Caspase 14

CASP14
Identifiers
Aliases	CASP14, caspase 14, ARCI12
External IDs	OMIM: 605848; MGI: 1335092; HomoloGene: 36304; GeneCards: CASP14; OMA:CASP14 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	15,058,293 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	78,554,128 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; skin of leg; ; skin of arm; ; vulva; ; testicle; ; vagina; ; human penis; ; skin of thigh; ; tibialis anterior muscle; ; mucosa of ileum;
	Top expressed in
	lip; ; esophagus; ; skin of back; ; belly cord; ; skin of abdomen; ; skin of external ear; ; left colon; ; sexually immature organism; ; epidermis; ; cornea;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase activity; cysteine-type endopeptidase activity; cysteine-type peptidase activity; protein binding; hydrolase activity; endopeptidase activity; cysteine-type endopeptidase activity involved in execution phase of apoptosis; cysteine-type endopeptidase activity involved in apoptotic process;
Cellular component	cytoplasm; keratin filament; nucleus; cytosol; mitochondrion;
Biological process	cornification; cell differentiation; keratinization; proteolysis; epidermis development; execution phase of apoptosis; apoptotic process; intrinsic apoptotic signaling pathway in response to DNA damage;
	Sources:Amigo / QuickGO
Orthologs
	23581
	12365
	ENSG00000105141
	ENSMUSG00000005355
	P31944
	O89094
	NM_012114
	NM_009809
	NP_036246
	NP_033939
	Wikidata
View/Edit Human	View/Edit Mouse

Caspase 14 is an enzyme that in humans is encoded by the CASP14 gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105141 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000005355 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Van de Craen M, Van Loo G, Pype S, Van Criekinge W, Van den brande I, Molemans F, Fiers W, Declercq W, Vandenabeele P (May 1999). "Identification of a new caspase homologue: caspase-14". Cell Death Differ. 5 (10): 838–46. doi:10.1038/sj.cdd.4400444. PMID 10203698.
^ Hu S, Snipas SJ, Vincenz C, Salvesen G, Dixit VM (Dec 1998). "Caspase-14 is a novel developmentally regulated protease". J Biol Chem. 273 (45): 29648–53. doi:10.1074/jbc.273.45.29648. PMID 9792675.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ "Entrez Gene: CASP14 caspase 14, apoptosis-related cysteine peptidase".

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

v t e Proteases: cysteine proteases (EC 3.4.22)
Caspase	Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase 13 Caspase 14
Fruit-derived	Papain Ficain Bromelain Actinidain
Calpain	CAPN1 CAPN2 CAPN3 CAPN5 CAPN6 CAPN7 CAPN8 CAPN9 CAPN10 CAPN11 CAPN12 CAPN13 CAPN14 CAPNS1 CAPNS2
Cathepsin	B C F H K L1/L2 O S W Z
Other	Clostripain Cancer procoagulant Separase Autophagin Cruzipain 3C-like protease Gingipain R Gingipain K