Nedocromil

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Nedocromil
Structural formula of nedocromil
Space-filling model of the nedocromil molecule
Clinical data
Trade names Alocril
AHFS/Drugs.com Monograph
MedlinePlus a601243
Routes of
administration
Inhalation and eye drops
ATC code
Legal status
Legal status
Pharmacokinetic data
Protein binding 89%
Metabolism not metabolized
Biological half-life ~3.3 hours
Excretion excreted unchanged
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard 100.233.208
Chemical and physical data
Formula C19H17NO7
Molar mass 371.341 g/mol
3D model (Jmol)
  (verify)

Nedocromil sodium is a medication considered as mast cell stabilizer which act to prevent wheezing, shortness of breath, and other breathing problems caused by asthma. It is administered by an inhaler under the brand name Tilade (although its effects in this form are far less than those in albuterol or other well-known inhaler medications) and as an eye drop under the brand name Alocril.[1][2] Liquid preparations are available in the UK under the name Rapitil for use for allergic eye reactions.[3]

Nedocromil is classified as a benzopyrone. Nedocromil acts as a mast cell stabilizer, inhibits the degranulation of mast cells, prevents release of histamine and tryptase, so preventing the synthesis of prostaglandins and leukotrienes. US Production of inhaled nedocromil ceased in April 2008.[4]

References[edit]

Media related to Nedocromil at Wikimedia Commons