At age 15, Hill and friends were participating in a soccer tournament in Park City, Utah. While on their way to a round of golf, a college student narrowly missed Hill's car and slammed into his mother's car following behind him. Hill's mother, Vicki, was killed as a result.
Hill was originally drafted by the Anaheim Angels in the 7th round of the June 2000 Draft. Hill turned down the offer, opting to attend Louisiana State University and play for the varsity Tigers baseball team. While at LSU, Hill posted a career .335 batting average with 23 home runs and 150 RBIs.
On April 4, 2008, Hill agreed to a four-year, $12 million deal that included a club option that could have run through the 2014 season. The contract would have been worth as much as $38 million if Toronto kept Hill in the fold for all seven years of the deal.
Hill returned from his concussion during spring training. On July 5, 2009, Hill was selected by managers and players to take part in the 2009 MLB All-Star Game in St. Louis. Hill finished the 2009 season with 37 doubles, 36 home runs, 108 runs batted in, and a batting average of .286. After the season, Hill received the 2009 AL Comeback Player of the Year. He was voted the Blue Jays Player of the Year. He was also honored with his second Fielding Bible Award.
Prior to the first game of the 2011 season, the Blue Jays announced that they had declined the three option years on Hill's contract. Hill was placed on the 15-day disabled list on April 24, retroactive to April 20, with a strained hamstring.
In Game 4 of the 2011 NLDS, Hill hit his first postseason home run. The Diamondbacks would, however, lose the division series to the Milwaukee Brewers in 5 games.
After the 2011 season, the Diamondbacks resigned Hill to a 2-year, $11 million contract extension.
On April 7, 2012, Hill, who got moved up in the order to the #2 spot, went 2-4 with 3 RBI and 2 home runs against the Giants in the 1st and 2nd innings, both off of Madison Bumgarner. This came after going 0-4 on Opening Day while hitting 8th. The D-Backs went on to win 5-4.