Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 07:24, 18 November 2007 (UTC)
[edit]Conflict: Ambiguous Proteins (1)
[edit]Proteins without matches (11)
[edit]Proteins with a High Potential Match (3)
[edit]Redirected Proteins (10)
[edit]Manual Inspection (Page not found) (15)
[edit]
Protein Status Grid - Date: 07:24, 18 November 2007 (UTC)
[edit]Vebose Log - Date: 07:24, 18 November 2007 (UTC)
[edit]- INFO: Beginning work on BCL2A1... {November 17, 2007 10:58:52 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 17, 2007 10:59:46 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = BCL2-related protein A1
| HGNCid = 991
| Symbol = BCL2A1
| AltSymbols =; ACC-1; ACC-2; BCL2L5; BFL1; GRS; HBPA1
| OMIM = 601056
| ECnumber =
| Homologene = 2988
| MGIid = 102687
| GeneAtlas_image1 = PBB_GE_BCL2A1_205681_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}}
| Process = {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 597
| Hs_Ensembl = ENSG00000140379
| Hs_RefseqProtein = NP_004040
| Hs_RefseqmRNA = NM_004049
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 15
| Hs_GenLoc_start = 78040290
| Hs_GenLoc_end = 78050698
| Hs_Uniprot = Q16548
| Mm_EntrezGene = 12044
| Mm_Ensembl = ENSMUSG00000074147
| Mm_RefseqmRNA = NM_009742
| Mm_RefseqProtein = NP_033872
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 88754793
| Mm_GenLoc_end = 88760309
| Mm_Uniprot = Q07440
}}
}}
'''BCL2-related protein A1''', also known as '''BCL2A1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: BCL2A1 BCL2-related protein A1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=597| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and has been shown to be up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival.<ref name="entrez">{{cite web | title = Entrez Gene: BCL2A1 BCL2-related protein A1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=597| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Choi SS, Park IC, Yun JW, ''et al.'' |title=A novel Bcl-2 related gene, Bfl-1, is overexpressed in stomach cancer and preferentially expressed in bone marrow. |journal=Oncogene |volume=11 |issue= 9 |pages= 1693-8 |year= 1995 |pmid= 7478596 |doi= }}
*{{cite journal | author=Lin EY, Orlofsky A, Berger MS, Prystowsky MB |title=Characterization of A1, a novel hemopoietic-specific early-response gene with sequence similarity to bcl-2. |journal=J. Immunol. |volume=151 |issue= 4 |pages= 1979-88 |year= 1993 |pmid= 8345191 |doi= }}
*{{cite journal | author=Savitsky K, Sfez S, Tagle DA, ''et al.'' |title=The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species. |journal=Hum. Mol. Genet. |volume=4 |issue= 11 |pages= 2025-32 |year= 1996 |pmid= 8589678 |doi= }}
*{{cite journal | author=Karsan A, Yee E, Kaushansky K, Harlan JM |title=Cloning of human Bcl-2 homologue: inflammatory cytokines induce human A1 in cultured endothelial cells. |journal=Blood |volume=87 |issue= 8 |pages= 3089-96 |year= 1996 |pmid= 8605321 |doi= }}
*{{cite journal | author=Karsan A, Yee E, Harlan JM |title=Endothelial cell death induced by tumor necrosis factor-alpha is inhibited by the Bcl-2 family member, A1. |journal=J. Biol. Chem. |volume=271 |issue= 44 |pages= 27201-4 |year= 1996 |pmid= 8910286 |doi= }}
*{{cite journal | author=Carrió R, López-Hoyos M, Jimeno J, ''et al.'' |title=A1 demonstrates restricted tissue distribution during embryonic development and functions to protect against cell death. |journal=Am. J. Pathol. |volume=149 |issue= 6 |pages= 2133-42 |year= 1997 |pmid= 8952545 |doi= }}
*{{cite journal | author=Kenny JJ, Knobloch TJ, Augustus M, ''et al.'' |title=GRS, a novel member of the Bcl-2 gene family, is highly expressed in multiple cancer cell lines and in normal leukocytes. |journal=Oncogene |volume=14 |issue= 8 |pages= 997-1001 |year= 1997 |pmid= 9050999 |doi= 10.1038/sj.onc.1200898 }}
*{{cite journal | author=Choi SS, Park SH, Kim UJ, Shin HS |title=Bfl-1, a Bcl-2-related gene, is the human homolog of the murine A1, and maps to chromosome 15q24.3. |journal=Mamm. Genome |volume=8 |issue= 10 |pages= 781-2 |year= 1997 |pmid= 9321477 |doi= }}
*{{cite journal | author=Hsu SY, Kaipia A, McGee E, ''et al.'' |title=Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 23 |pages= 12401-6 |year= 1997 |pmid= 9356461 |doi= }}
*{{cite journal | author=Takemoto Y, Furuta M, Sato M, ''et al.'' |title=Growth factor receptor-bound protein 2 (Grb2) association with hemopoietic specific protein 1: linkage between Lck and Grb2. |journal=J. Immunol. |volume=161 |issue= 2 |pages= 625-30 |year= 1998 |pmid= 9670936 |doi= }}
*{{cite journal | author=Zong WX, Edelstein LC, Chen C, ''et al.'' |title=The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis. |journal=Genes Dev. |volume=13 |issue= 4 |pages= 382-7 |year= 1999 |pmid= 10049353 |doi= }}
*{{cite journal | author=Holmgreen SP, Huang DC, Adams JM, Cory S |title=Survival activity of Bcl-2 homologs Bcl-w and A1 only partially correlates with their ability to bind pro-apoptotic family members. |journal=Cell Death Differ. |volume=6 |issue= 6 |pages= 525-32 |year= 1999 |pmid= 10381646 |doi= 10.1038/sj.cdd.4400519 }}
*{{cite journal | author=Lee HH, Dadgostar H, Cheng Q, ''et al.'' |title=NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 16 |pages= 9136-41 |year= 1999 |pmid= 10430908 |doi= }}
*{{cite journal | author=Wang CY, Guttridge DC, Mayo MW, Baldwin AS |title=NF-kappaB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis. |journal=Mol. Cell. Biol. |volume=19 |issue= 9 |pages= 5923-9 |year= 1999 |pmid= 10454539 |doi= }}
*{{cite journal | author=Tomayko MM, Punt JA, Bolcavage JM, ''et al.'' |title=Expression of the Bcl-2 family member A1 is developmentally regulated in T cells. |journal=Int. Immunol. |volume=11 |issue= 11 |pages= 1753-61 |year= 1999 |pmid= 10545479 |doi= }}
*{{cite journal | author=Zhang H, Cowan-Jacob SW, Simonen M, ''et al.'' |title=Structural basis of BFL-1 for its interaction with BAX and its anti-apoptotic action in mammalian and yeast cells. |journal=J. Biol. Chem. |volume=275 |issue= 15 |pages= 11092-9 |year= 2000 |pmid= 10753914 |doi= }}
*{{cite journal | author=Duriez PJ, Wong F, Dorovini-Zis K, ''et al.'' |title=A1 functions at the mitochondria to delay endothelial apoptosis in response to tumor necrosis factor. |journal=J. Biol. Chem. |volume=275 |issue= 24 |pages= 18099-107 |year= 2000 |pmid= 10849436 |doi= 10.1074/jbc.M908925199 }}
*{{cite journal | author=Harrington JJ, Sherf B, Rundlett S, ''et al.'' |title=Creation of genome-wide protein expression libraries using random activation of gene expression. |journal=Nat. Biotechnol. |volume=19 |issue= 5 |pages= 440-5 |year= 2001 |pmid= 11329013 |doi= 10.1038/88107 }}
*{{cite journal | author=Bae J, Hsu SY, Leo CP, ''et al.'' |title=Underphosphorylated BAD interacts with diverse antiapoptotic Bcl-2 family proteins to regulate apoptosis. |journal=Apoptosis |volume=6 |issue= 5 |pages= 319-30 |year= 2001 |pmid= 11483855 |doi= }}
*{{cite journal | author=Akari H, Bour S, Kao S, ''et al.'' |title=The human immunodeficiency virus type 1 accessory protein Vpu induces apoptosis by suppressing the nuclear factor kappaB-dependent expression of antiapoptotic factors. |journal=J. Exp. Med. |volume=194 |issue= 9 |pages= 1299-311 |year= 2001 |pmid= 11696595 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on BUB1... {November 17, 2007 10:59:46 PM PST}
- SEARCH REDIRECT: Control Box Found: BUB1 {November 17, 2007 11:00:43 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 17, 2007 11:00:51 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 17, 2007 11:00:51 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 17, 2007 11:00:51 PM PST}
- UPDATED: Updated protein page: BUB1 {November 17, 2007 11:01:06 PM PST}
- INFO: Beginning work on CD244... {November 17, 2007 11:16:36 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 17, 2007 11:17:13 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = CD244 molecule, natural killer cell receptor 2B4
| HGNCid = 18171
| Symbol = CD244
| AltSymbols =; 2B4; NAIL; NKR2B4; Nmrk; SLAMF4
| OMIM = 605554
| ECnumber =
| Homologene = 9493
| MGIid = 109294
| GeneAtlas_image1 = PBB_GE_CD244_220307_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0009897 |text = external side of plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0006968 |text = cellular defense response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 51744
| Hs_Ensembl = ENSG00000122223
| Hs_RefseqProtein = NP_057466
| Hs_RefseqmRNA = NM_016382
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 159066574
| Hs_GenLoc_end = 159099269
| Hs_Uniprot = Q9BZW8
| Mm_EntrezGene = 18106
| Mm_Ensembl =
| Mm_RefseqmRNA = XM_001000500
| Mm_RefseqProtein = XP_001000500
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''CD244 molecule, natural killer cell receptor 2B4''', also known as '''CD244''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CD244 CD244 molecule, natural killer cell receptor 2B4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51744| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Vaidya SV, Mathew PA |title=Of mice and men: different functions of the murine and human 2B4 (CD244) receptor on NK cells. |journal=Immunol. Lett. |volume=105 |issue= 2 |pages= 180-4 |year= 2006 |pmid= 16621032 |doi= 10.1016/j.imlet.2006.02.006 }}
*{{cite journal | author=Siu G, Strauss EC, Lai E, Hood LE |title=Analysis of a human V beta gene subfamily. |journal=J. Exp. Med. |volume=164 |issue= 5 |pages= 1600-14 |year= 1986 |pmid= 3772297 |doi= }}
*{{cite journal | author=Latchman Y, McKay PF, Reiser H |title=Identification of the 2B4 molecule as a counter-receptor for CD48. |journal=J. Immunol. |volume=161 |issue= 11 |pages= 5809-12 |year= 1998 |pmid= 9834056 |doi= }}
*{{cite journal | author=Brown MH, Boles K, van der Merwe PA, ''et al.'' |title=2B4, the natural killer and T cell immunoglobulin superfamily surface protein, is a ligand for CD48. |journal=J. Exp. Med. |volume=188 |issue= 11 |pages= 2083-90 |year= 1999 |pmid= 9841922 |doi= }}
*{{cite journal | author=Tangye SG, Lazetic S, Woollatt E, ''et al.'' |title=Cutting edge: human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP. |journal=J. Immunol. |volume=162 |issue= 12 |pages= 6981-5 |year= 1999 |pmid= 10358138 |doi= }}
*{{cite journal | author=Nakajima H, Cella M, Langen H, ''et al.'' |title=Activating interactions in human NK cell recognition: the role of 2B4-CD48. |journal=Eur. J. Immunol. |volume=29 |issue= 5 |pages= 1676-83 |year= 1999 |pmid= 10359122 |doi= }}
*{{cite journal | author=Boles KS, Nakajima H, Colonna M, ''et al.'' |title=Molecular characterization of a novel human natural killer cell receptor homologous to mouse 2B4. |journal=Tissue Antigens |volume=54 |issue= 1 |pages= 27-34 |year= 1999 |pmid= 10458320 |doi= }}
*{{cite journal | author=Kubin MZ, Parshley DL, Din W, ''et al.'' |title=Molecular cloning and biological characterization of NK cell activation-inducing ligand, a counterstructure for CD48. |journal=Eur. J. Immunol. |volume=29 |issue= 11 |pages= 3466-77 |year= 1999 |pmid= 10556801 |doi= }}
*{{cite journal | author=Parolini S, Bottino C, Falco M, ''et al.'' |title=X-linked lymphoproliferative disease. 2B4 molecules displaying inhibitory rather than activating function are responsible for the inability of natural killer cells to kill Epstein-Barr virus-infected cells. |journal=J. Exp. Med. |volume=192 |issue= 3 |pages= 337-46 |year= 2000 |pmid= 10934222 |doi= }}
*{{cite journal | author=Kumaresan PR, Mathew PA |title=Structure of the human natural killer cell receptor 2B4 gene and identification of a novel alternative transcript. |journal=Immunogenetics |volume=51 |issue= 11 |pages= 987-92 |year= 2000 |pmid= 11003394 |doi= }}
*{{cite journal | author=Watzl C, Stebbins CC, Long EO |title=NK cell inhibitory receptors prevent tyrosine phosphorylation of the activation receptor 2B4 (CD244). |journal=J. Immunol. |volume=165 |issue= 7 |pages= 3545-8 |year= 2000 |pmid= 11034353 |doi= }}
*{{cite journal | author=Tangye SG, Cherwinski H, Lanier LL, Phillips JH |title=2B4-mediated activation of human natural killer cells. |journal=Mol. Immunol. |volume=37 |issue= 9 |pages= 493-501 |year= 2001 |pmid= 11163399 |doi= }}
*{{cite journal | author=Chuang SS, Pham HT, Kumaresan PR, Mathew PA |title=A prominent role for activator protein-1 in the transcription of the human 2B4 (CD244) gene in NK cells. |journal=J. Immunol. |volume=166 |issue= 10 |pages= 6188-95 |year= 2001 |pmid= 11342640 |doi= }}
*{{cite journal | author=Morra M, Simarro-Grande M, Martin M, ''et al.'' |title=Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients. |journal=J. Biol. Chem. |volume=276 |issue= 39 |pages= 36809-16 |year= 2001 |pmid= 11477068 |doi= 10.1074/jbc.M101305200 }}
*{{cite journal | author=Morra M, Lu J, Poy F, ''et al.'' |title=Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells. |journal=EMBO J. |volume=20 |issue= 21 |pages= 5840-52 |year= 2001 |pmid= 11689425 |doi= 10.1093/emboj/20.21.5840 }}
*{{cite journal | author=Speiser DE, Colonna M, Ayyoub M, ''et al.'' |title=The activatory receptor 2B4 is expressed in vivo by human CD8+ effector alpha beta T cells. |journal=J. Immunol. |volume=167 |issue= 11 |pages= 6165-70 |year= 2002 |pmid= 11714776 |doi= }}
*{{cite journal | author=Chuang SS, Kumaresan PR, Mathew PA |title=2B4 (CD244)-mediated activation of cytotoxicity and IFN-gamma release in human NK cells involves distinct pathways. |journal=J. Immunol. |volume=167 |issue= 11 |pages= 6210-6 |year= 2002 |pmid= 11714782 |doi= }}
*{{cite journal | author=Bottino C, Parolini S, Biassoni R, ''et al.'' |title=X-linked lymphoproliferative disease: the dark side of 2b4 function. |journal=Adv. Exp. Med. Biol. |volume=495 |issue= |pages= 63-7 |year= 2002 |pmid= 11774610 |doi= }}
*{{cite journal | author=Aoukaty A, Tan R |title=Association of the X-linked lymphoproliferative disease gene product SAP/SH2D1A with 2B4, a natural killer cell-activating molecule, is dependent on phosphoinositide 3-kinase. |journal=J. Biol. Chem. |volume=277 |issue= 15 |pages= 13331-7 |year= 2002 |pmid= 11815622 |doi= 10.1074/jbc.M112029200 }}
*{{cite journal | author=Sivori S, Falco M, Marcenaro E, ''et al.'' |title=Early expression of triggering receptors and regulatory role of 2B4 in human natural killer cell precursors undergoing in vitro differentiation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 7 |pages= 4526-31 |year= 2002 |pmid= 11917118 |doi= 10.1073/pnas.072065999 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on DKK1... {November 17, 2007 11:16:06 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 17, 2007 11:16:36 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Dickkopf homolog 1 (Xenopus laevis)
| HGNCid = 2891
| Symbol = DKK1
| AltSymbols =; DKK-1; SK
| OMIM = 605189
| ECnumber =
| Homologene = 7689
| MGIid = 1329040
| GeneAtlas_image1 = PBB_GE_DKK1_204602_at_tn.png
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008083 |text = growth factor activity}} {{GNF_GO|id=GO:0050750 |text = low-density lipoprotein receptor binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}}
| Process = {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0016055 |text = Wnt receptor signaling pathway}} {{GNF_GO|id=GO:0030178 |text = negative regulation of Wnt receptor signaling pathway}} {{GNF_GO|id=GO:0030326 |text = embryonic limb morphogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 22943
| Hs_Ensembl = ENSG00000107984
| Hs_RefseqProtein = NP_036374
| Hs_RefseqmRNA = NM_012242
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 10
| Hs_GenLoc_start = 53744064
| Hs_GenLoc_end = 53747595
| Hs_Uniprot = O94907
| Mm_EntrezGene = 13380
| Mm_Ensembl = ENSMUSG00000024868
| Mm_RefseqmRNA = NM_010051
| Mm_RefseqProtein = NP_034181
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 30611873
| Mm_GenLoc_end = 30615493
| Mm_Uniprot = Q80UL5
}}
}}
'''Dickkopf homolog 1 (Xenopus laevis)''', also known as '''DKK1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DKK1 dickkopf homolog 1 (Xenopus laevis)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22943| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.<ref name="entrez">{{cite web | title = Entrez Gene: DKK1 dickkopf homolog 1 (Xenopus laevis)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22943| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Fedi P, Bafico A, Nieto Soria A, ''et al.'' |title=Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling. |journal=J. Biol. Chem. |volume=274 |issue= 27 |pages= 19465-72 |year= 1999 |pmid= 10383463 |doi= }}
*{{cite journal | author=Krupnik VE, Sharp JD, Jiang C, ''et al.'' |title=Functional and structural diversity of the human Dickkopf gene family. |journal=Gene |volume=238 |issue= 2 |pages= 301-13 |year= 1999 |pmid= 10570958 |doi= }}
*{{cite journal | author=Roessler E, Du Y, Glinka A, ''et al.'' |title=The genomic structure, chromosome location, and analysis of the human DKK1 head inducer gene as a candidate for holoprosencephaly. |journal=Cytogenet. Cell Genet. |volume=89 |issue= 3-4 |pages= 220-4 |year= 2000 |pmid= 10965128 |doi= }}
*{{cite journal | author=Mao B, Wu W, Li Y, ''et al.'' |title=LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. |journal=Nature |volume=411 |issue= 6835 |pages= 321-5 |year= 2001 |pmid= 11357136 |doi= 10.1038/35077108 }}
*{{cite journal | author=Semënov MV, Tamai K, Brott BK, ''et al.'' |title=Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6. |journal=Curr. Biol. |volume=11 |issue= 12 |pages= 951-61 |year= 2001 |pmid= 11448771 |doi= }}
*{{cite journal | author=Zorn AM |title=Wnt signalling: antagonistic Dickkopfs. |journal=Curr. Biol. |volume=11 |issue= 15 |pages= R592-5 |year= 2001 |pmid= 11516963 |doi= }}
*{{cite journal | author=Shou J, Ali-Osman F, Multani AS, ''et al.'' |title=Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA. |journal=Oncogene |volume=21 |issue= 6 |pages= 878-89 |year= 2002 |pmid= 11840333 |doi= 10.1038/sj.onc.1205138 }}
*{{cite journal | author=Mao B, Wu W, Davidson G, ''et al.'' |title=Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling. |journal=Nature |volume=417 |issue= 6889 |pages= 664-7 |year= 2002 |pmid= 12050670 |doi= 10.1038/nature756 }}
*{{cite journal | author=Brott BK, Sokol SY |title=Regulation of Wnt/LRP signaling by distinct domains of Dickkopf proteins. |journal=Mol. Cell. Biol. |volume=22 |issue= 17 |pages= 6100-10 |year= 2002 |pmid= 12167704 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Gregory CA, Singh H, Perry AS, Prockop DJ |title=The Wnt signaling inhibitor dickkopf-1 is required for reentry into the cell cycle of human adult stem cells from bone marrow. |journal=J. Biol. Chem. |volume=278 |issue= 30 |pages= 28067-78 |year= 2003 |pmid= 12740383 |doi= 10.1074/jbc.M300373200 }}
*{{cite journal | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
*{{cite journal | author=Tian E, Zhan F, Walker R, ''et al.'' |title=The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma. |journal=N. Engl. J. Med. |volume=349 |issue= 26 |pages= 2483-94 |year= 2004 |pmid= 14695408 |doi= 10.1056/NEJMoa030847 }}
*{{cite journal | author=Yamaguchi Y, Itami S, Watabe H, ''et al.'' |title=Mesenchymal-epithelial interactions in the skin: increased expression of dickkopf1 by palmoplantar fibroblasts inhibits melanocyte growth and differentiation. |journal=J. Cell Biol. |volume=165 |issue= 2 |pages= 275-85 |year= 2004 |pmid= 15117970 |doi= 10.1083/jcb.200311122 }}
*{{cite journal | author=Caricasole A, Copani A, Caraci F, ''et al.'' |title=Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain. |journal=J. Neurosci. |volume=24 |issue= 26 |pages= 6021-7 |year= 2004 |pmid= 15229249 |doi= 10.1523/JNEUROSCI.1381-04.2004 }}
*{{cite journal | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
*{{cite journal | author=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819-24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504 }}
*{{cite journal | author=Niida A, Hiroko T, Kasai M, ''et al.'' |title=DKK1, a negative regulator of Wnt signaling, is a target of the beta-catenin/TCF pathway. |journal=Oncogene |volume=23 |issue= 52 |pages= 8520-6 |year= 2004 |pmid= 15378020 |doi= 10.1038/sj.onc.1207892 }}
*{{cite journal | author=Lee AY, He B, You L, ''et al.'' |title=Dickkopf-1 antagonizes Wnt signaling independent of beta-catenin in human mesothelioma. |journal=Biochem. Biophys. Res. Commun. |volume=323 |issue= 4 |pages= 1246-50 |year= 2004 |pmid= 15451431 |doi= 10.1016/j.bbrc.2004.09.001 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on FHL2... {November 17, 2007 11:01:06 PM PST}
- SEARCH REDIRECT: Control Box Found: FHL2 {November 17, 2007 11:01:51 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 17, 2007 11:01:52 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 17, 2007 11:01:52 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 17, 2007 11:01:52 PM PST}
- UPDATED: Updated protein page: FHL2 {November 17, 2007 11:02:03 PM PST}
- INFO: Beginning work on FOXC1... {November 17, 2007 11:02:03 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 17, 2007 11:03:11 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_FOXC1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1d5v.
| PDB = {{PDB2|1d5v}}
| Name = Forkhead box C1
| HGNCid = 3800
| Symbol = FOXC1
| AltSymbols =; ARA; FKHL7; FREAC3; IGDA; IHG1; IRID1
| OMIM = 601090
| ECnumber =
| Homologene = 20373
| MGIid = 1347466
| GeneAtlas_image1 = PBB_GE_FOXC1_213260_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0008134 |text = transcription factor binding}} {{GNF_GO|id=GO:0008301 |text = DNA bending activity}} {{GNF_GO|id=GO:0016563 |text = transcription activator activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005720 |text = nuclear heterochromatin}}
| Process = {{GNF_GO|id=GO:0001503 |text = ossification}} {{GNF_GO|id=GO:0001654 |text = eye development}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007507 |text = heart development}} {{GNF_GO|id=GO:0042475 |text = odontogenesis (sensu Vertebrata)}} {{GNF_GO|id=GO:0045893 |text = positive regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0045930 |text = negative regulation of progression through mitotic cell cycle}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2296
| Hs_Ensembl = ENSG00000054598
| Hs_RefseqProtein = NP_001444
| Hs_RefseqmRNA = NM_001453
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 1555206
| Hs_GenLoc_end = 1559131
| Hs_Uniprot = Q12948
| Mm_EntrezGene = 17300
| Mm_Ensembl = ENSMUSG00000050295
| Mm_RefseqmRNA = XM_993078
| Mm_RefseqProtein = XP_998172
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 13
| Mm_GenLoc_start = 31814111
| Mm_GenLoc_end = 31818100
| Mm_Uniprot = Q9QWR9
}}
}}
'''Forkhead box C1''', also known as '''FOXC1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FOXC1 forkhead box C1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2296| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly.<ref name="entrez">{{cite web | title = Entrez Gene: FOXC1 forkhead box C1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2296| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Sperling R, Bustin M |title=Dynamic equilibrium in histone assembly: self-assembly of single histones and histone pairs. |journal=Biochemistry |volume=14 |issue= 15 |pages= 3322-31 |year= 1975 |pmid= 1170889 |doi= }}
*{{cite journal | author=Pierrou S, Hellqvist M, Samuelsson L, ''et al.'' |title=Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending. |journal=EMBO J. |volume=13 |issue= 20 |pages= 5002-12 |year= 1994 |pmid= 7957066 |doi= }}
*{{cite journal | author=Hromas R, Moore J, Johnston T, ''et al.'' |title=Drosophila forkhead homologues are expressed in a lineage-restricted manner in human hematopoietic cells. |journal=Blood |volume=81 |issue= 11 |pages= 2854-9 |year= 1993 |pmid= 8499623 |doi= }}
*{{cite journal | author=Larsson C, Hellqvist M, Pierrou S, ''et al.'' |title=Chromosomal localization of six human forkhead genes, freac-1 (FKHL5), -3 (FKHL7), -4 (FKHL8), -5 (FKHL9), -6 (FKHL10), and -8 (FKHL12). |journal=Genomics |volume=30 |issue= 3 |pages= 464-9 |year= 1997 |pmid= 8825632 |doi= 10.1006/geno.1995.1266 }}
*{{cite journal | author=Longhurst TJ, O'Neill GM, Harvie RM, Davey RA |title=The anthracycline resistance-associated (ara) gene, a novel gene associated with multidrug resistance in a human leukaemia cell line. |journal=Br. J. Cancer |volume=74 |issue= 9 |pages= 1331-5 |year= 1996 |pmid= 8912525 |doi= }}
*{{cite journal | author=Mears AJ, Mirzayans F, Gould DB, ''et al.'' |title=Autosomal dominant iridogoniodysgenesis anomaly maps to 6p25. |journal=Am. J. Hum. Genet. |volume=59 |issue= 6 |pages= 1321-7 |year= 1997 |pmid= 8940278 |doi= }}
*{{cite journal | author=Gould DB, Mears AJ, Pearce WG, Walter MA |title=Autosomal dominant Axenfeld-Rieger anomaly maps to 6p25. |journal=Am. J. Hum. Genet. |volume=61 |issue= 3 |pages= 765-8 |year= 1997 |pmid= 9326342 |doi= }}
*{{cite journal | author=Jordan T, Ebenezer N, Manners R, ''et al.'' |title=Familial glaucoma iridogoniodysplasia maps to a 6p25 region implicated in primary congenital glaucoma and iridogoniodysgenesis anomaly. |journal=Am. J. Hum. Genet. |volume=61 |issue= 4 |pages= 882-8 |year= 1997 |pmid= 9382099 |doi= }}
*{{cite journal | author=Nishimura DY, Swiderski RE, Alward WL, ''et al.'' |title=The forkhead transcription factor gene FKHL7 is responsible for glaucoma phenotypes which map to 6p25. |journal=Nat. Genet. |volume=19 |issue= 2 |pages= 140-7 |year= 1998 |pmid= 9620769 |doi= 10.1038/493 }}
*{{cite journal | author=Mears AJ, Jordan T, Mirzayans F, ''et al.'' |title=Mutations of the forkhead/winged-helix gene, FKHL7, in patients with Axenfeld-Rieger anomaly. |journal=Am. J. Hum. Genet. |volume=63 |issue= 5 |pages= 1316-28 |year= 1998 |pmid= 9792859 |doi= }}
*{{cite journal | author=Swiderski RE, Reiter RS, Nishimura DY, ''et al.'' |title=Expression of the Mf1 gene in developing mouse hearts: implication in the development of human congenital heart defects. |journal=Dev. Dyn. |volume=216 |issue= 1 |pages= 16-27 |year= 1999 |pmid= 10474162 |doi= 10.1002/(SICI)1097-0177(199909)216:1<16::AID-DVDY4>3.0.CO;2-1 }}
*{{cite journal | author=Mirzayans F, Gould DB, Héon E, ''et al.'' |title=Axenfeld-Rieger syndrome resulting from mutation of the FKHL7 gene on chromosome 6p25. |journal=Eur. J. Hum. Genet. |volume=8 |issue= 1 |pages= 71-4 |year= 2000 |pmid= 10713890 |doi= 10.1038/sj.ejhg.5200354 }}
*{{cite journal | author=Lehmann OJ, Ebenezer ND, Jordan T, ''et al.'' |title=Chromosomal duplication involving the forkhead transcription factor gene FOXC1 causes iris hypoplasia and glaucoma. |journal=Am. J. Hum. Genet. |volume=67 |issue= 5 |pages= 1129-35 |year= 2000 |pmid= 11007653 |doi= }}
*{{cite journal | author=Nishimura DY, Searby CC, Alward WL, ''et al.'' |title=A spectrum of FOXC1 mutations suggests gene dosage as a mechanism for developmental defects of the anterior chamber of the eye. |journal=Am. J. Hum. Genet. |volume=68 |issue= 2 |pages= 364-72 |year= 2001 |pmid= 11170889 |doi= }}
*{{cite journal | author=Wang WH, McNatt LG, Shepard AR, ''et al.'' |title=Optimal procedure for extracting RNA from human ocular tissues and expression profiling of the congenital glaucoma gene FOXC1 using quantitative RT-PCR. |journal=Mol. Vis. |volume=7 |issue= |pages= 89-94 |year= 2001 |pmid= 11320352 |doi= }}
*{{cite journal | author=Kawase C, Kawase K, Taniguchi T, ''et al.'' |title=Screening for mutations of Axenfeld-Rieger syndrome caused by FOXC1 gene in Japanese patients. |journal=J. Glaucoma |volume=10 |issue= 6 |pages= 477-82 |year= 2002 |pmid= 11740218 |doi= }}
*{{cite journal | author=Dintilhac A, Bernués J |title=HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences. |journal=J. Biol. Chem. |volume=277 |issue= 9 |pages= 7021-8 |year= 2002 |pmid= 11748221 |doi= 10.1074/jbc.M108417200 }}
*{{cite journal | author=Berry FB, Saleem RA, Walter MA |title=FOXC1 transcriptional regulation is mediated by N- and C-terminal activation domains and contains a phosphorylated transcriptional inhibitory domain. |journal=J. Biol. Chem. |volume=277 |issue= 12 |pages= 10292-7 |year= 2002 |pmid= 11782474 |doi= 10.1074/jbc.M110266200 }}
*{{cite journal | author=Borges AS, Susanna R, Carani JC, ''et al.'' |title=Genetic analysis of PITX2 and FOXC1 in Rieger Syndrome patients from Brazil. |journal=J. Glaucoma |volume=11 |issue= 1 |pages= 51-6 |year= 2002 |pmid= 11821690 |doi= }}
*{{cite journal | author=Freyaldenhoven BS, Fried C, Wielckens K |title=FOXD4a and FOXD4b, two new winged helix transcription factors, are expressed in human leukemia cell lines. |journal=Gene |volume=294 |issue= 1-2 |pages= 131-140 |year= 2003 |pmid= 12234674 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on HSPA9... {November 17, 2007 11:03:11 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 17, 2007 11:04:04 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Heat shock 70kDa protein 9 (mortalin)
| HGNCid = 5244
| Symbol = HSPA9
| AltSymbols =; CSA; GRP75; HSPA9B; MGC4500; MOT; MOT2; MTHSP75; PBP74; mot-2
| OMIM = 600548
| ECnumber =
| Homologene = 39452
| MGIid = 96245
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0051082 |text = unfolded protein binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0009986 |text = cell surface}}
| Process = {{GNF_GO|id=GO:0006457 |text = protein folding}} {{GNF_GO|id=GO:0006611 |text = protein export from nucleus}} {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}} {{GNF_GO|id=GO:0006986 |text = response to unfolded protein}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3313
| Hs_Ensembl =
| Hs_RefseqProtein = NP_004125
| Hs_RefseqmRNA = NM_004134
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 15526
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_010481
| Mm_RefseqProtein = NP_034611
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Heat shock 70kDa protein 9 (mortalin)''', also known as '''HSPA9''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HSPA9 heat shock 70kDa protein 9 (mortalin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3313| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The product encoded by this gene belongs to the heat shock protein 70 family which contains both heat-inducible and constitutively expressed members. The latter are called heat-shock cognate proteins. This gene encodes a heat-shock cognate protein. This protein plays a role in the control of cell proliferation. It may also act as a chaperone.<ref name="entrez">{{cite web | title = Entrez Gene: HSPA9 heat shock 70kDa protein 9 (mortalin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3313| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Kaul SC, Taira K, Pereira-Smith OM, Wadhwa R |title=Mortalin: present and prospective. |journal=Exp. Gerontol. |volume=37 |issue= 10-11 |pages= 1157-64 |year= 2003 |pmid= 12470827 |doi= }}
*{{cite journal | author=Yaguchi T, Aida S, Kaul SC, Wadhwa R |title=Involvement of mortalin in cellular senescence from the perspective of its mitochondrial import, chaperone, and oxidative stress management functions. |journal=Ann. N. Y. Acad. Sci. |volume=1100 |issue= |pages= 306-11 |year= 2007 |pmid= 17460192 |doi= 10.1196/annals.1395.032 }}
*{{cite journal | author=Hochstrasser DF, Frutiger S, Paquet N, ''et al.'' |title=Human liver protein map: a reference database established by microsequencing and gel comparison. |journal=Electrophoresis |volume=13 |issue= 12 |pages= 992-1001 |year= 1993 |pmid= 1286669 |doi= }}
*{{cite journal | author=Domanico SZ, DeNagel DC, Dahlseid JN, ''et al.'' |title=Cloning of the gene encoding peptide-binding protein 74 shows that it is a new member of the heat shock protein 70 family. |journal=Mol. Cell. Biol. |volume=13 |issue= 6 |pages= 3598-610 |year= 1993 |pmid= 7684501 |doi= }}
*{{cite journal | author=Kaul SC, Wadhwa R, Matsuda Y, ''et al.'' |title=Mouse and human chromosomal assignments of mortalin, a novel member of the murine hsp70 family of proteins. |journal=FEBS Lett. |volume=361 |issue= 2-3 |pages= 269-72 |year= 1995 |pmid= 7698336 |doi= }}
*{{cite journal | author=Bhattacharyya T, Karnezis AN, Murphy SP, ''et al.'' |title=Cloning and subcellular localization of human mitochondrial hsp70. |journal=J. Biol. Chem. |volume=270 |issue= 4 |pages= 1705-10 |year= 1995 |pmid= 7829505 |doi= }}
*{{cite journal | author=Furlini G, Vignoli M, Re MC, ''et al.'' |title=Human immunodeficiency virus type 1 interaction with the membrane of CD4+ cells induces the synthesis and nuclear translocation of 70K heat shock protein. |journal=J. Gen. Virol. |volume=75 ( Pt 1) |issue= |pages= 193-9 |year= 1994 |pmid= 7906708 |doi= }}
*{{cite journal | author=Matoba R, Okubo K, Hori N, ''et al.'' |title=The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression. |journal=Gene |volume=146 |issue= 2 |pages= 199-207 |year= 1994 |pmid= 8076819 |doi= }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal | author=Hughes GJ, Frutiger S, Paquet N, ''et al.'' |title=Human liver protein map: update 1993. |journal=Electrophoresis |volume=14 |issue= 11 |pages= 1216-22 |year= 1994 |pmid= 8313870 |doi= }}
*{{cite journal | author=Ji H, Reid GE, Moritz RL, ''et al.'' |title=A two-dimensional gel database of human colon carcinoma proteins. |journal=Electrophoresis |volume=18 |issue= 3-4 |pages= 605-13 |year= 1997 |pmid= 9150948 |doi= 10.1002/elps.1150180344 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal | author=Mizukoshi E, Suzuki M, Loupatov A, ''et al.'' |title=Fibroblast growth factor-1 interacts with the glucose-regulated protein GRP75/mortalin. |journal=Biochem. J. |volume=343 Pt 2 |issue= |pages= 461-6 |year= 1999 |pmid= 10510314 |doi= }}
*{{cite journal | author=O'Keeffe B, Fong Y, Chen D, ''et al.'' |title=Requirement for a kinase-specific chaperone pathway in the production of a Cdk9/cyclin T1 heterodimer responsible for P-TEFb-mediated tat stimulation of HIV-1 transcription. |journal=J. Biol. Chem. |volume=275 |issue= 1 |pages= 279-87 |year= 2000 |pmid= 10617616 |doi= }}
*{{cite journal | author=Kaula SC, Reddelb RR, Sugiharac T, ''et al.'' |title=Inactivation of p53 and life span extension of human diploid fibroblasts by mot-2. |journal=FEBS Lett. |volume=474 |issue= 2-3 |pages= 159-64 |year= 2000 |pmid= 10838077 |doi= }}
*{{cite journal | author=Agostini I, Popov S, Li J, ''et al.'' |title=Heat-shock protein 70 can replace viral protein R of HIV-1 during nuclear import of the viral preintegration complex. |journal=Exp. Cell Res. |volume=259 |issue= 2 |pages= 398-403 |year= 2000 |pmid= 10964507 |doi= 10.1006/excr.2000.4992 }}
*{{cite journal | author=Xie H, Hu Z, Chyna B, ''et al.'' |title=Human mortalin (HSPA9): a candidate for the myeloid leukemia tumor suppressor gene on 5q31. |journal=Leukemia |volume=14 |issue= 12 |pages= 2128-34 |year= 2001 |pmid= 11187902 |doi= }}
*{{cite journal | author=Andersen JS, Lyon CE, Fox AH, ''et al.'' |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1-11 |year= 2002 |pmid= 11790298 |doi= }}
*{{cite journal | author=Carette J, Lehnert S, Chow TY |title=Implication of PBP74/mortalin/GRP75 in the radio-adaptive response. |journal=Int. J. Radiat. Biol. |volume=78 |issue= 3 |pages= 183-90 |year= 2002 |pmid= 11869473 |doi= 10.1080/09553000110097208 }}
*{{cite journal | author=Wadhwa R, Yaguchi T, Hasan MK, ''et al.'' |title=Hsp70 family member, mot-2/mthsp70/GRP75, binds to the cytoplasmic sequestration domain of the p53 protein. |journal=Exp. Cell Res. |volume=274 |issue= 2 |pages= 246-53 |year= 2002 |pmid= 11900485 |doi= 10.1006/excr.2002.5468 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on IFNAR1... {November 17, 2007 11:04:04 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 17, 2007 11:04:48 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Interferon (alpha, beta and omega) receptor 1
| HGNCid = 5432
| Symbol = IFNAR1
| AltSymbols =; AVP; IFN-alpha-REC; IFNAR; IFNBR; IFRC
| OMIM = 107450
| ECnumber =
| Homologene = 524
| MGIid = 107658
| GeneAtlas_image1 = PBB_GE_IFNAR1_204191_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004905 |text = interferon-alpha/beta receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0007259 |text = JAK-STAT cascade}} {{GNF_GO|id=GO:0009615 |text = response to virus}} {{GNF_GO|id=GO:0045351 |text = interferon type I biosynthetic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3454
| Hs_Ensembl = ENSG00000142166
| Hs_RefseqProtein = NP_000620
| Hs_RefseqmRNA = NM_000629
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 21
| Hs_GenLoc_start = 33619079
| Hs_GenLoc_end = 33654038
| Hs_Uniprot = P17181
| Mm_EntrezGene = 15975
| Mm_Ensembl = ENSMUSG00000022967
| Mm_RefseqmRNA = NM_010508
| Mm_RefseqProtein = NP_034638
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 16
| Mm_GenLoc_start = 91374108
| Mm_GenLoc_end = 91396296
| Mm_Uniprot = Q3U5G8
}}
}}
'''Interferon (alpha, beta and omega) receptor 1''', also known as '''IFNAR1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: IFNAR1 interferon (alpha, beta and omega) receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3454| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor.<ref name="entrez">{{cite web | title = Entrez Gene: IFNAR1 interferon (alpha, beta and omega) receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3454| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Bürglin TR, Barnes TM |title=Introns in sequence tags. |journal=Nature |volume=357 |issue= 6377 |pages= 367-8 |year= 1992 |pmid= 1350660 |doi= 10.1038/357367a0 }}
*{{cite journal | author=Lutfalla G, Gardiner K, Proudhon D, ''et al.'' |title=The structure of the human interferon alpha/beta receptor gene. |journal=J. Biol. Chem. |volume=267 |issue= 4 |pages= 2802-9 |year= 1992 |pmid= 1370833 |doi= }}
*{{cite journal | author=Flores I, Mariano TM, Pestka S |title=Human interferon omega (omega) binds to the alpha/beta receptor. |journal=J. Biol. Chem. |volume=266 |issue= 30 |pages= 19875-7 |year= 1991 |pmid= 1834641 |doi= }}
*{{cite journal | author=Lutfalla G, Roeckel N, Mogensen KE, ''et al.'' |title=Assignment of the human interferon-alpha receptor gene to chromosome 21q22.1 by in situ hybridization. |journal=J. Interferon Res. |volume=10 |issue= 5 |pages= 515-7 |year= 1991 |pmid= 2148760 |doi= }}
*{{cite journal | author=Uzé G, Lutfalla G, Gresser I |title=Genetic transfer of a functional human interferon alpha receptor into mouse cells: cloning and expression of its cDNA. |journal=Cell |volume=60 |issue= 2 |pages= 225-34 |year= 1990 |pmid= 2153461 |doi= }}
*{{cite journal | author=Colamonici O, Yan H, Domanski P, ''et al.'' |title=Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase. |journal=Mol. Cell. Biol. |volume=14 |issue= 12 |pages= 8133-42 |year= 1994 |pmid= 7526154 |doi= }}
*{{cite journal | author=Uddin S, Chamdin A, Platanias LC |title=Interaction of the transcriptional activator Stat-2 with the type I interferon receptor. |journal=J. Biol. Chem. |volume=270 |issue= 42 |pages= 24627-30 |year= 1995 |pmid= 7559568 |doi= }}
*{{cite journal | author=Domanski P, Witte M, Kellum M, ''et al.'' |title=Cloning and expression of a long form of the beta subunit of the interferon alpha beta receptor that is required for signaling. |journal=J. Biol. Chem. |volume=270 |issue= 37 |pages= 21606-11 |year= 1995 |pmid= 7665574 |doi= }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal | author=Novick D, Cohen B, Rubinstein M |title=The human interferon alpha/beta receptor: characterization and molecular cloning. |journal=Cell |volume=77 |issue= 3 |pages= 391-400 |year= 1994 |pmid= 8181059 |doi= }}
*{{cite journal | author=Yan H, Krishnan K, Greenlund AC, ''et al.'' |title=Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein. |journal=EMBO J. |volume=15 |issue= 5 |pages= 1064-74 |year= 1996 |pmid= 8605876 |doi= }}
*{{cite journal | author=Yang CH, Shi W, Basu L, ''et al.'' |title=Direct association of STAT3 with the IFNAR-1 chain of the human type I interferon receptor. |journal=J. Biol. Chem. |volume=271 |issue= 14 |pages= 8057-61 |year= 1996 |pmid= 8626489 |doi= }}
*{{cite journal | author=Abramovich C, Yakobson B, Chebath J, Revel M |title=A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor. |journal=EMBO J. |volume=16 |issue= 2 |pages= 260-6 |year= 1997 |pmid= 9029147 |doi= 10.1093/emboj/16.2.260 }}
*{{cite journal | author=Eantuzzi L, Eid P, Malorni W, ''et al.'' |title=Post-translational up-regulation of the cell surface-associated alpha component of the human type I interferon receptor during differentiation of peripheral blood monocytes: role in the biological response to type I interferon. |journal=Eur. J. Immunol. |volume=27 |issue= 5 |pages= 1075-81 |year= 1997 |pmid= 9174595 |doi= }}
*{{cite journal | author=Gessani S, Borghi P, Fantuzzi L, ''et al.'' |title=Induction of cytokines by HIV-1 and its gp120 protein in human peripheral blood monocyte/macrophages and modulation of cytokine response during differentiation. |journal=J. Leukoc. Biol. |volume=62 |issue= 1 |pages= 49-53 |year= 1997 |pmid= 9225992 |doi= }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal | author=Krishnan K, Singh B, Krolewski JJ |title=Identification of amino acid residues critical for the Src-homology 2 domain-dependent docking of Stat2 to the interferon alpha receptor. |journal=J. Biol. Chem. |volume=273 |issue= 31 |pages= 19495-501 |year= 1998 |pmid= 9677371 |doi= }}
*{{cite journal | author=Richter MF, Duménil G, Uzé G, ''et al.'' |title=Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1. |journal=J. Biol. Chem. |volume=273 |issue= 38 |pages= 24723-9 |year= 1998 |pmid= 9733772 |doi= }}
*{{cite journal | author=Rani MR, Leaman DW, Han Y, ''et al.'' |title=Catalytically active TYK2 is essential for interferon-beta-mediated phosphorylation of STAT3 and interferon-alpha receptor-1 (IFNAR-1) but not for activation of phosphoinositol 3-kinase. |journal=J. Biol. Chem. |volume=274 |issue= 45 |pages= 32507-11 |year= 1999 |pmid= 10542297 |doi= }}
*{{cite journal | author=Hattori M, Fujiyama A, Taylor TD, ''et al.'' |title=The DNA sequence of human chromosome 21. |journal=Nature |volume=405 |issue= 6784 |pages= 311-9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on IL7R... {November 17, 2007 11:04:48 PM PST}
- SEARCH REDIRECT: Control Box Found: IL7R {November 17, 2007 11:05:30 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 17, 2007 11:05:33 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 17, 2007 11:05:33 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 17, 2007 11:05:33 PM PST}
- UPDATED: Updated protein page: IL7R {November 17, 2007 11:05:40 PM PST}
- INFO: Beginning work on ILF3... {November 17, 2007 11:05:40 PM PST}
- SEARCH REDIRECT: Control Box Found: ILF3 {November 17, 2007 11:06:38 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 17, 2007 11:06:41 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 17, 2007 11:06:41 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 17, 2007 11:06:41 PM PST}
- UPDATED: Updated protein page: ILF3 {November 17, 2007 11:06:47 PM PST}
- INFO: Beginning work on KISS1... {November 17, 2007 11:06:47 PM PST}
- SEARCH REDIRECT: Control Box Found: KISS1 {November 17, 2007 11:07:17 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 17, 2007 11:07:20 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 17, 2007 11:07:20 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 17, 2007 11:07:20 PM PST}
- UPDATED: Updated protein page: KISS1 {November 17, 2007 11:07:27 PM PST}
- INFO: Beginning work on KRT19... {November 17, 2007 11:07:27 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 17, 2007 11:07:57 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Keratin 19
| HGNCid = 6436
| Symbol = KRT19
| AltSymbols =; CK19; K19; K1CS; MGC15366
| OMIM = 148020
| ECnumber =
| Homologene = 1713
| MGIid = 96693
| GeneAtlas_image1 = PBB_GE_KRT19_201650_at_tn.png
| Function = {{GNF_GO|id=GO:0005200 |text = structural constituent of cytoskeleton}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008307 |text = structural constituent of muscle}}
| Component = {{GNF_GO|id=GO:0005882 |text = intermediate filament}} {{GNF_GO|id=GO:0030018 |text = Z disc}} {{GNF_GO|id=GO:0042383 |text = sarcolemma}} {{GNF_GO|id=GO:0043034 |text = costamere}}
| Process = {{GNF_GO|id=GO:0045214 |text = sarcomere organization}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3880
| Hs_Ensembl = ENSG00000171345
| Hs_RefseqProtein = NP_002267
| Hs_RefseqmRNA = NM_002276
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 36933396
| Hs_GenLoc_end = 36938160
| Hs_Uniprot = P08727
| Mm_EntrezGene = 16669
| Mm_Ensembl = ENSMUSG00000020911
| Mm_RefseqmRNA = NM_008471
| Mm_RefseqProtein = NP_032497
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 99956900
| Mm_GenLoc_end = 99962009
| Mm_Uniprot = P19001
}}
}}
'''Keratin 19''', also known as '''KRT19''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KRT19 keratin 19| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3880| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21.<ref name="entrez">{{cite web | title = Entrez Gene: KRT19 keratin 19| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3880| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Otsuka Y, Ichikawa Y, Kunisaki C, ''et al.'' |title=Correlating purity by microdissection with gene expression in gastric cancer tissue. |journal=Scand. J. Clin. Lab. Invest. |volume=67 |issue= 4 |pages= 367-79 |year= 2007 |pmid= 17558891 |doi= 10.1080/00365510601046334 }}
*{{cite journal | author=Rasmussen HH, van Damme J, Puype M, ''et al.'' |title=Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. |journal=Electrophoresis |volume=13 |issue= 12 |pages= 960-9 |year= 1993 |pmid= 1286667 |doi= }}
*{{cite journal | author=Bader BL, Magin TM, Hatzfeld M, Franke WW |title=Amino acid sequence and gene organization of cytokeratin no. 19, an exceptional tail-less intermediate filament protein. |journal=EMBO J. |volume=5 |issue= 8 |pages= 1865-75 |year= 1986 |pmid= 2428612 |doi= }}
*{{cite journal | author=Stasiak PC, Lane EB |title=Sequence of cDNA coding for human keratin 19. |journal=Nucleic Acids Res. |volume=15 |issue= 23 |pages= 10058 |year= 1988 |pmid= 2447559 |doi= }}
*{{cite journal | author=Eckert RL |title=Sequence of the human 40-kDa keratin reveals an unusual structure with very high sequence identity to the corresponding bovine keratin. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 4 |pages= 1114-8 |year= 1988 |pmid= 2448790 |doi= }}
*{{cite journal | author=Blumenberg M |title=Concerted gene duplications in the two keratin gene families. |journal=J. Mol. Evol. |volume=27 |issue= 3 |pages= 203-11 |year= 1988 |pmid= 2458477 |doi= }}
*{{cite journal | author=Bader BL, Jahn L, Franke WW |title=Low level expression of cytokeratins 8, 18 and 19 in vascular smooth muscle cells of human umbilical cord and in cultured cells derived therefrom, with an analysis of the chromosomal locus containing the cytokeratin 19 gene. |journal=Eur. J. Cell Biol. |volume=47 |issue= 2 |pages= 300-19 |year= 1989 |pmid= 2468493 |doi= }}
*{{cite journal | author=Stasiak PC, Purkis PE, Leigh IM, Lane EB |title=Keratin 19: predicted amino acid sequence and broad tissue distribution suggest it evolved from keratinocyte keratins. |journal=J. Invest. Dermatol. |volume=92 |issue= 5 |pages= 707-16 |year= 1989 |pmid= 2469734 |doi= }}
*{{cite journal | author=Shezen E, Okon E, Ben-Hur H, Abramsky O |title=Cytokeratin expression in human thymus: immunohistochemical mapping. |journal=Cell Tissue Res. |volume=279 |issue= 1 |pages= 221-31 |year= 1995 |pmid= 7534649 |doi= }}
*{{cite journal | author=Milisavljevic V, Freedberg IM, Blumenberg M |title=Close linkage of the two keratin gene clusters in the human genome. |journal=Genomics |volume=34 |issue= 1 |pages= 134-8 |year= 1996 |pmid= 8661035 |doi= 10.1006/geno.1996.0252 }}
*{{cite journal | author=Ceratto N, Dobkin C, Carter M, ''et al.'' |title=Human type I cytokeratin genes are a compact cluster. |journal=Cytogenet. Cell Genet. |volume=77 |issue= 3-4 |pages= 169-74 |year= 1997 |pmid= 9284906 |doi= }}
*{{cite journal | author=Kucharzik T, Lügering N, Schmid KW, ''et al.'' |title=Human intestinal M cells exhibit enterocyte-like intermediate filaments. |journal=Gut |volume=42 |issue= 1 |pages= 54-62 |year= 1998 |pmid= 9505886 |doi= }}
*{{cite journal | author=Yang GP, Ross DT, Kuang WW, ''et al.'' |title=Combining SSH and cDNA microarrays for rapid identification of differentially expressed genes. |journal=Nucleic Acids Res. |volume=27 |issue= 6 |pages= 1517-23 |year= 1999 |pmid= 10037815 |doi= }}
*{{cite journal | author=Zhou X, Liao J, Hu L, ''et al.'' |title=Characterization of the major physiologic phosphorylation site of human keratin 19 and its role in filament organization. |journal=J. Biol. Chem. |volume=274 |issue= 18 |pages= 12861-6 |year= 1999 |pmid= 10212274 |doi= }}
*{{cite journal | author=Salas PJ |title=Insoluble gamma-tubulin-containing structures are anchored to the apical network of intermediate filaments in polarized CACO-2 epithelial cells. |journal=J. Cell Biol. |volume=146 |issue= 3 |pages= 645-58 |year= 1999 |pmid= 10444072 |doi= }}
*{{cite journal | author=Whittock NV, Eady RA, McGrath JA |title=Genomic organization and amplification of the human keratin 15 and keratin 19 genes. |journal=Biochem. Biophys. Res. Commun. |volume=267 |issue= 1 |pages= 462-5 |year= 2000 |pmid= 10623642 |doi= 10.1006/bbrc.1999.1966 }}
*{{cite journal | author=Shi J, Sugrue SP |title=Dissection of protein linkage between keratins and pinin, a protein with dual location at desmosome-intermediate filament complex and in the nucleus. |journal=J. Biol. Chem. |volume=275 |issue= 20 |pages= 14910-5 |year= 2000 |pmid= 10809736 |doi= }}
*{{cite journal | author=Brembeck FH, Rustgi AK |title=The tissue-dependent keratin 19 gene transcription is regulated by GKLF/KLF4 and Sp1. |journal=J. Biol. Chem. |volume=275 |issue= 36 |pages= 28230-9 |year= 2000 |pmid= 10859317 |doi= 10.1074/jbc.M004013200 }}
*{{cite journal | author=Kagaya M, Kaneko S, Ohno H, ''et al.'' |title=Cloning and characterization of the 5'-flanking region of human cytokeratin 19 gene in human cholangiocarcinoma cell line. |journal=J. Hepatol. |volume=35 |issue= 4 |pages= 504-11 |year= 2002 |pmid= 11682035 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on LIMK1... {November 17, 2007 11:07:57 PM PST}
- SEARCH REDIRECT: Control Box Found: LIMK1 {November 17, 2007 11:08:22 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 17, 2007 11:08:25 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 17, 2007 11:08:25 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 17, 2007 11:08:25 PM PST}
- UPDATED: Updated protein page: LIMK1 {November 17, 2007 11:08:32 PM PST}
- INFO: Beginning work on ORM1... {November 17, 2007 11:08:32 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 17, 2007 11:09:12 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Orosomucoid 1
| HGNCid = 8498
| Symbol = ORM1
| AltSymbols =; AGP1; ORM; AGP-A; AGP-B; AGP-B'; AGP2
| OMIM = 138600
| ECnumber =
| Homologene = 88334
| MGIid = 97445
| GeneAtlas_image1 = PBB_GE_ORM1_205041_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ORM1_205040_at_tn.png
| GeneAtlas_image3 = PBB_GE_ORM1_214465_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005488 |text = binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0006953 |text = acute-phase response}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5004
| Hs_Ensembl = ENSG00000187681
| Hs_RefseqProtein = NP_000598
| Hs_RefseqmRNA = NM_000607
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 116125157
| Hs_GenLoc_end = 116128576
| Hs_Uniprot = P02763
| Mm_EntrezGene = 18407
| Mm_Ensembl = ENSMUSG00000028359
| Mm_RefseqmRNA = NM_013623
| Mm_RefseqProtein = NP_038651
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 62842523
| Mm_GenLoc_end = 62845872
| Mm_Uniprot = Q80VW8
}}
}}
'''Orosomucoid 1''', also known as '''ORM1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ORM1 orosomucoid 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5004| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression.<ref name="entrez">{{cite web | title = Entrez Gene: ORM1 orosomucoid 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5004| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Treuheit MJ, Costello CE, Halsall HB |title=Analysis of the five glycosylation sites of human alpha 1-acid glycoprotein. |journal=Biochem. J. |volume=283 ( Pt 1) |issue= |pages= 105-12 |year= 1992 |pmid= 1567356 |doi= }}
*{{cite journal | author=Dente L, Ciliberto G, Cortese R |title=Structure of the human alpha 1-acid glycoprotein gene: sequence homology with other human acute phase protein genes. |journal=Nucleic Acids Res. |volume=13 |issue= 11 |pages= 3941-52 |year= 1985 |pmid= 2409529 |doi= }}
*{{cite journal | author=Dubé JY, Paradis G, Têtu B, Tremblay RR |title=Synthesis of alpha 1-acid glycoprotein by the human prostate. |journal=Prostate |volume=15 |issue= 3 |pages= 251-8 |year= 1989 |pmid= 2479939 |doi= }}
*{{cite journal | author=Zuffardi O, Caiulo A, Maraschio P, ''et al.'' |title=Regional assignment of the loci for adenylate kinase to 9q32 and for alpha 1-acid glycoprotein to 9q31-q32. A locus for Goltz syndrome in region 9q32-qter? |journal=Hum. Genet. |volume=82 |issue= 1 |pages= 17-9 |year= 1989 |pmid= 2541064 |doi= }}
*{{cite journal | author=Dente L, Pizza MG, Metspalu A, Cortese R |title=Structure and expression of the genes coding for human alpha 1-acid glycoprotein. |journal=EMBO J. |volume=6 |issue= 8 |pages= 2289-96 |year= 1987 |pmid= 2822385 |doi= }}
*{{cite journal | author=Merritt CM, Board PG |title=Structure and characterisation of a duplicated human alpha 1 acid glycoprotein gene. |journal=Gene |volume=66 |issue= 1 |pages= 97-106 |year= 1988 |pmid= 2970990 |doi= }}
*{{cite journal | author=Dente L, Rüther U, Tripodi M, ''et al.'' |title=Expression of human alpha 1-acid glycoprotein genes in cultured cells and in transgenic mice. |journal=Genes Dev. |volume=2 |issue= 2 |pages= 259-66 |year= 1988 |pmid= 3360326 |doi= }}
*{{cite journal | author=Rocchi M, Roncuzzi L, Santamaria R, ''et al.'' |title=Mapping through somatic cell hybrids and cDNA probes of protein C to chromosome 2, factor X to chromosome 13, and alpha 1-acid glycoprotein to chromosome 9. |journal=Hum. Genet. |volume=74 |issue= 1 |pages= 30-3 |year= 1986 |pmid= 3463531 |doi= }}
*{{cite journal | author=Board PG, Jones IM, Bentley AK |title=Molecular cloning and nucleotide sequence of human alpha 1 acid glycoprotein cDNA. |journal=Gene |volume=44 |issue= 1 |pages= 127-31 |year= 1986 |pmid= 3770479 |doi= }}
*{{cite journal | author=Krauss E, Polnaszek CF, Scheeler DA, ''et al.'' |title=Interaction between human serum albumin and alpha 1-acid glycoprotein in the binding of lidocaine to purified protein fractions and sera. |journal=J. Pharmacol. Exp. Ther. |volume=239 |issue= 3 |pages= 754-9 |year= 1987 |pmid= 3795040 |doi= }}
*{{cite journal | author=Ikenaka T, Ishiguro M, Emura J, ''et al.'' |title=Isolation and partial characterization of the cyanogen bromide fragments of 1 -acid glycoprotein and the elucidation of the amino acid sequence of the carboxyl-terminal cyanogen bromide fragment. |journal=Biochemistry |volume=11 |issue= 20 |pages= 3817-29 |year= 1972 |pmid= 4561179 |doi= }}
*{{cite journal | author=Schmid K, Bürgi W, Collins JH, Nanno S |title=The disulfide bonds of alpha1-acid glycoprotein. |journal=Biochemistry |volume=13 |issue= 13 |pages= 2694-7 |year= 1974 |pmid= 4603214 |doi= }}
*{{cite journal | author=Schmid K, Kaufmann H, Isemura S, ''et al.'' |title=Structure of 1 -acid glycoprotein. The complete amino acid sequence, multiple amino acid substitutions, and homology with the immunoglobulins. |journal=Biochemistry |volume=12 |issue= 14 |pages= 2711-24 |year= 1973 |pmid= 4711474 |doi= }}
*{{cite journal | author=Mbuyi JM, Dequeker J, Bloemmen F, Stevens E |title=Plasma proteins in human cortical bone: enrichment of alpha 2 HS-glycoprotein, alpha 1 acid-glycoprotein, and IgE. |journal=Calcif. Tissue Int. |volume=34 |issue= 3 |pages= 229-31 |year= 1982 |pmid= 6809283 |doi= }}
*{{cite journal | author=Rabehi L, Ferriere F, Saffar L, Gattegno L |title=alpha 1-Acid glycoprotein binds human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein via N-linked glycans. |journal=Glycoconj. J. |volume=12 |issue= 1 |pages= 7-16 |year= 1995 |pmid= 7795416 |doi= }}
*{{cite journal | author=Matoba R, Okubo K, Hori N, ''et al.'' |title=The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression. |journal=Gene |volume=146 |issue= 2 |pages= 199-207 |year= 1994 |pmid= 8076819 |doi= }}
*{{cite journal | author=Nakamura T, Board PG, Matsushita K, ''et al.'' |title=Alpha 1-acid glycoprotein expression in human leukocytes: possible correlation between alpha 1-acid glycoprotein and inflammatory cytokines in rheumatoid arthritis. |journal=Inflammation |volume=17 |issue= 1 |pages= 33-45 |year= 1993 |pmid= 8432561 |doi= }}
*{{cite journal | author=Yuasa I, Umetsu K, Vogt U, ''et al.'' |title=Human orosomucoid polymorphism: molecular basis of the three common ORM1 alleles, ORM1*F1, ORM1*F2, and ORM1*S. |journal=Hum. Genet. |volume=99 |issue= 3 |pages= 393-8 |year= 1997 |pmid= 9050929 |doi= }}
*{{cite journal | author=Morin D, Simon N, Deprés-Brummer P, ''et al.'' |title=Melatonin high-affinity binding to alpha-1-acid glycoprotein in human serum. |journal=Pharmacology |volume=54 |issue= 5 |pages= 271-5 |year= 1997 |pmid= 9380773 |doi= }}
*{{cite journal | author=Nakamura H, Yuasa I, Umetsu K, ''et al.'' |title=The rearrangement of the human alpha(1)-acid glycoprotein/orosomucoid gene: evidence for tandemly triplicated genes consisting of two AGP1 and one AGP2. |journal=Biochem. Biophys. Res. Commun. |volume=276 |issue= 2 |pages= 779-84 |year= 2000 |pmid= 11027547 |doi= 10.1006/bbrc.2000.3522 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PI3... {November 17, 2007 11:09:12 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 17, 2007 11:09:44 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PI3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1fle.
| PDB = {{PDB2|1fle}}, {{PDB2|2rel}}
| Name = Peptidase inhibitor 3, skin-derived (SKALP)
| HGNCid = 8947
| Symbol = PI3
| AltSymbols =; ESI; MGC13613; SKALP; WAP3; WFDC14
| OMIM = 182257
| ECnumber =
| Homologene = 48118
| MGIid =
| GeneAtlas_image1 = PBB_GE_PI3_41469_at_tn.png
| GeneAtlas_image2 = PBB_GE_PI3_203691_at_tn.png
| Function = {{GNF_GO|id=GO:0004867 |text = serine-type endopeptidase inhibitor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005578 |text = proteinaceous extracellular matrix}}
| Process = {{GNF_GO|id=GO:0007620 |text = copulation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5266
| Hs_Ensembl = ENSG00000124102
| Hs_RefseqProtein = NP_002629
| Hs_RefseqmRNA = NM_002638
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 20
| Hs_GenLoc_start = 43236912
| Hs_GenLoc_end = 43238598
| Hs_Uniprot = P19957
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Peptidase inhibitor 3, skin-derived (SKALP)''', also known as '''PI3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PI3 peptidase inhibitor 3, skin-derived (SKALP)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5266| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes an elastase-specific inhibitor, which contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster.<ref name="entrez">{{cite web | title = Entrez Gene: PI3 peptidase inhibitor 3, skin-derived (SKALP)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5266| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Sallenave JM |title=The role of secretory leukocyte proteinase inhibitor and elafin (elastase-specific inhibitor/skin-derived antileukoprotease) as alarm antiproteinases in inflammatory lung disease. |journal=Respir. Res. |volume=1 |issue= 2 |pages= 87-92 |year= 2003 |pmid= 11667971 |doi= }}
*{{cite journal | author=Saheki T, Ito F, Hagiwara H, ''et al.'' |title=Primary structure of the human elafin precursor preproelafin deduced from the nucleotide sequence of its gene and the presence of unique repetitive sequences in the prosegment. |journal=Biochem. Biophys. Res. Commun. |volume=185 |issue= 1 |pages= 240-5 |year= 1992 |pmid= 1339270 |doi= }}
*{{cite journal | author=Sallenave JM, Marsden MD, Ryle AP |title=Isolation of elafin and elastase-specific inhibitor (ESI) from bronchial secretions. Evidence of sequence homology and immunological cross-reactivity. |journal=Biol. Chem. Hoppe-Seyler |volume=373 |issue= 1 |pages= 27-33 |year= 1992 |pmid= 1536690 |doi= }}
*{{cite journal | author=Chang A, Schalkwijk J, Happle R, van de Kerkhof PC |title=Elastase-inhibiting activity in scaling skin disorders. |journal=Acta Derm. Venereol. |volume=70 |issue= 2 |pages= 147-51 |year= 1990 |pmid= 1969201 |doi= }}
*{{cite journal | author=Schalkwijk J, de Roo C, de Jongh GJ |title=Skin-derived antileukoproteinase (SKALP), an elastase inhibitor from human keratinocytes. Purification and biochemical properties. |journal=Biochim. Biophys. Acta |volume=1096 |issue= 2 |pages= 148-54 |year= 1991 |pmid= 2001428 |doi= }}
*{{cite journal | author=Sallenave JM, Ryle AP |title=Purification and characterization of elastase-specific inhibitor. Sequence homology with mucus proteinase inhibitor. |journal=Biol. Chem. Hoppe-Seyler |volume=372 |issue= 1 |pages= 13-21 |year= 1991 |pmid= 2039600 |doi= }}
*{{cite journal | author=Wiedow O, Schröder JM, Gregory H, ''et al.'' |title=Elafin: an elastase-specific inhibitor of human skin. Purification, characterization, and complete amino acid sequence. |journal=J. Biol. Chem. |volume=265 |issue= 25 |pages= 14791-5 |year= 1990 |pmid= 2394696 |doi= }}
*{{cite journal | author=Molhuizen HO, Alkemade HA, Zeeuwen PL, ''et al.'' |title=SKALP/elafin: an elastase inhibitor from cultured human keratinocytes. Purification, cDNA sequence, and evidence for transglutaminase cross-linking. |journal=J. Biol. Chem. |volume=268 |issue= 16 |pages= 12028-32 |year= 1993 |pmid= 7685029 |doi= }}
*{{cite journal | author=Zhang M, Zou Z, Maass N, Sager R |title=Differential expression of elafin in human normal mammary epithelial cells and carcinomas is regulated at the transcriptional level. |journal=Cancer Res. |volume=55 |issue= 12 |pages= 2537-41 |year= 1995 |pmid= 7780965 |doi= }}
*{{cite journal | author=Molhuizen HO, Zeeuwen PL, Olde Weghuis D, ''et al.'' |title=Assignment of the human gene encoding the epidermal serine proteinase inhibitor SKALP (PI3) to chromosome region 20q12-->q13. |journal=Cytogenet. Cell Genet. |volume=66 |issue= 2 |pages= 129-31 |year= 1994 |pmid= 8287685 |doi= }}
*{{cite journal | author=Sallenave JM, Silva A |title=Characterization and gene sequence of the precursor of elafin, an elastase-specific inhibitor in bronchial secretions. |journal=Am. J. Respir. Cell Mol. Biol. |volume=8 |issue= 4 |pages= 439-45 |year= 1993 |pmid= 8476637 |doi= }}
*{{cite journal | author=Tsunemi M, Matsuura Y, Sakakibara S, Katsube Y |title=Crystal structure of an elastase-specific inhibitor elafin complexed with porcine pancreatic elastase determined at 1.9 A resolution. |journal=Biochemistry |volume=35 |issue= 36 |pages= 11570-6 |year= 1996 |pmid= 8794736 |doi= 10.1021/bi960900l }}
*{{cite journal | author=Pfundt R, van Ruissen F, van Vlijmen-Willems IM, ''et al.'' |title=Constitutive and inducible expression of SKALP/elafin provides anti-elastase defense in human epithelia. |journal=J. Clin. Invest. |volume=98 |issue= 6 |pages= 1389-99 |year= 1996 |pmid= 8823304 |doi= }}
*{{cite journal | author=Steinert PM, Marekov LN |title=Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte cornified cell envelope. |journal=J. Biol. Chem. |volume=272 |issue= 3 |pages= 2021-30 |year= 1997 |pmid= 8999895 |doi= }}
*{{cite journal | author=Francart C, Dauchez M, Alix AJ, Lippens G |title=Solution structure of R-elafin, a specific inhibitor of elastase. |journal=J. Mol. Biol. |volume=268 |issue= 3 |pages= 666-77 |year= 1997 |pmid= 9171290 |doi= 10.1006/jmbi.1997.0983 }}
*{{cite journal | author=Kuijpers AL, Pfundt R, Zeeuwen PL, ''et al.'' |title=SKALP/elafin gene polymorphisms are not associated with pustular forms of psoriasis. |journal=Clin. Genet. |volume=54 |issue= 1 |pages= 96-101 |year= 1998 |pmid= 9727750 |doi= }}
*{{cite journal | author=Mihaila A, Tremblay GM |title=Human alveolar macrophages express elafin and secretory leukocyte protease inhibitor. |journal=Z. Naturforsch., C, J. Biosci. |volume=56 |issue= 3-4 |pages= 291-7 |year= 2001 |pmid= 11371023 |doi= }}
*{{cite journal | author=Simpson AJ, Wallace WA, Marsden ME, ''et al.'' |title=Adenoviral augmentation of elafin protects the lung against acute injury mediated by activated neutrophils and bacterial infection. |journal=J. Immunol. |volume=167 |issue= 3 |pages= 1778-86 |year= 2001 |pmid= 11466403 |doi= }}
*{{cite journal | author=Sumi Y, Inoue N, Azumi H, ''et al.'' |title=Expression of tissue transglutaminase and elafin in human coronary artery: implication for plaque instability. |journal=Atherosclerosis |volume=160 |issue= 1 |pages= 31-9 |year= 2002 |pmid= 11755920 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PRKAB1... {November 17, 2007 11:09:44 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 17, 2007 11:10:17 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PRKAB1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1z0m.
| PDB = {{PDB2|1z0m}}, {{PDB2|1z0n}}
| Name = Protein kinase, AMP-activated, beta 1 non-catalytic subunit
| HGNCid = 9378
| Symbol = PRKAB1
| AltSymbols =; AMPK; HAMPKb; MGC17785
| OMIM = 602740
| ECnumber =
| Homologene = 38160
| MGIid = 1336167
| GeneAtlas_image1 = PBB_GE_PRKAB1_201835_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PRKAB1_201834_at_tn.png
| Function = {{GNF_GO|id=GO:0004553 |text = hydrolase activity, hydrolyzing O-glycosyl compounds}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0005975 |text = carbohydrate metabolic process}} {{GNF_GO|id=GO:0006633 |text = fatty acid biosynthetic process}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5564
| Hs_Ensembl = ENSG00000111725
| Hs_RefseqProtein = NP_006244
| Hs_RefseqmRNA = NM_006253
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 118590144
| Hs_GenLoc_end = 118603799
| Hs_Uniprot = Q9Y478
| Mm_EntrezGene = 19079
| Mm_Ensembl = ENSMUSG00000029513
| Mm_RefseqmRNA = NM_031869
| Mm_RefseqProtein = NP_114075
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 116274585
| Mm_GenLoc_end = 116285427
| Mm_Uniprot = Q3U5I9
}}
}}
'''Protein kinase, AMP-activated, beta 1 non-catalytic subunit''', also known as '''PRKAB1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5564| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.<ref name="entrez">{{cite web | title = Entrez Gene: PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5564| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Carling D |title=The AMP-activated protein kinase cascade--a unifying system for energy control. |journal=Trends Biochem. Sci. |volume=29 |issue= 1 |pages= 18-24 |year= 2004 |pmid= 14729328 |doi= }}
*{{cite journal | author=Stapleton D, Mitchelhill KI, Gao G, ''et al.'' |title=Mammalian AMP-activated protein kinase subfamily. |journal=J. Biol. Chem. |volume=271 |issue= 2 |pages= 611-4 |year= 1996 |pmid= 8557660 |doi= }}
*{{cite journal | author=Gao G, Fernandez CS, Stapleton D, ''et al.'' |title=Non-catalytic beta- and gamma-subunit isoforms of the 5'-AMP-activated protein kinase. |journal=J. Biol. Chem. |volume=271 |issue= 15 |pages= 8675-81 |year= 1996 |pmid= 8621499 |doi= }}
*{{cite journal | author=Woods A, Cheung PC, Smith FC, ''et al.'' |title=Characterization of AMP-activated protein kinase beta and gamma subunits. Assembly of the heterotrimeric complex in vitro. |journal=J. Biol. Chem. |volume=271 |issue= 17 |pages= 10282-90 |year= 1996 |pmid= 8626596 |doi= }}
*{{cite journal | author=Dyck JR, Gao G, Widmer J, ''et al.'' |title=Regulation of 5'-AMP-activated protein kinase activity by the noncatalytic beta and gamma subunits. |journal=J. Biol. Chem. |volume=271 |issue= 30 |pages= 17798-803 |year= 1996 |pmid= 8663446 |doi= }}
*{{cite journal | author=Stapleton D, Woollatt E, Mitchelhill KI, ''et al.'' |title=AMP-activated protein kinase isoenzyme family: subunit structure and chromosomal location. |journal=FEBS Lett. |volume=409 |issue= 3 |pages= 452-6 |year= 1997 |pmid= 9224708 |doi= }}
*{{cite journal | author=Mitchelhill KI, Michell BJ, House CM, ''et al.'' |title=Posttranslational modifications of the 5'-AMP-activated protein kinase beta1 subunit. |journal=J. Biol. Chem. |volume=272 |issue= 39 |pages= 24475-9 |year= 1997 |pmid= 9305909 |doi= }}
*{{cite journal | author=Thornton C, Snowden MA, Carling D |title=Identification of a novel AMP-activated protein kinase beta subunit isoform that is highly expressed in skeletal muscle. |journal=J. Biol. Chem. |volume=273 |issue= 20 |pages= 12443-50 |year= 1998 |pmid= 9575201 |doi= }}
*{{cite journal | author=Cheung PC, Salt IP, Davies SP, ''et al.'' |title=Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding. |journal=Biochem. J. |volume=346 Pt 3 |issue= |pages= 659-69 |year= 2000 |pmid= 10698692 |doi= }}
*{{cite journal | author=da Silva Xavier G, Leclerc I, Salt IP, ''et al.'' |title=Role of AMP-activated protein kinase in the regulation by glucose of islet beta cell gene expression. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 8 |pages= 4023-8 |year= 2000 |pmid= 10760274 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Lemieux K, Konrad D, Klip A, Marette A |title=The AMP-activated protein kinase activator AICAR does not induce GLUT4 translocation to transverse tubules but stimulates glucose uptake and p38 mitogen-activated protein kinases alpha and beta in skeletal muscle. |journal=FASEB J. |volume=17 |issue= 12 |pages= 1658-65 |year= 2003 |pmid= 12958172 |doi= 10.1096/fj.02-1125com }}
*{{cite journal | author=Landree LE, Hanlon AL, Strong DW, ''et al.'' |title=C75, a fatty acid synthase inhibitor, modulates AMP-activated protein kinase to alter neuronal energy metabolism. |journal=J. Biol. Chem. |volume=279 |issue= 5 |pages= 3817-27 |year= 2004 |pmid= 14615481 |doi= 10.1074/jbc.M310991200 }}
*{{cite journal | author=Inoki K, Zhu T, Guan KL |title=TSC2 mediates cellular energy response to control cell growth and survival. |journal=Cell |volume=115 |issue= 5 |pages= 577-90 |year= 2004 |pmid= 14651849 |doi= }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Andersson U, Filipsson K, Abbott CR, ''et al.'' |title=AMP-activated protein kinase plays a role in the control of food intake. |journal=J. Biol. Chem. |volume=279 |issue= 13 |pages= 12005-8 |year= 2004 |pmid= 14742438 |doi= 10.1074/jbc.C300557200 }}
*{{cite journal | author=Pilon G, Dallaire P, Marette A |title=Inhibition of inducible nitric-oxide synthase by activators of AMP-activated protein kinase: a new mechanism of action of insulin-sensitizing drugs. |journal=J. Biol. Chem. |volume=279 |issue= 20 |pages= 20767-74 |year= 2004 |pmid= 14985344 |doi= 10.1074/jbc.M401390200 }}
*{{cite journal | author=Shaw RJ, Kosmatka M, Bardeesy N, ''et al.'' |title=The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 10 |pages= 3329-35 |year= 2004 |pmid= 14985505 |doi= 10.1073/pnas.0308061100 }}
*{{cite journal | author=Kim EK, Miller I, Aja S, ''et al.'' |title=C75, a fatty acid synthase inhibitor, reduces food intake via hypothalamic AMP-activated protein kinase. |journal=J. Biol. Chem. |volume=279 |issue= 19 |pages= 19970-6 |year= 2004 |pmid= 15028725 |doi= 10.1074/jbc.M402165200 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PSMA4... {November 17, 2007 11:10:17 PM PST}
- SEARCH REDIRECT: Control Box Found: PSMA4 {November 17, 2007 11:10:52 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 17, 2007 11:10:54 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 17, 2007 11:10:54 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 17, 2007 11:10:54 PM PST}
- UPDATED: Updated protein page: PSMA4 {November 17, 2007 11:11:00 PM PST}
- INFO: Beginning work on PSMB1... {November 17, 2007 11:11:00 PM PST}
- SEARCH REDIRECT: Control Box Found: PSMB1 {November 17, 2007 11:11:34 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 17, 2007 11:11:35 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 17, 2007 11:11:35 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 17, 2007 11:11:35 PM PST}
- UPDATED: Updated protein page: PSMB1 {November 17, 2007 11:11:43 PM PST}
- INFO: Beginning work on PTGDS... {November 17, 2007 11:11:43 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 17, 2007 11:12:36 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Prostaglandin D2 synthase 21kDa (brain)
| HGNCid = 9592
| Symbol = PTGDS
| AltSymbols =; PDS; PGD2; PGDS; PGDS2
| OMIM = 176803
| ECnumber =
| Homologene = 737
| MGIid = 99261
| GeneAtlas_image1 = PBB_GE_PTGDS_212187_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_PTGDS_211663_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_PTGDS_211748_x_at_tn.png
| Function = {{GNF_GO|id=GO:0004667 |text = prostaglandin-D synthase activity}} {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0005488 |text = binding}} {{GNF_GO|id=GO:0005501 |text = retinoid binding}} {{GNF_GO|id=GO:0016853 |text = isomerase activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005635 |text = nuclear envelope}} {{GNF_GO|id=GO:0005791 |text = rough endoplasmic reticulum}} {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0001516 |text = prostaglandin biosynthetic process}} {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0006633 |text = fatty acid biosynthetic process}} {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0045187 |text = regulation of circadian sleep/wake cycle, sleep}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5730
| Hs_Ensembl = ENSG00000107317
| Hs_RefseqProtein = NP_000945
| Hs_RefseqmRNA = NM_000954
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 138989367
| Hs_GenLoc_end = 139000031
| Hs_Uniprot = P41222
| Mm_EntrezGene = 19215
| Mm_Ensembl = ENSMUSG00000015090
| Mm_RefseqmRNA = XM_974597
| Mm_RefseqProtein = XP_979691
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 25286029
| Mm_GenLoc_end = 25291745
| Mm_Uniprot =
}}
}}
'''Prostaglandin D2 synthase 21kDa (brain)''', also known as '''PTGDS''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PTGDS prostaglandin D2 synthase 21kDa (brain)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5730| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep.<ref name="entrez">{{cite web | title = Entrez Gene: PTGDS prostaglandin D2 synthase 21kDa (brain)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5730| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=White DM, Mikol DD, Espinosa R, ''et al.'' |title=Structure and chromosomal localization of the human gene for a brain form of prostaglandin D2 synthase. |journal=J. Biol. Chem. |volume=267 |issue= 32 |pages= 23202-8 |year= 1992 |pmid= 1385416 |doi= }}
*{{cite journal | author=Kuruvilla AP, Hochwald GM, Ghiso J, ''et al.'' |title=Isolation and amino terminal sequence of beta-trace, a novel protein from human cerebrospinal fluid. |journal=Brain Res. |volume=565 |issue= 2 |pages= 337-40 |year= 1993 |pmid= 1726844 |doi= }}
*{{cite journal | author=Nagata A, Suzuki Y, Igarashi M, ''et al.'' |title=Human brain prostaglandin D synthase has been evolutionarily differentiated from lipophilic-ligand carrier proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 9 |pages= 4020-4 |year= 1991 |pmid= 1902577 |doi= }}
*{{cite journal | author=Zahn M, Mäder M, Schmidt B, ''et al.'' |title=Purification and N-terminal sequence of beta-trace, a protein abundant in human cerebrospinal fluid. |journal=Neurosci. Lett. |volume=154 |issue= 1-2 |pages= 93-5 |year= 1993 |pmid= 7689714 |doi= }}
*{{cite journal | author=Harrington MG, Aebersold R, Martin BM, ''et al.'' |title=Identification of a brain-specific human cerebrospinal fluid glycoprotein, beta-trace protein. |journal=Appl. Theor. Electrophor. |volume=3 |issue= 5 |pages= 229-34 |year= 1993 |pmid= 7692978 |doi= }}
*{{cite journal | author=Bastien L, Sawyer N, Grygorczyk R, ''et al.'' |title=Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype. |journal=J. Biol. Chem. |volume=269 |issue= 16 |pages= 11873-7 |year= 1994 |pmid= 8163486 |doi= }}
*{{cite journal | author=Funk CD, Furci L, FitzGerald GA, ''et al.'' |title=Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype. |journal=J. Biol. Chem. |volume=268 |issue= 35 |pages= 26767-72 |year= 1994 |pmid= 8253813 |doi= }}
*{{cite journal | author=Abramovitz M, Boie Y, Nguyen T, ''et al.'' |title=Cloning and expression of a cDNA for the human prostanoid FP receptor. |journal=J. Biol. Chem. |volume=269 |issue= 4 |pages= 2632-6 |year= 1994 |pmid= 8300593 |doi= }}
*{{cite journal | author=Hoffmann A, Conradt HS, Gross G, ''et al.'' |title=Purification and chemical characterization of beta-trace protein from human cerebrospinal fluid: its identification as prostaglandin D synthase. |journal=J. Neurochem. |volume=61 |issue= 2 |pages= 451-6 |year= 1993 |pmid= 8336134 |doi= }}
*{{cite journal | author=Leone MG, Saso L, Del Vecchio A, ''et al.'' |title=Micropurification of two human cerebrospinal fluid proteins by high performance electrophoresis chromatography. |journal=J. Neurochem. |volume=61 |issue= 2 |pages= 533-40 |year= 1993 |pmid= 8336140 |doi= }}
*{{cite journal | author=Giacomelli S, Leone MG, Grima J, ''et al.'' |title=Astrocytes synthesize and secrete prostaglandin D synthetase in vitro. |journal=Biochim. Biophys. Acta |volume=1310 |issue= 3 |pages= 269-76 |year= 1996 |pmid= 8599604 |doi= }}
*{{cite journal | author=Blödorn B, Mäder M, Urade Y, ''et al.'' |title=Choroid plexus: the major site of mRNA expression for the beta-trace protein (prostaglandin D synthase) in human brain. |journal=Neurosci. Lett. |volume=209 |issue= 2 |pages= 117-20 |year= 1996 |pmid= 8761996 |doi= }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
*{{cite journal | author=Yamashima T, Sakuda K, Tohma Y, ''et al.'' |title=Prostaglandin D synthase (beta-trace) in human arachnoid and meningioma cells: roles as a cell marker or in cerebrospinal fluid absorption, tumorigenesis, and calcification process. |journal=J. Neurosci. |volume=17 |issue= 7 |pages= 2376-82 |year= 1999 |pmid= 9065498 |doi= }}
*{{cite journal | author=White DM, Takeda T, DeGroot LJ, ''et al.'' |title=Beta-trace gene expression is regulated by a core promoter and a distal thyroid hormone response element. |journal=J. Biol. Chem. |volume=272 |issue= 22 |pages= 14387-93 |year= 1997 |pmid= 9162076 |doi= }}
*{{cite journal | author=Eguchi Y, Eguchi N, Oda H, ''et al.'' |title=Expression of lipocalin-type prostaglandin D synthase (beta-trace) in human heart and its accumulation in the coronary circulation of angina patients. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 26 |pages= 14689-94 |year= 1998 |pmid= 9405674 |doi= }}
*{{cite journal | author=Tokugawa Y, Kunishige I, Kubota Y, ''et al.'' |title=Lipocalin-type prostaglandin D synthase in human male reproductive organs and seminal plasma. |journal=Biol. Reprod. |volume=58 |issue= 2 |pages= 600-7 |year= 1998 |pmid= 9475419 |doi= }}
*{{cite journal | author=Saso L, Leone MG, Sorrentino C, ''et al.'' |title=Quantification of prostaglandin D synthetase in cerebrospinal fluid: a potential marker for brain tumor. |journal=Biochem. Mol. Biol. Int. |volume=46 |issue= 4 |pages= 643-56 |year= 1999 |pmid= 9844724 |doi= }}
*{{cite journal | author=Blödorn B, Brück W, Tumani H, ''et al.'' |title=Expression of the beta-trace protein in human pachymeninx as revealed by in situ hybridization and immunocytochemistry. |journal=J. Neurosci. Res. |volume=57 |issue= 5 |pages= 730-4 |year= 1999 |pmid= 10462696 |doi= }}
*{{cite journal | author=Pinzar E, Kanaoka Y, Inui T, ''et al.'' |title=Prostaglandin D synthase gene is involved in the regulation of non-rapid eye movement sleep. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 9 |pages= 4903-7 |year= 2000 |pmid= 10781097 |doi= 10.1073/pnas.090093997 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RAB6A... {November 17, 2007 11:12:36 PM PST}
- SEARCH: Multiple Conflicting Pages. Need Resolution. {November 17, 2007 11:13:11 PM PST}
- AMBIGUITY: More than one potential page found for updating, RAB6A RAB6A {November 17, 2007 11:13:11 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_RAB6A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1yzq.
| PDB = {{PDB2|1yzq}}, {{PDB2|2fe4}}, {{PDB2|2ffq}}, {{PDB2|2gil}}
| Name = RAB6A, member RAS oncogene family
| HGNCid = 9786
| Symbol = RAB6A
| AltSymbols =; RAB6; RAB6A'; RAB6B
| OMIM = 179513
| ECnumber =
| Homologene = 55697
| MGIid = 894313
| GeneAtlas_image1 = PBB_GE_RAB6A_210406_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_RAB6A_201045_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_RAB6A_201047_x_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}}
| Process = {{GNF_GO|id=GO:0006888 |text = ER to Golgi vesicle-mediated transport}} {{GNF_GO|id=GO:0007264 |text = small GTPase mediated signal transduction}} {{GNF_GO|id=GO:0015031 |text = protein transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5870
| Hs_Ensembl = ENSG00000175582
| Hs_RefseqProtein = NP_002860
| Hs_RefseqmRNA = NM_002869
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 73064342
| Hs_GenLoc_end = 73149849
| Hs_Uniprot = P20340
| Mm_EntrezGene = 19346
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_024287
| Mm_RefseqProtein = NP_077249
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''RAB6A, member RAS oncogene family''', also known as '''RAB6A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RAB6A RAB6A, member RAS oncogene family| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5870| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Rousseau-Merck MF, Zahraoui A, Touchot N, ''et al.'' |title=Chromosome assignment of four RAS-related RAB genes. |journal=Hum. Genet. |volume=86 |issue= 4 |pages= 350-4 |year= 1991 |pmid= 1999336 |doi= }}
*{{cite journal | author=Goud B, Zahraoui A, Tavitian A, Saraste J |title=Small GTP-binding protein associated with Golgi cisternae. |journal=Nature |volume=345 |issue= 6275 |pages= 553-6 |year= 1990 |pmid= 2112230 |doi= 10.1038/345553a0 }}
*{{cite journal | author=Zahraoui A, Touchot N, Chardin P, Tavitian A |title=The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion. |journal=J. Biol. Chem. |volume=264 |issue= 21 |pages= 12394-401 |year= 1989 |pmid= 2501306 |doi= }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal | author=Beranger F, Cadwallader K, Porfiri E, ''et al.'' |title=Determination of structural requirements for the interaction of Rab6 with RabGDI and Rab geranylgeranyltransferase. |journal=J. Biol. Chem. |volume=269 |issue= 18 |pages= 13637-43 |year= 1994 |pmid= 8175798 |doi= }}
*{{cite journal | author=Cremers FP, Armstrong SA, Seabra MC, ''et al.'' |title=REP-2, a Rab escort protein encoded by the choroideremia-like gene. |journal=J. Biol. Chem. |volume=269 |issue= 3 |pages= 2111-7 |year= 1994 |pmid= 8294464 |doi= }}
*{{cite journal | author=Karniguian A, Zahraoui A, Tavitian A |title=Identification of small GTP-binding rab proteins in human platelets: thrombin-induced phosphorylation of rab3B, rab6, and rab8 proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 16 |pages= 7647-51 |year= 1993 |pmid= 8356066 |doi= }}
*{{cite journal | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
*{{cite journal | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi= }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal | author=Echard A, Jollivet F, Martinez O, ''et al.'' |title=Interaction of a Golgi-associated kinesin-like protein with Rab6. |journal=Science |volume=279 |issue= 5350 |pages= 580-5 |year= 1998 |pmid= 9438855 |doi= }}
*{{cite journal | author=Cuif MH, Possmayer F, Zander H, ''et al.'' |title=Characterization of GAPCenA, a GTPase activating protein for Rab6, part of which associates with the centrosome. |journal=EMBO J. |volume=18 |issue= 7 |pages= 1772-82 |year= 1999 |pmid= 10202141 |doi= 10.1093/emboj/18.7.1772 }}
*{{cite journal | author=Barr FA |title=A novel Rab6-interacting domain defines a family of Golgi-targeted coiled-coil proteins. |journal=Curr. Biol. |volume=9 |issue= 7 |pages= 381-4 |year= 1999 |pmid= 10209123 |doi= }}
*{{cite journal | author=Bucci C, Chiariello M, Lattero D, ''et al.'' |title=Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1). |journal=Biochem. Biophys. Res. Commun. |volume=258 |issue= 3 |pages= 657-62 |year= 1999 |pmid= 10329441 |doi= 10.1006/bbrc.1999.0651 }}
*{{cite journal | author=Caillol N, Pasqualini E, Lloubes R, Lombardo D |title=Impairment of bile salt-dependent lipase secretion in human pancreatic tumoral SOJ-6 cells. |journal=J. Cell. Biochem. |volume=79 |issue= 4 |pages= 628-47 |year= 2000 |pmid= 10996854 |doi= }}
*{{cite journal | author=Shan J, Mason JM, Yuan L, ''et al.'' |title=Rab6c, a new member of the rab gene family, is involved in drug resistance in MCF7/AdrR cells. |journal=Gene |volume=257 |issue= 1 |pages= 67-75 |year= 2001 |pmid= 11054569 |doi= }}
*{{cite journal | author=Echard A, Opdam FJ, de Leeuw HJ, ''et al.'' |title=Alternative splicing of the human Rab6A gene generates two close but functionally different isoforms. |journal=Mol. Biol. Cell |volume=11 |issue= 11 |pages= 3819-33 |year= 2001 |pmid= 11071909 |doi= }}
*{{cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi= }}
*{{cite journal | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RGS2... {November 17, 2007 11:13:11 PM PST}
- SEARCH REDIRECT: Control Box Found: RGS2 {November 17, 2007 11:13:36 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 17, 2007 11:13:37 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 17, 2007 11:13:37 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 17, 2007 11:13:37 PM PST}
- UPDATED: Updated protein page: RGS2 {November 17, 2007 11:13:44 PM PST}
- INFO: Beginning work on SFTPC... {November 17, 2007 11:13:44 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 17, 2007 11:14:19 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_SFTPC_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1spf.
| PDB = {{PDB2|1spf}}
| Name = Surfactant, pulmonary-associated protein C
| HGNCid = 10802
| Symbol = SFTPC
| AltSymbols =; PSP-C; SFTP2; SP-C
| OMIM = 178620
| ECnumber =
| Homologene = 2271
| MGIid = 109517
| GeneAtlas_image1 = PBB_GE_SFTPC_38691_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SFTPC_205982_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_SFTPC_211735_x_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0007585 |text = respiratory gaseous exchange}} {{GNF_GO|id=GO:0050828 |text = regulation of liquid surface tension}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6440
| Hs_Ensembl = ENSG00000168484
| Hs_RefseqProtein = NP_003009
| Hs_RefseqmRNA = NM_003018
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 8
| Hs_GenLoc_start = 22075113
| Hs_GenLoc_end = 22077928
| Hs_Uniprot = P11686
| Mm_EntrezGene = 20389
| Mm_Ensembl = ENSMUSG00000022097
| Mm_RefseqmRNA = NM_011359
| Mm_RefseqProtein = NP_035489
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 69256020
| Mm_GenLoc_end = 69259150
| Mm_Uniprot = Q6P8P8
}}
}}
'''Surfactant, pulmonary-associated protein C''', also known as '''SFTPC''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SFTPC surfactant, pulmonary-associated protein C| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6440| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Pérez-Gil J |title=Lipid-protein interactions of hydrophobic proteins SP-B and SP-C in lung surfactant assembly and dynamics. |journal=Pediatric pathology & molecular medicine |volume=20 |issue= 6 |pages= 445-69 |year= 2002 |pmid= 11699574 |doi= }}
*{{cite journal | author=Solarin KO, Wang WJ, Beers MF |title=Synthesis and post-translational processing of surfactant protein C. |journal=Pediatric pathology & molecular medicine |volume=20 |issue= 6 |pages= 471-500 |year= 2002 |pmid= 11699575 |doi= }}
*{{cite journal | author=Johansson J, Curstedt T, Robertson B |title=Artificial surfactants based on analogues of SP-B and SP-C. |journal=Pediatric pathology & molecular medicine |volume=20 |issue= 6 |pages= 501-18 |year= 2002 |pmid= 11699576 |doi= }}
*{{cite journal | author=Nogee LM |title=Alterations in SP-B and SP-C expression in neonatal lung disease. |journal=Annu. Rev. Physiol. |volume=66 |issue= |pages= 601-23 |year= 2004 |pmid= 14977415 |doi= 10.1146/annurev.physiol.66.032102.134711 }}
*{{cite journal | author=Brasch F, Griese M, Tredano M, ''et al.'' |title=Interstitial lung disease in a baby with a de novo mutation in the SFTPC gene. |journal=Eur. Respir. J. |volume=24 |issue= 1 |pages= 30-9 |year= 2005 |pmid= 15293602 |doi= }}
*{{cite journal | author=Keller A, Eistetter HR, Voss T, Schäfer KP |title=The pulmonary surfactant protein C (SP-C) precursor is a type II transmembrane protein. |journal=Biochem. J. |volume=277 ( Pt 2) |issue= |pages= 493-9 |year= 1991 |pmid= 1859376 |doi= }}
*{{cite journal | author=Curstedt T, Johansson J, Persson P, ''et al.'' |title=Hydrophobic surfactant-associated polypeptides: SP-C is a lipopeptide with two palmitoylated cysteine residues, whereas SP-B lacks covalently linked fatty acyl groups. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 8 |pages= 2985-9 |year= 1990 |pmid= 2326260 |doi= }}
*{{cite journal | author=Simatos GA, Forward KB, Morrow MR, Keough KM |title=Interaction between perdeuterated dimyristoylphosphatidylcholine and low molecular weight pulmonary surfactant protein SP-C. |journal=Biochemistry |volume=29 |issue= 24 |pages= 5807-14 |year= 1990 |pmid= 2383558 |doi= }}
*{{cite journal | author=Glasser SW, Korfhagen TR, Perme CM, ''et al.'' |title=Two SP-C genes encoding human pulmonary surfactant proteolipid. |journal=J. Biol. Chem. |volume=263 |issue= 21 |pages= 10326-31 |year= 1988 |pmid= 2839484 |doi= }}
*{{cite journal | author=Glasser SW, Korfhagen TR, Weaver TE, ''et al.'' |title=cDNA, deduced polypeptide structure and chromosomal assignment of human pulmonary surfactant proteolipid, SPL(pVal). |journal=J. Biol. Chem. |volume=263 |issue= 1 |pages= 9-12 |year= 1988 |pmid= 3335510 |doi= }}
*{{cite journal | author=Johansson J, Jörnvall H, Eklund A, ''et al.'' |title=Hydrophobic 3.7 kDa surfactant polypeptide: structural characterization of the human and bovine forms. |journal=FEBS Lett. |volume=232 |issue= 1 |pages= 61-4 |year= 1988 |pmid= 3366248 |doi= }}
*{{cite journal | author=Warr RG, Hawgood S, Buckley DI, ''et al.'' |title=Low molecular weight human pulmonary surfactant protein (SP5): isolation, characterization, and cDNA and amino acid sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 22 |pages= 7915-9 |year= 1987 |pmid= 3479771 |doi= }}
*{{cite journal | author=Young WA |title=Familial fibrocystic pulmonary dysplasia: a new case in a known affected family. |journal=Canadian Medical Association journal |volume=94 |issue= 20 |pages= 1059-61 |year= 1966 |pmid= 5942662 |doi= }}
*{{cite journal | author=Wood S, Yaremko ML, Schertzer M, ''et al.'' |title=Mapping of the pulmonary surfactant SP5 (SFTP2) locus to 8p21 and characterization of a microsatellite repeat marker that shows frequent loss of heterozygosity in human carcinomas. |journal=Genomics |volume=24 |issue= 3 |pages= 597-600 |year= 1995 |pmid= 7713515 |doi= 10.1006/geno.1994.1673 }}
*{{cite journal | author=Hatzis D, Deiter G, deMello DE, Floros J |title=Human surfactant protein-C: genetic homogeneity and expression in RDS; comparison with other species. |journal=Exp. Lung Res. |volume=20 |issue= 1 |pages= 57-72 |year= 1994 |pmid= 8181452 |doi= }}
*{{cite journal | author=Nogee LM, Dunbar AE, Wert SE, ''et al.'' |title=A mutation in the surfactant protein C gene associated with familial interstitial lung disease. |journal=N. Engl. J. Med. |volume=344 |issue= 8 |pages= 573-9 |year= 2001 |pmid= 11207353 |doi= }}
*{{cite journal | author=Glasser SW, Burhans MS, Korfhagen TR, ''et al.'' |title=Altered stability of pulmonary surfactant in SP-C-deficient mice. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 11 |pages= 6366-71 |year= 2001 |pmid= 11344267 |doi= 10.1073/pnas.101500298 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SUV39H1... {November 17, 2007 11:14:19 PM PST}
- SEARCH REDIRECT: Control Box Found: SUV39H1 {November 17, 2007 11:14:55 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 17, 2007 11:14:58 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 17, 2007 11:14:58 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 17, 2007 11:14:58 PM PST}
- UPDATED: Updated protein page: SUV39H1 {November 17, 2007 11:15:05 PM PST}
- INFO: Beginning work on TAPBP... {November 17, 2007 11:15:05 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 17, 2007 11:15:41 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = TAP binding protein (tapasin)
| HGNCid = 11566
| Symbol = TAPBP
| AltSymbols =; NGS17; TAPA; TPN; TPSN
| OMIM = 601962
| ECnumber =
| Homologene = 2401
| MGIid = 1201689
| GeneAtlas_image1 = PBB_GE_TAPBP_210294_at_tn.png
| GeneAtlas_image2 = PBB_GE_TAPBP_208829_at_tn.png
| Function = {{GNF_GO|id=GO:0015433 |text = peptide antigen-transporting ATPase activity}} {{GNF_GO|id=GO:0042288 |text = MHC class I protein binding}} {{GNF_GO|id=GO:0042605 |text = peptide antigen binding}} {{GNF_GO|id=GO:0046978 |text = TAP1 binding}} {{GNF_GO|id=GO:0046979 |text = TAP2 binding}} {{GNF_GO|id=GO:0051082 |text = unfolded protein binding}}
| Component = {{GNF_GO|id=GO:0000139 |text = Golgi membrane}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005789 |text = endoplasmic reticulum membrane}} {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0042824 |text = MHC class I peptide loading complex}}
| Process = {{GNF_GO|id=GO:0006461 |text = protein complex assembly}} {{GNF_GO|id=GO:0006890 |text = retrograde vesicle-mediated transport, Golgi to ER}} {{GNF_GO|id=GO:0006952 |text = defense response}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0019885 |text = antigen processing and presentation of endogenous peptide antigen via MHC class I}} {{GNF_GO|id=GO:0050823 |text = peptide antigen stabilization}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6892
| Hs_Ensembl = ENSG00000112493
| Hs_RefseqProtein = NP_003181
| Hs_RefseqmRNA = NM_003190
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 33375449
| Hs_GenLoc_end = 33390142
| Hs_Uniprot = O15533
| Mm_EntrezGene = 21356
| Mm_Ensembl = ENSMUSG00000024308
| Mm_RefseqmRNA = NM_001025313
| Mm_RefseqProtein = NP_001020484
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 33529932
| Mm_GenLoc_end = 33537169
| Mm_Uniprot = Q3TCU5
}}
}}
'''TAP binding protein (tapasin)''', also known as '''TAPBP''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TAPBP TAP binding protein (tapasin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6892| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms.<ref name="entrez">{{cite web | title = Entrez Gene: TAPBP TAP binding protein (tapasin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6892| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Turnquist HR, Vargas SE, Schenk EL, ''et al.'' |title=The interface between tapasin and MHC class I: identification of amino acid residues in both proteins that influence their interaction. |journal=Immunol. Res. |volume=25 |issue= 3 |pages= 261-9 |year= 2002 |pmid= 12018464 |doi= }}
*{{cite journal | author=Momburg F, Tan P |title=Tapasin-the keystone of the loading complex optimizing peptide binding by MHC class I molecules in the endoplasmic reticulum. |journal=Mol. Immunol. |volume=39 |issue= 3-4 |pages= 217-33 |year= 2002 |pmid= 12200052 |doi= }}
*{{cite journal | author=Dissemond J, Kothen T, Mörs J, ''et al.'' |title=Downregulation of tapasin expression in progressive human malignant melanoma. |journal=Arch. Dermatol. Res. |volume=295 |issue= 2 |pages= 43-9 |year= 2004 |pmid= 12682852 |doi= 10.1007/s00403-003-0393-8 }}
*{{cite journal | author=Paulsson K, Wang P |title=Chaperones and folding of MHC class I molecules in the endoplasmic reticulum. |journal=Biochim. Biophys. Acta |volume=1641 |issue= 1 |pages= 1-12 |year= 2003 |pmid= 12788224 |doi= }}
*{{cite journal | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
*{{cite journal | author=Sadasivan B, Lehner PJ, Ortmann B, ''et al.'' |title=Roles for calreticulin and a novel glycoprotein, tapasin, in the interaction of MHC class I molecules with TAP. |journal=Immunity |volume=5 |issue= 2 |pages= 103-14 |year= 1996 |pmid= 8769474 |doi= }}
*{{cite journal | author=Lewis JW, Neisig A, Neefjes J, Elliott T |title=Point mutations in the alpha 2 domain of HLA-A2.1 define a functionally relevant interaction with TAP. |journal=Curr. Biol. |volume=6 |issue= 7 |pages= 873-83 |year= 1997 |pmid= 8805302 |doi= }}
*{{cite journal | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi= }}
*{{cite journal | author=Li S, Sjögren HO, Hellman U, ''et al.'' |title=Cloning and functional characterization of a subunit of the transporter associated with antigen processing. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 16 |pages= 8708-13 |year= 1997 |pmid= 9238042 |doi= }}
*{{cite journal | author=Ortmann B, Copeman J, Lehner PJ, ''et al.'' |title=A critical role for tapasin in the assembly and function of multimeric MHC class I-TAP complexes. |journal=Science |volume=277 |issue= 5330 |pages= 1306-9 |year= 1997 |pmid= 9271576 |doi= }}
*{{cite journal | author=Herberg JA, Sgouros J, Jones T, ''et al.'' |title=Genomic analysis of the Tapasin gene, located close to the TAP loci in the MHC. |journal=Eur. J. Immunol. |volume=28 |issue= 2 |pages= 459-67 |year= 1998 |pmid= 9521053 |doi= }}
*{{cite journal | author=Lindquist JA, Jensen ON, Mann M, Hämmerling GJ |title=ER-60, a chaperone with thiol-dependent reductase activity involved in MHC class I assembly. |journal=EMBO J. |volume=17 |issue= 8 |pages= 2186-95 |year= 1998 |pmid= 9545232 |doi= 10.1093/emboj/17.8.2186 }}
*{{cite journal | author=Herberg JA, Beck S, Trowsdale J |title=TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC. |journal=J. Mol. Biol. |volume=277 |issue= 4 |pages= 839-57 |year= 1998 |pmid= 9545376 |doi= 10.1006/jmbi.1998.1637 }}
*{{cite journal | author=Furukawa H, Kashiwase K, Yabe T, ''et al.'' |title=Polymorphism of TAPASIN and its linkage disequilibria with HLA class II genes in the Japanese population. |journal=Tissue Antigens |volume=52 |issue= 3 |pages= 279-81 |year= 1999 |pmid= 9802609 |doi= }}
*{{cite journal | author=El Ouakfaoui S, Heitz D, Paquin R, Beaulieu AD |title=Granulocyte-macrophage colony-stimulating factor modulates tapasin expression in human neutrophils. |journal=J. Leukoc. Biol. |volume=65 |issue= 2 |pages= 205-10 |year= 1999 |pmid= 10088603 |doi= }}
*{{cite journal | author=Bangia N, Lehner PJ, Hughes EA, ''et al.'' |title=The N-terminal region of tapasin is required to stabilize the MHC class I loading complex. |journal=Eur. J. Immunol. |volume=29 |issue= 6 |pages= 1858-70 |year= 1999 |pmid= 10382748 |doi= }}
*{{cite journal | author=Knittler MR, Alberts P, Deverson EV, Howard JC |title=Nucleotide binding by TAP mediates association with peptide and release of assembled MHC class I molecules. |journal=Curr. Biol. |volume=9 |issue= 18 |pages= 999-1008 |year= 2000 |pmid= 10508608 |doi= }}
*{{cite journal | author=Li S, Paulsson KM, Chen S, ''et al.'' |title=Tapasin is required for efficient peptide binding to transporter associated with antigen processing. |journal=J. Biol. Chem. |volume=275 |issue= 3 |pages= 1581-6 |year= 2000 |pmid= 10636848 |doi= }}
*{{cite journal | author=Tan P, Kropshofer H, Mandelboim O, ''et al.'' |title=Recruitment of MHC class I molecules by tapasin into the transporter associated with antigen processing-associated complex is essential for optimal peptide loading. |journal=J. Immunol. |volume=168 |issue= 4 |pages= 1950-60 |year= 2002 |pmid= 11823531 |doi= }}
*{{cite journal | author=Mayer WE, Klein J |title=Is tapasin a modified Mhc class I molecule? |journal=Immunogenetics |volume=53 |issue= 9 |pages= 719-23 |year= 2002 |pmid= 11862402 |doi= 10.1007/s00251-001-0403-y }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TPI1... {November 17, 2007 11:15:41 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 17, 2007 11:16:06 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TPI1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1hti.
| PDB = {{PDB2|1hti}}, {{PDB2|1r2r}}, {{PDB2|1r2s}}, {{PDB2|1r2t}}, {{PDB2|1wyi}}
| Name = Triosephosphate isomerase 1
| HGNCid = 12009
| Symbol = TPI1
| AltSymbols =; MGC88108; TPI
| OMIM = 190450
| ECnumber =
| Homologene = 311
| MGIid = 98797
| Function = {{GNF_GO|id=GO:0004807 |text = triose-phosphate isomerase activity}} {{GNF_GO|id=GO:0016853 |text = isomerase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006094 |text = gluconeogenesis}} {{GNF_GO|id=GO:0006096 |text = glycolysis}} {{GNF_GO|id=GO:0006098 |text = pentose-phosphate shunt}} {{GNF_GO|id=GO:0006633 |text = fatty acid biosynthetic process}} {{GNF_GO|id=GO:0008152 |text = metabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7167
| Hs_Ensembl =
| Hs_RefseqProtein = NP_000356
| Hs_RefseqmRNA = NM_000365
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 21991
| Mm_Ensembl = ENSMUSG00000023456
| Mm_RefseqmRNA = NM_009415
| Mm_RefseqProtein = NP_033441
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 124776334
| Mm_GenLoc_end = 124780031
| Mm_Uniprot = Q3TJH2
}}
}}
'''Triosephosphate isomerase 1''', also known as '''TPI1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TPI1 triosephosphate isomerase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7167| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Ationu A, Humphries A |title=The feasibility of replacement therapy for inherited disorder of glycolysis: triosephosphate isomerase deficiency (review). |journal=Int. J. Mol. Med. |volume=2 |issue= 6 |pages= 701-4 |year= 1999 |pmid= 9850739 |doi= }}
*{{cite journal | author=Oláh J, Orosz F, Keserü GM, ''et al.'' |title=Triosephosphate isomerase deficiency: a neurodegenerative misfolding disease. |journal=Biochem. Soc. Trans. |volume=30 |issue= 2 |pages= 30-8 |year= 2002 |pmid= 12023819 |doi= 10.1042/ }}
*{{cite journal | author=Rethoré MO, Kaplan JC, Junien C, Lejeune J |title=12pter to 12p12.2: possible assignment of human triose phosphate isomerase. |journal=Hum. Genet. |volume=36 |issue= 2 |pages= 235-7 |year= 1977 |pmid= 858628 |doi= }}
*{{cite journal | author=Perry BA, Mohrenweiser HW |title=Human triosephosphate isomerase: substitution of Arg for Gly at position 122 in a thermolabile electromorph variant, TPI-Manchester. |journal=Hum. Genet. |volume=88 |issue= 6 |pages= 634-8 |year= 1992 |pmid= 1339398 |doi= }}
*{{cite journal | author=Dawson SJ, White LA |title=Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin. |journal=J. Infect. |volume=24 |issue= 3 |pages= 317-20 |year= 1992 |pmid= 1602151 |doi= }}
*{{cite journal | author=Boyer TG, Maquat LE |title=Minimal sequence and factor requirements for the initiation of transcription from an atypical, TATATAA box-containing housekeeping promoter. |journal=J. Biol. Chem. |volume=265 |issue= 33 |pages= 20524-32 |year= 1990 |pmid= 2243103 |doi= }}
*{{cite journal | author=Maquat LE, Chilcote R, Ryan PM |title=Human triosephosphate isomerase cDNA and protein structure. Studies of triosephosphate isomerase deficiency in man. |journal=J. Biol. Chem. |volume=260 |issue= 6 |pages= 3748-53 |year= 1985 |pmid= 2579079 |doi= }}
*{{cite journal | author=Daar IO, Artymiuk PJ, Phillips DC, Maquat LE |title=Human triose-phosphate isomerase deficiency: a single amino acid substitution results in a thermolabile enzyme. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue= 20 |pages= 7903-7 |year= 1986 |pmid= 2876430 |doi= }}
*{{cite journal | author=Boyer TG, Krug JR, Maquat LE |title=Transcriptional regulatory sequences of the housekeeping gene for human triosephosphate isomerase. |journal=J. Biol. Chem. |volume=264 |issue= 9 |pages= 5177-87 |year= 1989 |pmid= 2925688 |doi= }}
*{{cite journal | author=Brown JR, Daar IO, Krug JR, Maquat LE |title=Characterization of the functional gene and several processed pseudogenes in the human triosephosphate isomerase gene family. |journal=Mol. Cell. Biol. |volume=5 |issue= 7 |pages= 1694-706 |year= 1985 |pmid= 4022011 |doi= }}
*{{cite journal | author=Lu HS, Yuan PM, Gracy RW |title=Primary structure of human triosephosphate isomerase. |journal=J. Biol. Chem. |volume=259 |issue= 19 |pages= 11958-68 |year= 1984 |pmid= 6434534 |doi= }}
*{{cite journal | author=Mande SC, Mainfroid V, Kalk KH, ''et al.'' |title=Crystal structure of recombinant human triosephosphate isomerase at 2.8 A resolution. Triosephosphate isomerase-related human genetic disorders and comparison with the trypanosomal enzyme. |journal=Protein Sci. |volume=3 |issue= 5 |pages= 810-21 |year= 1994 |pmid= 8061610 |doi= }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal | author=Chang ML, Artymiuk PJ, Wu X, ''et al.'' |title=Human triosephosphate isomerase deficiency resulting from mutation of Phe-240. |journal=Am. J. Hum. Genet. |volume=52 |issue= 6 |pages= 1260-9 |year= 1993 |pmid= 8503454 |doi= }}
*{{cite journal | author=Watanabe M, Zingg BC, Mohrenweiser HW |title=Molecular analysis of a series of alleles in humans with reduced activity at the triosephosphate isomerase locus. |journal=Am. J. Hum. Genet. |volume=58 |issue= 2 |pages= 308-16 |year= 1996 |pmid= 8571957 |doi= }}
*{{cite journal | author=Mainfroid V, Terpstra P, Beauregard M, ''et al.'' |title=Three hTIM mutants that provide new insights on why TIM is a dimer. |journal=J. Mol. Biol. |volume=257 |issue= 2 |pages= 441-56 |year= 1996 |pmid= 8609635 |doi= 10.1006/jmbi.1996.0174 }}
*{{cite journal | author=Ansari-Lari MA, Muzny DM, Lu J, ''et al.'' |title=A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13. |journal=Genome Res. |volume=6 |issue= 4 |pages= 314-26 |year= 1996 |pmid= 8723724 |doi= }}
*{{cite journal | author=Ansari-Lari MA, Shen Y, Muzny DM, ''et al.'' |title=Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination. |journal=Genome Res. |volume=7 |issue= 3 |pages= 268-80 |year= 1997 |pmid= 9074930 |doi= }}
*{{cite journal | author=Rasmussen RK, Ji H, Eddes JS, ''et al.'' |title=Two-dimensional electrophoretic analysis of human breast carcinoma proteins: mapping of proteins that bind to the SH3 domain of mixed lineage kinase MLK2. |journal=Electrophoresis |volume=18 |issue= 3-4 |pages= 588-98 |year= 1997 |pmid= 9150946 |doi= 10.1002/elps.1150180342 }}
*{{cite journal | author=Ji H, Reid GE, Moritz RL, ''et al.'' |title=A two-dimensional gel database of human colon carcinoma proteins. |journal=Electrophoresis |volume=18 |issue= 3-4 |pages= 605-13 |year= 1997 |pmid= 9150948 |doi= 10.1002/elps.1150180344 }}
}}
{{refend}}
{{protein-stub}}
end log.
