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Syntrophin, gamma 1
Symbols SNTG1 ; G1SYN; SYN4
External IDs OMIM608714 MGI1918346 HomoloGene56834 GeneCards: SNTG1 Gene
RNA expression pattern
PBB GE SNTG1 220405 at tn.png
More reference expression data
Species Human Mouse
Entrez 54212 71096
Ensembl ENSG00000147481 ENSMUSG00000025909
UniProt Q9NSN8 Q925E1
RefSeq (mRNA) NM_001287813 NM_001290390
RefSeq (protein) NP_001274742 NP_001277319
Location (UCSC) Chr 8:
49.91 – 50.79 Mb
Chr 1:
8.36 – 9.3 Mb
PubMed search [1] [2]

Gamma-1-syntrophin is a protein that in humans is encoded by the SNTG1 gene.[1][2]

The protein encoded by this gene is a member of the syntrophin family. Syntrophins are cytoplasmic peripheral membrane proteins that typically contain 2 pleckstrin homology (PH) domains, a PDZ domain that bisects the first PH domain, and a C-terminal domain that mediates dystrophin binding. This gene is specifically expressed in the brain. Transcript variants for this gene have been described, but their full-length nature has not been determined.[2]


  1. ^ Piluso G, Mirabella M, Ricci E, Belsito A, Abbondanza C, Servidei S, Puca AA, Tonali P, Puca GA, Nigro V (Jun 2000). "Gamma1- and gamma2-syntrophins, two novel dystrophin-binding proteins localized in neuronal cells". J Biol Chem 275 (21): 15851–60. doi:10.1074/jbc.M000439200. PMID 10747910. 
  2. ^ a b "Entrez Gene: SNTG1 syntrophin, gamma 1". 

Further reading[edit]