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Javed Agrewala

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Javed Agrewala
Born (1961-05-14) 14 May 1961 (age 63)
Agra, Uttar Pradesh, India
NationalityIndian
EducationDr. B. R. Ambedkar University, Sarojini Naidu Medical College
Known forStudies on Tuberculosis
Awards
Scientific career
Fields
Institutions

Javed Naim Agrewala (born 14 May 1961) is an Indian immunologist and the chief scientist and professor at the Institute of Microbial Technology, Chandigarh. Known for his research on Tuberculosis, Agrewala is an elected fellow of all the three major Indian science academies viz. National Academy of Sciences, India, Indian National Science Academy and Indian Academy of Sciences. The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards for his contributions to Medical Sciences in 2005.[1][note 1] He is also a recipient of the National Bioscience Award for Career Development of the Department of Biotechnology.

Biography

Saranac Laboratory, precursor to the Trudeau Institute

Javed N. Agrewala, born in Agra in the Indian state of Uttar Pradesh, graduated in science from Dr. B. R. Ambedkar University in 1980 and earned a master's degree from the same institution in 1982 after which he did his doctoral studies at Sarojini Naidu Medical College to secure a PhD in 1986.[2] In 1989, he joined Institute of Microbial Technology, Chandigarh as a faculty member and scientist where he has been working since then and serves as the chief scientist and professor.[3] In between, he had two sabbaticals, initially at Royal Postgraduate Medical School of Hammersmith Hospital (1994–1996) and later at Trudeau Institute (2001–2002).[4][note 2] In 2014, he was short-listed among the three possible candidates to become the vice chancellor of the University of Kashmir[5] but the position eventually went to Khurshid Iqbal Andrabi.[6] At IMT, he heads a laboratory, The Agrewala Lab, where he hosts a number of researchers and students engaged in the studies on self-adjuvanting peptide vaccines and immunomodulation therapy[7] and serves as a biosafety officer.[4]

Agrawala lives at IMTECH Housing Sector 39-A in Chandigarh.[8]

Legacy

Tuberculosis – a video explanation

Agrewala's immunological research has been focusing on the host-pathogen interactions and the complex roles played by macrophages and T cells in defense against pathogens.[9] The team led by him studied Caerulomycin A, a pyridine-derived broad-spectrum antiobiotic and its immunosuppressive activity, work that is being developed by Nostrum Pharmaceuticals which bought it for a reported US$ 3 million.[4] His studies identified the migratory properties of CD4+ T cell memory and demonstrated that immune response can be regulated by using costimulatory molecules. His team also developed a vaccination process against intracellular parasites.[10] His work has assisted in widening the understanding of Th1 and Th2 cells and their bi-directional regulation.[11] His current research interests are centered on prophylactic and therapeutic aspects of immunity, the causal factors for developing active tuberculosis, the role played by macrophages in protecting the host and nurturing bacteria at the same time, the pathogenesis of M. tuberculosis from infection to clinical disease status and the signal transmissions between macrophages and effector T cells.[9] His studies have been documented by way of a number of articles[12][13][note 3] of which many have been listed by online article repositories such as Google Scholar[14] and ResearchGate.[15] Besides, he has contributed chapters to books published by others[16][17] and his work has drawn citations in a number of texts.[18][19]

Agrewala has been involved in clinical investigations such as the Department of Innovation, Industry, Science and Research-sponsored project, Novel Vaccine Delivery Systems that Elicit Robust and Enduring T Cell Memory Responses: Alternatives to BCG Vaccination in Tuberculosis Endemic Regions Grant, under the aegis of Australia-India Strategic Research Fund (AISRF) during 2012–16.[20] He is a member of the senate of Academy of Scientific and Innovative Research (AcSIR), a national institute promoting research-based doctoral or post-doctoral degrees[21] and is an associate editor of BMC Immunology journal.[22] He sits in the editorial board PLoS One[23] and has been associated with journals such as Recent Patents on Anti-Infective Drug Discovery, Amino Acids, European Journal of Immunology, Journal of Neuroimmunology, Infection and Immunity, Clinical and Experimental Immunology, The Journal of Infectious Diseases, Journal of Bacteriology, Journal of Proteome Research, Vaccine (journal), Brain, Behavior, and Immunity, Journal of Medical Microbiology, Cancer Letters, International Immunopharmacology , Experimental Parasitology and Current Science as an editorial board member or reviewer.[4][9] He serves as an expert member for Indo-Hungarian bilateral program, Nehru Science Postdoctoral Research Fellowship of the Council of Scientific and Industrial Research and INSPIRE program of the Department of Biotechnology. He is a member of the award selection committee of Shanti Swarup Bhatnagar Prize and the scientist selection committee of Indian Institute of Petroleum.[4] Invited speeches or keynote addresses delivered by him include the international conference on biotechnology jointly organized by National Institute of Interdisciplinary Science and Technology and Biotech Research Society of India in November 2015,[24] the World Congress on Infectious Diseases in London in August 2015,[25] the inaugural lecture at the 82nd Annual Meeting of the Indian Academy of Sciences in November 2016[26][27] and Systems Oncology Conference of Butterfly Cancer Care Foundation in March 2017.[28]

Awards and honors

A Biotechnology Overseas Associate of the Department of Biotechnology and a member of the American Association of Immunologists,[9] Agrewala was elected as a fellow of the National Academy of Sciences, India in 2004.[29] The Council of Scientific and Industrial Research awarded him Shanti Swarup Bhatnagar Prize, one of the highest Indian science awards in 2005.[30] and he received the National Bioscience Award for Career Development of the Department of Biotechnology in 2006.[31] He became an elected fellow of the Indian National Science Academy in 2010[32] and the Indian Academy of Sciences in 2015.[33] He also is a recipient of the New Idea Research Talent Award of the Council of Scientific and Industrial Research.[34]

Selected bibliography

Book chapters

  • Neville Vassallo (editor); M. A. Mir (Chapter author), J. N. Agrewala (Chapter author) (2008). "Dietary Polyphenols in Modulation of the Immune System". Polyphenols and Health: New and Recent Advances. Nova Publishers. pp. 245–. ISBN 978-1-60456-349-8. {{cite book}}: |author1= has generic name (help)
  • Sudhir Gupta (editor), Eugene Butcher (editor), William E. Paul (editor); S. L. Swain (chapter author), J. N. Agrewala (chapter author), D. M. Brown (chapter author), E. Roman (chapter author) (6 December 2012). "Regulation of Memory CD4 T Cells: Generation, Localization and Persistence". Lymphocyte Activation and Immune Regulation IX: Homeostasis and Lymphocyte Traffic. Springer Science & Business Media. pp. 113–. ISBN 978-1-4615-0757-4. {{cite book}}: |author1= has generic name (help)CS1 maint: multiple names: authors list (link)

Articles

  • Nargis Khan, Uthaman Gowthaman, Susanta Pahari, Javed N. Agrewala (2012). "Manipulation of Costimulatory Molecules by Intracellular Pathogens: Veni, Vidi, Vici!!". PLOS Pathogens. 8 (6): e1002676. doi:10.1371/journal.ppat.1002676.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  • Shweta Jain, Sathi Babu Chodisetti, Javed N. Agrewala (2011). "CD40 Signaling Synergizes with TLR-2 in the BCR Independent Activation of Resting B Cells". PLoS One. doi:10.1371/journal.pone.0020651.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  • Uthaman Gowthaman, Javed N. Agrewala (2008). "In Silico Tools for Predicting Peptides Binding to HLA-Class II Molecules: More Confusion than Conclusion". J. Proteome Res. 7 (1): 154–163. doi:10.1021/pr070527b.
  • Susan L. Swain, Javed N. Agrewala, Deborah M. Brown, Dawn M. Jelley-Gibbs, Susanne Golech, Gail Huston, Stephen C. Jones, Cris Kamperschroer, Won-Ha Lee, K. Kai McKinstry, Eulogia Román, Tara Strutt, Nan-ping Weng (2006). "CD4+ T-cell memory: generation and multi-faceted roles for CD4+ T cells in protective immunity to influenza". Immunological Reviews. 211 (1): a. doi:10.1111/j.0105-2896.2006.00388.x. PMC 2266984.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Vasudeva Raghavendra, Vinod Singh, Shrinivas K. Kulkarni, Javed N. Agrewala (2001). "Melatonin enhances Th2 cell mediated immune responses: Lack of sensitivity to reversal by naltrexone or benzodiazepine receptor antagonists". Molecular and Cellular Biochemistry. 221 (1): 57–62. doi:10.1023/A:1010968611716.{{cite journal}}: CS1 maint: multiple names: authors list (link)

Patents

See also

Notes

  1. ^ Long link – please select award year to see details
  2. ^ Please click A and select JN Agrewala to see details
  3. ^ Please see Selected bibliography section

References

  1. ^ "View Bhatnagar Awardees". Shanti Swarup Bhatnagar Prize. 2016. Retrieved 12 November 2016.
  2. ^ "215. Javed N Agrewala". Indian Muslim Legends. 2017.
  3. ^ "Scientific Staff". Institute of Microbial Technology. 2017.
  4. ^ a b c d e "Indian fellow". Indian National Science Academy. 2017.
  5. ^ "New Vice-Chancellor for University of Kashmir". Early Times. 28 August 2014.
  6. ^ "Prof Andrabi appointed as new VC of Kashmir University". DNA India. 17 October 2014.
  7. ^ "Agrewala Lab". Institute of Microbial Technology. 2017.
  8. ^ "NASI fellows". National Academy of Sciences, India. 2017. Archived from the original on 26 July 2013. {{cite web}}: Unknown parameter |deadurl= ignored (|url-status= suggested) (help)
  9. ^ a b c d "Faculty profile". Institute of Microbial Technology. 2017.
  10. ^ "Brief Profile of the Awardee". Shanti Swarup Bhatnagar Prize. 2017.
  11. ^ "Handbook of Shanti Swarup Bhatnagar Prize Winners" (PDF). Council of Scientific and Industrial Research. 1999. p. 71.
  12. ^ "Javed Naim Agrewala on Loop". Loop. 2017.
  13. ^ "Browse by Fellow". Indian Academy of Sciences. 2017.
  14. ^ "On Google Scholar". Google Scholar. 2017.
  15. ^ "On ResearchGate". On ResearchGate. 2017.
  16. ^ Sudhir Gupta (editor), Eugene Butcher (editor), William E. Paul (editor); S. L. Swain (chapter author), J. N. Agrewala (chapter author), D. M. Brown (chapter author), E. Roman (chapter author) (6 December 2012). "Regulation of Memory CD4 T Cells: Generation, Localization and Persistence". Lymphocyte Activation and Immune Regulation IX: Homeostasis and Lymphocyte Traffic. Springer Science & Business Media. pp. 113–. ISBN 978-1-4615-0757-4. {{cite book}}: |author1= has generic name (help)CS1 maint: multiple names: authors list (link)
  17. ^ Neville Vassallo (editor); M. A. Mir (Chapter author), J. N. Agrewala (Chapter author) (2008). "Dietary Polyphenols in Modulation of the Immune System". Polyphenols and Health: New and Recent Advances. Nova Publishers. pp. 245–. ISBN 978-1-60456-349-8. {{cite book}}: |author1= has generic name (help)
  18. ^ Sushil Kumar (1994). Tropical diseases: molecular biology and control strategies. Publications & Information Directorate.
  19. ^ Indian Journal of Medical Research. Indian Council of Medical Research. 1986.
  20. ^ "Find an Expert". University of Melbourne. 2017.
  21. ^ "Member of the Senate" (PDF). Academy of Scientific and Innovative Research. 2013.
  22. ^ "Editorial Board BMC". BMC Immunology. 2017.
  23. ^ "Editorial Board PLoS One". PLoS One. 2017.
  24. ^ "Seminar to discuss the latest in biotechnology". The Hindu. 22 November 2015.
  25. ^ "World Congress on Infectious Diseases". conferenceseries.com. 2015.
  26. ^ "82nd Annual Meeting" (PDF). Indian Academy of Sciences. 2016. Archived from the original (PDF) on 30 March 2017. {{cite web}}: Unknown parameter |deadurl= ignored (|url-status= suggested) (help)
  27. ^ "Session 1C – Inaugural Lecture". Indian Academy of Sciences. 2017.
  28. ^ "Systems Oncology conference" (PDF). Butterfly Cancer Care Foundation. 2017.
  29. ^ "NASI Year Book 2015" (PDF). National Academy of Sciences, India. 2017. Archived from the original (PDF) on 6 August 2015. {{cite web}}: Unknown parameter |deadurl= ignored (|url-status= suggested) (help)
  30. ^ "Medical Sciences". Council of Scientific and Industrial Research. 2017. Archived from the original on 24 February 2013. {{cite web}}: Unknown parameter |deadurl= ignored (|url-status= suggested) (help)
  31. ^ "Awardees of National Bioscience Awards for Career Development" (PDF). Department of Biotechnology. 2017.
  32. ^ "INSA Year Book 2016" (PDF). Indian National Science Academy. 2017.
  33. ^ "Fellow profile". Indian Academy of Sciences. 2017.
  34. ^ "National Bioscienceawards for Career Development 2006". Public Information Bureau. 2006.

Further reading

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