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ATP-binding cassette, sub-family C (CFTR/MRP), member 11
Symbols ABCC11 ; EWWD; MRP8; WW
External IDs OMIM607040 HomoloGene69511 IUPHAR: 786 GeneCards: ABCC11 Gene
Species Human Mouse
Entrez 85320 n/a
Ensembl ENSG00000121270 n/a
UniProt Q96J66 n/a
RefSeq (mRNA) NM_032583 n/a
RefSeq (protein) NP_115972 n/a
Location (UCSC) Chr 16:
48.17 – 48.25 Mb
PubMed search [1] n/a

ATP-binding cassette transporter sub-family C member 11 is a protein that in humans is encoded by the ABCC11 gene.[1][2][3]

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This ABC full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. The product of this gene participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides. In addition, an SNP in this gene is responsible for determination of human earwax type and presence of underarm odour. This gene and family member ABCC12 are determined to be derived by duplication and are both localized to chromosome 16q12.1. Multiple alternatively spliced transcript variants have been described for this gene.[3]

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  1. ^ Tammur J, Prades C, Arnould I, Rzhetsky A, Hutchinson A, Adachi M, Schuetz JD, Swoboda KJ, Ptacek LJ, Rosier M, Dean M, Allikmets R (Aug 2001). "Two new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome 16q12". Gene 273 (1): 89–96. doi:10.1016/S0378-1119(01)00572-8. PMID 11483364. 
  2. ^ Dean M, Rzhetsky A, Allikmets R (Jul 2001). "The human ATP-binding cassette (ABC) transporter superfamily". Genome Res 11 (7): 1156–66. doi:10.1101/gr.184901. PMID 11435397. 
  3. ^ a b "Entrez Gene: ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11". 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.