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S. Murty Srinivasula

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Prof. S. Murty Srinivasula
Prof. S. Murty Srinivasula
Born1963 (age 60–61)
NationalityIndian
Alma mater
Known forStudies on novel regulators of Apoptosis and Autophagy
Scientific career
FieldsBiology, cell biology, apoptosis, autophagy
Institutions

Srinivasa Murty Srinivasula is an Indian cell biologist, a professor at the School of Biology at the Indian Institute of Science Education and Research, Thiruvananthapuram (IISER Thiruvananthapuram) in Kerala, India. His research field is apoptosis, autophagy and oncology.[1][2]

Life and career

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Professor Murty received his B.Sc and M.Sc degrees from the Andhra University and his PhD from the Banaras Hindu University in Varanasi, India. He later moved to the Thomas Jefferson University as a research associate and became an instructor at the Sidney Kimmel Cancer Center at Thomas Jefferson University in Philadelphia, United States. During 2003–2012, he was the principal investigator at National Cancer Institute, NIH, Bethesda.[3][4] He was Professor-in-charge (administration) at the IISER Thiruvananthapuram,[5][6] as well as the member of the IISER TVM Senate.[7] He also served on several institute committees.[8][9][10][11] Currently he is Deputy Director of the institute.[12]

Key awards and distinctions

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Professor Murty has received the following awards:

Publications

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Professor Murty has published around 100 papers and reviews in international scientific journals.[14]

Key publications

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  1. Gan X, Wang J, Wang C, Sommer E, Kozasa T, Srinivasula S, Alessi D, Offermanns S, Simon MI, Wu D. (2012). PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα (12). Nat. Cell Biol[15]
  2. Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S. M., Ahmad, M., Alnemri, E. S., & Wang, X. (1997). Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade. Cell, 91(4), 479–489.[16]
  3. Fujita K and Srinivasula SM. (2011). TLR4-mediated autophagy in macrophages is a p62-dependent type of selective autophagy of aggresome-like induced structures (ALIS). Autophagy, 7: 29–31.[17]
  4. Fujita K, Xiao Q, Maeda D and Srinivasula SM. (2011). Nrf2-mediated induction of p62 controls TLR4-driven ALIS formation and autophagic degradation, Proc Nat Acad Sci, USA, 108: 1427–32.[18]
  5. Shukla S, Fujita K, Xiao Q, and Srinivasula SM. (2011). A shear stress responsive gene product PP1201 protects against Fas-mediated apoptosis by reducing Fas expression on the cell surface. Apoptosis, 16: 162–173.[19]
  6. Liao, W, Fujita K, Xiao Q, Tchikov V, Yang W, Gunsor, M, Garfield S, Goldsmith, P. El-Deiry WS, Schutze S, and Srinivasula SM. (2009). CARP1 Regulates Induction of NF-κB by TNF-a. Current Biology. 19: R17-R19[20]
  7. Liao, W, Xiao Q, Tchikov V, Fujita K, Yang W, Wincovitch S, Garfield S, Schutze S, El-Deiry WS, and Srinivasula SM. (2008). CARP-2 is an endosome-associated ubiquitin ligase for RIP and regulates TNF-induced NF-?B activation. Current Biology (article). 18: 641–9.[21]
  8. Srinivasula SM, Jones JM., Datta P., Ji W., Gupta S., Zhang Z., Davies E., Hajnóczky G., Saunders TL., Van Keuren ML., Alnemri T., Meisler ML and Alnemri ES. (2003). Loss of Omi/HtrA2 protease activity causes the neuromuscular disorder of mnd2 mutant mice. Nature. 425: 721–727.[22]
  9. Srinivasula SM, Datta P, Kobayashi M, Wu J-W, Fujioka M, Hegde R, Zhang Z, Mukattash, Fernandes-Alnemri T, Shi Y, Jaynes JB, Alnemri ES. (2002). Sickle, a novel Drosophila death gene in the reaper/hid/grim region encodes an IAP-inhibitory protein. Curr Biol. 12: 125–30.[23]
  10. Srinivasula SM, Hegde R, Saleh A, Datta P, Shiozaki E, Chai J, Lee RA., Robbins PD, Fernandes-Alnemri T, Shi Y., Alnemri ES. (2001). A conserved XIAP-interaction motif in caspase-9 and Smac/Diablo regulates caspase activity and apoptosis. Nature. 410: 112–16.[24]
  11. Srinivasula SM, Saleh A, Balkir L, Robbins PD, and Alnemri ES. (2000). Negative regulation of the Apaf-1 apoptosome by Hsp70. Nature Cell Biol 2: 476–483.[25]

Book chapters

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  1. Fujita, K and Srinivasula SM. (2009). Ubiquitination and Death-receptor signaling. Death Receptors and Cognate Ligands in Cancer. Results Probl Cell Differ, SpringerLinks Publisher. 49: 87-114.[26]
  2. Srinivasula SM, Saleh A, Ahmad M, Fernandes-Alnemri T, Alnemri ES. (2001). Isolation and Assay of Caspases. Ch. 1. Methods in Cell Biol. 66:1-27.[27]
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References

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  1. ^ "IRINS Profile page".
  2. ^ "Google Scholar profile".
  3. ^ "NIH PI".
  4. ^ "Linkedin profile".
  5. ^ "COVID-19: IISER, IIST suspend classes". The Hindu. 14 March 2020. ISSN 0971-751X. Retrieved 26 August 2020.
  6. ^ "Prof. S. Murty Srinivasula - Personal | IISER Thiruvananthapuram". www.iisertvm.ac.in. Retrieved 26 August 2020.
  7. ^ "Senate committee".
  8. ^ "Building and work committee IISER TVM".
  9. ^ "students_grievance_committee".
  10. ^ "students_grievance_committee" (PDF).
  11. ^ "SC/ST cell" (PDF).
  12. ^ "Deputy Director | IISER Thiruvananthapuram". www.iisertvm.ac.in. Retrieved 17 June 2022.
  13. ^ "Indian Research Information Network System".
  14. ^ "INDIAN RESEARCH INFORMATION NETWORK SYSTEM". irins.inflibnet.ac.in. Retrieved 26 August 2020.
  15. ^ Gan, Xiaoqing; Wang, Jiyong; Wang, Chen; Sommer, Eeva; Kozasa, Tohru; Srinivasula, Srinivasa; Alessi, Dario; Offermanns, Stefan; Simon, Melvin I.; Wu, Dianqing (20 May 2012). "PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12". Nature Cell Biology. 14 (7): 686–696. doi:10.1038/ncb2507. ISSN 1476-4679. PMC 3389271. PMID 22609986.
  16. ^ Li, Peng; Nijhawan, Deepak; Budihardjo, Imawati; Srinivasula, Srinivasa M; Ahmad, Manzoor; Alnemri, Emad S; Wang, Xiaodong (November 1997). "Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade". Cell. 91 (4): 479–489. doi:10.1016/S0092-8674(00)80434-1. PMID 9390557.
  17. ^ Fujita, Ken-Ichi; Srinivasula, Srinivasa M. (May 2011). "TLR4-mediated autophagy in macrophages is a p62-dependent type of selective autophagy of aggresome-like induced structures (ALIS)". Autophagy. 7 (5): 552–554. doi:10.4161/auto.7.5.15101. ISSN 1554-8635. PMC 3127216. PMID 21412052.
  18. ^ Fujita, Ken-ichi; Maeda, Daisuke; Xiao, Qi; Srinivasula, Srinivasa M. (25 January 2011). "Nrf2-mediated induction of p62 controls Toll-like receptor-4-driven aggresome-like induced structure formation and autophagic degradation". Proceedings of the National Academy of Sciences of the United States of America. 108 (4): 1427–1432. Bibcode:2011PNAS..108.1427F. doi:10.1073/pnas.1014156108. ISSN 1091-6490. PMC 3029726. PMID 21220332.
  19. ^ Shukla, Sudhanshu; Fujita, Ken-ichi; Xiao, Qi; Liao, Zhiyong; Garfield, Susan; Srinivasula, Srinivasa M. (25 November 2010). "A shear stress responsive gene product PP1201 protects against Fas-mediated apoptosis by reducing Fas expression on the cell surface". Apoptosis. 16 (2): 162–173. doi:10.1007/s10495-010-0556-y. ISSN 1360-8185. PMC 6993143. PMID 21107705.
  20. ^ Liao, Wentao; Fujita, Ken-ichi; Xiao, Qi; Tchikov, Vladimir; Yang, Wensheng; Gunsor, Michele; Garfield, Susan; Goldsmith, Paul; El-Deiry, Wafik S.; Schutze, Stefan; Srinivasula, Srinivasa M. (13 January 2009). "Response: CARP1 regulates induction of NF-κB by TNFα". Current Biology. 19 (1): R17–R19. doi:10.1016/j.cub.2008.11.041. ISSN 0960-9822.
  21. ^ Liao, Wentao; Xiao, Qi; Tchikov, Vladimir; Fujita, Ken-ichi; Yang, Wensheng; Wincovitch, Stephen; Garfield, Susan; Conze, Dietrich; El-Deiry, Wafik S.; Schütze, Stefan; Srinivasula, Srinivasa M. (6 May 2008). "CARP-2 is an endosome-associated ubiquitin ligase for RIP and regulates TNF-induced NF-kappaB activation". Current Biology. 18 (9): 641–649. doi:10.1016/j.cub.2008.04.017. ISSN 0960-9822. PMC 2587165. PMID 18450452.
  22. ^ Jones, Julie M.; Datta, Pinaki; Srinivasula, Srinivasa M.; Ji, Weizhen; Gupta, Sanjeev; Zhang, ZhiJia; Davies, Erika; Hajnóczky, György; Saunders, Thomas L.; Van Keuren, Margaret L.; Fernandes-Alnemri, Teresa (16 October 2003). "Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice". Nature. 425 (6959): 721–727. Bibcode:2003Natur.425..721J. doi:10.1038/nature02052. hdl:2027.42/62561. ISSN 1476-4687. PMID 14534547. S2CID 4372496.
  23. ^ Srinivasula, Srinivasa M.; Datta, Pinaki; Kobayashi, Masatomo; Wu, Jia Wei; Fujioka, Miki; Hegde, Ramesh; Zhang, ZhiJia; Mukattash, Rula; Fernandes-Alnemri, Teresa; Shi, Yigong; Jaynes, James B. (22 January 2002). "sickle, a novel Drosophila death gene in the reaper/hid/grim region, encodes an IAP-inhibitory protein". Current Biology. 12 (2): 125–130. doi:10.1016/s0960-9822(01)00657-1. ISSN 0960-9822. PMC 2743937. PMID 11818063.
  24. ^ Srinivasula, S. M.; Hegde, R.; Saleh, A.; Datta, P.; Shiozaki, E.; Chai, J.; Lee, R. A.; Robbins, P. D.; Fernandes-Alnemri, T.; Shi, Y.; Alnemri, E. S. (1 March 2001). "A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis". Nature. 410 (6824): 112–116. Bibcode:2001Natur.410..112S. doi:10.1038/35065125. ISSN 0028-0836. PMID 11242052. S2CID 4380050.
  25. ^ Saleh, A.; Srinivasula, S. M.; Balkir, L.; Robbins, P. D.; Alnemri, E. S. (August 2000). "Negative regulation of the Apaf-1 apoptosome by Hsp70". Nature Cell Biology. 2 (8): 476–483. doi:10.1038/35019510. ISSN 1465-7392. PMID 10934467. S2CID 20374981.
  26. ^ Death Receptors and Cognate Ligands in Cancer (PDF). Results and Problems in Cell Differentiation. Vol. 49. 2009. doi:10.1007/978-3-642-03045-1. ISBN 978-3-642-03044-4.
  27. ^ Srinivasula, Srinivasa M.; Saleh, Ayman; Ahmad, Manzoor; Fernandes-Alnemri, Teresa; Alnemri, Emad S. (1 January 2001). "Chapter 1 Isolation and assay of caspases". Apoptosis. Methods in Cell Biology. Vol. 66. Academic Press. pp. 1–27. doi:10.1016/S0091-679X(01)66002-3. ISBN 9780125441650. PMID 11395999. Retrieved 19 April 2020.
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