|Classification and external resources|
|ICD-10||N00, N01, N03, N05|
Nephritic syndrome (or acute nephritic syndrome) is a syndrome comprising signs of nephritis, which is kidney disease involving inflammation. It often occurs in glomerulonephritis, which is characterized by a thin glomerular basement membrane and small pores in the podocytes of the glomerulus, large enough to permit proteins and red blood cells to pass into the urine (yielding proteinuria and hematuria). By contrast, nephrotic syndrome is characterized by only proteins moving into the urine. Nephritic syndrome, like nephrotic syndrome, may involve hypoalbuminemia due to the protein albumin moving from the blood to the urine.[medical citation needed]
Signs and symptoms
Symptoms consistent with nephritic syndrome are:
- Hematuria (blood in the urine)
- Proteinuria (protein in the urine)
- Blurred vision
- Oliguria (low urine output <400 mL/day)
Nephritic syndrome is caused by inflammation of glomerulus and has urine waste, furthermore the cause can be infectious, autoimmune or thrombotic. The causes can be divided between age groups as follows:
- IgA nephropathy
- Post-streptococcal glomerulonephritis
- Hemolytic uremic syndrome
- Henoch–Schönlein purpura
The pathophysiology of nephritic syndrome is dependent on where damage is done by antibody-antigen complexes (in glomerulus). In the case of IgA nephropathy, the glomerulus cannot filter IgA antibody-antigen, and this causes an inflammatory response, then release of cytokines (and growth factors), and finally results in glomerular scarring.
Treatment of nephritic syndrome is consistent with administration of antihypertensives and anti-inflammatory medication. Furthermore, a reduction in potassium (K+) and salt, as well as physical rest.
Because nephritic syndrome is not a disease, the prognosis depends on the underlying etiology. The prognosis of nephritic syndome in children due to post-streptococcal glomerulonephritis is [clarify].
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