CRYAA

CRYAA
Identifiers
Aliases	CRYAA, CRYA1, CTRCT9, HSPB4, crystallin alpha A
External IDs	OMIM: 123580; MGI: 88515; HomoloGene: 48053; GeneCards: CRYAA; OMA:CRYAA - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	43,172,805 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	31,900,707 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; duodenum; ; prefrontal cortex; ; human kidney; ; primary visual cortex; ; temporal lobe; ; amygdala; ; hippocampus proper; ; anterior cingulate cortex; ; caudate nucleus;
	Top expressed in
	lens; ; epithelium of lens; ; corneal stroma; ; neural layer of retina; ; ciliary body; ; conjunctival fornix; ; retinal pigment epithelium; ; iris; ; decidua; ; gastrula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	unfolded protein binding; protein binding; metal ion binding; structural constituent of eye lens; identical protein binding;
Cellular component	cytoplasm; nucleus; nucleoplasm; cytosol;
Biological process	negative regulation of intracellular transport; negative regulation of apoptotic process; protein homooligomerization; protein refolding; response to stimulus; visual perception; protein stabilization;
	Sources:Amigo / QuickGO
Orthologs
	1409
	12954
	ENSG00000160202
	ENSMUSG00000024041
	P02489
	P24622
	NM_000394; NM_001363766
	NM_001278569; NM_001278570; NM_013501
	NP_000385; NP_001350695; NP_001300979; NP_001307648
	NP_001265498; NP_001265499; NP_038529
	Wikidata
View/Edit Human	View/Edit Mouse

Alpha-crystallin A chain is a protein that in humans is encoded by the CRYAA gene.^[5]

Interactions

CRYAA has been shown to interact with CRYBB2,^[6] Hsp27,^[6] CRYGC^[6] and CRYAB.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000160202 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024041 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: CRYAA crystallin, alpha A".
^ ^a ^b ^c ^d Fu, Ling; Liang Jack J-N (Feb 2002). "Detection of protein-protein interactions among lens crystallins in a mammalian two-hybrid system assay". J. Biol. Chem. 277 (6). United States: 4255–60. doi:10.1074/jbc.M110027200. ISSN 0021-9258. PMID 11700327. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help)CS1 maint: unflagged free DOI (link)

Human CRYAA genome location and CRYAA gene details page in the UCSC Genome Browser.