Cepharanthine

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Cepharanthine
Cepharanthine-.png
Clinical data
Synonyms Cepharantin, O-Methylcepharanoline
AHFS/Drugs.com International Drug Names
ATC code
  • none
Identifiers
PubChem CID
ChemSpider
ChEMBL
ECHA InfoCard 100.208.632
Chemical and physical data
Formula C37H38N2O6
Molar mass 606.70742 g/mol
3D model (JSmol)

Cepharanthine is an antiinflammatory and antineoplastic compound isolated from Stephania.[1] Due to these modalities, it has been shown effective against HTLV in lab research. [2] Additionally, it has successfully been used to treat a diverse range of medical conditions, including radiation-induced leukopenia, idiopathic thrombocytopenic purpura, alopecia areata, alopecia pityrodes, venomous snakebites, xerostomia, sarcoidosis, refractory anemia and various cancer-related conditions. No safety issues have been observed with CEP, and side effects are very rarely reported. [3]

References[edit]

  1. ^ Huang, H.; Hu, G.; Wang, C.; Xu, H.; Chen, X.; Qian, A. (2013). "Cepharanthine, an Alkaloid from Stephania cepharantha Hayata, Inhibits the Inflammatory Response in the RAW264.7 Cell and Mouse Models". Inflammation. 37 (1): 235–46. doi:10.1007/s10753-013-9734-8. PMID 24045962. 
  2. ^ Toyama, M; Hamasaki, T; Uto, T; Aoyama, H; Okamoto, M; Hashmoto, Y; Baba, M (2012). "Synergistic inhibition of HTLV-1-infected cell proliferation by combination of cepharanthine and a tetramethylnaphthalene derivative". Anticancer Res. 32: 2639–45. PMID 22753721. 
  3. ^ Rogosnitzky, M; Danks, R. "Therapeutic potential of the biscoclaurine alkaloid, cepharanthine, for a range of clinical conditions". Pharmacol Rep. 63: 337–47. PMID 21602589.