Cathepsin H

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Cathepsin H
Protein CTSH PDB 1nb3.png
PDB rendering based on 1nb3.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CTSH ; ACC-4; ACC-5; ACC4; ACC5; CPSB; minichain
External IDs OMIM116820 MGI107285 HomoloGene36159 ChEMBL: 2225 GeneCards: CTSH Gene
EC number
RNA expression pattern
PBB GE CTSH 202295 s at tn.png
More reference expression data
Species Human Mouse
Entrez 1512 13036
Ensembl ENSG00000103811 ENSMUSG00000032359
UniProt P09668 P49935
RefSeq (mRNA) NM_004390 NM_007801
RefSeq (protein) NP_004381 NP_031827
Location (UCSC) Chr 15:
78.92 – 78.95 Mb
Chr 9:
90.05 – 90.08 Mb
PubMed search [1] [2]

Cathepsin H is a protein that in humans is encoded by the CTSH gene.[1][2]

The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. Two transcript variants encoding different isoforms have been found for this gene.[2]


  1. ^ Fuchs R, Machleidt W, Gassen HG (Feb 1989). "Molecular cloning and sequencing of a cDNA coding for mature human kidney cathepsin H". Biol Chem Hoppe Seyler 369 (6): 469–75. doi:10.1515/bchm3.1988.369.1.469. PMID 2849458. 
  2. ^ a b "Entrez Gene: CTSH cathepsin H". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: C01.040