From Wikipedia, the free encyclopedia
Serpin A9 also known as centerin or GCET1 is a protein that in humans is encoded by the SERPINA9 gene located on chromosome 14q 32.1.[ 5] serpin family of ser ine p rotease in hibitors.
Function
The expression of SERPINA9 is restricted to germinal center B cells and lymphoid malignancies . SERPINA9 is likely to function in vivo in the germinal center as an efficient inhibitor of trypsin-like proteases.[ 6] [ 7] [ 8]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000170054 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000058260 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: SERPINA9" .^ Paterson MA, Horvath AJ, Pike RN, Coughlin PB (August 2007). "Molecular characterization of centerin, a germinal centre cell serpin" . Biochem. J . 405 (3): 489–94. doi :10.1042/BJ20070174 . PMC 2267310 PMID 17447896 . ^ Montes-Moreno S, Roncador G, Maestre L, Martínez N, Sanchez-Verde L, Camacho FI, Cannata J, Martinez-Torrecuadrada JL, Shen Y, Chan WC, Piris MA (January 2008). "Gcet1 (centerin), a highly restricted marker for a subset of germinal center-derived lymphomas" . Blood . 111 (1): 351–8. doi :10.1182/blood-2007-06-094151 PMID 17898315 . ^ Paterson MA, Hosking PS, Coughlin PB (July 2008). "Expression of the serpin centerin defines a germinal center phenotype in B-cell lymphomas" . Am. J. Clin. Pathol . 130 (1): 117–26. doi :10.1309/9QKE68QU7B825A3U PMID 18550480 .
Further reading
Luke MM, O'Meara ES, Rowland CM, et al. (2009). "Gene variants associated with ischemic stroke: the cardiovascular health study" . Stroke . 40 (2): 363–8. doi :10.1161/STROKEAHA.108.521328 . PMC 2881155 PMID 19023099 . Frazer JK, Jackson DG, Gaillard JP, et al. (2000). "Identification of centerin: a novel human germinal center B cell-restricted serpin" . Eur. J. Immunol . 30 (10): 3039–48. doi :10.1002/1521-4141(200010)30:10<3039::AID-IMMU3039>3.0.CO;2-H PMID 11069088 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Morrison AC, Bare LA, Luke MM, et al. (2008). "Single nucleotide polymorphisms associated with coronary heart disease predict incident ischemic stroke in the atherosclerosis risk in communities study" . Cerebrovasc. Dis . 26 (4): 420–4. doi :10.1159/000155637 . PMC 2662496 PMID 18799872 . Shiffman D, O'Meara ES, Bare LA, et al. (2008). "Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study" . Arterioscler. Thromb. Vasc. Biol . 28 (1): 173–9. doi :10.1161/ATVBAHA.107.153981 . PMC 2636623 PMID 17975119 . Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment" . Genome Res . 13 (10): 2265–70. doi :10.1101/gr.1293003 . PMC 403697 PMID 12975309 . Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 . PMC 139241 PMID 12477932 . Montes-Moreno S, Roncador G, Maestre L, et al. (2008). "Gcet1 (centerin), a highly restricted marker for a subset of germinal center-derived lymphomas" . Blood . 111 (1): 351–8. doi :10.1182/blood-2007-06-094151 PMID 17898315 . Pan Z, Shen Y, Du C, et al. (2003). "Two newly characterized germinal center B-cell-associated genes, GCET1 and GCET2, have differential expression in normal and neoplastic B cells" . Am. J. Pathol . 163 (1): 135–44. doi :10.1016/S0002-9440(10)63637-1 . PMC 1868163 PMID 12819018 . Namciu SJ, Friedman RD, Marsden MD, et al. (2004). "Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1". Mamm. Genome . 15 (3): 162–78. doi :10.1007/s00335-003-2311-y . PMID 15014966 .
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