Tisopurine

Tisopurine
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	M04AA02 (WHO) ;
Identifiers
	IUPAC name 1,2-Dihydro-4H-pyrazolo[3,4-d]pyrimidine-4-thione;
CAS Number	5334-23-6 ;
PubChem CID	667510;
ChemSpider	580886;
UNII	79F9I2R16M;
KEGG	D07278 ;
CompTox Dashboard (EPA)	DTXSID90201488 ;
ECHA InfoCard	100.023.865
Chemical and physical data
Formula	C5H4N4S
Molar mass	152.18 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES c1c2c([nH]n1)ncnc2S;
	InChI InChI=1S/C5H4N4S/c10-5-3-1-8-9-4(3)6-2-7-5/h1-2H,(H2,6,7,8,9,10); Key:PYAOPMWCFSVFOT-UHFFFAOYSA-N;
	(verify)

Tisopurine (or thiopurinol) is a drug used in the treatment of gout in some countries.^[1] It reduces uric acid production through inhibiting an early stage in its production.^[2]

References

^ DEAN, B.M.; PERRETT, D.; SIMMONDS, H.A.; GRAHAME, R (April 1974). "THIOPURINOL: COMPARATIVE ENZYME INHIBITION AND PROTEIN BINDING STUDIES WITH ALLOPURINOL, OXIPURINOL AND 6-MERCAPTOPURINE". British Journal of Clinical Pharmacology. 1 (2): 119–127. doi:10.1111/j.1365-2125.1974.tb00220.x. Retrieved 31 August 2015.
^ Jawad, A.S.M (1987). "Alternatives to allopurinol" (PDF). Annals of the Rheumatic Diseases. 46: 493. doi:10.1136/ard.46.6.493-a. Retrieved 31 August 2015.

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[BJClinPharm1974-1] DEAN, B.M.; PERRETT, D.; SIMMONDS, H.A.; GRAHAME, R (April 1974). "THIOPURINOL: COMPARATIVE ENZYME INHIBITION AND PROTEIN BINDING STUDIES WITH ALLOPURINOL, OXIPURINOL AND 6-MERCAPTOPURINE". British Journal of Clinical Pharmacology. 1 (2): 119–127. doi:10.1111/j.1365-2125.1974.tb00220.x. Retrieved 31 August 2015.

[AnnRhudis1987-2] Jawad, A.S.M (1987). "Alternatives to allopurinol" (PDF). Annals of the Rheumatic Diseases. 46: 493. doi:10.1136/ard.46.6.493-a. Retrieved 31 August 2015.

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