GPX2 (gene)

GPX2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2HE3
Identifiers
Aliases	GPX2, GI-GPx, GPRP, GPRP-2, GPx-2, GPx-GI, GSHPX-GI, GSHPx-2, glutathione peroxidase 2
External IDs	OMIM: 138319; MGI: 106609; HomoloGene: 20479; GeneCards: GPX2; OMA:GPX2 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	64,942,746 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	76,842,273 bp
RNA expression pattern
	Top expressed in
	gallbladder; ; rectum; ; pancreatic ductal cell; ; islet of Langerhans; ; right lobe of liver; ; appendix; ; urinary bladder; ; gums; ; duodenum; ; epithelium of esophagus;
	Top expressed in
	crypt of lieberkuhn of small intestine; ; esophagus; ; large intestine; ; colon; ; duodenum; ; jejunum; ; left colon; ; mucous cell of stomach; ; epithelium of stomach; ; superior surface of tongue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	electron transfer activity; oxidoreductase activity; glutathione peroxidase activity; peroxidase activity;
Cellular component	cytoplasm; cytosol;
Biological process	response to oxidative stress; cellular oxidant detoxification; cellular response to oxidative stress; electron transport chain;
	Sources:Amigo / QuickGO
Orthologs
	2877
	14776
	ENSG00000176153
	ENSMUSG00000042808
	P18283
	Q9JHC0
	NM_002083
	NM_030677
	NP_002074
	NP_109602
	Wikidata
View/Edit Human	View/Edit Mouse

Glutathione peroxidase 2 is an enzyme that in humans is encoded by the GPX2 gene.^[5]^[6]^[7]

Template:PBB Summary

The antioxidant enzyme glutathione peroxidase 2 (Gpx2) is one out of eight known glutathione peroxidases (Gpx1-8) in humans. Mammalian Gpx1, GPx2 (this protein), Gpx3, and Gpx4 have been shown to be selenium-containing enzymes, whereas Gpx6 is a selenoprotein in humans with cysteine-containing homologues in rodents. In selenoproteins, the 21st amino acid selenocysteine is inserted in the nascent polypeptide chain during the process of translational recoding of the UGA stop codon.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000176153 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042808 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chu FF, Doroshow JH, Esworthy RS (Mar 1993). "Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI". J Biol Chem. 268 (4): 2571–6. PMID 8428933.
^ Chu FF (Feb 1994). "The human glutathione peroxidase genes GPX2, GPX3, and GPX4 map to chromosomes 14, 5, and 19, respectively". Cytogenet Cell Genet. 66 (2): 96–8. doi:10.1159/000133675. PMID 8287691.
^ "Entrez Gene: GPX2 glutathione peroxidase 2 (gastrointestinal)".

v t e Oxidoreductases: peroxidases (EC 1.11)
1.11.1.1-14	NADH peroxidase NADPH peroxidase Fatty-acid peroxidase Catalase Cytochrome c peroxidase Eosinophil peroxidase Glutathione peroxidase GPX 1 2 3 4 5 6 7 8 Horseradish peroxidase Lactoperoxidase Myeloperoxidase Thyroid peroxidase Deiodinase Iodothyronine deiodinase Iodotyrosine deiodinase
1.11.1.15 (peroxiredoxin)	1 2 3 4 5 6

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

References

Further reading