Legumain
Legumain (EC 3.4.22.34, asparaginyl endopeptidase, citvac, proteinase B, hemoglobinase, PRSC1 gene product or LGMN (Homo sapiens), vicilin peptidohydrolase, bean endopeptidase) is an enzyme[1][2][3] that in humans is encoded by the LGMN gene (previous symbol PRSC1). This enzyme catalyses the following chemical reaction
- Hydrolysis of proteins and small molecule substrates at -Asn-Xaa- bonds
This enzyme is present in legume seeds, the trematode Schistosoma mansoni and mammalian lysosomes.
References
- ^ Hara-Nishimura, I. (1998). "Asparaginyl endopeptidase". In Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (ed.). Handbook of Proteolytic Enzymes. London: Academic Press. pp. 746–749.
{{cite book}}: CS1 maint: multiple names: editors list (link) - ^ Dalton, J.P. and Brindley, P.J. (1998). "Schistosome legumain". In Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (ed.). Handbook of Proteolytic Enzymes. London: Academic Press. pp. 749–754.
{{cite book}}: CS1 maint: multiple names: authors list (link) - ^ Chen, J.-M., Rawlings, N.D., Stevens, R.A.E. and Barrett, A.J. (1998). "Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopeptidases". FEBS Lett. 441: 361–365. doi:10.1016/S0014-5793(98)01574-9. PMID 9891971.
{{cite journal}}: CS1 maint: multiple names: authors list (link)
External links
- Legumain at the U.S. National Library of Medicine Medical Subject Headings (MeSH)