Drotaverine

Drotaverine
Clinical data
Trade names	No-Spa
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral, intravenous, intramuscular
ATC code	A03AD02 (WHO) ;
Legal status
Legal status	OTC (tablets), ℞-only (solution for injection) (RU);
Pharmacokinetic data
Bioavailability	Highly variable (~65%), peak at 45–60 min
Protein binding	95–98%
Metabolism	Hepatic
Elimination half-life	7–16 hours
Excretion	>50% in urine and ~30% in bile
Identifiers
	IUPAC name (Z)-1-(3,4-diethoxybenzylidene)-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline;
CAS Number	985-12-6 ;
PubChem CID	1712095;
DrugBank	DB06751 ;
ChemSpider	1361582 ;
UNII	98QS4N58TW;
KEGG	D07879 ;
ChEMBL	ChEMBL551978 ;
CompTox Dashboard (EPA)	DTXSID60161227 ;
ECHA InfoCard	100.110.916
Chemical and physical data
Formula	C24H31NO4
Molar mass	397.507 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O(c1ccc(cc1OCC)\C=C3\c2c(cc(OCC)c(OCC)c2)CCN3)CC;
	InChI InChI=1S/C24H31NO4/c1-5-26-21-10-9-17(14-22(21)27-6-2)13-20-19-16-24(29-8-4)23(28-7-3)15-18(19)11-12-25-20/h9-10,13-16,25H,5-8,11-12H2,1-4H3/b20-13- ; Key:OMFNSKIUKYOYRG-MOSHPQCFSA-N ;
	(verify)

Drotaverine (INN, also known as drotaverin) is an antispasmodic drug, used to enhance cervical dilation during childbirth.^[2]^: 283

It is structurally related to papaverine, is a selective inhibitor of phosphodiesterase 4, and has no anticholinergic effects.^[3]

It is available in Asian and Eastern European countries under several brand names, with No-Spa being one of them.^[4]^[5]

References

^ ^a ^b "Инструкция по применению препарата Но-шпа^® // No-Spa^® (tablets) Full Prescribing Information". National Register of Drugs (in Russian). Chinoin Pharmaceutical and Chemical Works. pp. 3–8.
^ Padubidri V and Anand E. Title Textbook of Obstetrics. BI Publications Pvt Ltd, 2006 ISBN 9788172252236
^ "The DrugBank database: Drotaverine". DrugBank Version 4.1. The Metabolomics Innovation Centre. Retrieved 9 August 2014.
^ Drotaverine - Drugs.com Drugs.com international listings for drotaverine Page accessed June 28, 2015
^ No-Spa - Drugs.com No-Spa contents