Talk:Acamprosate

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Former good article Acamprosate was one of the Natural sciences good articles, but it has been removed from the list. There are suggestions below for improving the article to meet the good article criteria. Once these issues have been addressed, the article can be renominated. Editors may also seek a reassessment of the decision if they believe there was a mistake.
Article milestones
Date Process Result
April 25, 2006 Peer review Reviewed
December 8, 2006 Good article nominee Listed
February 24, 2008 Good article reassessment Delisted
Current status: Delisted good article

Structual Similarities[edit]

Should there be a section on structural/chemical similarities to taurine? I know it might seem unwarranted, but the effects are nearly identical: GabaA activation, neuroprotection (both excitotoxic and ischemic). Although taurine has more widespread effects, I think it should be brought up that they have very similar receptor activation. 69.205.97.220 (talk) 22:02, 9 April 2009 (UTC)

[1] says it is calcium acetylhomotaurinate. Is mentioned under Names unsourced. See also Homotaurine. - Rod57 (talk) 14:40, 20 December 2016 (UTC)

Comment on GA nomination[edit]

Nice to find you here, MessedRocker.

I've made some improvements. Also, I suggest removing the table with the study outcomes. It's generally not a good idea to discuss individual studies in too great detail in encyclopedia articles.--Steven Fruitsmaak (Reply) 15:42, 29 November 2006 (UTC)

A bit later, but I would echo the suggestion to remove the study table, for the same reason. It's too much detail on a single study. Instead I'd recommend a short prose summary of the findings. delldot on a public computer talk 02:40, 13 January 2008 (UTC)

Referencing[edit]

Looking good - any reason why the references are in the "notes" section, and that there is only one real "reference"? Dr Aaron 10:55, 7 December 2006 (UTC)

Good question. Anyways, it was redundant, so I removed it. MESSEDROCKER 11:50, 7 December 2006 (UTC)
I think this article is up there for GA status - I'm going away for a few days, but if it hasn't been reviewed by the time I get back, I'll take another look at it. All the best, Dr Aaron 22:54, 7 December 2006 (UTC)

Tinnitus[edit]

Hi, I suffer from tinnitus and found out some information about Acamprosate while looking for information on the internet. I know nothing about drugs and haven't a medical or pharmacological(?) background. Can someone with the appropriate knowledge check out the information ? It might be worth mentionning (or maybe not). externallink. —Preceding unsigned comment added by 91.86.19.193 (talk) 22:02, 18 October 2007 (UTC)

There are clinical trials preparing to begin at OHSU--or have all ready begun--under William Martin, PhD. [2] Cole (talk) 17:04, 11 March 2008 (UTC)

Better to have a structure image without explict CH2s?[edit]

Is it better to have a structure image without explict CH2s? What are the Wikipedia rules for drawing structures if any?--ChemSpiderMan (talk) 00:20, 25 January 2008 (UTC)

They're at Wikipedia:WikiProject Chemistry/Structure drawing. Fvasconcellos (t·c) 00:27, 25 January 2008 (UTC)
I've added a structure without explicit hydrogens and in not the calcium salt form, so that the image matches the data in the box. -- Ed (Edgar181) 15:55, 25 January 2008 (UTC)

Good article reassessment[edit]

This article was nominated for good article reassessment to determine whether or not it met the good article criteria and so can be listed as a good article. The article was delisted. Please see the archived discussion for further information. Geometry guy 23:13, 24 February 2008 (UTC)

Rating Start class[edit]

Without anything on contraindications and interactions, very little on side effects, no kinetics, and practically no chemistry, this is far from B class. I'm rating it Start. Sorry I haven't the time for expansion. --ἀνυπόδητος (talk) 20:49, 7 January 2013 (UTC)

Use for benzodiazepine dependence - deleted[edit]

I think the wording of this article heavily suggests a use of acamprosate in the treatment of benzodiazepine dependence that is not supported by the current references and the current literature on the topic. My quick Google Scholar and EMBASE search both turn up nothing to support this use outside of comorbid alcohol and benzodiazepine dependence. I would recommend this be better reflected in the article unless there is some good evidence to suggest otherwise. Xeldarith (talk) 01:51, 17 September 2014 (UTC)

Finally had some time to review all the citations for the comments on benzodiazepine withdrawal (Azevedo and Figuieredo, De Witte et al, Williams, Man et al. and Mayer et al.) and none mentioned acamprosate in the use of benzodiazepine withdrawal. I have removed all the comments regarding its use for such and updated the sections to refer only to alcohol withdrawal. If there are other studies that support acamprosate's use in benzodiazepine withdrawal they should be added and the appropriate sections updated. Xeldarith (talk) 22:35, 16 August 2015 (UTC)

Also studied for the treatment of Alzheimer’s disease[edit]

Exploratory Phase 2 Results of Combination Oral Therapy for Alzheimer’s Justify Further Study says "PLEODIAL-I (NCT02361424) was a Phase 2, 12-week preliminary efficacy study of several doses of PXT-864 (a fixed combination of acamprosate and baclofen at low dose) in 45 treatment-naive patients with mild AD". - Rod57 (talk) 14:24, 20 December 2016 (UTC)