Jump to content

Unethical human experimentation

From Wikipedia, the free encyclopedia

This is an old revision of this page, as edited by Citing (talk | contribs) at 02:28, 7 August 2018 (→Empire of Japan: ce). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Unethical human experimentation is human experimentation that violates the principles of medical ethics. Such practices have included denying patients the right to informed consent, using pseudoscientific frameworks such as race science, and torturing people under the guise of research. Around World War II, Imperial Japan and Nazi Germany carried out brutal experiments on prisoners and civilians through groups like Unit 731 or individuals like Josef Mengele; the Nuremburg Code was developed after the war in response to the Nazi experiments. The Declaration of Helsinki, developed by the World Medical Association (WMA), is widely regarded as the cornerstone document on human research ethics.[1][2][3]

Countries have carried out unethical experiments on marginalized populations. Examples include American abuses during Project MKUltra and the Tuskegee syphilis experiments, and the mistreatment of indigenous populations in Canada and Australia.

Nazi Germany

Main articles: Nazi human experimentation and Doctors' Trial

Nazi Germany performed human experimentation on large numbers of prisoners (including children), largely Jews from across Europe, but also Romani, Sinti, ethnic Poles, Soviet POWs, homosexuals and disabled Germans, in its concentration camps mainly in the early 1940s, during World War II and the Holocaust. Prisoners were forced into participating; they did not willingly volunteer and no consent was given for the procedures. Typically, the experiments resulted in death, trauma, illness, shortening of life, disfigurement, or permanent disability, and as such are considered as examples of medical torture since the participants had to endure mass amounts of pain.

At Auschwitz and other German camps, under the direction of Eduard Wirths, selected inmates were subjected to various hazardous experiments that were designed to help German military personnel in combat situations, develop new weapons, aid in the recovery of military personnel who had been injured, and to advance the racial ideology backed by the Third Reich.[4] Aribert Heim conducted similar medical experiments at Mauthausen. Carl Værnet is known to have conducted experiments on homosexual prisoners in attempts to "cure" homosexuality.

After the war, these crimes were tried at what became known as the Doctors' Trial, and the abuses perpetrated led to the development of the Nuremberg Code of medical ethics.[5] During the Nuremberg Trials, 23 Nazi doctors and scientists were tried for the unethical treatment of concentration camp inmates, who were often used as research subjects with fatal consequences. Of those 23, 16 were convicted (15 were convicted for the unethical treatment, while one of them was only convicted of SS membership), 7 were condemned to death, 9 received prison sentences from 10 years to life, and 7 were acquitted.[6]

Before WWII

The Law for the Prevention of Genetically Defective Progeny, passed on 14 July 1933, legalized the involuntary sterilization of persons with diseases claimed to be hereditary: weak-mindedness, schizophrenia, alcohol abuse, insanity, blindness, deafness, and physical deformities. The law was used to encourage growth of the Aryan race through the sterilization of persons who fell under the quota of being genetically defective.[7] 1% of citizens between the age of 17 to 24 had been sterilized within 2 years of the law passing. Within 4 years, 300,000 patients had been sterilized.[8] From about March 1941 to about January 1945, sterilization experiments were conducted at Auschwitz, Ravensbrück, and other places by Dr. Carl Clauberg.[9] The purpose of these experiments was to develop a method of sterilization which would be suitable for sterilizing millions of people with a minimum of time and effort. These experiments were conducted by means of X-ray, surgery and various drugs. Thousands of victims were sterilized. Aside from its experimentation, the Nazi government sterilized around 400,000 people as part of its compulsory sterilization program.[10] Intravenous injections of solutions speculated to contain iodine and silver nitrate were successful, but had unwanted side effects such as vaginal bleeding, severe abdominal pain, and cervical cancer.[11] Therefore, radiation treatment became the favored choice of sterilization. Specific amounts of exposure to radiation destroyed a person’s ability to produce ova or sperm. The radiation was administered through deception. Prisoners were brought into a room and asked to complete forms, which took two to three minutes. In this time, the radiation treatment was administered and, unknown to the prisoners, they were rendered completely sterile. Many suffered severe radiation burns.[12]

Dr. Eugen Fischer began sterilization experimentation in German-occupied South West Africa during World War I. A supporter of forced sterilization as a means to prevent the growth of inferior populations and a member of the Nazi Party, Fischer focused his experimentation on mixed-race children in order to justify the Nazi Party's ban on interracial marriage. As a result of Fischer's research in Namibia, Germany prohibited marriages between people of different races in its colonies.[13]

During WWII

Jewish twins were kept alive to be used in Josef Mengele's medical experiments. These children from Auschwitz were liberated by the Red Army in January 1945.

The Luftwaffe performed a series of 360 to 400 experiments at Dachau and Auschwitz, in which hypothermia was induced in 280 to 300 victims.[14][15] These were conducted for the Nazi high command to simulate the conditions the armies suffered on the Eastern Front, as the German forces were ill-prepared for the cold weather they encountered. Many experiments were conducted on captured Russian troops; the Nazis wondered whether their genetics gave them superior resistance to cold.[16] Approximately 100 people are reported to have died as a result of these experiments.[17]

In early 1942, prisoners at Dachau concentration camp were used by Sigmund Rascher in experiments to aid German pilots who had to eject at high altitudes. A low-pressure chamber containing these prisoners was used to simulate conditions at altitudes of up to 20,000 m (66,000 ft).[18] Of the 200 subjects, 80 died outright, and the others were executed.[16]

Other experiments included: experiments on twins (such as sewing twins together in attempts to create conjoined twins),[19][20][21] an experiment in repeated head injury which drove a boy insane,[22] experiments at Buchenwald where poisons were secretly administered in food,[9] experiments to test the effect of various pharmaceutical preparations on phosphorus burns induced with material from incendiary bombs,[9] experiments at Ravensbrück to investigate the effectiveness of sulfonamide after infection with bacteria such as Clostridium perfringens (the causative agent in gas gangrene) and Clostridium tetani (the causative agent in tetanus),[23][24] experiments conducted to attempt treatments of chemical burns induced by mustard gas and similar compounds,[9] and experiments at Dachau to study various methods of making sea water drinkable.[16][25]

Many of the subjects died as a result of the experiments, while many others were executed after the tests were completed to study the effect post mortem.[26] Those who survived were often left mutilated, suffering permanent disability, weakened bodies, and mental distress.[16][27]

The results of the Dachau freezing experiments have been used in some modern research into the treatment of hypothermia, with at least 45 publications having referenced the experiments since the Second World War.[15] This, together with the recent use of data from Nazi research into the effects of phosgene gas, has proven controversial and presents an ethical dilemma for modern physicians who do not agree with the methods used to obtain this data.[25] Some object on an ethical basis, and others have rejected Nazi research purely on scientific grounds, pointing out methodological inconsistencies. In an often-cited review of the Dachau hypothermia experiments, Berger states that the study has "all the ingredients of a scientific fraud" and that the data "cannot advance science or save human lives."[15]

Several Nazi experimenters were after the war employed by the United States government in Operation Paperclip and later similar efforts.

Japan

Empire of Japan

Japanese Unit 731 Complex that used humans for experimentation for biological and chemical weapons, as well as live vivisections and other experiments

Human subject research in Japan began in World War II. It continued for some years after. Unit 731, a department of the Imperial Japanese Army located near Harbin (then in the puppet state of Manchukuo, in northeast China), experimented on prisoners by conducting vivisections, dismemberments, and bacterial inoculations. It induced epidemics on a very large scale from 1932 onward through the Second Sino-Japanese war.[28] It also conducted biological and chemical weapons tests on prisoners and captured POWs. With the expansion of the empire during World War II, similar units were set up in conquered cities such as Nanking (Unit 1644), Beijing (Unit 1855), Guangzhou (Unit 8604) and Singapore (Unit 9420). After the war, Supreme Commander of the Occupation Douglas MacArthur gave immunity in the name of the United States to Shiro Ishii and all members of the units in exchange for all of the results of their experiments.[28] The United States blocked Soviet access to this information. The Soviets prosecuted some of the Unit 731 members during its Khabarovsk War Crime Trials.

In November 2006, Doctor Akira Makino confessed to Kyodo news that he had performed surgery and amputations on condemned prisoners, including women and children, in 1944 and 1945 while he was stationed on Mindanao.[29] Most of Makino's victims were Moro Muslims.[30][31][32][33][34] In 2007, Doctor Ken Yuasa testified to The Japan Times and said that he believes that at least 1,000 persons working for the Shōwa regime, including surgeons, conducted surgical research on mainland China.[35]

State of Japan

In incidents throughout the 1950s, former Unit 731 members infected prisoners and mental health patients with deadly diseases.[36] In 1958, a large number of infants were brought to Kobe Medical School and forcibly administered sugar by having needles inserted through their noses and into their stomachs. A tube was inserted into their anuses to determine how the sugar was processed by their digestive systems. Many of the infants experienced diarrhea and anal bleeding. The parents were never informed that their children were being used as test subjects.[37]

Aboriginal Australians

In the 1920s and 1930s, Aboriginal Australians were subject to medical experiments on how they experienced pain and where body measurements and blood samples were forcibly taken. The experiments were motivated by a system of scientific racism and were carried out by researchers from the University of Adelaide. In 2002, the vice chancellor of the university described the experiments as "degrading and in some cases barbarous" and the school issued a formal apology to Aboriginal and Torres Strait Islander groups.[38][39]

Indigenous populations in Canada

See also: Canadian Indian residential school system

Canada has historically carried out unethical medical experiments on indigenous populations in concert with its policies of forced cultural assimilation. In 1933, about 600 Native children from the reserves near Qu'Appelle, Saskatchewan were enrolled in a trial to test the tuberculosis vaccine. In both the control and treatment groups nearly a fifth died from exposure, malnutrition, and other causes. Parental consent was not sought for indigenous children, though it was sought for the non-indigenous.[40][41] Between 1942 and 1952, malnourished children from six residential schools were used in experiments without consent or parental notification. They were split into treatment and control groups and denied adequate nutrition as they were used to determine whether certain combinations of supplements mitigated problems. Children died, developed anemia, and were denied dental care as they developed carries and gingivitis. The experiments were run by the Department of Indian Affairs of Canada and directed by Percy Moore and Frederick Tisdall, a former president of the Canadian Paediatric Society.[42] In 2014, the Society released a statement outlining guidelines for community-based participatory research involving Inuit, Métis, and First Nations youth.[43]

Guatemala

Main article: Syphilis experiments in Guatemala

From 1946 to 1948 U.S. scientific researchers in Guatemala infected hundreds of mental patients with sexually transmitted diseases (STD). Researchers from the U.S. Public Health Service (PHS) conducted experiments on approximately 1,500 male and female patients housed at Guatemala's National Mental Health Hospital.[44] The scientists injected the patients with gonorrhea and syphilis—and encouraged many of them to pass the disease on to others. The experiments were done in cooperation with the Guatemalan government. The PHS carried out the experiments under the guise of syphilis inoculations. In 2010 these experiments were revealed by Susan Reverby of Wellesley College, who was researching a book on the Tuskegee syphilis experiments. The US Secretary of State Hillary Clinton issued an official apology to Guatemala.[45] President Barack Obama apologized to President Álvaro Colom, who had called these experiments 'a crime against humanity'.[46]

Vipeholm experiments

The Vipeholm experiments were a series of human experiments where patients of Vipeholm Mental Hospital in Lund, Sweden were fed large amounts of sweets to provoke dental caries (1945-1955). The experiments were sponsored both by the sugar industry and dentist community, in an effort to determine whether carbohydrates affected the formation of cavities. The experiments provided extensive knowledge about dental health and resulted in enough empirical data to link the intake of sugar to dental caries.[47] However, today they are considered to have violated the principles of medical ethics.

United Kingdom

De-classified documents of the National Archives revealed that during the 1930s and 1940s, the British Army used hundreds of British and native British Indian Army soldiers as "guinea pigs" in their experiments to determine if mustard gas inflicted greater damage on Indian skin compared to British skin. It is unclear whether the trial subjects, some of whom were hospitalised by their injuries, were all volunteers.[48]

In the United Kingdom, voluntary human experimentation conducted in a negligent and unethical manner at Porton Down in the 1950s caused the unlawful death of Ronald Maddison.[49][50]

United States

Main article: Unethical human experimentation in the United States

Since the late 19th century, numerous human experiments were performed in the United States, which were later characterized as unethical. They were often performed illegally, without the knowledge, consent, or informed consent of the test subjects. Examples have included the deliberate infection of people with deadly or debilitating diseases, exposing people to biological and chemical weapons, human radiation experiments, injecting people with toxic and radioactive chemicals, surgical experiments, interrogation/torture experiments, tests involving mind-altering substances, and a wide variety of others. Many of these tests were performed on children and mentally disabled individuals. In many of the studies, a large number of the subjects were poor, racial minorities, and/or prisoners. Often, subjects were sick or disabled people, whose doctors told them that they were receiving "medical treatment." They were used as the subjects of harmful and deadly experiments, without their knowledge or consent. In reaction to this, interest groups and institutions have worked to design policies and oversight to ensure that future human subject research in the United States would be ethical and legal.

During World War II, Fort Detrick in Maryland was the headquarters of US biological warfare experiments. Operation Whitecoat involved the injection of infectious agents into military forces to observe their effects in human subjects.[51]

Public outcry over the discovery of government experiments on human subjects led to numerous congressional investigations and hearings, including the Church Committee, Rockefeller Commission, and Advisory Committee on Human Radiation Experiments, amongst others. These inquiries have not resulted in prosecutions. Not all subjects involved in the trials have been compensated or notified that they were subjects of such trials.

From the 1950s-60's, Chester M. Southam injected HeLa cancer cells into healthy individuals, cancer patients, and prison inmates from the Ohio Penitentiary .[52] This experiment raised many bioethical concerns involving informed consent, non-maleficence, and beneficence. Some of Southam's subjects, namely those that already had cancer, were unaware that they were being injected with malignant cells. [53] Additionally, in one of these patients, the cells metastasized to her lymph nodes. [53]

In 1962, the Kefauver-Harris Drug Amendment was passed by the United States Congress. This amendment made changes to the Federal Food Drug & Consumer Act by requiring drug companies to prove both safety and effectiveness of their products. Consequently, drugs were required to have Food and Drug Administration (FDA) approval before being marketed to consumers. Additionally, informed consent became a participation requirement and rules were put into place. This regulation was influenced by the results of 1950 use of thalidomide in Western Europe for pregnant women. They were prescribed the sedative thalidomide, which was inaccurately marketed as a morning sickness treatment. Women gave birth to more than 12,000 infants born with deformities due to effects from the drug in utero.

In the Tuskegee syphilis experiment from 1932 to 1972, the United States Public Health Service contracted with the Tuskegee Institute for a long-term study of syphilis. During the study, more than 600 African-American men were studied who were not told they had syphilis. In an effort to better understand the disease, researchers denied the men access to the known treatment of the antibiotic penicillin. They recorded observations of the effects of the disease over time. Under the impression they were being treated for "bad blood", the participants were given free healthcare by the government.[54] As ineffective treatment was given to the subjects, two-thirds of the group had died by the end of the 40-year experiment. A leak in 1972 led to cessation of the study and severe legal ramifications. It has been widely regarded as the "most infamous biomedical research study in U.S. history".[55] Because of the public outrage, in 1974 Congress passed the National Research Act, to provide for protection of human subjects in experiments. The National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research was established. It was tasked with establishing the boundary between research and routine practice, the role of risk-benefit analysis, guidelines for participation, and the definition of informed consent. Its Belmont Report established three tenets of ethical research: respect for persons, beneficence, and justice.[56]

Project MKUltra — sometimes referred to as the "CIA's mind control program" — was the code name given to an illegal program of experiments on human subjects, designed and undertaken by the United States Central Intelligence Agency (CIA). Experiments on humans were intended to identify and develop drugs and procedures to be used in interrogations and torture, in order to weaken the individual to force confessions through mind control. Organized through the Scientific Intelligence Division of the CIA, the project coordinated with the Special Operations Division of the U.S. Army's Chemical Corps.[57] The program began in the early 1950s, was officially sanctioned in 1953, was reduced in scope in 1964, further curtailed in 1967 and officially halted in 1973.[58] The program engaged in many illegal activities;[59][60][61] in particular it used unwitting U.S. and Canadian citizens as its test subjects, which led to controversy regarding its legitimacy.[59]: 74 [62][63][64] MKUltra used numerous methodologies to manipulate people's mental states and alter brain functions, including the surreptitious administration of drugs (especially LSD) and other chemicals, hypnosis, sensory deprivation, isolation, verbal and sexual abuse, as well as various forms of torture.[65]

Beecher Paper

In a 1966 paper noted Harvard anesthesiologist Henry K. Beecher described 22 published medical studies in which patients had been subjects with no expected benefit to the patient of the experiment.[66] This has been characterized as unethical. For example, patients infused with live cancer cells had been told in one study that they were receiving "some cells," without being told this was cancer. Though identities of the authors and institutions had been stripped, the 22 studies were later identified as having been conducted by mainstream researchers and published in prestigious journals within approximately the previous decade. The 22 cases had been selected from a set of 50 that Beecher had collected. He presented evidence that such unethical studies were widespread and represented a systemic problem in medical research rather than exceptions.[66][67]

Beecher had been writing about human experimentation and publicizing cases that he considered to be bad practice for nearly a decade. His 1965 briefing to science writers and his 1966 paper gained widespread news coverage and stimulated public reaction.[67][68] The paper has been described as "the most influential single paper ever written about experimentation involving human subjects."[69] The United States Office for Human Research Protections credits Beecher through this paper as "ultimately contributing to the impetus for the first NIH and FDA regulations."[70]

Beecher was instrumental in developing solutions to such abuses. He noted that a common element in these studies was that some experimental subjects, such as military personnel or mentally handicapped children in institutions, were not in a position to freely decline consent.[67] Beecher believed that rules requiring informed consent were not alone sufficient, as truly informed consent was an unattainable ideal. He worked both to define the rules and conditions for informed consent, and to establish institutional review boards as an additional layer of oversight regarding research protocols.[67][68]

International drug trials

Since the late 20th century, African nations have often been the sites of clinical testing by large international pharmaceutical companies. In some cases, rural communities have developed iatrophobia (fear of doctors) after undergoing or learning of highly controversial medical experimentation. The fundamental distrust lies in the potential confrontation of Hobson's choice: "Experimental medicine or no medicine at all". Multiple cases of ethically questionable experiments have been documented.[71]

In the late 20th century, Depo-Provera was clinically tested on Zimbabwean women. Once approved, the drug was used as a population control measure in the 1970s. Commercial farm owners put pressure on native women workers to accept the use of Depo-Provera.[72] Population control interests motivated many of the family planning programs. This led to its eventual ban in Zimbabwe.[72]

A 1996 clinical trial in Kano, Nigeria involving the Pfizer drug Trovan to treat meningitis resulted in 200 children being disabled and the deaths of 11. Because of these casualties, the Nigerian government sued Pfizer over whether it had appropriately obtained informed consent.[73][74] Pfizer argued in court that it had met all regulations for drug testing. Many Nigerians mistrust the use of medical vaccines and also refuse to participate in medical trials.[73]

In 1994 United States drug companies began conducting trials of the drug AZT on HIV-positive African subjects with the goal of developing treatments to reduce the transmission of HIV/AIDs during childbirth.[75] With funding from the National Institutes of Health (NIH) and Centers for Disease Control (CDC), the program tested over 17,000 Zimbabwean women for the efficacy of AZT in preventing transmission of HIV/AIDS during childbirth. Half of the women were given a placebo rather than the drug, and the subjects were not informed of the potential dangers of the treatment. According to Peter Lamptey, the head of the AIDS Control and Prevention Program, "if you interviewed the people in the study, most wouldn't understand to what they had actually consented."[75] An estimated 1000 newborns of women in the study contracted HIV/AIDS, although this could have been avoided by treating the women with known drugs. The testing was ceased in 1998 when the CDC claimed to have obtained sufficient data from experiments in Thailand.[75]

See also

References

  1. ^ WMA Press Release: WMA revises the Declaration of Helsinki. 9 October 2000 Archived 27 September 2006 at the Wayback Machine
  2. ^ Snežana, Bošnjak (2001). "The declaration of Helsinki: The cornerstone of research ethics". Archive of Oncology. 9 (3): 179–84.
  3. ^ Tyebkhan, G (2003). "Declaration of Helsinki: the ethical cornerstone of human clinical research". Indian journal of dermatology, venereology and leprology. 69 (3): 245–7. PMID 17642902.
  4. ^ "Nazi Medical Experimentation". US Holocaust Memorial Museum. Retrieved 23 March 2008.
  5. ^ "Angel of Death: Josef Mengele". Auschwitz website. Retrieved 11 March 2013.
  6. ^ Mitscherlich, A; Mielke F (1992). "Epilogue: Seven Were Hanged". The Nazi Doctors And The Nuremberg Code - Human Rights in Human Experimentation. New York: Oxford University Press. pp. 105–107. {{cite book}}: Unknown parameter |editors= ignored (|editor= suggested) (help)
  7. ^ Gardella, JE (1999). "The cost-effectiveness of killing: an overview of Nazi "euthanasia". Medical Sentinel. 4: 132–5.
  8. ^ Dahl M. [Selection and destruction-treatment of "unworthy-to-live" children in the Third Reich and the role of child and adolescent psychiatry], Prax Kinderpsychol Kinderpsychiatr 2001;50:170-91.
  9. ^ a b c d "Introduction to NMT Case 1: U.S.A. v. Karl Brandt et al". Harvard Law Library, Nuremberg Trials Project: A Digital Document Collection. Retrieved 23 March 2008.
  10. ^ Piotrowski, Christa (21 July 2000). "Dark Chapter of American History: U.S. Court Battle Over Forced Sterilization". CommonDreams.org News Center. Archived from the original on 15 April 2008. Retrieved 23 March 2008. {{cite web}}: Unknown parameter |deadurl= ignored (|url-status= suggested) (help)
  11. ^ Meric, Vesna (27 January 2005). "Forced to take part in experiments". BBC News.
  12. ^ "Medical Experiments at Auschwitz". Jewish Virtual Library. Retrieved 23 March 2008.
  13. ^ Friedlander, Henry. 1997. The Origins of Nazi Genocide: From Euthanasia to the Final Solution', University of North Carolina Press
  14. ^ Bogod, David. "The Nazi Hypothermia Experiments: Forbidden Data?", Anaesthesia, Volume 59 Issue 12 Page 1155, December 2004.
  15. ^ a b c Robert L. Berger, M.D. (1990). "Nazi Science — The Dachau Hypothermia Experiments". The New England Journal of Medicine. 322 (20): 1435–1440. doi:10.1056/NEJM199005173222006. PMID 2184357.
  16. ^ a b c d Tyson, Peter. "Holocaust on Trial: The Experiments". NOVA Online. Retrieved 23 March 2008.
  17. ^ Neurnberg Military Tribunal, Volume I · Page 200
  18. ^ Cockburn, Alexander (1998). Whiteout:The CIA, Drugs, and the Press. Verso. ISBN 1-85984-139-2.
  19. ^ Josef Mengele and Experimentation on Human Twins at Auschwitz Archived 2015-04-14 at the Wayback Machine, Children of the Flames; Dr. Josef Mengele and the Untold Story of the Twins of Auschwitz, Lucette Matalon Lagnado and Sheila Cohn Dekel, and Mengele: the Complete Story by Gerald Posner and John Ware.
  20. ^ Black, Edwin (2004). War Against the Weak: Eugenics and America's Campaign to Create a Master Race. United States: Thunder's Mouth Press. ISBN 1-56858-258-7. Retrieved 14 April 2008.
  21. ^ Berenbaum, Michael (1993). The world must know: the history of the Holocaust as told in the United States Holocaust Memorial Museum. Boston: Little, Brown. pp. 194–5. ISBN 0-316-09134-0.
  22. ^ Small, Martin; Vic Shayne. "Remember Us: My Journey from the Shtetl through the Holocaust", Page 135, 2009.
  23. ^ Schaefer, Naomi. The Legacy of Nazi Medicine, The New Atlantis, Number 5, Spring 2004, pp. 54–60.
  24. ^ Spitz, Vivien (2005). Doctors from Hell: The Horrific Account of Nazi Experiments on Humans. Sentient Publications. ISBN 1-59181-032-9.
  25. ^ a b Cohen, Baruch C. "The Ethics Of Using Medical Data From Nazi Experiments". Jewish Law: Articles. Retrieved 23 March 2008.
  26. ^ Rosenberg, Jennifer. "Mengele's Children – The Twins of Auschwitz". about.com. Retrieved 23 March 2008.
  27. ^ "Sterilization Experiments". Jewish Virtual Library. Retrieved 23 March 2008.
  28. ^ a b Gold, H (2003). Unit 731 Testimony (5 ed.). Tuttle Publishing. pp. 109. ISBN 0-8048-3565-9.
  29. ^ "Japanese doctor admits POW abuse". BBC News. 26 November 2006.
  30. ^ AFP A life haunted by WWII surgical killings 2007. Archived 2014-12-13 at the Wayback Machine
  31. ^ AFP Japanese veteran haunted by WWII surgical killings 2007.
  32. ^ Ozawa Japanese war veteran speaks of atrocities in the Philippines 2007.
  33. ^ Parry, "The Australian" Dissect them alive: chilling Imperial that order could not be disobeyed 2007.
  34. ^ Parry, "The Times" Dissect them alive: order not to be disobeyed 2007.
  35. ^ Hongo, Jun. "Vivisectionnist recalls his day of reckoning". The Japan Times. I was afraid during my first vivisection, but the second time around, it was much easier. By the third time, I was willing to do it.
  36. ^ 日本弁護士連合会『人権白書昭和43年版』日本弁護士連合会、. 1968. pp. 126–136.
  37. ^ 清水昭美『増補・生体実験』三一新書、1979年；日比逸郎「臨床研究と生体実験」『ジュリスト臨時増刊・医療と人権』(No.548)、有斐閣、1973年11月、pp.18-23
  38. ^ Template:Cite article
  39. ^ "APOLOGY FOR PAST EXPERIMENTS ON ABORIGINAL PEOPLE". 2002-02-08. Retrieved 2018-08-04. {{cite web}}: Unknown parameter |authors= ignored (help)
  40. ^ Lux, M. (1998). "Perfect subjects: race, tuberculosis, and the Qu'Appelle BCG Vaccine Trial". Canadian Bulletin of Medical History. 15 (2): 277-295.
  41. ^ Leslie Young (2016-02-08). "What happened to Jim? Experiments on Canada's indigenous populations". Global News. Retrieved 2018-08-04.
  42. ^ Template:Cite article
  43. ^ Template:Cite article
  44. ^ "Fact Sheet on the 1946-1948 U.S. Public Health Service Sexually Transmitted Diseases (STD) Inoculation Study". United States Department of Health and Human Services. n.d. Retrieved 2013-04-15.
  45. ^ "U.S. Apologizes for Syphilis Experiment". The New York Times. 1 October 2010. Retrieved 2 October 2010.
  46. ^ "US medical tests in Guatemala 'crime against humanity'". BBC News. 1 October 2010. Retrieved 2 October 2010.
  47. ^ Gustafsson, BE; Quensel, CE; Lanke, LS; Lundqvist, C; Grahnen, H; Bonow, BE; Krasse, B (1954). "The Vipeholm dental caries study; the effect of different levels of carbohydrate intake on caries activity in 436 individuals observed for five years". Acta Odontologica Scandinavica. 11 (3–4): 232–64. doi:10.3109/00016355308993925. PMID 13196991.
  48. ^ "Report: Britain Tested Chemical Weapons on Indian Colonial Troops". Voice of America. 2007-09-02. Retrieved 2011-06-02.
  49. ^ "Organophosphate Report" (PDF). Aerotoxic Association.[permanent dead link]
  50. ^ "Nerve gas death was 'unlawful'". BBC News. 15 November 2004. Retrieved 2013-01-20.
  51. ^ "Hidden history of US germ testing". BBC News. 2006-02-13. Retrieved 2010-05-04.
  52. ^ Skloot 2010, p. 128-134.
  53. ^ a b Skloot 2010, p. 128.
  54. ^ Gray, Fred D. The Tuskegee Syphilis Study, Montgomery: New South Books, 1998.
  55. ^ Katz RV, Kegeles SS, Kressin NR, et al. (November 2006). "The Tuskegee Legacy Project: willingness of Minorities to Participate in Biomedical Research". J Health Care Poor Underserved. 17 (4): 698–715. doi:10.1353/hpu.2006.0126. PMC 1780164. PMID 17242525.
  56. ^ National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research (1978-09-30), The Belmont Report: Ethical Principles and Guidelines for the Protection of Human Subjects of Research (pdf), United States Department of Health, Education and Welfare
  57. ^ Advisory on Human Radiation Experiments, July 5, 1994, National Security Archives, retrieved January 16, 2014 Archived July 13, 2013, at the Wayback Machine
  58. ^ Jo Thomas (3 Sep 1977). "C.I.A Says It Found More Secret Papers on Behavior Control: Senate Panel Puts Off Hearing to Study Data Dozen Witnesses Said To Have Misled Inquiry C.I.A. Tells Of Finding Secret Data". New York Times.
  59. ^ a b "Project MKUltra, the Central Intelligence Agency's Program of Research into Behavioral Modification. Joint Hearing before the Select Committee on Intelligence and the Subcommittee on Health and Scientific Research of the Committee on Human Resources, United States Senate, Ninety-Fifth Congress, First Session" (PDF). U.S. Government Printing Office (copy hosted at the New York Times website). August 8, 1977. Retrieved 2010-04-18.
  60. ^ Chapter 3: Supreme Court Dissents Invoke the Nuremberg Code: CIA and DOD Human Subjects Research Scandals Archived 2013-03-31 at the Wayback Machine
  61. ^ U.S. Senate Report on CIA MKULTRA Behavioral Modification Program 1977 | Public Intelligence
  62. ^ Richelson, JT (ed.) (2001-09-10). "Science, Technology and the CIA: A National Security Archive Electronic Briefing Book". George Washington University. Retrieved 2009-06-12. {{cite web}}: |first= has generic name (help)
  63. ^ "Chapter 3, part 4: Supreme Court Dissents Invoke the Nuremberg Code: CIA and DOD Human Subjects Research Scandals". Advisory Committee on Human Radiation Experiments Final Report. Retrieved 2005-08-24.
  64. ^ "The Select Committee to Study Governmental Operations with Respect to Intelligence Activities, Foreign and Military Intelligence". Church Committee report, no. 94-755, 94th Cong., 2d Sess. Washington, D.C..: United States Congress. 1976. p. 392.
  65. ^ Dick Russell (2008). On the trail of the JFK assassins. Skyhorse Publishing. p. 273.
  66. ^ a b Beecher, H. K. (1966). "Ethics and Clinical Research" (pdf). New England Journal of Medicine. 274 (24): 1354–1360. doi:10.1056/NEJM196606162742405. PMID 5327352Reprint in Harkness, Lederer & Wikler, 2001, PMID 11357216 {{cite journal}}: External link in |postscript= (help); templatestyles stripmarker in |postscript= at position 46 (help)CS1 maint: postscript (link)
  67. ^ a b c d Rothman, D. J. (1987). "Ethics and Human Experimentation" (pdf). New England Journal of Medicine. 317 (19): 1195–1199. doi:10.1056/NEJM198711053171906. PMID 3309660.
  68. ^ a b Kopp, V. (1999). "Henry Knowles Beecher and the development of informed consent in anesthesia research". Anesthesiology. 90 (6): 1756–1765. doi:10.1097/00000542-199906000-00034. PMID 10360876.
  69. ^ Harkness, J.; Lederer, S.; Wikler, D. (2001). "Laying ethical foundations for clinical research" (pdf). Bulletin of the World Health Organization. 79 (4): 365–366. PMC 2566394. PMID 11357216.
  70. ^ "History of the Human Subjects Protection System". Institutional Review Board Guidebook. Office for Human Research Protections. 1993. Retrieved 2011-06-03.
  71. ^ Washington, Harriet A. Medical Apartheid, Anchor Books, 2006, p394
  72. ^ a b Kaler, Amy (1998). "A Threat to the Nation and a Threat to the Men: the Banning of Depo-Provera in Zimbabwe, 1981". Journal of Southern African Studies. 24 (2): 347. doi:10.1080/03057079808708580.
  73. ^ a b Washington, Harriet A. Medical Apartheid, Anchor Books, 2006, p392-393
  74. ^ "Africa | Nigeria sues drugs giant Pfizer". BBC News. 2007-06-05. Retrieved 2010-11-12.
  75. ^ a b c Meier, Benjamin Mason: "International Protection of Persons Undergoing Medical Experimentation: Protecting the Right of Informed Consent," Berkeley Journal of International Law [1085-5718] Meier yr:2002 vol:20 iss:3 pg:513 -554
Retrieved from "https://en.wikipedia.org/w/index.php?title=Unethical_human_experimentation&oldid=853803958"