Mucin 2

MUC2
Identifiers
Aliases	MUC2, MLP, MUC-2, SMUC, mucin 2, oligomeric mucus/gel-forming
External IDs	OMIM: 158370; MGI: 1339364; HomoloGene: 136755; GeneCards: MUC2; OMA:MUC2 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	1,110,511 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	141,308,430 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; rectum; ; duodenum; ; appendix; ; epithelium of colon; ; smooth muscle tissue; ; olfactory zone of nasal mucosa; ; muscle layer of sigmoid colon; ; right coronary artery; ; urinary bladder;
	Top expressed in
	jejunum; ; colon; ; ileum; ; duodenum; ; neural layer of retina; ; urinary bladder; ; zygote; ; tail of embryo; ; embryo; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	extracellular region; outer mucus layer; Golgi lumen; inner mucus layer; mucus layer; plasma membrane; collagen-containing extracellular matrix;
Biological process	O-glycan processing; maintenance of gastrointestinal epithelium; stimulatory C-type lectin receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	4583
	17831
	ENSG00000198788
	ENSMUSG00000025515
	Q02817
	n/a
	NM_002457
	NM_023566
	NP_002448
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Mucin 2, oligomeric mucus gel-forming, also known as MUC2, is a protein that in humans is encoded by the MUC2 gene.^[5]^[6]

Function

This gene encodes a member of the mucin protein family. The protein encoded by this gene, also called mucin 2, is secreted onto mucosal surfaces.^[5]

Mucin 2 is particularly prominent in the gut where it is secreted from goblet cells in the epithelial lining into the lumen of the large intestine. There, mucin 2, along with small amounts of related-mucin proteins, polymerizes into a gel of which 80% by weight is oligosaccharide side-chains that are added as post-translational modifications to the mucin proteins. This gel provides an insoluble mucous barrier that serves to protect the intestinal epithelium.

Genetics

The mucin 2 protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.^[7]

References

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198788 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025515 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Allen A, Hutton DA, Pearson JP (July 1998). "The MUC2 gene product: a human intestinal mucin". Int. J. Biochem. Cell Biol. 30 (7): 797–801. doi:10.1016/S1357-2725(98)00028-4. PMID 9722984.
^ Rousseau K, Byrne C, Kim YS, Gum JR, Swallow DM, Toribara NW (May 2004). "The complete genomic organization of the human MUC6 and MUC2 mucin genes". Genomics. 83 (5): 936–9. doi:10.1016/j.ygeno.2003.11.003. PMID 15081123.
^ "Entrez Gene: MUC2 mucin 2, oligomeric mucus/gel-forming".

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198788 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025515 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9722984-5] Allen A, Hutton DA, Pearson JP (July 1998). "The MUC2 gene product: a human intestinal mucin". Int. J. Biochem. Cell Biol. 30 (7): 797–801. doi:10.1016/S1357-2725(98)00028-4. PMID 9722984.

[pmid15081123-6] Rousseau K, Byrne C, Kim YS, Gum JR, Swallow DM, Toribara NW (May 2004). "The complete genomic organization of the human MUC6 and MUC2 mucin genes". Genomics. 83 (5): 936–9. doi:10.1016/j.ygeno.2003.11.003. PMID 15081123.

[7] "Entrez Gene: MUC2 mucin 2, oligomeric mucus/gel-forming".

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