  12. ^ "Indian Research Information Network System".
  13. ^ Gan, Xiaoqing; Wang, Jiyong; Wang, Chen; Sommer, Eeva; Kozasa, Tohru; Srinivasula, Srinivasa; Alessi, Dario; Offermanns, Stefan; Simon, Melvin I.; Wu, Dianqing (20 May 2012). "PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12". Nature Cell Biology. 14 (7): 686–696. doi:10.1038/ncb2507. ISSN 1476-4679. PMC 3389271. PMID 22609986.
  14. ^ Li, Peng; Nijhawan, Deepak; Budihardjo, Imawati; Srinivasula, Srinivasa M; Ahmad, Manzoor; Alnemri, Emad S; Wang, Xiaodong (November 1997). "Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade". Cell. 91 (4): 479–489. doi:10.1016/S0092-8674(00)80434-1.
  15. ^ Fujita, Ken-Ichi; Srinivasula, Srinivasa M. (May 2011). "TLR4-mediated autophagy in macrophages is a p62-dependent type of selective autophagy of aggresome-like induced structures (ALIS)". Autophagy. 7 (5): 552–554. doi:10.4161/auto.7.5.15101. ISSN 1554-8635. PMC 3127216. PMID 21412052.
  16. ^ Fujita, Ken-ichi; Maeda, Daisuke; Xiao, Qi; Srinivasula, Srinivasa M. (25 January 2011). "Nrf2-mediated induction of p62 controls Toll-like receptor-4-driven aggresome-like induced structure formation and autophagic degradation". Proceedings of the National Academy of Sciences of the United States of America. 108 (4): 1427–1432. Bibcode:2011PNAS..108.1427F. doi:10.1073/pnas.1014156108. ISSN 1091-6490. PMC 3029726. PMID 21220332.
  17. ^ Shukla, Sudhanshu; Fujita, Ken-ichi; Xiao, Qi; Liao, Zhiyong; Garfield, Susan; Srinivasula, Srinivasa M. (25 November 2010). "A shear stress responsive gene product PP1201 protects against Fas-mediated apoptosis by reducing Fas expression on the cell surface". Apoptosis. 16 (2): 162–173. doi:10.1007/s10495-010-0556-y. ISSN 1360-8185. PMC 6993143. PMID 21107705.
  18. ^ Liao, Wentao; Fujita, Ken-ichi; Xiao, Qi; Tchikov, Vladimir; Yang, Wensheng; Gunsor, Michele; Garfield, Susan; Goldsmith, Paul; El-Deiry, Wafik S.; Schutze, Stefan; Srinivasula, Srinivasa M. (13 January 2009). "Response: CARP1 regulates induction of NF-κB by TNFα". Current Biology. 19 (1): R17–R19. doi:10.1016/j.cub.2008.11.041. ISSN 0960-9822.
  19. ^ Liao, Wentao; Xiao, Qi; Tchikov, Vladimir; Fujita, Ken-ichi; Yang, Wensheng; Wincovitch, Stephen; Garfield, Susan; Conze, Dietrich; El-Deiry, Wafik S.; Schütze, Stefan; Srinivasula, Srinivasa M. (6 May 2008). "CARP-2 is an endosome-associated ubiquitin ligase for RIP and regulates TNF-induced NF-kappaB activation". Current Biology: CB. 18 (9): 641–649. doi:10.1016/j.cub.2008.04.017. ISSN 0960-9822. PMC 2587165. PMID 18450452.
  20. ^ Jones, Julie M.; Datta, Pinaki; Srinivasula, Srinivasa M.; Ji, Weizhen; Gupta, Sanjeev; Zhang, ZhiJia; Davies, Erika; Hajnóczky, György; Saunders, Thomas L.; Van Keuren, Margaret L.; Fernandes-Alnemri, Teresa (16 October 2003). "Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice". Nature. 425 (6959): 721–727. Bibcode:2003Natur.425..721J. doi:10.1038/nature02052. hdl:2027.42/62561. ISSN 1476-4687. PMID 14534547.
  21. ^ Srinivasula, Srinivasa M.; Datta, Pinaki; Kobayashi, Masatomo; Wu, Jia Wei; Fujioka, Miki; Hegde, Ramesh; Zhang, ZhiJia; Mukattash, Rula; Fernandes-Alnemri, Teresa; Shi, Yigong; Jaynes, James B. (22 January 2002). "sickle, a novel Drosophila death gene in the reaper/hid/grim region, encodes an IAP-inhibitory protein". Current Biology: CB. 12 (2): 125–130. doi:10.1016/s0960-9822(01)00657-1. ISSN 0960-9822. PMC 2743937. PMID 11818063.
  22. ^ Srinivasula, S. M.; Hegde, R.; Saleh, A.; Datta, P.; Shiozaki, E.; Chai, J.; Lee, R. A.; Robbins, P. D.; Fernandes-Alnemri, T.; Shi, Y.; Alnemri, E. S. (1 March 2001). "A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis". Nature. 410 (6824): 112–116. Bibcode:2001Natur.410..112S. doi:10.1038/35065125. ISSN 0028-0836. PMID 11242052.
  23. ^ Saleh, A.; Srinivasula, S. M.; Balkir, L.; Robbins, P. D.; Alnemri, E. S. (August 2000). "Negative regulation of the Apaf-1 apoptosome by Hsp70". Nature Cell Biology. 2 (8): 476–483. doi:10.1038/35019510. ISSN 1465-7392. PMID 10934467.
  24. ^ Death Receptors and Cognate Ligands in Cancer | SpringerLink (PDF). Results and Problems in Cell Differentiation. Vol. 49. 2009. doi:10.1007/978-3-642-03045-1. ISBN 978-3-642-03044-4.
  25. ^ Srinivasula, Srinivasa M.; Saleh, Ayman; Ahmad, Manzoor; Fernandes-Alnemri, Teresa; Alnemri, Emad S. (1 January 2001). "Chapter 1 Isolation and assay of caspases". Apoptosis. Apoptosis. Vol. 66. Academic Press. pp. 1–27. doi:10.1016/S0091-679X(01)66002-3. ISBN 9780125441650. PMID 11395999. Retrieved 19 April 2020. {{cite book}}: |journal= ignored (help)
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