TB-21007

TB-21007
Identifiers
	IUPAC name 6,6-dimethyl-3-(2-hydroxyethyl)thio-1-(thiazol-2-yl)-6,7-dihydro-2-benzothiophen-4(5H)-one;
CAS Number	207306-50-1 ;
PubChem CID	6918633;
ChemSpider	5293826 ;
ChEMBL	ChEMBL17603 ;
CompTox Dashboard (EPA)	DTXSID40426083 ;
Chemical and physical data
Formula	C15H17NO2S3
Molar mass	339.495 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES s3ccnc3-c2sc(SCCO)c1c2CC(C)(C)CC1=O;
	InChI InChI=1S/C15H17NO2S3/c1-15(2)7-9-11(10(18)8-15)14(20-6-4-17)21-12(9)13-16-3-5-19-13/h3,5,17H,4,6-8H2,1-2H3 ; Key:QILRYFCEXLFIDS-UHFFFAOYSA-N ;
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TB-21007 is a nootropic drug which acts as a subtype-selective inverse agonist at the α₅ containing GABA_A receptors.^[1]^[2]

References

^ Chambers MS, Atack JR, Bromidge FA, et al. (2002). "6,7-Dihydro-2-benzothiophen-4(5H)-ones: a novel class of GABA-A alpha5 receptor inverse agonists". J. Med. Chem. 45 (6): 1176–9. doi:10.1021/jm010471b. PMID 11881985.
^ Chambers MS, Atack JR, Broughton HB, et al. (2003). "Identification of a novel, selective GABA(A) alpha5 receptor inverse agonist which enhances cognition". J. Med. Chem. 46 (11): 2227–40. doi:10.1021/jm020582q. PMID 12747794.

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