Calicivirin
| Calicivirin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.4.22.66 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Calicivirin (EC 3.4.22.66, Camberwell virus processing peptidase, Chiba virus processing peptidase, Norwalk virus processing peptidase, Southampton virus processing peptidase, norovirus virus processing peptidase, calicivirus trypsin-like cysteine protease, calicivirus TCP, calicivirus 3C-like protease, calicivirus endopeptidase, rabbit hemorrhagic disease virus 3C endopeptidase) is an enzyme.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- Endopeptidase with a preference for cleavage when the P1 position is occupied by Glu- and the P1- position is occupied by Gly-
Viruses that are members of the Norovirus genus (Caliciviridae family) are a major cause of epidemic acute viral gastroenteritis.
References
- ^ Meyers, G.; Rossi, C.; Thiel, H.J. (2004). "Calicivirus endopeptidases". In Barrett, A.J.; Rawlings, N.D.; Woessner, J.F. (eds.). Handbook of Proteolytic Enzymes (2nd ed.). London: Elsevier. pp. 1380–1382.
- ^ Wirblich, C.; Sibilia, M.; Boniotti, M.B.; Rossi, C.; Thiel, H.J.; Meyers, G. (1995). "3C-like protease of rabbit hemorrhagic disease virus: identification of cleavage sites in the ORF1 polyprotein and analysis of cleavage specificity". J. Virol. 69: 7159–7168. PMID 7474137.
- ^ Martin Alonso, J.M.; Casais, R.; Boga, J.A.; Parra, F. (1996). "Processing of rabbit hemorrhagic disease virus polyprotein". J. Virol. 70: 1261–1265. PMID 8551592.
- ^ Liu, B.; Clarke, I.N.; Lambden, P.R. (1996). "Polyprotein processing in Southampton virus: identification of 3C-like protease cleavage sites by in vitro mutagenesis". J. Virol. 70: 2605–2610. PMID 8642693.
- ^ Liu, B.L.; Viljoen, G.J.; Clarke, I.N.; Lambden, P.R. (1999). "Identification of further proteolytic cleavage sites in the Southampton calicivirus polyprotein by expression of the viral protease in E. coli". J. Gen. Virol. 80: 291–296. PMID 10073687.
External links
- Calicivirin at the U.S. National Library of Medicine Medical Subject Headings (MeSH)