Oligodendrocyte progenitor cell

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Oligodendrocyte progenitor cell
NG-2 progenitors and astrocytes in culture.tif
NG-2 positive oligodendrocyte progenitor cells (green color) and GFAP-positive astrocytes (red color) in culture.
Latin Cellula oligodendrocytoprogenetrix
Code TH H2.
NeuroLex ID Oligodendrocyte precursor cell
Anatomical terminology

Oligodendrocyte progenitor cells (OPCs), also known as oligodendrocyte precursor cells, NG2-glia or polydendrocytes, are a subtype of glial cells in the central nervous system.[1] They are precursors to oligodendrocytes and may also be able to differentiate into neurons and astrocytes. Differentiated oligodendrocytes support axons and provide electrical insulation in the form of a myelin sheath, enabling faster action potential propagation and high fidelity transmission without a need for an increase in axonal diameter.[2] The loss or lack of OPCs, and consequent lack of differentiated oligodendrocytes, is associated with a loss of myelination and subsequent impairment of neurological functions.[3]


Oligodendrocyte progenitor cells are a subtype of glial cells in the central nervous system, characterized by expression of the proteoglycans PDGFRA, and CSPG4.[1] OPCs are smaller than neurons, of comparable size to other glia, and can either have a bipolar or complex multipolar morphology with processes reaching up to ~50 um.[4]

OPCs encompass approximately 3-4% of cells in the grey matter and 7-8% in white matter, making them the fourth largest group of glia after astrocytes, microglia and oligodendrocytes.[5]

OPCs are particularly prevalent in the hippocampus and in all layers of the neocortex.[6][7] In white matter, OPCs are found along unmyelinated axons [8] as well as along myelinated axons, engulfing nodes of Ranvier.[9][10] Recently, OPCs have been shown to reside in close contact with NG2-expressing pericytes in cerebral white matter, as well.[11]

OPCs have a remarkable homogenic distribution throughout the brain. This is achieved through active self-repulsion, causing the cells to be generally equally spaced from one another.[4][12] OPCs constantly survey their surroundings through actively extending and retracting growth cones. Death or differentiation of an OPC is rapidly followed by migration or local proliferation of a neighbouring cell.

OPCs receive synaptic contacts onto their processes from both glutamatergic[13] and GABAergic neurons.[1][14] Recently, it has been shown that OPCs receive preferred somatic contacts from fast-spiking GABAergic neurons, while non-fast spiking interneurons have a preference for contacting the processes.[15] These inhibitory connections have been shown in mice to occur mainly during a very specific period in development, from postnatal day 8 till postnatal day 13.


OPCs were long held to function purely as progenitors to oligodendrocytes, hence the name. More recently, however, several other functions for OPCs have been suggested.

The primary function of OPCs is to serve as precursor for oligodendrocytes as well as some protoplasmic astrocytes in grey matter.[16] Postnatally, OPCs remain lineage-restricted and generally only differentiate into oligodendrocytes.

Whereas some earlier studies have suggested that OPCs can generate cortical neurons, more recent studies have refuted these findings.[17] However, the issue is not yet resolved, as studies continue to appear that certain populations of OPCs can form neurons during development.[18]

Recently, it has been shown that OPCs synthesize the neuromodulatory factors prostaglandin D2 synthase (PTGDS) and neuronal pentraxin 2 (Nptx2).[19] This has been shown to be mediated by the protein NG2, whose intracellular domain can be cleaved by the γ-secretase [20][21] and translocated to the nucleus.

Finally, the two N-terminal LNS (laminin/neurexin/sex hormone-binding globulin-domain) domains of the NG2 ectodomain can modulate signalling via AMPA and NMDA receptors of neuronal synapses within the cortex, including neuronal LTP. The NG2 ectodomain is released into the ECM from the full-length NG2 protein by constitutive and activity-dependent activity of the ADAM10 protease (α-secretase activity). Showing that NG2 can modulate the neuronal glutamatergic system.[20][21]


OPCs originate from the neuroepithelium of the spine and migrate to other areas of the brain.[22] There are several waves of OPC production and migration that lead to the generation of OLGs (oligodendrocytes).[23] OPCs are highly proliferative and migratory bipolar cells[24] The first wave of OPC production originates in the ganglionic eminence and as development progresses a second and third wave of OPCs originate from the lateral and caudal ganglionic eminences and generate the majority of adult OLGs. [25] OPCs then spread to populate most of the future brain. They migrate to populate the brain and spinal cord and eventually myelinate the entire CNS.[26] They differentiate into the less mobile, pro-oligodendrocytes which further differentiate into oligodendrocytes, a process characterized by the emergence of the expression of myelin basic protein (MBP), proteolipid protein (PLP), or myelin-associated glycoprotein (MAG).[24] Following terminal differentiation in vivo, mature oligodendrocytes wrap around and myelinate axons. In vitro, oligodendrocytes create an extensive network of myelin-like sheets. The process of [differentiation] can be observed both through morphological changes and cell surface markers specific to the discrete stage of differentiation, though the signals for differentiation are unknown.[27] The various waves of OPCs could myelinate distinct regions of the brain, which suggests that there are distinct functional subpopulations of OPCs which have different functions.[28]

There are OPC's in both white matter and in gray matter in the brain. However, there is a much higher density of OPCs in white matter than in gray matter because there is a higher rate of proliferation in white matter than in gray matter. The white matter OPCs proliferate and contribute to adult oligodendrogenesis, while the gray matter OPCs are the slowly proliferative or quiescent state OPCs that mostly remain in an immature state.[29] White matter and gray matter OPCs have different resting membrane potentials and ion channel expression. Gray matter lacks voltage-gated sodium channels and the white does not and produces action potentials. The ones that produce action potentials can receive signals from other neurons.[30] There is evidence that these differences in the OPCs function depends on their different locations in the brain. Through maturation, OPCs are produced in the sub-ventricular zone (SVZ). The stem cells in the SVZ generate C cells which produce OPCs that go into the olfactory bulb.[31] The number of oligodendrocytes that are later formed depends on the part of the SVZ they came from. More OLGs are produced from the dorsal part of the SVZ rather than the ventrolateral part, and more are produced from the posterior part rather than the rostral part.[32][33] This is due to the different environmental factors in these different locations. The Wnt in the dorsal part favors OPC specification and the Bmp in the ventral part inhibits it.[34] These molecules help cause the expression of certain transcription factors. Expression of Olig2 generates motor neurons and produces OPCs, which is dependent on the Shh and regulated by the Notch signaling pathway. This regulation limits the number of motor neurons and allows more oligodendrocytes to be produced.[35][36] Olig2 is one of the most important transcription factors involved in regulated oligodendrocyte production. A study has shown that Olig2 inactivation during development leads to less OPC production.[37]

Differentiation of OPCs into oligodendrocytes involves massive reorganization of cytoskeleton proteins ultimately resulting in increased cell branching and lamella extension, allowing oligodendrocytes to myelinate multiple axons.[24] We know that laminin, a component of the extracellular matrix, plays an important role regulating OLG production because a study showed that mice lacking laminin alpha2-subunit had less OPC's produced in the SVZ.[38] MicroRNA has also been found to play a role in the regulation of OLG differentiation and myelin maintenance. Deletion of Dicer1 in miRNA disrupts normal brain myelination. However, miR-7a, and miRNA in OPCs, actually promotes OPC production during brain development.[39]

Several distinct pathways have been identified as the cause of oligodendrocyte branching, but their specific contributions have yet to be elucidated and the process by which oligodendrocytes extend and wrap around multiple axons remains poorly understood.[24]

Endogenous Remyelination[edit]

Spontaneous myelin repair was first observed in feline models,[40] but was later discovered to occur in the human central nervous system as well, specifically in cases of multiple sclerosis.[41] Spontaneous myelin repair does not result in morphologically normal oligodendrocytes and is associated with thinner myelin compared to axonal diameter than normal myelin.[42] Despite morphological abnormalities, however, remyelination does restore normal conduction.[43] In addition, spontaneous remyelination does not appear to be a rare event, at least in the case of multiple sclerosis. Studies of multiple sclerosis lesions have reported the average extent of remyelination to be as high as 47%,[44] and comparative studies of cortical lesions reported a greater proportion of remyelination in the cortex as opposed to white matter lesions.[41]

Cell Types Involved[edit]

Mature oligodendrocytes, however, are unlikely to contribute to spontaneous remyelination even if they survive the original demyelinating injury.[45] New oligodendrocytes have been observed in areas of myelin damage, though the source of these new cells is not entirely clear. One possibility is that mature oligodendrocytes from uninjured areas migrate to the site of injury and re-engage in myelination, though this is considered to be an unlikely scenario as the transplantation of mature human oligodendrocytes achieve minimal myelin formation in the demyelinated rodent central nervous system. Another possibility is that mature oligodendrocytes de-differentiate into proliferative oligodendrocyte progenitors, that are then able to proliferate and remyelinate though there is little experimental support for this view.

Source of New Oligodendrocytes[edit]

There is evidence, however, to suggest that the source of these new oligodendrocytes is proliferative adult oligodendrocyte precursor cells. Such cells have been demonstrated to exist in the adult rodent central nervous system[46] as well as the human central nervous system.[47] These oligodendrocyte precursor cells appear to play a major role in remyelination and are, unlike mature oligodendrocytes, able to cause extensive remyelination after transplantation into areas of myelin damage.[48] The role of these cells when there is no local demyelination, however, is still very much under investigation and the fact that oligodendrocyte progenitors exhibit electrophysiological properties related to the expression of a range of glutamate receptors allowing communication with the neuron-axon unit suggests that oligodendrocyte progenitors are likely to have additional functions.[49]

The observation of oligodendrocyte progenitors in multiple sclerosis lesions that have not remyelinated has led to the hypothesis that the differentiation of these progenitors has been inhibited. One proposed mechanism involves the accumulation of myelin debris at the axon, suggesting that the inflammatory environment may be conducive to remyelination, as does the release of growth factors by inflammatory cells and activated microglia.[50] Alternatively, the accumulation of glycosaminoglycan hyaluronan at the site of the lesion, inhibiting the ability of oligodendrocyte progenitors to differentiate into mature oligodendrocytes and the release of oligodendrocyte progenitor-specific antibodies by chronically demyelinated axons have been implicated as the reason remyelination is not more extensive.[51] Other proposed mechanisms posit that oligodendrocyte progenitor migration is inhibited by either molecules expressed by chronically demyelinated axons or the accumulation of unreactive astrocytes in multiple sclerosis lesions.[51]


Oligodendrocyte progenitor transplants have been demonstrated to contribute to remyelination, but it is difficult to maintain such cells in reasonable concentrations at high purity. Finding a source for these cells, however, is impractical at the moment. Should adult cells be used for transplantation, a brain biopsy would be required for every patient, added to the risk of immune rejection. Embryonically derived stem cells have been demonstrated to carry out remyelination under laboratory conditions, but carry ethical implications. Adult central nervous system stem cells have also been shown to generate myelinating oligodendrocytes, but are not readily accessible.[52]

Even if a viable source of oligodendrocyte progenitors were found, identifying and monitoring the outcome of remyelination remains difficult, though multimodal measures of conduction velocity and emerging magnetic resonance imaging techniques offer improved sensitivity versus other imaging methods.[53] In addition, the interaction between transplanted cells and immune cells has yet to be fully characterized as does the effect of inflammatory immune cells on remyelination. If the failure of the endogenous remyelination mechanism is due to an unfavorable differentiation environment, then this will have to be addressed prior to any transplantation attempt.


  1. ^ a b c Nishiyama, A.; Komitova, M.; Suzuki, R.; Zhu, X. (2009). "Polydendrocytes (NG2 cells): Multifunctional cells with lineage plasticity". Nature Reviews Neuroscience. 10 (1): 9–22. doi:10.1038/nrn2495. PMID 19096367. 
  2. ^ Swiss, V. A.; Nguyen, T.; Dugas, J.; Ibrahim, A.; Barres, B.; Androulakis, I. P.; Casaccia, P. (2011). Feng, Yue, ed. "Identification of a Gene Regulatory Network Necessary for the Initiation of Oligodendrocyte Differentiation". PLoS ONE. 6 (4): e18088. doi:10.1371/journal.pone.0018088. PMC 3072388Freely accessible. PMID 21490970. 
  3. ^ Buller, B., Chopp, M., Ueno, Y., Zhang, L., Zhang, R. L., Morris, D., Zhang, Y. and Zhang, Z. G (2012). "Regulation of serum response factor by miRNA-200 and miRNA-9 modulates OPC differentiation". Glia. 60 (12): 1906–14. doi:10.1002/glia.22406. PMC 3474880Freely accessible. PMID 22907787. 
  4. ^ a b Hughes, E. G.; Kang, S. H.; Fukaya, M; Bergles, D. E. (2013). "Oligodendrocyte progenitors balance growth with self-repulsion to achieve homeostasis in the adult brain". Nature Neuroscience. 16 (6): 668–76. doi:10.1038/nn.3390. PMC 3807738Freely accessible. PMID 23624515. 
  5. ^ Dawson, M. R.; Polito, A.; Levine, J. M.; Reynolds, R. (2003). "NG2-expressing glial progenitor cells: An abundant and widespread population of cycling cells in the adult rat CNS". Molecular and cellular neurosciences. 24 (2): 476–488. doi:10.1016/S1044-7431(03)00210-0. PMID 14572468. 
  6. ^ Ong, W. Y.; Levine, J. M. (1999). "A light and electron microscopic study of NG2 chondroitin sulfate proteoglycan-positive oligodendrocyte precursor cells in the normal and kainate-lesioned rat hippocampus". Neuroscience. 92 (1): 83–95. doi:10.1016/S0306-4522(98)00751-9. PMID 10392832. 
  7. ^ Bergles, D. E.; Jahr, C. E. (1997). "Synaptic Activation of Glutamate Transporters in Hippocampal Astrocytes". Neuron. 19 (6): 1297–1308. doi:10.1016/S0896-6273(00)80420-1. PMID 9427252. 
  8. ^ Ziskin, J. L.; Nishiyama, A.; Rubio, M.; Fukaya, M.; Bergles, D. E. (2007). "Vesicular release of glutamate from unmyelinated axons in white matter". Nature Neuroscience. 10 (3): 321–330. doi:10.1038/nn1854. PMC 2140234Freely accessible. PMID 17293857. 
  9. ^ Butt, A. M.; Duncan, A.; Hornby, M. F.; Kirvell, S. L.; Hunter, A.; Levine, J. M.; Berry, M. (1999). "Cells expressing the NG2 antigen contact nodes of Ranvier in adult CNS white matter". Glia. 26 (1): 84–91. doi:10.1002/(SICI)1098-1136(199903)26:1<84::AID-GLIA9>3.0.CO;2-L. PMID 10088675. 
  10. ^ Miller, R. H. (1996). "Oligodendrocyte origins". Trends in Neurosciences. 19 (3): 92–96. doi:10.1016/S0166-2236(96)80036-1. PMID 9054062. 
  11. ^ Maki, T; Maeda, M; Uemura, M; Lo, E. K.; Terasaki, Y; Liang, A. C.; Shindo, A; Choi, Y. K.; Taguchi, A; Matsuyama, T; Takahashi, R; Ihara, M; Arai, K (2015). "Potential interactions between pericytes and oligodendrocyte precursor cells in perivascular regions of cerebral white matter". Neuroscience Letters. 597: 164–9. doi:10.1016/j.neulet.2015.04.047. PMC 4443478Freely accessible. PMID 25936593. 
  12. ^ Birey, F; Aguirre, A (2015). "Age-Dependent Netrin-1 Signaling Regulates NG2+ Glial Cell Spatial Homeostasis in Normal Adult Gray Matter". Journal of Neuroscience. 35 (17): 6946–51. doi:10.1523/JNEUROSCI.0356-15.2015. PMC 4412904Freely accessible. PMID 25926469. 
  13. ^ Bergles, D. E.; Roberts, J. D. B.; Somogyi, P.; Jahr, C. E. (2000). "Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus". Nature. 405 (6783): 187–191. doi:10.1038/35012083. PMID 10821275. 
  14. ^ Steinhäuser, C.; Gallo, V. (1996). "News on glutamate receptors in glial cells". Trends in Neurosciences. 19 (8): 339–345. doi:10.1016/0166-2236(96)10043-6. PMID 8843603. 
  15. ^ Orduz, D; Maldonado, P. P.; Balia, M; Vélez-Fort, M; De Sars, V; Yanagawa, Y; Emiliani, V; Angulo, M. C. (2015). "Interneurons and oligodendrocyte progenitors form a structured synaptic network in the developing neocortex". ELife. 4. doi:10.7554/eLife.06953. PMC 4432226Freely accessible. PMID 25902404. 
  16. ^ Zhu, X.; Bergles, D. E.; Nishiyama, A. (2007). "NG2 cells generate both oligodendrocytes and gray matter astrocytes". Development. 135 (1): 145–157. doi:10.1242/dev.004895. PMID 18045844. 
  17. ^ Clarke, L. E.; Young, K. M.; Hamilton, N. B.; Li, H.; Richardson, W. D.; Attwell, D. (2012). "Properties and Fate of Oligodendrocyte Progenitor Cells in the Corpus Callosum, Motor Cortex, and Piriform Cortex of the Mouse". Journal of Neuroscience. 32 (24): 8173–8185. doi:10.1523/JNEUROSCI.0928-12.2012. PMC 3378033Freely accessible. PMID 22699898. 
  18. ^ Tsoa, R. W.; Coskun, V; Ho, C. K.; De Vellis, J; Sun, Y. E. (2014). "Spatiotemporally different origins of NG2 progenitors produce cortical interneurons versus glia in the mammalian forebrain". Proceedings of the National Academy of Sciences. 111 (20): 7444–9. doi:10.1073/pnas.1400422111. PMC 4034245Freely accessible. PMID 24799701. 
  19. ^ Sakry, D; Yigit, H; Dimou, L; Trotter, J (2015). "Oligodendrocyte precursor cells synthesize neuromodulatory factors". PLoS ONE. 10 (5): e0127222. doi:10.1371/journal.pone.0127222. PMC 4429067Freely accessible. PMID 25966014. 
  20. ^ a b Sakry, D; Trotter, J (2015). "The role of the NG2 proteoglycan in OPC and CNS network function". Brain Research. doi:10.1016/j.brainres.2015.06.003. PMID 26100334. 
  21. ^ a b Sakry, D; Neitz, A; Singh, J; Frischknecht, R; Marongiu, D; Binamé, F; Perera, S. S.; Endres, K; Lutz, B; Radyushkin, K; Trotter, J; Mittmann, T (2014). "Oligodendrocyte precursor cells modulate the neuronal network by activity-dependent ectodomain cleavage of glial NG2". PLoS Biology. 12 (11): e1001993. doi:10.1371/journal.pbio.1001993. PMC 4227637Freely accessible. PMID 25387269. 
  22. ^ Donna J. Osterhout; Amy Wolven; Rebecca M. Wolf; Marilyn D. Resh & Moses V. Chao (1999). "Morphological Differentiation of Oligodendrocytes Requires Activation of Fyn Tyrosine Kinase" (PDF). Journal of Cell Biol. 
  23. ^ Spassky, N; Olivier, C; Cobos, I; Lebras, B; Goujet-Zalc, C; Martínez, S; Zalc, B; Thomas, J. L. (2001). "The early steps of oligodendrogenesis: Insights from the study of the plp lineage in the brain of chicks and rodents". Developmental neuroscience. 23 (4–5): 318–26. doi:10.1159/000048715. PMID 11756747. 
  24. ^ a b c d Pfeiffer, Steve E. Warrington, Art E. Bansal, Rashmi. (1993). "The oligodendrocyte and its many cellular processes". Trends in Cell Biology. doi:10.1016/0962-8924+(93)90213-K (inactive 2015-11-08). 
  25. ^ Kessaris, N.; Fogarty, M.; Iannarelli, P.; Grist, M.; Wegner, M.; Richardson, W. D. (2005). "Competing waves of oligodendrocytes in the forebrain and postnatal elimination of an embryonic lineage". Nature Neuroscience. 9 (2): 173–179. doi:10.1038/nn1620. PMID 16388308. 
  26. ^ El Waly, B; MacChi, M; Cayre, M; Durbec, P (2014). "Oligodendrogenesis in the normal and pathological central nervous system". Frontiers in Neuroscience. 8: 145. doi:10.3389/fnins.2014.00145. PMC 4054666Freely accessible. PMID 24971048. 
  27. ^ Wang, H.; Rusielewicz, T.; Tewari, A.; Leitman, E. M.; Einheber, S.; Melendez-Vasquez, C. V. (2012). "Myosin II is a negative regulator of oligodendrocyte morphological differentiation". Journal of Neuroscience Research. 90 (8): 1547–1556. doi:10.1002/jnr.23036. PMC 3370114Freely accessible. PMID 22437915. 
  28. ^ Tripathi, R. B.; Clarke, L. E.; Burzomato, V; Kessaris, N; Anderson, P. N.; Attwell, D; Richardson, W. D. (2011). "Dorsally and ventrally derived oligodendrocytes have similar electrical properties but myelinate preferred tracts". Journal of Neuroscience. 31 (18): 6809–19. doi:10.1523/JNEUROSCI.6474-10.2011. PMC 4227601Freely accessible. PMID 21543611. 
  29. ^ Dimou, L.; Simon, C.; Kirchhoff, F.; Takebayashi, H.; Gotz, M. (2008). "Progeny of Olig2-Expressing Progenitors in the Gray and White Matter of the Adult Mouse Cerebral Cortex". Journal of Neuroscience. 28 (41): 10434–10442. doi:10.1523/JNEUROSCI.2831-08.2008. PMID 18842903. 
  30. ^ Káradóttir, R; Hamilton, N. B.; Bakiri, Y; Attwell, D (2008). "Spiking and nonspiking classes of oligodendrocyte precursor glia in CNS white matter". Nature Neuroscience. 11 (4): 450–6. doi:10.1038/nn2060. PMC 2615224Freely accessible. PMID 18311136. 
  31. ^ Doetsch, F; Caillé, I; Lim, D. A.; García-Verdugo, J. M.; Alvarez-Buylla, A (1999). "Subventricular zone astrocytes are neural stem cells in the adult mammalian brain". Cell. 97 (6): 703–16. doi:10.1016/s0092-8674(00)80783-7. PMID 10380923. 
  32. ^ Ortega, F; Gascón, S; Masserdotti, G; Deshpande, A; Simon, C; Fischer, J; Dimou, L; Chichung Lie, D; Schroeder, T; Berninger, B (2013). "Oligodendrogliogenic and neurogenic adult subependymal zone neural stem cells constitute distinct lineages and exhibit differential responsiveness to Wnt signalling". Nature Cell Biology. 15 (6): 602–13. doi:10.1038/ncb2736. PMID 23644466. 
  33. ^ Menn, B; Garcia-Verdugo, J. M.; Yaschine, C; Gonzalez-Perez, O; Rowitch, D; Alvarez-Buylla, A (2006). "Origin of oligodendrocytes in the subventricular zone of the adult brain". Journal of Neuroscience. 26 (30): 7907–18. doi:10.1523/JNEUROSCI.1299-06.2006. PMID 16870736. 
  34. ^ Colak, D; Mori, T; Brill, M. S.; Pfeifer, A; Falk, S; Deng, C; Monteiro, R; Mummery, C; Sommer, L; Götz, M (2008). "Adult neurogenesis requires Smad4-mediated bone morphogenic protein signaling in stem cells". Journal of Neuroscience. 28 (2): 434–46. doi:10.1523/JNEUROSCI.4374-07.2008. PMID 18184786. 
  35. ^ Dessaud, E; Ribes, V; Balaskas, N; Yang, L. L.; Pierani, A; Kicheva, A; Novitch, B. G.; Briscoe, J; Sasai, N (2010). "Dynamic assignment and maintenance of positional identity in the ventral neural tube by the morphogen sonic hedgehog". PLoS Biology. 8 (6): e1000382. doi:10.1371/journal.pbio.1000382. PMC 2879390Freely accessible. PMID 20532235. 
  36. ^ Kim, H; Shin, J; Kim, S; Poling, J; Park, H. C.; Appel, B (2008). "Notch-regulated oligodendrocyte specification from radial glia in the spinal cord of zebrafish embryos". Developmental Dynamics. 237 (8): 2081–9. doi:10.1002/dvdy.21620. PMC 2646814Freely accessible. PMID 18627107. 
  37. ^ Lu, Q. R.; Sun, T; Zhu, Z; Ma, N; Garcia, M; Stiles, C. D.; Rowitch, D. H. (2002). "Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection". Cell. 109 (1): 75–86. doi:10.1016/s0092-8674(02)00678-5. PMID 11955448. 
  38. ^ Relucio, J; Menezes, M. J.; Miyagoe-Suzuki, Y; Takeda, S; Colognato, H (2012). "Laminin regulates postnatal oligodendrocyte production by promoting oligodendrocyte progenitor survival in the subventricular zone". Glia. 60 (10): 1451–67. doi:10.1002/glia.22365. PMID 22706957. 
  39. ^ Zhao, X; He, X; Han, X; Yu, Y; Ye, F; Chen, Y; Hoang, T; Xu, X; Mi, Q. S.; Xin, M; Wang, F; Appel, B; Lu, Q. R. (2010). "MicroRNA-mediated control of oligodendrocyte differentiation". Neuron. 65 (5): 612–26. doi:10.1016/j.neuron.2010.02.018. PMC 2855245Freely accessible. PMID 20223198. 
  40. ^ Bunge, Mary Bartlett; Bunge, Richard P.; Ris, Hans (1961). "Ultrastructural Study of Remyelination in an Experimental Lesion in Adult Cat Spinal Cord". Journal of the Neurological Sciences. 10: 67–94. doi:10.1083/jcb.10.1.67. PMC 2225064Freely accessible. PMID 13688845. 
  41. ^ a b Pierre, O. & Gregoire, A. (1965). "Electron Microscopic Features of Multiple Sclerosis Lesions". Brain. 88 (5): 937–52. doi:10.1093/brain/88.5.937. PMID 5864468. 
  42. ^ Blakemore, W.F. (1974). "Pattern of remyelination in the CNS". Nature. 249 (5457): 577–578. Bibcode:1974Natur.249..577B. doi:10.1038/249577a0. 
  43. ^ Smith, K.J., Bostock, H. Hall, S.M. (1982). "Saltatory conduction precedes remyelination in axons demyelinated with lysophosphatidyl choline". Journal of the Neurological Sciences. 54 (1): 13–31. doi:10.1016/0022-510X(82)90215-5. PMID 6804606. 
  44. ^ Albert, Monika Antel, Jack Bruic, Wolfgang Stadelmann, Christine (2007). "Extensive Remyelination in patients with Chronic Multiple Sclerosis". Brain Pathology. 17 (2): 129–38. doi:10.1111/j.1750-3639.2006.00043.x. PMID 17388943. 
  45. ^ Keirstead, H.S., Blakemore, W.F. (1997). "Identification of post-mitotic oligodendrocytes incapable of remyelination within the demyelinated adult spinal cord". J Neuropathol Exp Neurol. 56 (11): 1191–201. doi:10.1097/00005072-199711000-00003. ISSN 0022-3069. PMID 9370229. 
  46. ^ Ffrench-Constant, C. Raff, M. C. (1986). "Proliferating bipotential glial progenitor cells in adult rat optic nerve". Nature. 319 (6053): 499–502. Bibcode:1986Natur.319..499F. doi:10.1038/319499a0. PMID 3945333. 
  47. ^ Scolding, N. J. Rayner, P. J. Sussman, J. Shaw, C. Compston, D. A. (1995). "A proliferative adult human oligodendrocyte progenitor". NeuroReport. 6 (3): 441–5. doi:10.1097/00001756-199502000-00009. ISSN 0959-4965. PMID 7766839. 
  48. ^ Zhang, S. C. Ge, B. Duncan, I. D.; Ge; Duncan (1999). "Adult brain retains the potential to generate oligodendroglial progenitors with extensive myelination capacity". Proc Natl Acad Sci U S A. 96 (7): 4089–94. Bibcode:1999PNAS...96.4089Z. doi:10.1073/pnas.96.7.4089. ISSN 0027-8424. PMC 22425Freely accessible. PMID 10097168. 
  49. ^ Luyt, K. Varadi, A. Halfpenny, C. A. Scolding, N. J. Molnar, E. (2004). "Metabotropic glutamate receptors are expressed in adult human glial progenitor cells". Biochem Biophys Res Commun. 319 (1): 120–9. doi:10.1016/j.bbrc.2004.04.158. PMID 15158450. 
  50. ^ Heese, K. Hock, C. Otten, U. (1998). "Inflammatory signals induce neurotrophin expression in human microglial cells". J Neurochem. 70 (2): 699–707. doi:10.1046/j.1471-4159.1998.70020699.x. ISSN 0022-3042. PMID 9453564. 
  51. ^ a b Niehaus, A. Shi, J. Grzenkowski, M. Diers-Fenger, M. Archelos, J. Hartung, H. P. Toyka, K. Bruck, W. Trotter, J. (2000). "Patients with active relapsing-remitting multiple sclerosis synthesize antibodies recognizing oligodendrocyte progenitor cell surface protein: implications for remyelination". Annals of Neurology. 48 (3): 362–71. doi:10.1002/1531-8249(200009)48:3<362::AID-ANA11>3.0.CO;2-6. ISSN 0364-5134. PMID 10976643. 
  52. ^ Lakatos, A. Franklin, R. J. Barnett, S. C. (2000). "Olfactory ensheathing cells and Schwann cells differ in their in vitro interactions with astrocytes". Glia. 32 (3): 214–25. doi:10.1002/1098-1136(200012)32:3<214::AID-GLIA20>3.0.CO;2-7. ISSN 0894-1491. PMID 11102963. 
  53. ^ Behrens, T. E. Johansen-Berg, H. Woolrich, M. W. Smith, S. M. Wheeler-Kingshott, C. A. Boulby, P. A. Barker, G. J. Sillery, E. L. Sheehan, K. Ciccarelli, O. Thompson, A. J. Brady, J. M. Matthews, P. M. (2003). "Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging". Annals of Neurology. 6 (7): 750–757. doi:10.1038/nn1075.