Serpin A9 also known as centerin or GCET1 is a protein that in humans is encoded by the SERPINA9gene located on chromosome 14q32.1.[5] Serpin A9 is a member of the serpin family of serine protease inhibitors.
Function
The expression of SERPINA9 is restricted to germinal centerB cells and lymphoid malignancies. SERPINA9 is likely to function in vivo in the germinal center as an efficient inhibitor of trypsin-like proteases.[6][7][8]
^Montes-Moreno S, Roncador G, Maestre L, Martínez N, Sanchez-Verde L, Camacho FI, Cannata J, Martinez-Torrecuadrada JL, Shen Y, Chan WC, Piris MA (January 2008). "Gcet1 (centerin), a highly restricted marker for a subset of germinal center-derived lymphomas". Blood. 111 (1): 351–8. doi:10.1182/blood-2007-06-094151. PMID17898315.
^Paterson MA, Hosking PS, Coughlin PB (July 2008). "Expression of the serpin centerin defines a germinal center phenotype in B-cell lymphomas". Am. J. Clin. Pathol. 130 (1): 117–26. doi:10.1309/9QKE68QU7B825A3U. PMID18550480.
Namciu SJ, Friedman RD, Marsden MD, et al. (2004). "Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1". Mamm. Genome. 15 (3): 162–78. doi:10.1007/s00335-003-2311-y. PMID15014966.
External links
The MEROPS online database for peptidases and their inhibitors: I04.082