Iotroxic acid

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Iotroxic acid
Clinical data
Trade namesBiliscopin, others
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
  • 3-{2-[2-(2-{[(3-carboxy-2,4,6-triiodophenyl)carbamoyl]methoxy}ethoxy)ethoxy]acetamido}-2,4,6-triiodobenzoic acid
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.051.726 Edit this at Wikidata
Chemical and physical data
FormulaC22H18I6N2O9
Molar mass1215.818 g·mol−1
3D model (JSmol)
  • O=C(Nc1c(I)c(c(I)cc1I)C(=O)O)COCCOCCOCC(=O)Nc2c(I)c(C(=O)O)c(I)cc2I

Iotroxic acid, also known as meglumine iotroxate, is a molecule used as a contrast medium during X-rays.[1][2] It is specifically used during tests looking at the gallbladder and biliary tract.[2] It is given by slow injection into a vein.[2]

Side effects are uncommon.[3] They include vomiting, skin flushing, headache, itchiness, and low blood pressure.[2] Rare side effects include seizures and allergic reactions.[2] It should not be used by those who have a iodine allergy.[2] Iotroxic acid is an iodine containing contrast media of the diionic dimer type.[4]

Iotroxic acid was first made in 1976.[5] It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system.[6] It is rarely used in the developed world due to the availability of magnetic resonance cholangiopancreatography (MRCP).[7]

References

  1. ^ "Iotroxic Acid - Drugs.com". www.drugs.com. Archived from the original on 31 December 2016. Retrieved 31 December 2016.
  2. ^ a b c d e f World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. pp. 315, 318. hdl:10665/44053. ISBN 9789241547659.
  3. ^ Neugebauer, Edmund; Sauerland, Stefan (2014). Recommendations for evidence-based endoscopic surgery: The updated EAES consensus development conferences. Springer Science & Business Media. p. 67. ISBN 9782817808499. Archived from the original on 2017-01-01.
  4. ^ Schaefer, Christof; Peters, Paul W. J.; Miller, Richard K. (2014). Drugs During Pregnancy and Lactation: Treatment Options and Risk Assessment. Academic Press. p. 532. ISBN 9780124079014. Archived from the original on 2017-01-01.
  5. ^ Korolkovas, Andrejus (1988). Essentials of Medicinal Chemistry. Wiley. p. 1063. ISBN 9780471883562. Archived from the original on 2017-01-01.
  6. ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  7. ^ Sherlock, Shiela; Dooley, James (2008). Diseases of the Liver and Biliary System. John Wiley & Sons. p. 568. ISBN 9780470986813. Archived from the original on 2017-01-01.

External links

  • "Iotroxic Acid". Drug Information Portal. U.S. National Library of Medicine.


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