Simian-T-lymphotropic virus

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Simian-T-lymphotropic viruses, also Simian T-cell leukemia viruses (STLVs), are retroviruses closely related to the human sexually and breastfeeding transmissible viruses HTLV. They have subtypes 1 thru 4 as compared to HTLV 1 thru 4, each subtype have their own serovars.[1] Together they comprise PTLVs (Primate T-lymphotropic viruses)[1] A study has shown that STLV-1 Tax and SBZ proteins have similar functions to their counterparts of HTLV-1. STLV-1 is oncogenic in Japanese macaques.[2]

In particular, the HTLV-I/STLV-I history might suggest a simian migration from Asia to Africa not much earlier than 19,500-60,000 years ago.[1]


  1. ^ a b c Salemi M, Desmyter J, Vandamme AM (March 2000). "Tempo and mode of human and simian T-lymphotropic virus (HTLV/STLV) evolution revealed by analyses of full-genome sequences". Molecular Biology and Evolution. 17 (3): 374–86. doi:10.1093/oxfordjournals.molbev.a026317. PMID 10723738. 
  2. ^ Miura, Michi; Tanabe, Junko; Sugata, Kenji; Zhao, Tiejun; Ma, Guangyong; Miyazato, Paola; Yasunaga, Jun-Ichiro; Matsuoka, Masao (2014). "STLV-1-infected Japanese macaque as a model of HTLV-1 infection". Retrovirology. 11 (Suppl 1): O12. doi:10.1186/1742-4690-11-S1-O12.