ATP-binding cassette transporter sub-family C member 11 is a protein that in humans is encoded by the ABCC11gene.
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This ABC full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. The product of this gene participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides. In addition, an SNP in this gene is responsible for determination of human earwax type and presence of underarm odour. This gene and family member ABCC12 are determined to be derived by duplication and are both localized to chromosome 16q12.1. Multiple alternatively spliced transcript variants have been described for this gene.
^Tammur J, Prades C, Arnould I, Rzhetsky A, Hutchinson A, Adachi M, Schuetz JD, Swoboda KJ, Ptacek LJ, Rosier M, Dean M, Allikmets R (Aug 2001). "Two new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome 16q12". Gene273 (1): 89–96. doi:10.1016/S0378-1119(01)00572-8. PMID11483364.
^Dean M, Rzhetsky A, Allikmets R (Jul 2001). "The human ATP-binding cassette (ABC) transporter superfamily". Genome Res11 (7): 1156–66. doi:10.1101/gr.184901. PMID11435397.
Yabuuchi H, Shimizu H, Takayanagi S, Ishikawa T (2001). "Multiple splicing variants of two new human ATP-binding cassette transporters, ABCC11 and ABCC12". Biochem. Biophys. Res. Commun.288 (4): 933–9. doi:10.1006/bbrc.2001.5865. PMID11688999.
Guo Y, Kotova E, Chen ZS; et al. (2003). "MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2',3'-dideoxycytidine and 9'-(2'-phosphonylmethoxyethyl)adenine". J. Biol. Chem.278 (32): 29509–14. doi:10.1074/jbc.+M304059200. PMID12764137.
Bouma G, Lam-Tse WK, Wierenga-Wolf AF; et al. (2004). "Increased serum levels of MRP-8/14 in type 1 diabetes induce an increased expression of CD11b and an enhanced adhesion of circulating monocytes to fibronectin". Diabetes53 (8): 1979–86. doi:10.2337/diabetes.53.8.1979. PMID15277376.
Vogl T, Ludwig S, Goebeler M; et al. (2005). "MRP8 and MRP14 control microtubule reorganization during transendothelial migration of phagocytes". Blood104 (13): 4260–8. doi:10.1182/blood-2004-02-0446. PMID15331440.
Chen ZS, Guo Y, Belinsky MG; et al. (2005). "Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11)". Mol. Pharmacol.67 (2): 545–57. doi:10.1124/mol.104.007138. PMID15537867.
Bortfeld M, Rius M, König J; et al. (2006). "Human multidrug resistance protein 8 (MRP8/ABCC11), an apical efflux pump for steroid sulfates, is an axonal protein of the CNS and peripheral nervous system". Neuroscience137 (4): 1247–57. doi:10.1016/j.neuroscience.2005.10.025. PMID16359813.
Yoshiura K, Kinoshita A, Ishida T; et al. (2006). "A SNP in the ABCC11 gene is the determinant of human earwax type". Nat. Genet.38 (3): 324–30. doi:10.1038/ng1733. PMID16444273.
Viemann D, Barczyk K, Vogl T; et al. (2007). "MRP8/MRP14 impairs endothelial integrity and induces a caspase-dependent and -independent cell death program". Blood109 (6): 2453–60. doi:10.1182/blood-2006-08-040444. PMID17095618.