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Royal jelly

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For the short story by Roald Dahl, see Royal Jelly (short story).
Developing queen larvae surrounded by royal jelly

Royal jelly is a honey bee secretion that is used in the nutrition of larvae, as well as adult queens.[1] It is secreted from the glands in the hypopharynx of worker bees, and fed to all larvae in the colony, regardless of sex or caste.[2]

When worker bees decide to make a new queen, because the old one is either weakening or dead, they choose several small larvae and feed them with copious amounts of royal jelly in specially constructed queen cells. This type of feeding triggers the development of queen morphology, including the fully developed ovaries needed to lay eggs.[3]

Cultivation

Royal jelly is secreted from the glands in the heads of worker bees, and is fed to all bee larvae, whether they are destined to become drones (males), workers (sterile females), or queens (fertile females). After three days, the drone and worker larvae are no longer fed with royal jelly, but queen larvae continue to be fed this special substance throughout their development. It is harvested by humans by stimulating colonies with movable frame hives to produce queen bees. Royal jelly is collected from each individual queen cell (honeycomb) when the queen larvae are about four days old. It is collected from queen cells because these are the only cells in which large amounts are deposited; when royal jelly is fed to worker larvae, it is fed directly to them, and they consume it as it is produced, while the cells of queen larvae are "stocked" with royal jelly much faster than the larvae can consume it. Therefore, only in queen cells is the harvest of royal jelly practical. A well-managed hive during a season of 5–6 months can produce approximately 500 g of royal jelly. Since the product is perishable, producers must have immediate access to proper cold storage (e.g., a household refrigerator or freezer) in which the royal jelly is stored until it is sold or conveyed to a collection center. Sometimes honey or beeswax are added to the royal jelly, which is thought to aid its preservation.

Composition

The overall composition of royal jelly is 67% water, 12.5% crude protein, including small amounts of many different amino acids, and 11% simple sugars (monosaccharides), also including a relatively high amount (5%) of fatty acids. It also contains many trace minerals, some enzymes, antibacterial and antibiotic components, pantothenic acid (vitamin B5), vitamin B6 (pyridoxine) and trace amounts of vitamin C,[2] but none of the fat-soluble vitamins, A, D, E and K.[4]

Royalactin

The component of royal jelly that causes a bee to develop into a queen appears to be a single protein that has been called royalactin. Jelly which had been rendered inactive by prolonged storage had a fresh addition of each of the components subject to decay and was fed to bees; only jelly laced with royalactin caused the larvae to become queens.[5] Royalactin also induces similar phenotypical change in the fruitfly (Drosophila melanogaster), marked by increased body size and ovary development.

Epigenetic effects

The honey bee queens and workers represent one of the most striking examples of environmentally controlled phenotypic polymorphism. In spite of their identical clonal nature at the DNA level, they are strongly differentiated across a wide range of characteristics including anatomical and physiological differences, longevity of the queen, and reproductive capacity.[6] Queens constitute the sexual caste and have large active ovaries, whereas workers have only rudimentary, inactive ovaries and are functionally sterile. The queen/worker developmental divide is controlled epigenetically by differential feeding with royal jelly; this appears to be due specifically to the protein royalactin. A female larva destined to become a queen is fed large quantities of royal jelly; this triggers a cascade of molecular events resulting in development of a queen.[3] It has been shown that this phenomenon is mediated by an epigenetic modification of DNA known as CpG methylation.[7] Silencing the expression of an enzyme that methylates DNA in newly hatched larvae led to a royal jelly-like effect on the larval developmental trajectory; the majority of individuals with reduced DNA methylation levels emerged as queens with fully developed ovaries. This finding suggests that DNA methylation in honey bees allows the expression of epigenetic information to be differentially altered by nutritional input.

Uses

Royal jelly is collected and sold as a dietary supplement for humans, claiming various health benefits because of components such as B-complex vitamins.

It is also used as a component in some skin care and natural beauty products. In holistic healing circles and popular alternative medicine folklore, royal jelly is believed to have anti-aging properties. Some alternative medicine practitioners attribute this to its amino acid content and broad spectrum of vitamins and minerals.

Adverse effects

Royal jelly may cause allergic reactions in humans ranging from hives, asthma, to even fatal anaphylaxis.[8][9][10][11][12][13] The incidence of allergic side effect in people who consume royal jelly is unknown. The risk of having an allergy to royal jelly is higher in people who have other allergies.[8]

Experimental research

Royal jelly has been reported as a possible immunomodulatory agent in Graves' disease.[14] It has also been reported to stimulate the growth of glial cells[15] and neural stem cells in the brain.[16] To date, there is preliminary evidence that it may have some cholesterol-lowering, anti-inflammatory, wound-healing, and antibiotic effects, though the last three of these effects are unlikely to be realized if ingested (due to the destruction of the substances involved through digestion, or neutralization by changes in pH).[17] Research also suggests that queen bee acid (10-hydroxy-2-decenoic acid, 10-HDA) found in royal jelly may inhibit the vascularization of tumors.[18] The European Food and Safety Authority has rejected most of these claims.[19]

See also

Wikimedia Commons has media related to Royal jelly.

Notes

  1. ^ Jung-Hoffmann L: Die Determination von Königin und Arbeiterin der Honigbiene. Z Bienenforsch 1966, 8:296-322.
  2. ^ a b Graham, J. (ed.) (1992) The Hive and the Honey Bee (Revised Edition). Dadant & Sons.
  3. ^ a b Maleszka, R, Epigenetic integration of environmental and genomic signals in honey bees: the critical interplay of nutritional, brain and reproductive networks. Epigenetics. 2008, 3, 188-192.
  4. ^ "Value-added products from beekeeping. Chapter 6".
  5. ^ Attention: This template ({{cite doi}}) is deprecated. To cite the publication identified by doi:10.1038/nature10093, please use {{cite journal}} (if it was published in a bona fide academic journal, otherwise {{cite report}} with |doi=10.1038/nature10093 instead.
  6. ^ Winston, M, The Biology of the Honey Bee, 1987, Harvard University Press
  7. ^ Kucharski R, Maleszka, J, Foret, S, Maleszka, R (2008). "Nutritional Control of Reproductive Status in Honeybees via DNA Methylation". Science. 319 (5871): 1827–1833. doi:10.1126/science.1153069.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  8. ^ a b Leung, R; Ho, A; Chan, J; Choy, D; Lai, CK (March 1997). "Royal jelly consumption and hypersensitivity in the community". Clin. Exp. Allergy. 27 (3): 333–6. doi:10.1111/j.1365-2222.1997.tb00712.x. PMID 9088660.
  9. ^ Takahama H, Shimazu T (2006). "Food-induced anaphylaxis caused by ingestion of royal jelly". J Dermatol. 33 (6): 424–426. doi:10.1111/j.1346-8138.2006.00100.x. PMID 16700835.
  10. ^ Lombardi C, Senna GE, Gatti B, Feligioni M, Riva G, Bonadonna P, Dama AR, Canonica GW, Passalacqua G (1998). "Allergic reactions to honey and royal jelly and their relationship with sensitization to compositae". Allergol Immunopathol (Madr). 26 (6): 288–290.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  11. ^ Thien FC, Leung R, Baldo BA, Weiner JA, Plomley R, Czarny D (1996). "Asthma and anaphylaxis induced by royal jelly". Clin Exp Allergy. 26 (2): 216–222. doi:10.1111/j.1365-2222.1996.tb00082.x. PMID 8835130.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  12. ^ >Leung R, Thien FC, Baldo B, Czarny D (1995). "Royal jelly-induced asthma and anaphylaxis: clinical characteristics and immunologic correlations". J Allergy Clin Immunol. 96 (6 Pt 1): 1004–1007. doi:10.1016/S0091-6749(95)70242-3. PMID 8543734.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  13. ^ Bullock RJ, Rohan A, Straatmans JA (1994). "Fatal royal jelly-induced asthma". Med J Aust. 160 (1): 44.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  14. ^ Erem C, Deger O, Ovali E, Barlak Y. The effects of royal jelly on autoimmunity in Graves' disease. Endocrine. 2006 Oct;30(2):175-83.
  15. ^ Hashimoto, M.; Kanda, M.; Ikeno, K.; Hayashi, Y.; Nakamura, T.; Ogawa, Y.; Fukumitsu, H.; Nomoto, H.; Furukawa, S. (April 2005). "Oral administration of royal jelly facilitates mRNA expression of glial cell line-derived neurotrophic factor and neurofilament H in the hippocampus of the adult mouse brain" (PDF). Bioscience, Biotechnology, and Biochemistry. 69 (4): 800–805. doi:10.1271/bbb.69.800. PMID 15849420.
  16. ^ Hattori, N.; Nomoto, H.; Fukumitsu, H.; Mishima, S.; Furukawa, S. (October 2007). "Royal jelly and its unique fatty acid, 10-hydroxy-trans-2-decenoic acid, promote neurogenesis by neural stem/progenitor cells in vitro". Biomedical research (Tokyo, Japan). 28 (5): 261–266. PMID 18000339.
  17. ^ PDR Health, Royal Jelly. available online[dead link]
  18. ^ Izuta, Hiroshi (October 22, 2007). "10-Hydroxy-2-decenoic Acid, a Major Fatty Acid from Royal Jelly, Inhibits VEGF-induced Angiogenesis in Human Umbilical Vein Endothelial Cells". Oxford Journals. Retrieved 2009-10-02. {{cite web}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)
  19. ^ EFSA Journal 2011;9(4):2083 http://www.efsa.europa.eu/en/efsajournal/doc/2083.pdf

References

  • Balch, Phyllis A.; Balch, James F. (2000). Prescription for Nutritional Healing, Third Edition. New York: Avery. ISBN 1-58333-077-1.{{cite book}}: CS1 maint: multiple names: authors list (link)
  • Ammon, R. and Zoch, E. (1957) Zur Biochemie des Futtersaftes der Bienenkoenigin. Arzneimittel Forschung 7: 699-702
  • Blum, M.S., Novak A.F. and Taber III, 5. (1959). 10-Hydroxy-decenoic acid, an antibiotic found in royal jelly. Science, 130 : 452-453
  • Bonomi, A. (1983) Acquisizioni in tema di composizione chimica e di attivita' biologica della pappa reale. Apitalia, 10 (15): 7-13.
  • Braines, L.N. (1959). Royal jelly I. Inform. Bull. Inst. Pchelovodstva, 31 pp (with various articles)
  • Braines, L.N. (1960). Royal jelly II. Inform. Bull. Inst. Pchelovodstva, 40 pp.
  • Braines, L.N. (1962). Royal jelly III. Inform. Bull. Inst. Pchelovodstva, 40
  • Chauvin, R. and Louveaux, 1. (1956) Etdue macroscopique et microscopique de lagelee royale. L'apiculteur.
  • Cho, Y.T. (1977). Studies on royal jelly and abnormal cholesterol and triglycerides. Amer. Bee 1., 117 : 36-38
  • De Belfever, B. (1958) La gelee royale des abeilles. Maloine, Paris.
  • Destrem, H. (1956) Experimentation de la gelee royale d'abeille en pratique geriatrique (134 cas). Rev. Franc. Geront, 3.
  • Giordani, G. (1961). [Effect of royal jelly on chickens.] Avicoltura 30 (6): 114-120
  • Hattori N, Nomoto H, Fukumitsu H, Mishima S, Furukawa S. [Royal jelly and its unique fatty acid, 10-hydroxy-trans-2-decenoic acid, promote neurogenesis by neural stem/progenitor cells in vitro.] Biomed Res. 2007 Oct;28(5):261-6.
  • Hashimoto M, Kanda M, Ikeno K, Hayashi Y, Nakamura T, Ogawa Y, Fukumitsu H, Nomoto H, Furukawa S. (2005) Oral administration of royal jelly facilitates mRNA expression of glial cell line-derived neurotrophic factor and neurofilament H in the hippocampus of the adult mouse brain. Biosci Biotechnol Biochem. 2005 Apr;69(4):800-5.
  • Inoue, T. (1986). The use and utilization of royal jelly and the evaluation of the medical efficacy of royal jelly in Japan. Proceeding sof the XXXth International Congress of Apiculture, Nagoya, 1985, Apimondia, 444-447
  • Jean, E. (1956). A process of royal jelly absorption for its incorporation into assimilable substances. Fr. Pat., 1,118,123
  • Jacoli, G. (1956) Ricerche sperimentali su alcune proprieta' biologiche della gelatina reale. Apicoltore d'Italia, 23 (9-10): 211-214.
  • Jung-Hoffmann L: Die Determination von Königin und Arbeiterin der Honigbiene. Z Bienenforsch 1966, 8:296-322.
  • Karaali, A., Meydanoglu, F. and Eke, D. (1988) Studies on composition, freeze drying and storage of Turkish royal jelly. J. Apic. Res., 27 (3): 182-185.
  • Kucharski R, Maleszka, J, Foret, S, Maleszka, R, Nutritional Control of Reproductive Status in Honeybees via DNA Methylation. Science. 2008 Mar 28;319(5871):1827-3
  • Lercker, G., Capella, P., Conte, L.S., Ruini, F. and Giordani, G. (1982) Components of royal jelly: II. The lipid fraction, hydrocarbons and sterolds. J. Apic. Res. 21(3):178-184.
  • Lercker, G., Vecchi, M.A., Sabatini, A.G. and Nanetti, A. 1984. Controllo chimicoanalitico della gelatina reale. Riv. Merceol. 23 (1): 83-94.
  • Lercker, G., Savioli, S., Vecchi, M.A., Sabatini, A.G., Nanetti, A. and Piana, L. (1986) Carbohydrate Determination of Royal Jelly by High Resolution Gas Chromatography (HRGC). Food Chemistry, 19: 255-264.
  • Lercker, G., Caboni, M.F., Vecchi, M.A., Sabatini, A.G. and Nanetti, A. (1992) Caratterizzazione dei principali costituenti della gelatina reale. Apicoltura 8:11-21.
  • Maleszka, R, Epigenetic integration of environmental and genomic signals in honey bees: the critical interplay of nutritional, brain and reproductive networks. Epigenetics. 2008, 3, 188-192.
  • Nakamura, T. (1986) Quality standards of royal jelly for medical use. proceedings of the XXXth International Congress of Apiculture, Nagoya, 1985 Apimondia (1986) 462-464.
  • Rembold, H. (1965) Biological active sustance in royal jelly. Vitamins and hormones 23:359-382.
  • Salama, A., Mogawer, H.H. and El-Tohamy, M. 1977 Royal jelly a revelation or a fable. Egyptian Journal of Veterinary Science 14 (2): 95-102.
  • Takenaka, T. Nitrogen components and carboxylic acids of royal jelly. In Chemistry and biology of social insects (edited by Eder, J., Rembold, H.). Munich, German Federal Republic, Verlag J. Papemy (1987): 162-163.
  • Wagner, H., Dobler, I., Thiem, I. Effect of royal jelly on the peirpheral blood and survival rate of mice after irradiation of the entire body with X-rays. Radiobiologia Radiotherapia (1970) 11(3): 323-328.
  • Winston, M, The Biology of the Honey Bee, 1987, Harvard University Press
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