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Protein TAP1 PDB 1jj7.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases TAP1, ABC17, ABCB2, APT1, D6S114E, PSF-1, PSF1, RING4, TAP1*0102N, TAP1N, transporter 1, ATP-binding cassette, sub-family B (MDR/TAP), transporter 1, ATP binding cassette subfamily B member
External IDs MGI: 98483 HomoloGene: 495 GeneCards: TAP1
Gene location (Human)
Chromosome 6 (human)
Chr. Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for TAP1
Genomic location for TAP1
Band 6p21.32 Start 32,845,209 bp[1]
End 32,853,978 bp[1]
RNA expression pattern
PBB GE TAP1 202307 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 6: 32.85 – 32.85 Mb Chr 6: 34.19 – 34.2 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Transporter associated with Antigen Processing 1 is a protein that in humans is encoded by the TAP1 gene.[5][6]


The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease.[7]

See also[edit]


TAP1 has been shown to interact with:


  1. ^ a b c ENSG00000168394, ENSG00000224212, ENSG00000230705, ENSG00000206297, ENSG00000227816, ENSG00000224748, ENSG00000232367 GRCh38: Ensembl release 89: ENSG00000226173, ENSG00000168394, ENSG00000224212, ENSG00000230705, ENSG00000206297, ENSG00000227816, ENSG00000224748, ENSG00000232367 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037321 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Bodmer JG, Marsh SG, Albert ED, Bodmer WF, Dupont B, Erlich HA, Mach B, Mayr WR, Parham P, Sasazuki T (Oct 1992). "Nomenclature for factors of the HLA system, 1991. WHO Nomenclature Committee for factors of the HLA system". Tissue Antigens. 39 (4): 161–73. doi:10.1111/j.1399-0039.1992.tb01932.x. PMID 1529427. 
  6. ^ Bahram S, Arnold D, Bresnahan M, Strominger JL, Spies T (Dec 1991). "Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region". Proc Natl Acad Sci U S A. 88 (22): 10094–8. doi:10.1073/pnas.88.22.10094. PMC 52874Freely accessible. PMID 1946428. 
  7. ^ "Entrez Gene: TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)". 
  8. ^ a b Paulsson KM, Kleijmeer MJ, Griffith J, Jevon M, Chen S, Anderson PO, Sjogren HO, Li S, Wang P (May 2002). "Association of tapasin and COPI provides a mechanism for the retrograde transport of major histocompatibility complex (MHC) class I molecules from the Golgi complex to the endoplasmic reticulum". J. Biol. Chem. 277 (21): 18266–71. doi:10.1074/jbc.M201388200. PMID 11884415. 
  9. ^ Raghuraman G, Lapinski PE, Raghavan M (Nov 2002). "Tapasin interacts with the membrane-spanning domains of both TAP subunits and enhances the structural stability of TAP1 x TAP2 Complexes". J. Biol. Chem. 277 (44): 41786–94. doi:10.1074/jbc.M207128200. PMID 12213826. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.