BSPP (drug)

BSPP
Clinical data
ATC code	none;
Identifiers
	IUPAC name 2,6-di-tert-butyl-4-{[1-(hydroxymethyl)cyclopentyl]methyl}phenol;
PubChem CID	16079861;
ChemSpider	17238838 ;
CompTox Dashboard (EPA)	DTXSID001028427 ;
Chemical and physical data
Formula	C21H34O2
Molar mass	318.492 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C(C)(C)(C)C1=C(C(=CC(=C1)CC1(CCCC1)CO)C(C)(C)C)O;
	InChI InChI=1S/C21H34O2/c1-19(2,3)16-11-15(12-17(18(16)23)20(4,5)6)13-21(14-22)9-7-8-10-21/h11-12,22-23H,7-10,13-14H2,1-6H3 ; Key:CTFKOMUXSHQLLL-UHFFFAOYSA-N ;
	(verify)

BSPP is a compound used in scientific research which acts as a positive allosteric modulator at the GABA_B receptor.^[1] It has a synergistic effect with GABA_B agonists such as baclofen at GABA_B autoreceptors but not heteroreceptors, suggesting it may be useful for distinguishing between these GABA_B receptor subtypes.^[2]

References

^ Kerr DIB, Khalafy J, Ong J, Perkins MV, Prager RH, Puspawati NM, Rimaz M. Synthesis and Biological Activity of Allosteric Modulators of GABAB Receptors, Part 2. 3-(2,6-Bis-tert-butyl-4-hydroxyphenyl)propanols. Australian Journal of Chemistry. 2006;59:457-462.
^ Parker DA, Marino V, Ong J, Puspawati NM, Prager RH. The CGP7930 analogue 2,6-di-tert-butyl-4-(3-hydroxy-2-spiropentylpropyl)-phenol (BSPP) potentiates baclofen action at GABA(B) autoreceptors. Clinical and Experimental Pharmacology and Physiology. 2008 Sep;35(9):1113-5. PMID 18430050

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[1] Kerr DIB, Khalafy J, Ong J, Perkins MV, Prager RH, Puspawati NM, Rimaz M. Synthesis and Biological Activity of Allosteric Modulators of GABAB Receptors, Part 2. 3-(2,6-Bis-tert-butyl-4-hydroxyphenyl)propanols. Australian Journal of Chemistry. 2006;59:457-462.

[2] Parker DA, Marino V, Ong J, Puspawati NM, Prager RH. The CGP7930 analogue 2,6-di-tert-butyl-4-(3-hydroxy-2-spiropentylpropyl)-phenol (BSPP) potentiates baclofen action at GABA(B) autoreceptors. Clinical and Experimental Pharmacology and Physiology. 2008 Sep;35(9):1113-5. PMID 18430050

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