DCP2

DCP2
Identifiers
Aliases	DCP2, NUDT20, decapping mRNA 2
External IDs	OMIM: 609844; MGI: 1917890; HomoloGene: 13968; GeneCards: DCP2; OMA:DCP2 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	113,022,195 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	44,558,036 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; trabecular bone; ; sperm; ; parietal pleura; ; placenta; ; monocyte; ; bone marrow; ; visceral pleura; ; epithelium of nasopharynx;
	Top expressed in
	hand; ; otolith organ; ; utricle; ; primitive streak; ; superior cervical ganglion; ; vas deferens; ; condyle; ; vestibular membrane of cochlear duct; ; abdominal wall; ; trigeminal ganglion;
	More reference expression data
	n/a
Gene ontology
Molecular function	m7G(5')pppN diphosphatase activity; manganese ion binding; metal ion binding; protein binding; exoribonuclease activity, producing 5'-phosphomonoesters; RNA binding; hydrolase activity; 5'-3' exoribonuclease activity; telomerase RNA binding;
Cellular component	cytoplasm; RISC complex; cytosol; P-body; nucleoplasm; cell junction; nucleus; cytoplasmic ribonucleoprotein granule;
Biological process	mRNA catabolic process; regulation of mRNA stability; deadenylation-dependent decapping of nuclear-transcribed mRNA; exonucleolytic catabolism of deadenylated mRNA; histone mRNA catabolic process; RNA phosphodiester bond hydrolysis, exonucleolytic; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; negative regulation of telomere maintenance via telomerase; regulation of telomerase RNA localization to Cajal body;
	Sources:Amigo / QuickGO
Orthologs
	167227
	70640
	ENSG00000172795
	ENSMUSG00000024472
	Q8IU60
	Q9CYC6
	NM_001242377; NM_152624
	NM_027490
	NP_001229306; NP_689837
	NP_081766
	Wikidata
View/Edit Human	View/Edit Mouse

mRNA-decapping enzyme 2 is a protein that in humans is encoded by the DCP2 gene.^[5]^[6]^[7]

Template:PBB Summary

Interactions

DCP2 has been shown to interact with DCP1A^[8] and UPF1.^[6]^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000172795 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024472 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wang Z, Jiao X, Carr-Schmid A, Kiledjian M (Oct 2002). "The hDcp2 protein is a mammalian mRNA decapping enzyme pro-caratine". Proc Natl Acad Sci U S A. 99 (20): 12663–8. doi:10.1073/pnas.192445599. PMC 130517. PMID 12218187.
^ ^a ^b Lykke-Andersen J (Nov 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay". Mol Cell Biol. 22 (23): 8114–21. doi:10.1128/MCB.22.23.8114-8121.2002. PMC 134073. PMID 12417715.
^ "Entrez Gene: DCP2 DCP2 decapping enzyme homolog (S. cerevisiae)".
^ Lykke-Andersen, Jens (Dec 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay". Mol. Cell. Biol. 22 (23). United States: 8114–21. doi:10.1128/MCB.22.23.8114-8121.2002. ISSN 0270-7306. PMC 134073. PMID 12417715. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Lejeune, Fabrice; Li Xiaojie; Maquat Lynne E (Sep 2003). "Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities". Mol. Cell. 12 (3). United States: 675–87. doi:10.1016/S1097-2765(03)00349-6. ISSN 1097-2765. PMID 14527413. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help)

Interactions

References

Further reading