When originally created in 1918, the South division of the Parliamentary Borough of Leicester was defined as including the municipal wards of Aylestone, Castle, Charnwood, De Montfort, Knighton, Martin's, and Wycliffe.
The initial report of the Boundary Commission for England dated October 1947 and published in December 1947 recommended that Leicester retain three seats, including a revised Leicester South constituency consisting of the wards of Aylestone, De Montfort, Knighton, North Braunstone and Spinney Hill, giving an electorate of 67,574 as of the review date of 15 October 1946. When the Representation of the People Bill enacting the Commission's recommendations was debated in the House of Commons, the Government brought forward amendments at Committee stage on 24 March 1948 to allow 17 more constituencies in England. Home Secretary James Chuter Ede announced that the Boundary Commission would be invited to consider an additional constituency to each of nine cities, including Leicester. The Government issued a White Paper proposing the new boundaries which created new borough constituencies of Leicester South East and Leicester South West in place of Leicester South. The Boundary Commission recommended no alteration to the proposals, and the revised constituencies were therefore enacted.
In 1969, the Second Periodical Report of the Parliamentary Boundary Commission for England reduced Leicester from four seats to three, and recreated Leicester South as a borough constituency consisting of the Aylestone, Castle, De Montfort, Knighton, Spinney Hill and Wycliffe wards of Leicester.
Minor boundary changes were made as a result of the Third Periodical Report of the Boundary Commission in 1983. Ward boundaries having changed, the constituency was defined as including the Aylestone, Castle, Crown Hills, East Knighton, Eyres Monsell, Saffron, Spinney Hill, Stoneygate, West Knighton and Wycliffe wards. The new constituency took in about 3,000 voters who were previously in other Leicester seats. No changes were made in the Fourth Periodical Report of the Boundary Commission in 1995, and in the Fifth Periodical Report of the Boundary Commission in 2007, the constituency had only minor changes with 73 voters being added from Leicester West.
Presently the seat is centred on the southern part of Leicester, and covers leafy suburbs such as Stoneygate and Knighton, inner-city areas with a strong Asian community, and deprived outer estates such as Saffron and Eyres Monsell. The constituency encompasses the council wards of Spinney Hills, Stoneygate, Knighton, Freemen, Aylestone, Eyres Monsell and virtually all of Castle. Another demographic feature is the presence of a large number of students studying at the University of Leicester and De Montfort University, which are both situated in the constituency.
Leicester South is a varied constituency. It contains some of the most pleasant and affluent areas of Leicester such as Stoneygate, Knighton and Aylestone, as well as more deprived areas such as Saffron and Eyres Monsell. The centre of Leicester, also within the constituency, is more ethnically diverse than the southern part of the area. The seat also contains HM Prison Leicester and both of Leicester's universities.
The expansion of the city's suburbs and commuter belt has altered the incomes and other demographic measures of the constituency. The seat saw close contests between Conservative and Labour candidates in the 1980s, with Jim Marshall losing the seat by 7 votes to the Conservatives in the 1983 general election, but regaining it in 1987.
Marshall died in 2004, and the resulting by-election was fiercely contested. As in a by-election in Birmingham Hodge Hill held on the same day, the Liberal Democrat candidates hoped—despite having additional competition for the anti-Iraq War vote from Respect—to build on their previous by-election gain at Brent East. The seat was won by the Liberal Democrat Parmjit Singh Gill, with a majority of 1,654.
Sir Peter Soulsby won the seat at the 2005 election, and was re-elected in 2010. Sir Peter resigned to seek election for the new position of Mayor of Leicester in 2011, triggering a by-election on 5 May 2011 that coincided with the referendum on the voting system.Jon Ashworth was elected as his successor, holding the seat for the Labour Party; he was re-elected in 2015.