Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 08:52, 19 November 2007 (UTC)[edit]
Proteins without matches (15)[edit]
Proteins with a High Potential Match (3)[edit]
Redirected Proteins (7)[edit]
Manual Inspection (Page not found) (18)[edit]
Updated (7)[edit]
Protein Status Grid - Date: 08:52, 19 November 2007 (UTC)[edit]
Vebose Log - Date: 08:52, 19 November 2007 (UTC)[edit]
- INFO: Beginning work on ACVR1B... {November 19, 2007 12:30:21 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 19, 2007 12:30:49 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ACVR1B_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1rw8.
| PDB = {{PDB2|1rw8}}
| Name = Activin A receptor, type IB
| HGNCid = 172
| Symbol = ACVR1B
| AltSymbols =; ACTRIB; ACVRLK4; ALK4; SKR2
| OMIM = 601300
| ECnumber =
| Homologene = 20906
| MGIid = 1338944
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016361 |text = activin receptor activity, type I}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0019838 |text = growth factor binding}} {{GNF_GO|id=GO:0030145 |text = manganese ion binding}} {{GNF_GO|id=GO:0046332 |text = SMAD binding}} {{GNF_GO|id=GO:0048185 |text = activin binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0009986 |text = cell surface}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0000082 |text = G1/S transition of mitotic cell cycle}} {{GNF_GO|id=GO:0001701 |text = in utero embryonic development}} {{GNF_GO|id=GO:0001942 |text = hair follicle development}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007178 |text = transmembrane receptor protein serine/threonine kinase signaling pathway}} {{GNF_GO|id=GO:0009790 |text = embryonic development}} {{GNF_GO|id=GO:0030308 |text = negative regulation of cell growth}} {{GNF_GO|id=GO:0045449 |text = regulation of transcription}} {{GNF_GO|id=GO:0045648 |text = positive regulation of erythrocyte differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 91
| Hs_Ensembl = ENSG00000135503
| Hs_RefseqProtein = NP_004293
| Hs_RefseqmRNA = NM_004302
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 50494095
| Hs_GenLoc_end = 50677124
| Hs_Uniprot = P36896
| Mm_EntrezGene = 11479
| Mm_Ensembl = ENSMUSG00000000532
| Mm_RefseqmRNA = NM_007395
| Mm_RefseqProtein = NP_031421
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 101002159
| Mm_GenLoc_end = 101040635
| Mm_Uniprot = Q3TZF1
}}
}}
'''Activin A receptor, type IB''', also known as '''ACVR1B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ACVR1B activin A receptor, type IB| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=91| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type IB receptor, composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed.<ref name="entrez">{{cite web | title = Entrez Gene: ACVR1B activin A receptor, type IB| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=91| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Welt CK |title=The physiology and pathophysiology of inhibin, activin and follistatin in female reproduction. |journal=Curr. Opin. Obstet. Gynecol. |volume=14 |issue= 3 |pages= 317-23 |year= 2002 |pmid= 12032389 |doi= }}
*{{cite journal | author=Liu F, Ventura F, Doody J, Massagué J |title=Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs. |journal=Mol. Cell. Biol. |volume=15 |issue= 7 |pages= 3479-86 |year= 1995 |pmid= 7791754 |doi= }}
*{{cite journal | author=Xu J, Matsuzaki K, McKeehan K, ''et al.'' |title=Genomic structure and cloned cDNAs predict that four variants in the kinase domain of serine/threonine kinase receptors arise by alternative splicing and poly(A) addition. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 17 |pages= 7957-61 |year= 1994 |pmid= 8058741 |doi= }}
*{{cite journal | author=Cárcamo J, Weis FM, Ventura F, ''et al.'' |title=Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin. |journal=Mol. Cell. Biol. |volume=14 |issue= 6 |pages= 3810-21 |year= 1994 |pmid= 8196624 |doi= }}
*{{cite journal | author=ten Dijke P, Ichijo H, Franzén P, ''et al.'' |title=Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity. |journal=Oncogene |volume=8 |issue= 10 |pages= 2879-87 |year= 1993 |pmid= 8397373 |doi= }}
*{{cite journal | author=De Winter JP, De Vries CJ, Van Achterberg TA, ''et al.'' |title=Truncated activin type II receptors inhibit bioactivity by the formation of heteromeric complexes with activin type I. receptors. |journal=Exp. Cell Res. |volume=224 |issue= 2 |pages= 323-34 |year= 1996 |pmid= 8612709 |doi= }}
*{{cite journal | author=Attisano L, Wrana JL, Montalvo E, Massagué J |title=Activation of signalling by the activin receptor complex. |journal=Mol. Cell. Biol. |volume=16 |issue= 3 |pages= 1066-73 |year= 1996 |pmid= 8622651 |doi= }}
*{{cite journal | author=Lebrun JJ, Vale WW |title=Activin and inhibin have antagonistic effects on ligand-dependent heteromerization of the type I and type II activin receptors and human erythroid differentiation. |journal=Mol. Cell. Biol. |volume=17 |issue= 3 |pages= 1682-91 |year= 1997 |pmid= 9032295 |doi= }}
*{{cite journal | author=Röijer E, Miyazono K, Aström AK, ''et al.'' |title=Chromosomal localization of three human genes encoding members of the TGF-beta superfamily of type I serine/threonine kinase receptors. |journal=Mamm. Genome |volume=9 |issue= 3 |pages= 266-8 |year= 1998 |pmid= 9501322 |doi= }}
*{{cite journal | author=Souchelnytskyi S, Nakayama T, Nakao A, ''et al.'' |title=Physical and functional interaction of murine and Xenopus Smad7 with bone morphogenetic protein receptors and transforming growth factor-beta receptors. |journal=J. Biol. Chem. |volume=273 |issue= 39 |pages= 25364-70 |year= 1998 |pmid= 9738003 |doi= }}
*{{cite journal | author=Hashimoto O, Yamato K, Koseki T, ''et al.'' |title=The role of activin type I receptors in activin A-induced growth arrest and apoptosis in mouse B-cell hybridoma cells. |journal=Cell. Signal. |volume=10 |issue= 10 |pages= 743-9 |year= 1999 |pmid= 9884026 |doi= }}
*{{cite journal | author=Lebrun JJ, Takabe K, Chen Y, Vale W |title=Roles of pathway-specific and inhibitory Smads in activin receptor signaling. |journal=Mol. Endocrinol. |volume=13 |issue= 1 |pages= 15-23 |year= 1999 |pmid= 9892009 |doi= }}
*{{cite journal | author=Gray PC, Greenwald J, Blount AL, ''et al.'' |title=Identification of a binding site on the type II activin receptor for activin and inhibin. |journal=J. Biol. Chem. |volume=275 |issue= 5 |pages= 3206-12 |year= 2000 |pmid= 10652306 |doi= }}
*{{cite journal | author=Zhou Y, Sun H, Danila DC, ''et al.'' |title=Truncated activin type I receptor Alk4 isoforms are dominant negative receptors inhibiting activin signaling. |journal=Mol. Endocrinol. |volume=14 |issue= 12 |pages= 2066-75 |year= 2001 |pmid= 11117535 |doi= }}
*{{cite journal | author=Su GH, Bansal R, Murphy KM, ''et al.'' |title=ACVR1B (ALK4, activin receptor type 1B) gene mutations in pancreatic carcinoma. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 6 |pages= 3254-7 |year= 2001 |pmid= 11248065 |doi= 10.1073/pnas.051484398 }}
*{{cite journal | author=Chapman SC, Woodruff TK |title=Modulation of activin signal transduction by inhibin B and inhibin-binding protein (INhBP). |journal=Mol. Endocrinol. |volume=15 |issue= 4 |pages= 668-79 |year= 2001 |pmid= 11266516 |doi= }}
*{{cite journal | author=Wurthner JU, Frank DB, Felici A, ''et al.'' |title=Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone. |journal=J. Biol. Chem. |volume=276 |issue= 22 |pages= 19495-502 |year= 2001 |pmid= 11278302 |doi= 10.1074/jbc.M006473200 }}
*{{cite journal | author=Parks WT, Frank DB, Huff C, ''et al.'' |title=Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases. |journal=J. Biol. Chem. |volume=276 |issue= 22 |pages= 19332-9 |year= 2001 |pmid= 11279102 |doi= 10.1074/jbc.M100606200 }}
*{{cite journal | author=Birkey Reffey S, Wurthner JU, Parks WT, ''et al.'' |title=X-linked inhibitor of apoptosis protein functions as a cofactor in transforming growth factor-beta signaling. |journal=J. Biol. Chem. |volume=276 |issue= 28 |pages= 26542-9 |year= 2001 |pmid= 11356828 |doi= 10.1074/jbc.M100331200 }}
*{{cite journal | author=Bianco C, Adkins HB, Wechselberger C, ''et al.'' |title=Cripto-1 activates nodal- and ALK4-dependent and -independent signaling pathways in mammary epithelial Cells. |journal=Mol. Cell. Biol. |volume=22 |issue= 8 |pages= 2586-97 |year= 2002 |pmid= 11909953 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ADCYAP1R1... {November 19, 2007 12:30:49 AM PST}
- SEARCH REDIRECT: Control Box Found: ADCYAP1R1 {November 19, 2007 12:31:18 AM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 19, 2007 12:31:23 AM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 19, 2007 12:31:23 AM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 19, 2007 12:31:23 AM PST}
- UPDATED: Updated protein page: ADCYAP1R1 {November 19, 2007 12:31:29 AM PST}
- INFO: Beginning work on BANF1... {November 19, 2007 12:40:59 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 19, 2007 12:41:37 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_BANF1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ci4.
| PDB = {{PDB2|1ci4}}, {{PDB2|1qck}}, {{PDB2|2bzf}}, {{PDB2|2ezx}}, {{PDB2|2ezy}}, {{PDB2|2ezz}}, {{PDB2|2odg}}
| Name = Barrier to autointegration factor 1
| HGNCid = 17397
| Symbol = BANF1
| AltSymbols =; BAF; BCRP1; D14S1460; MGC111161
| OMIM = 603811
| ECnumber =
| Homologene = 2866
| MGIid = 1346330
| GeneAtlas_image1 = PBB_GE_BANF1_210125_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005694 |text = chromosome}}
| Process = {{GNF_GO|id=GO:0009615 |text = response to virus}} {{GNF_GO|id=GO:0015074 |text = DNA integration}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8815
| Hs_Ensembl = ENSG00000175334
| Hs_RefseqProtein = NP_003851
| Hs_RefseqmRNA = NM_003860
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 65526126
| Hs_GenLoc_end = 65528192
| Hs_Uniprot = O75531
| Mm_EntrezGene = 23825
| Mm_Ensembl = ENSMUSG00000024844
| Mm_RefseqmRNA = NM_001038231
| Mm_RefseqProtein = NP_001033320
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 5364641
| Mm_GenLoc_end = 5366651
| Mm_Uniprot = O54962
}}
}}
'''Barrier to autointegration factor 1''', also known as '''BANF1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: BANF1 barrier to autointegration factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8815| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene was identified by its ability to protect retroviruses from intramolecular integration and therefore promote intermolecular integration into the host cell genome. The endogenous function of the protein is unknown. The protein forms a homodimer which localizes to the nucleus and is specifically associated with chromosomes during mitosis. This protein binds to DNA in a non-specific manner and studies in rodents suggest that it also binds to lamina-associated polypeptide 2, a component of the nuclear lamina.<ref name="entrez">{{cite web | title = Entrez Gene: BANF1 barrier to autointegration factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8815| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Goldberg M, Harel A, Gruenbaum Y |title=The nuclear lamina: molecular organization and interaction with chromatin. |journal=Crit. Rev. Eukaryot. Gene Expr. |volume=9 |issue= 3-4 |pages= 285-93 |year= 2000 |pmid= 10651245 |doi= }}
*{{cite journal | author=Segura-Totten M, Wilson KL |title=BAF: roles in chromatin, nuclear structure and retrovirus integration. |journal=Trends Cell Biol. |volume=14 |issue= 5 |pages= 261-6 |year= 2004 |pmid= 15130582 |doi= 10.1016/j.tcb.2004.03.004 }}
*{{cite journal | author=Van Maele B, Debyser Z |title=HIV-1 integration: an interplay between HIV-1 integrase, cellular and viral proteins. |journal=AIDS reviews |volume=7 |issue= 1 |pages= 26-43 |year= 2005 |pmid= 15875659 |doi= }}
*{{cite journal | author=Van Maele B, Busschots K, Vandekerckhove L, ''et al.'' |title=Cellular co-factors of HIV-1 integration. |journal=Trends Biochem. Sci. |volume=31 |issue= 2 |pages= 98-105 |year= 2006 |pmid= 16403635 |doi= 10.1016/j.tibs.2005.12.002 }}
*{{cite journal | author=Lee MS, Craigie R |title=Protection of retroviral DNA from autointegration: involvement of a cellular factor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 21 |pages= 9823-7 |year= 1994 |pmid= 7937898 |doi= }}
*{{cite journal | author=Lee MS, Craigie R |title=A previously unidentified host protein protects retroviral DNA from autointegration. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 4 |pages= 1528-33 |year= 1998 |pmid= 9465049 |doi= }}
*{{cite journal | author=Dear PH, Bankier AT, Piper MB |title=A high-resolution metric HAPPY map of human chromosome 14. |journal=Genomics |volume=48 |issue= 2 |pages= 232-41 |year= 1998 |pmid= 9521877 |doi= 10.1006/geno.1997.5140 }}
*{{cite journal | author=Lynch RA, Piper M, Bankier A, ''et al.'' |title=Genomic and functional map of the chromosome 14 t(12;14) breakpoint cluster region in uterine leiomyoma. |journal=Genomics |volume=52 |issue= 1 |pages= 17-26 |year= 1999 |pmid= 9740667 |doi= 10.1006/geno.1998.5406 }}
*{{cite journal | author=Cai M, Huang Y, Zheng R, ''et al.'' |title=Solution structure of the cellular factor BAF responsible for protecting retroviral DNA from autointegration. |journal=Nat. Struct. Biol. |volume=5 |issue= 10 |pages= 903-9 |year= 1998 |pmid= 9783751 |doi= 10.1038/2345 }}
*{{cite journal | author=Furukawa K |title=LAP2 binding protein 1 (L2BP1/BAF) is a candidate mediator of LAP2-chromatin interaction. |journal=J. Cell. Sci. |volume=112 ( Pt 15) |issue= |pages= 2485-92 |year= 1999 |pmid= 10393804 |doi= }}
*{{cite journal | author=Zheng R, Ghirlando R, Lee MS, ''et al.'' |title=Barrier-to-autointegration factor (BAF) bridges DNA in a discrete, higher-order nucleoprotein complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 16 |pages= 8997-9002 |year= 2000 |pmid= 10908652 |doi= 10.1073/pnas.150240197 }}
*{{cite journal | author=Umland TC, Wei SQ, Craigie R, Davies DR |title=Structural basis of DNA bridging by barrier-to-autointegration factor. |journal=Biochemistry |volume=39 |issue= 31 |pages= 9130-8 |year= 2000 |pmid= 10924106 |doi= }}
*{{cite journal | author=Harris D, Engelman A |title=Both the structure and DNA binding function of the barrier-to-autointegration factor contribute to reconstitution of HIV type 1 integration in vitro. |journal=J. Biol. Chem. |volume=275 |issue= 50 |pages= 39671-7 |year= 2001 |pmid= 11005805 |doi= 10.1074/jbc.M002626200 }}
*{{cite journal | author=Lee KK, Haraguchi T, Lee RS, ''et al.'' |title=Distinct functional domains in emerin bind lamin A and DNA-bridging protein BAF. |journal=J. Cell. Sci. |volume=114 |issue= Pt 24 |pages= 4567-73 |year= 2002 |pmid= 11792821 |doi= }}
*{{cite journal | author=Haraguchi T, Koujin T, Segura-Totten M, ''et al.'' |title=BAF is required for emerin assembly into the reforming nuclear envelope. |journal=J. Cell. Sci. |volume=114 |issue= Pt 24 |pages= 4575-85 |year= 2002 |pmid= 11792822 |doi= }}
*{{cite journal | author=Segura-Totten M, Kowalski AK, Craigie R, Wilson KL |title=Barrier-to-autointegration factor: major roles in chromatin decondensation and nuclear assembly. |journal=J. Cell Biol. |volume=158 |issue= 3 |pages= 475-85 |year= 2002 |pmid= 12163470 |doi= 10.1083/jcb.200202019 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Holaska JM, Lee KK, Kowalski AK, Wilson KL |title=Transcriptional repressor germ cell-less (GCL) and barrier to autointegration factor (BAF) compete for binding to emerin in vitro. |journal=J. Biol. Chem. |volume=278 |issue= 9 |pages= 6969-75 |year= 2003 |pmid= 12493765 |doi= 10.1074/jbc.M208811200 }}
*{{cite journal | author=Lin CW, Engelman A |title=The barrier-to-autointegration factor is a component of functional human immunodeficiency virus type 1 preintegration complexes. |journal=J. Virol. |volume=77 |issue= 8 |pages= 5030-6 |year= 2003 |pmid= 12663813 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on C1R... {November 19, 2007 12:31:29 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 19, 2007 12:31:46 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_C1R_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1apq.
| PDB = {{PDB2|1apq}}, {{PDB2|1gpz}}, {{PDB2|1md7}}, {{PDB2|1md8}}
| Name = Complement component 1, r subcomponent
| HGNCid = 1246
| Symbol = C1R
| AltSymbols =;
| OMIM = 216950
| ECnumber =
| Homologene = 1313
| MGIid = 1355313
| Function = {{GNF_GO|id=GO:0003815 |text = complement component C1r activity}} {{GNF_GO|id=GO:0003816 |text = complement component C1s activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0006958 |text = complement activation, classical pathway}} {{GNF_GO|id=GO:0045087 |text = innate immune response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 715
| Hs_Ensembl =
| Hs_RefseqProtein = NP_001724
| Hs_RefseqmRNA = NM_001733
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 50909
| Mm_Ensembl =
| Mm_RefseqmRNA = XM_001005373
| Mm_RefseqProtein = XP_001005373
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Complement component 1, r subcomponent''', also known as '''C1R''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: C1R complement component 1, r subcomponent| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=715| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Lee SL, Wallace SL, Barone R, ''et al.'' |title=Familial deficiency of two subunits of the first component of complement. C1r and C1s associated with a lupus erythematosus-like disease. |journal=Arthritis Rheum. |volume=21 |issue= 8 |pages= 958-67 |year= 1979 |pmid= 737019 |doi= }}
*{{cite journal | author=Ward SL, Ingham KC |title=A calcium-binding monoclonal antibody that recognizes a non-calcium-binding epitope in the short consensus repeat units (SCRs) of complement C1r. |journal=Mol. Immunol. |volume=29 |issue= 1 |pages= 83-93 |year= 1992 |pmid= 1370572 |doi= }}
*{{cite journal | author=Luo C, Thielens NM, Gagnon J, ''et al.'' |title=Recombinant human complement subcomponent C1s lacking beta-hydroxyasparagine, sialic acid, and one of its two carbohydrate chains still reassembles with C1q and C1r to form a functional C1 complex. |journal=Biochemistry |volume=31 |issue= 17 |pages= 4254-62 |year= 1992 |pmid= 1533159 |doi= }}
*{{cite journal | author=Busby TF, Ingham KC |title=NH2-terminal calcium-binding domain of human complement C1s- mediates the interaction of C1r- with C1q. |journal=Biochemistry |volume=29 |issue= 19 |pages= 4613-8 |year= 1990 |pmid= 2372546 |doi= }}
*{{cite journal | author=Lyons LA, Kamboh MI, Ferrell RE |title=Genetic studies of low-abundance human plasma proteins. XI. Linkage analysis and population genetics of the C1S subcomponent of the first complement component. |journal=Complement and inflammation |volume=6 |issue= 2 |pages= 81-7 |year= 1989 |pmid= 2541966 |doi= }}
*{{cite journal | author=Arlaud GJ, Van Dorsselaer A, Bell A, ''et al.'' |title=Identification of erythro-beta-hydroxyasparagine in the EGF-like domain of human C1r. |journal=FEBS Lett. |volume=222 |issue= 1 |pages= 129-34 |year= 1987 |pmid= 2820791 |doi= }}
*{{cite journal | author=Nguyen VC, Tosi M, Gross MS, ''et al.'' |title=Assignment of the complement serine protease genes C1r and C1s to chromosome 12 region 12p13. |journal=Hum. Genet. |volume=78 |issue= 4 |pages= 363-8 |year= 1988 |pmid= 2834284 |doi= }}
*{{cite journal | author=Leytus SP, Kurachi K, Sakariassen KS, Davie EW |title=Nucleotide sequence of the cDNA coding for human complement C1r. |journal=Biochemistry |volume=25 |issue= 17 |pages= 4855-63 |year= 1986 |pmid= 3021205 |doi= }}
*{{cite journal | author=Journet A, Tosi M |title=Cloning and sequencing of full-length cDNA encoding the precursor of human complement component C1r. |journal=Biochem. J. |volume=240 |issue= 3 |pages= 783-7 |year= 1987 |pmid= 3030286 |doi= }}
*{{cite journal | author=Arlaud GJ, Willis AC, Gagnon J |title=Complete amino acid sequence of the A chain of human complement-classical-pathway enzyme C1r. |journal=Biochem. J. |volume=241 |issue= 3 |pages= 711-20 |year= 1987 |pmid= 3036070 |doi= }}
*{{cite journal | author=Chesne S, Villiers CL, Arlaud GJ, ''et al.'' |title=Fluid-phase interaction of C1 inhibitor (C1 Inh) and the subcomponents C1r and C1s of the first component of complement, C1. |journal=Biochem. J. |volume=201 |issue= 1 |pages= 61-70 |year= 1982 |pmid= 6282262 |doi= }}
*{{cite journal | author=Arlaud GJ, Gagnon J |title=Complete amino acid sequence of the catalytic chain of human complement subcomponent C1-r. |journal=Biochemistry |volume=22 |issue= 8 |pages= 1758-64 |year= 1983 |pmid= 6303394 |doi= }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal | author=Nöthen MM, Dewald G |title=A common amino acid polymorphism in complement component C1R. |journal=Hum. Mol. Genet. |volume=3 |issue= 1 |pages= 217 |year= 1994 |pmid= 8162045 |doi= }}
*{{cite journal | author=Gasque P, Ischenko A, Legoedec J, ''et al.'' |title=Expression of the complement classical pathway by human glioma in culture. A model for complement expression by nerve cells. |journal=J. Biol. Chem. |volume=268 |issue= 33 |pages= 25068-74 |year= 1993 |pmid= 8227070 |doi= }}
*{{cite journal | author=Pelloux S, Thielens NM, Hudry-Clergeon G, ''et al.'' |title=Identification of a cryptic protein kinase CK2 phosphorylation site in human complement protease Clr, and its use to probe intramolecular interaction. |journal=FEBS Lett. |volume=386 |issue= 1 |pages= 15-20 |year= 1996 |pmid= 8635594 |doi= }}
*{{cite journal | author=Bradley K, North J, Saunders D, ''et al.'' |title=Synthesis of classical pathway complement components by chondrocytes. |journal=Immunology |volume=88 |issue= 4 |pages= 648-56 |year= 1996 |pmid= 8881771 |doi= }}
*{{cite journal | author=Lacroix M, Rossi V, Gaboriaud C, ''et al.'' |title=Structure and assembly of the catalytic region of human complement protease C1r: a three-dimensional model based on chemical cross-linking and homology modeling. |journal=Biochemistry |volume=36 |issue= 21 |pages= 6270-82 |year= 1997 |pmid= 9174342 |doi= 10.1021/bi962719i }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal | author=Bersch B, Hernandez JF, Marion D, Arlaud GJ |title=Solution structure of the epidermal growth factor (EGF)-like module of human complement protease C1r, an atypical member of the EGF family. |journal=Biochemistry |volume=37 |issue= 5 |pages= 1204-14 |year= 1998 |pmid= 9477945 |doi= 10.1021/bi971851v }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CACNA1H... {November 19, 2007 12:41:37 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 19, 2007 12:42:05 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Calcium channel, voltage-dependent, T type, alpha 1H subunit
| HGNCid = 1395
| Symbol = CACNA1H
| AltSymbols =; CACNA1HB; Cav3.2; FLJ90484
| OMIM = 607904
| ECnumber =
| Homologene = 56913
| MGIid = 1928842
| GeneAtlas_image1 = PBB_GE_CACNA1H_205845_at_tn.png
| Function = {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0008332 |text = low voltage-gated calcium channel activity}}
| Component = {{GNF_GO|id=GO:0005891 |text = voltage-gated calcium channel complex}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006816 |text = calcium ion transport}} {{GNF_GO|id=GO:0006936 |text = muscle contraction}} {{GNF_GO|id=GO:0007517 |text = muscle development}} {{GNF_GO|id=GO:0007520 |text = myoblast fusion}} {{GNF_GO|id=GO:0008016 |text = regulation of heart contraction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8912
| Hs_Ensembl = ENSG00000196557
| Hs_RefseqProtein = NP_001005407
| Hs_RefseqmRNA = NM_001005407
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 16
| Hs_GenLoc_start = 1143739
| Hs_GenLoc_end = 1211772
| Hs_Uniprot = O95180
| Mm_EntrezGene = 58226
| Mm_Ensembl = ENSMUSG00000024112
| Mm_RefseqmRNA = NM_021415
| Mm_RefseqProtein = NP_067390
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 25101887
| Mm_GenLoc_end = 25161385
| Mm_Uniprot = Q6PE92
}}
}}
'''Calcium channel, voltage-dependent, T type, alpha 1H subunit''', also known as '''CACNA1H''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8912| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a T-type member of the alpha-1 subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. The alpha-1 subunit has 24 transmembrane segments and forms the pore through which ions pass into the cell. There are multiple isoforms of each of the proteins in the complex, either encoded by different genes or the result of alternative splicing of transcripts. Alternate transcriptional splice variants, encoding different isoforms, have been characterized for the gene described here. Studies suggest certain mutations in this gene lead to childhood absence epilepsy (CAE).<ref name="entrez">{{cite web | title = Entrez Gene: CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8912| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Crunelli V, Tóth TI, Cope DW, ''et al.'' |title=The 'window' T-type calcium current in brain dynamics of different behavioural states. |journal=J. Physiol. (Lond.) |volume=562 |issue= Pt 1 |pages= 121-9 |year= 2005 |pmid= 15498803 |doi= 10.1113/jphysiol.2004.076273 }}
*{{cite journal | author=Catterall WA, Perez-Reyes E, Snutch TP, Striessnig J |title=International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 411-25 |year= 2006 |pmid= 16382099 |doi= 10.1124/pr.57.4.5 }}
*{{cite journal | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
*{{cite journal | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi= }}
*{{cite journal | author=Cribbs LL, Lee JH, Yang J, ''et al.'' |title=Cloning and characterization of alpha1H from human heart, a member of the T-type Ca2+ channel gene family. |journal=Circ. Res. |volume=83 |issue= 1 |pages= 103-9 |year= 1998 |pmid= 9670923 |doi= }}
*{{cite journal | author=Williams ME, Washburn MS, Hans M, ''et al.'' |title=Structure and functional characterization of a novel human low-voltage activated calcium channel. |journal=J. Neurochem. |volume=72 |issue= 2 |pages= 791-9 |year= 1999 |pmid= 9930755 |doi= }}
*{{cite journal | author=Perez-Reyes E, Lee JH, Cribbs LL |title=Molecular characterization of two members of the T-type calcium channel family. |journal=Ann. N. Y. Acad. Sci. |volume=868 |issue= |pages= 131-43 |year= 1999 |pmid= 10414291 |doi= }}
*{{cite journal | author=Bijlenga P, Liu JH, Espinos E, ''et al.'' |title=T-type alpha 1H Ca2+ channels are involved in Ca2+ signaling during terminal differentiation (fusion) of human myoblasts. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 13 |pages= 7627-32 |year= 2000 |pmid= 10861024 |doi= }}
*{{cite journal | author=Daniels RJ, Peden JF, Lloyd C, ''et al.'' |title=Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. |journal=Hum. Mol. Genet. |volume=10 |issue= 4 |pages= 339-52 |year= 2001 |pmid= 11157797 |doi= }}
*{{cite journal | author=Jagannathan S, Punt EL, Gu Y, ''et al.'' |title=Identification and localization of T-type voltage-operated calcium channel subunits in human male germ cells. Expression of multiple isoforms. |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 8449-56 |year= 2002 |pmid= 11751928 |doi= 10.1074/jbc.M105345200 }}
*{{cite journal | author=Mariot P, Vanoverberghe K, Lalevee N, ''et al.'' |title=Overexpression of an alpha 1H (Cav3.2) T-type calcium channel during neuroendocrine differentiation of human prostate cancer cells. |journal=J. Biol. Chem. |volume=277 |issue= 13 |pages= 10824-33 |year= 2002 |pmid= 11799114 |doi= 10.1074/jbc.M108754200 }}
*{{cite journal | author=Chemin J, Monteil A, Perez-Reyes E, ''et al.'' |title=Specific contribution of human T-type calcium channel isotypes (alpha(1G), alpha(1H) and alpha(1I)) to neuronal excitability. |journal=J. Physiol. (Lond.) |volume=540 |issue= Pt 1 |pages= 3-14 |year= 2002 |pmid= 11927664 |doi= }}
*{{cite journal | author=Shin JB, Martinez-Salgado C, Heppenstall PA, Lewin GR |title=A T-type calcium channel required for normal function of a mammalian mechanoreceptor. |journal=Nat. Neurosci. |volume=6 |issue= 7 |pages= 724-30 |year= 2003 |pmid= 12808460 |doi= 10.1038/nn1076 }}
*{{cite journal | author=Wolfe JT, Wang H, Howard J, ''et al.'' |title=T-type calcium channel regulation by specific G-protein betagamma subunits. |journal=Nature |volume=424 |issue= 6945 |pages= 209-13 |year= 2003 |pmid= 12853961 |doi= 10.1038/nature01772 }}
*{{cite journal | author=Kaku T, Lee TS, Arita M, ''et al.'' |title=The gating and conductance properties of Cav3.2 low-voltage-activated T-type calcium channels. |journal=Jpn. J. Physiol. |volume=53 |issue= 3 |pages= 165-72 |year= 2004 |pmid= 14529577 |doi= }}
*{{cite journal | author=Welsby PJ, Wang H, Wolfe JT, ''et al.'' |title=A mechanism for the direct regulation of T-type calcium channels by Ca2+/calmodulin-dependent kinase II. |journal=J. Neurosci. |volume=23 |issue= 31 |pages= 10116-21 |year= 2003 |pmid= 14602827 |doi= }}
*{{cite journal | author=Chen CC, Lamping KG, Nuno DW, ''et al.'' |title=Abnormal coronary function in mice deficient in alpha1H T-type Ca2+ channels. |journal=Science |volume=302 |issue= 5649 |pages= 1416-8 |year= 2003 |pmid= 14631046 |doi= 10.1126/science.1089268 }}
*{{cite journal | author=Khosravani H, Altier C, Simms B, ''et al.'' |title=Gating effects of mutations in the Cav3.2 T-type calcium channel associated with childhood absence epilepsy. |journal=J. Biol. Chem. |volume=279 |issue= 11 |pages= 9681-4 |year= 2004 |pmid= 14729682 |doi= 10.1074/jbc.C400006200 }}
*{{cite journal | author=Martin J, Han C, Gordon LA, ''et al.'' |title=The sequence and analysis of duplication-rich human chromosome 16. |journal=Nature |volume=432 |issue= 7020 |pages= 988-94 |year= 2005 |pmid= 15616553 |doi= 10.1038/nature03187 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CCNU... {November 19, 2007 12:42:38 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 19, 2007 12:43:07 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cyclin U
| HGNCid = 18576
| Symbol = CCNU
| AltSymbols =; FLJ22422; UDG2; UNG2
| OMIM = 607752
| ECnumber =
| Homologene = 50171
| MGIid = 2145534
| GeneAtlas_image1 = PBB_GE_CCNU_210021_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004844 |text = uracil DNA N-glycosylase activity}} {{GNF_GO|id=GO:0016798 |text = hydrolase activity, acting on glycosyl bonds}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005654 |text = nucleoplasm}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0006284 |text = base-excision repair}} {{GNF_GO|id=GO:0008152 |text = metabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 10309
| Hs_Ensembl = ENSG00000152669
| Hs_RefseqProtein = NP_001019763
| Hs_RefseqmRNA = NM_001024592
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 54562740
| Hs_GenLoc_end = 54565265
| Hs_Uniprot = P22674
| Mm_EntrezGene = 218630
| Mm_Ensembl = ENSMUSG00000042417
| Mm_RefseqmRNA = XM_127523
| Mm_RefseqProtein = XP_127523
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 13
| Mm_GenLoc_start = 114108776
| Mm_GenLoc_end = 114111654
| Mm_Uniprot = P0C242
}}
}}
'''Cyclin U''', also known as '''CCNU''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CCNU cyclin U| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10309| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Caradonna S, Muller-Weeks S |title=The nature of enzymes involved in uracil-DNA repair: isoform characteristics of proteins responsible for nuclear and mitochondrial genomic integrity. |journal=Curr. Protein Pept. Sci. |volume=2 |issue= 4 |pages= 335-47 |year= 2002 |pmid= 12369930 |doi= }}
*{{cite journal | author=Muller SJ, Caradonna S |title=Isolation and characterization of a human cDNA encoding uracil-DNA glycosylase. |journal=Biochim. Biophys. Acta |volume=1088 |issue= 2 |pages= 197-207 |year= 1991 |pmid= 2001396 |doi= }}
*{{cite journal | author=Muller SJ, Caradonna S |title=Cell cycle regulation of a human cyclin-like gene encoding uracil-DNA glycosylase. |journal=J. Biol. Chem. |volume=268 |issue= 2 |pages= 1310-9 |year= 1993 |pmid= 8419333 |doi= }}
*{{cite journal | author=Otterlei M, Warbrick E, Nagelhus TA, ''et al.'' |title=Post-replicative base excision repair in replication foci. |journal=EMBO J. |volume=18 |issue= 13 |pages= 3834-44 |year= 1999 |pmid= 10393198 |doi= 10.1093/emboj/18.13.3834 }}
*{{cite journal | author=Mer G, Bochkarev A, Gupta R, ''et al.'' |title=Structural basis for the recognition of DNA repair proteins UNG2, XPA, and RAD52 by replication factor RPA. |journal=Cell |volume=103 |issue= 3 |pages= 449-56 |year= 2000 |pmid= 11081631 |doi= }}
*{{cite journal | author=Kavli B, Sundheim O, Akbari M, ''et al.'' |title=hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup. |journal=J. Biol. Chem. |volume=277 |issue= 42 |pages= 39926-36 |year= 2002 |pmid= 12161446 |doi= 10.1074/jbc.M207107200 }}
*{{cite journal | author=Ohta S, Shiomi Y, Sugimoto K, ''et al.'' |title=A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein. |journal=J. Biol. Chem. |volume=277 |issue= 43 |pages= 40362-7 |year= 2002 |pmid= 12171929 |doi= 10.1074/jbc.M206194200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Priet S, Navarro JM, Gros N, ''et al.'' |title=Differential incorporation of uracil DNA glycosylase UNG2 into HIV-1, HIV-2, and SIV(MAC) viral particles. |journal=Virology |volume=307 |issue= 2 |pages= 283-9 |year= 2003 |pmid= 12667798 |doi= }}
*{{cite journal | author=Elder RT, Zhu X, Priet S, ''et al.'' |title=A fission yeast homologue of the human uracil-DNA-glycosylase and their roles in causing DNA damage after overexpression. |journal=Biochem. Biophys. Res. Commun. |volume=306 |issue= 3 |pages= 693-700 |year= 2003 |pmid= 12810074 |doi= }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Lu X, Bocangel D, Nannenga B, ''et al.'' |title=The p53-induced oncogenic phosphatase PPM1D interacts with uracil DNA glycosylase and suppresses base excision repair. |journal=Mol. Cell |volume=15 |issue= 4 |pages= 621-34 |year= 2004 |pmid= 15327777 |doi= 10.1016/j.molcel.2004.08.007 }}
*{{cite journal | author=Schmutz J, Martin J, Terry A, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 5. |journal=Nature |volume=431 |issue= 7006 |pages= 268-74 |year= 2004 |pmid= 15372022 |doi= 10.1038/nature02919 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Hirst R, Gosden R, Miller D |title=The cyclin-like uracil DNA glycosylase (UDG) of murine oocytes and its relationship to human and chimpanzee homologues. |journal=Gene |volume=375 |issue= |pages= 95-102 |year= 2006 |pmid= 16697536 |doi= 10.1016/j.gene.2006.02.030 }}
*{{cite journal | author=Verma SC, Bajaj BG, Cai Q, ''et al.'' |title=Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus recruits uracil DNA glycosylase 2 at the terminal repeats and is important for latent persistence of the virus. |journal=J. Virol. |volume=80 |issue= 22 |pages= 11178-90 |year= 2006 |pmid= 16928741 |doi= 10.1128/JVI.01334-06 }}
*{{cite journal | author=Yang B, Chen K, Zhang C, ''et al.'' |title=Virion-associated uracil DNA glycosylase-2 and apurinic/apyrimidinic endonuclease are involved in the degradation of APOBEC3G-edited nascent HIV-1 DNA. |journal=J. Biol. Chem. |volume=282 |issue= 16 |pages= 11667-75 |year= 2007 |pmid= 17272283 |doi= 10.1074/jbc.M606864200 }}
*{{cite journal | author=Schröfelbauer B, Hakata Y, Landau NR |title=HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 10 |pages= 4130-5 |year= 2007 |pmid= 17360488 |doi= 10.1073/pnas.0610167104 }}
*{{cite journal | author=Pettersen HS, Sundheim O, Gilljam KM, ''et al.'' |title=Uracil-DNA glycosylases SMUG1 and UNG2 coordinate the initial steps of base excision repair by distinct mechanisms. |journal=Nucleic Acids Res. |volume=35 |issue= 12 |pages= 3879-92 |year= 2007 |pmid= 17537817 |doi= 10.1093/nar/gkm372 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CD79B... {November 19, 2007 12:31:46 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 19, 2007 12:32:24 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = CD79b molecule, immunoglobulin-associated beta
| HGNCid = 1699
| Symbol = CD79B
| AltSymbols =; B29; IGB
| OMIM = 147245
| ECnumber =
| Homologene = 521
| MGIid = 96431
| GeneAtlas_image1 = PBB_GE_CD79B_205297_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004888 |text = transmembrane receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0009897 |text = external side of plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0019815 |text = B cell receptor complex}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0050853 |text = B cell receptor signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 974
| Hs_Ensembl = ENSG00000007312
| Hs_RefseqProtein = NP_000617
| Hs_RefseqmRNA = NM_000626
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 59359832
| Hs_GenLoc_end = 59363446
| Hs_Uniprot = P40259
| Mm_EntrezGene = 15985
| Mm_Ensembl = ENSMUSG00000040592
| Mm_RefseqmRNA = NM_008339
| Mm_RefseqProtein = NP_032365
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 106127431
| Mm_GenLoc_end = 106130760
| Mm_Uniprot = Q4FJP4
}}
}}
'''CD79b molecule, immunoglobulin-associated beta''', also known as '''CD79B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CD79B CD79b molecule, immunoglobulin-associated beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=974| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described.<ref name="entrez">{{cite web | title = Entrez Gene: CD79B CD79b molecule, immunoglobulin-associated beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=974| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Reth M |title=Antigen receptors on B lymphocytes. |journal=Annu. Rev. Immunol. |volume=10 |issue= |pages= 97-121 |year= 1992 |pmid= 1591006 |doi= 10.1146/annurev.iy.10.040192.000525 }}
*{{cite journal | author=Müller B, Cooper L, Terhorst C |title=Cloning and sequencing of the cDNA encoding the human homologue of the murine immunoglobulin-associated protein B29. |journal=Eur. J. Immunol. |volume=22 |issue= 6 |pages= 1621-5 |year= 1992 |pmid= 1534761 |doi= }}
*{{cite journal | author=Lankester AC, van Schijndel GM, Cordell JL, ''et al.'' |title=CD5 is associated with the human B cell antigen receptor complex. |journal=Eur. J. Immunol. |volume=24 |issue= 4 |pages= 812-6 |year= 1994 |pmid= 7512031 |doi= }}
*{{cite journal | author=Vasile S, Coligan JE, Yoshida M, Seon BK |title=Isolation and chemical characterization of the human B29 and mb-1 proteins of the B cell antigen receptor complex. |journal=Mol. Immunol. |volume=31 |issue= 6 |pages= 419-27 |year= 1994 |pmid= 7514267 |doi= }}
*{{cite journal | author=Brown VK, Ogle EW, Burkhardt AL, ''et al.'' |title=Multiple components of the B cell antigen receptor complex associate with the protein tyrosine phosphatase, CD45. |journal=J. Biol. Chem. |volume=269 |issue= 25 |pages= 17238-44 |year= 1994 |pmid= 7516335 |doi= }}
*{{cite journal | author=Rowley RB, Burkhardt AL, Chao HG, ''et al.'' |title=Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation. |journal=J. Biol. Chem. |volume=270 |issue= 19 |pages= 11590-4 |year= 1995 |pmid= 7538118 |doi= }}
*{{cite journal | author=Pani G, Kozlowski M, Cambier JC, ''et al.'' |title=Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling. |journal=J. Exp. Med. |volume=181 |issue= 6 |pages= 2077-84 |year= 1995 |pmid= 7539038 |doi= }}
*{{cite journal | author=Müller B, Cooper L, Terhorst C |title=Interplay between the human TCR/CD3 epsilon and the B-cell antigen receptor associated Ig-beta (B29). |journal=Immunol. Lett. |volume=44 |issue= 2-3 |pages= 97-103 |year= 1995 |pmid= 7541024 |doi= }}
*{{cite journal | author=Saouaf SJ, Kut SA, Fargnoli J, ''et al.'' |title=Reconstitution of the B cell antigen receptor signaling components in COS cells. |journal=J. Biol. Chem. |volume=270 |issue= 45 |pages= 27072-8 |year= 1995 |pmid= 7592958 |doi= }}
*{{cite journal | author=Hashimoto S, Chiorazzi N, Gregersen PK |title=Alternative splicing of CD79a (Ig-alpha/mb-1) and CD79b (Ig-beta/B29) RNA transcripts in human B cells. |journal=Mol. Immunol. |volume=32 |issue= 9 |pages= 651-9 |year= 1995 |pmid= 7643857 |doi= }}
*{{cite journal | author=Hashimoto S, Chiorazzi N, Gregersen PK |title=The complete sequence of the human CD79b (Ig beta/B29) gene: identification of a conserved exon/intron organization, immunoglobulin-like regulatory regions, and allelic polymorphism. |journal=Immunogenetics |volume=40 |issue= 2 |pages= 145-9 |year= 1994 |pmid= 7913081 |doi= }}
*{{cite journal | author=Gold MR, Chiu R, Ingham RJ, ''et al.'' |title=Activation and serine phosphorylation of the p56lck protein tyrosine kinase in response to antigen receptor cross-linking in B lymphocytes. |journal=J. Immunol. |volume=153 |issue= 6 |pages= 2369-80 |year= 1994 |pmid= 8077654 |doi= }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal | author=Hashimoto S, Gregersen PK, Chiorazzi N |title=The human Ig-beta cDNA sequence, a homologue of murine B29, is identical in B cell and plasma cell lines producing all the human Ig isotypes. |journal=J. Immunol. |volume=150 |issue= 2 |pages= 491-8 |year= 1993 |pmid= 8419481 |doi= }}
*{{cite journal | author=Wood WJ, Thompson AA, Korenberg J, ''et al.'' |title=Isolation and chromosomal mapping of the human immunoglobulin-associated B29 gene (IGB). |journal=Genomics |volume=16 |issue= 1 |pages= 187-92 |year= 1993 |pmid= 8486355 |doi= 10.1006/geno.1993.1157 }}
*{{cite journal | author=Thompson AA, Wood WJ, Gilly MJ, ''et al.'' |title=The promoter and 5' flanking sequences controlling human B29 gene expression. |journal=Blood |volume=87 |issue= 2 |pages= 666-73 |year= 1996 |pmid= 8555489 |doi= }}
*{{cite journal | author=Astsaturov IA, Matutes E, Morilla R, ''et al.'' |title=Differential expression of B29 (CD79b) and mb-1 (CD79a) proteins in acute lymphoblastic leukaemia. |journal=Leukemia |volume=10 |issue= 5 |pages= 769-73 |year= 1996 |pmid= 8656670 |doi= }}
*{{cite journal | author=Koyama M, Nakamura T, Higashihara M, ''et al.'' |title=The novel variants of mb-1 and B29 transcripts generated by alternative mRNA splicing. |journal=Immunol. Lett. |volume=47 |issue= 3 |pages= 151-6 |year= 1996 |pmid= 8747711 |doi= }}
*{{cite journal | author=Carter RH, Doody GM, Bolen JB, Fearon DT |title=Membrane IgM-induced tyrosine phosphorylation of CD19 requires a CD19 domain that mediates association with components of the B cell antigen receptor complex. |journal=J. Immunol. |volume=158 |issue= 7 |pages= 3062-9 |year= 1997 |pmid= 9120258 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CEACAM5... {November 19, 2007 12:32:24 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 19, 2007 12:32:49 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CEACAM5_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1e07.
| PDB = {{PDB2|1e07}}
| Name = Carcinoembryonic antigen-related cell adhesion molecule 5
| HGNCid = 1817
| Symbol = CEACAM5
| AltSymbols =; CD66e; CEA; DKFZp781M2392
| OMIM = 114890
| ECnumber =
| Homologene =
| MGIid =
| Function = {{GNF_GO|id=GO:0048503 |text = GPI anchor binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process =
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1048
| Hs_Ensembl = ENSG00000105388
| Hs_RefseqProtein = NP_004354
| Hs_RefseqmRNA = NM_004363
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 46904408
| Hs_GenLoc_end = 46923112
| Hs_Uniprot = P06731
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Carcinoembryonic antigen-related cell adhesion molecule 5''', also known as '''CEACAM5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1048| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Willcocks TC, Craig IW |title=Characterization of the genomic organization of human carcinoembryonic antigen (CEA): comparison with other family members and sequence analysis of 5' controlling region. |journal=Genomics |volume=8 |issue= 3 |pages= 492-500 |year= 1991 |pmid= 2286372 |doi= }}
*{{cite journal | author=Barnett T, Zimmermann W |title=Workshop report: proposed nomenclature for the carcinoembryonic antigen (CEA) gene family. |journal=Tumour Biol. |volume=11 |issue= 1-2 |pages= 59-63 |year= 1990 |pmid= 2309067 |doi= }}
*{{cite journal | author=Schrewe H, Thompson J, Bona M, ''et al.'' |title=Cloning of the complete gene for carcinoembryonic antigen: analysis of its promoter indicates a region conveying cell type-specific expression. |journal=Mol. Cell. Biol. |volume=10 |issue= 6 |pages= 2738-48 |year= 1990 |pmid= 2342461 |doi= }}
*{{cite journal | author=Kamarck ME, Elting JJ, Hart JT, ''et al.'' |title=Carcinoembryonic antigen family: expression in a mouse L-cell transfectant and characterization of a partial cDNA in bacteriophage lambda gt11. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 15 |pages= 5350-4 |year= 1987 |pmid= 2955415 |doi= }}
*{{cite journal | author=Zimmermann W, Ortlieb B, Friedrich R, von Kleist S |title=Isolation and characterization of cDNA clones encoding the human carcinoembryonic antigen reveal a highly conserved repeating structure. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 9 |pages= 2960-4 |year= 1987 |pmid= 3033671 |doi= }}
*{{cite journal | author=Barnett T, Goebel SJ, Nothdurft MA, Elting JJ |title=Carcinoembryonic antigen family: characterization of cDNAs coding for NCA and CEA and suggestion of nonrandom sequence variation in their conserved loop-domains. |journal=Genomics |volume=3 |issue= 1 |pages= 59-66 |year= 1989 |pmid= 3220478 |doi= }}
*{{cite journal | author=Zimmermann W, Weber B, Ortlieb B, ''et al.'' |title=Chromosomal localization of the carcinoembryonic antigen gene family and differential expression in various tumors. |journal=Cancer Res. |volume=48 |issue= 9 |pages= 2550-4 |year= 1988 |pmid= 3356015 |doi= }}
*{{cite journal | author=Beauchemin N, Benchimol S, Cournoyer D, ''et al.'' |title=Isolation and characterization of full-length functional cDNA clones for human carcinoembryonic antigen. |journal=Mol. Cell. Biol. |volume=7 |issue= 9 |pages= 3221-30 |year= 1987 |pmid= 3670312 |doi= }}
*{{cite journal | author=Oikawa S, Nakazato H, Kosaki G |title=Primary structure of human carcinoembryonic antigen (CEA) deduced from cDNA sequence. |journal=Biochem. Biophys. Res. Commun. |volume=142 |issue= 2 |pages= 511-8 |year= 1987 |pmid= 3814146 |doi= }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal | author=Hart SP, Ross JA, Ross K, ''et al.'' |title=Molecular characterization of the surface of apoptotic neutrophils: implications for functional downregulation and recognition by phagocytes. |journal=Cell Death Differ. |volume=7 |issue= 5 |pages= 493-503 |year= 2000 |pmid= 10800083 |doi= 10.1038/sj.cdd.4400680 }}
*{{cite journal | author=Guignot J, Peiffer I, Bernet-Camard MF, ''et al.'' |title=Recruitment of CD55 and CD66e brush border-associated glycosylphosphatidylinositol-anchored proteins by members of the Afa/Dr diffusely adhering family of Escherichia coli that infect the human polarized intestinal Caco-2/TC7 cells. |journal=Infect. Immun. |volume=68 |issue= 6 |pages= 3554-63 |year= 2000 |pmid= 10816511 |doi= }}
*{{cite journal | author=Boehm MK, Perkins SJ |title=Structural models for carcinoembryonic antigen and its complex with the single-chain Fv antibody molecule MFE23. |journal=FEBS Lett. |volume=475 |issue= 1 |pages= 11-6 |year= 2000 |pmid= 10854848 |doi= }}
*{{cite journal | author=Screaton RA, DeMarte L, Dráber P, Stanners CP |title=The specificity for the differentiation blocking activity of carcinoembryonic antigen resides in its glycophosphatidyl-inositol anchor. |journal=J. Cell Biol. |volume=150 |issue= 3 |pages= 613-26 |year= 2000 |pmid= 10931872 |doi= }}
*{{cite journal | author=Bajenova OV, Zimmer R, Stolper E, ''et al.'' |title=Heterogeneous RNA-binding protein M4 is a receptor for carcinoembryonic antigen in Kupffer cells. |journal=J. Biol. Chem. |volume=276 |issue= 33 |pages= 31067-73 |year= 2001 |pmid= 11406629 |doi= 10.1074/jbc.M104093200 }}
*{{cite journal | author=Wirth T, Soeth E, Czubayko F, Juhl H |title=Inhibition of endogenous carcinoembryonic antigen (CEA) increases the apoptotic rate of colon cancer cells and inhibits metastatic tumor growth. |journal=Clin. Exp. Metastasis |volume=19 |issue= 2 |pages= 155-60 |year= 2002 |pmid= 11964079 |doi= }}
*{{cite journal | author=Louhimo J, Carpelan-Holmström M, Alfthan H, ''et al.'' |title=Serum HCG beta, CA 72-4 and CEA are independent prognostic factors in colorectal cancer. |journal=Int. J. Cancer |volume=101 |issue= 6 |pages= 545-8 |year= 2002 |pmid= 12237895 |doi= 10.1002/ijc.90009 }}
*{{cite journal | author=Hampton R, Walker M, Marshall J, Juhl H |title=Differential expression of carcinoembryonic antigen (CEA) splice variants in whole blood of colon cancer patients and healthy volunteers: implication for the detection of circulating colon cancer cells. |journal=Oncogene |volume=21 |issue= 51 |pages= 7817-23 |year= 2002 |pmid= 12420218 |doi= 10.1038/sj.onc.1205906 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CHM... {November 19, 2007 12:32:49 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 19, 2007 12:33:34 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Choroideremia (Rab escort protein 1)
| HGNCid = 1940
| Symbol = CHM
| AltSymbols =; DXS540; FLJ38564; GGTA; HSD-32; MGC102710; REP-1; TCD
| OMIM = 300390
| ECnumber =
| Homologene = 334
| MGIid = 892979
| GeneAtlas_image1 = PBB_GE_CHM_207099_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004663 |text = Rab-protein geranylgeranyltransferase activity}} {{GNF_GO|id=GO:0005084 |text = Rab escort protein activity}} {{GNF_GO|id=GO:0005096 |text = GTPase activator activity}}
| Component = {{GNF_GO|id=GO:0005968 |text = Rab-protein geranylgeranyltransferase complex}}
| Process = {{GNF_GO|id=GO:0001568 |text = blood vessel development}} {{GNF_GO|id=GO:0006886 |text = intracellular protein transport}} {{GNF_GO|id=GO:0007601 |text = visual perception}} {{GNF_GO|id=GO:0018348 |text = protein amino acid geranylgeranylation}} {{GNF_GO|id=GO:0043087 |text = regulation of GTPase activity}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1121
| Hs_Ensembl = ENSG00000188419
| Hs_RefseqProtein = NP_000381
| Hs_RefseqmRNA = NM_000390
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 85002841
| Hs_GenLoc_end = 85189222
| Hs_Uniprot = P24386
| Mm_EntrezGene = 12662
| Mm_Ensembl =
| Mm_RefseqmRNA = XM_991490
| Mm_RefseqProtein = XP_996584
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Choroideremia (Rab escort protein 1)''', also known as '''CHM''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CHM choroideremia (Rab escort protein 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1121| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The choroideremia gene encodes for a protein, the Rab escort protein-1 (REP1), which is involved in membrane trafficking.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: CHM choroideremia (Rab escort protein 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1121| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Sankila EM, Tolvanen R, van den Hurk JA, ''et al.'' |title=Aberrant splicing of the CHM gene is a significant cause of choroideremia. |journal=Nat. Genet. |volume=1 |issue= 2 |pages= 109-13 |year= 1993 |pmid= 1302003 |doi= 10.1038/ng0592-109 }}
*{{cite journal | author=Molloy CM, van de Pol TJ, Brohet RM, ''et al.'' |title=Three RFLPs for pZ11 (DXS540) in the choroideremia gene at Xq21.2. |journal=Nucleic Acids Res. |volume=20 |issue= 6 |pages= 1434 |year= 1992 |pmid= 1373238 |doi= }}
*{{cite journal | author=Merry DE, Jänne PA, Landers JE, ''et al.'' |title=Isolation of a candidate gene for choroideremia. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 6 |pages= 2135-9 |year= 1992 |pmid= 1549574 |doi= }}
*{{cite journal | author=van den Hurk JA, van de Pol TJ, Molloy CM, ''et al.'' |title=Detection and characterization of point mutations in the choroideremia candidate gene by PCR-SSCP analysis and direct DNA sequencing. |journal=Am. J. Hum. Genet. |volume=50 |issue= 6 |pages= 1195-202 |year= 1992 |pmid= 1598901 |doi= }}
*{{cite journal | author=Fodor E, Lee RT, O'Donnell JJ |title=Analysis of choroideraemia gene. |journal=Nature |volume=351 |issue= 6328 |pages= 614 |year= 1991 |pmid= 1904992 |doi= 10.1038/351614b0 }}
*{{cite journal | author=Cremers FP, van de Pol DJ, van Kerkhoff LP, ''et al.'' |title=Cloning of a gene that is rearranged in patients with choroideraemia. |journal=Nature |volume=347 |issue= 6294 |pages= 674-7 |year= 1990 |pmid= 2215697 |doi= 10.1038/347674a0 }}
*{{cite journal | author=Cremers FP, Sankila EM, Brunsmann F, ''et al.'' |title=Deletions in patients with classical choroideremia vary in size from 45 kb to several megabases. |journal=Am. J. Hum. Genet. |volume=47 |issue= 4 |pages= 622-8 |year= 1990 |pmid= 2220804 |doi= }}
*{{cite journal | author=Donnelly P, Menet H, Fouanon C, ''et al.'' |title=Missense mutation in the choroideremia gene. |journal=Hum. Mol. Genet. |volume=3 |issue= 6 |pages= 1017 |year= 1994 |pmid= 7951216 |doi= }}
*{{cite journal | author=Alexandrov K, Horiuchi H, Steele-Mortimer O, ''et al.'' |title=Rab escort protein-1 is a multifunctional protein that accompanies newly prenylated rab proteins to their target membranes. |journal=EMBO J. |volume=13 |issue= 22 |pages= 5262-73 |year= 1994 |pmid= 7957092 |doi= }}
*{{cite journal | author=van Bokhoven H, van den Hurk JA, Bogerd L, ''et al.'' |title=Cloning and characterization of the human choroideremia gene. |journal=Hum. Mol. Genet. |volume=3 |issue= 7 |pages= 1041-6 |year= 1995 |pmid= 7981670 |doi= }}
*{{cite journal | author=Cremers FP, Armstrong SA, Seabra MC, ''et al.'' |title=REP-2, a Rab escort protein encoded by the choroideremia-like gene. |journal=J. Biol. Chem. |volume=269 |issue= 3 |pages= 2111-7 |year= 1994 |pmid= 8294464 |doi= }}
*{{cite journal | author=Seabra MC, Brown MS, Goldstein JL |title=Retinal degeneration in choroideremia: deficiency of rab geranylgeranyl transferase. |journal=Science |volume=259 |issue= 5093 |pages= 377-81 |year= 1993 |pmid= 8380507 |doi= }}
*{{cite journal | author=Schwartz M, Rosenberg T, van den Hurk JA, ''et al.'' |title=Identification of mutations in Danish choroideremia families. |journal=Hum. Mutat. |volume=2 |issue= 1 |pages= 43-7 |year= 1993 |pmid= 8477262 |doi= 10.1002/humu.1380020108 }}
*{{cite journal | author=Overmeyer JH, Wilson AL, Erdman RA, Maltese WA |title=The putative "switch 2" domain of the Ras-related GTPase, Rab1B, plays an essential role in the interaction with Rab escort protein. |journal=Mol. Biol. Cell |volume=9 |issue= 1 |pages= 223-35 |year= 1998 |pmid= 9437002 |doi= }}
*{{cite journal | author=Alexandrov K, Simon I, Iakovenko A, ''et al.'' |title=Moderate discrimination of REP-1 between Rab7 x GDP and Rab7 x GTP arises from a difference of an order of magnitude in dissociation rates. |journal=FEBS Lett. |volume=425 |issue= 3 |pages= 460-4 |year= 1998 |pmid= 9563513 |doi= }}
*{{cite journal | author=Raffaniello RD, Raufman JP |title=Cytosolic RAB3D is associated with RAB escort protein (REP), not RAB-GDP dissociation inhibitor (GDI), in dispersed chief cells from guinea pig stomach. |journal=J. Cell. Biochem. |volume=72 |issue= 4 |pages= 540-8 |year= 1999 |pmid= 10022613 |doi= }}
*{{cite journal | author=Thomä NH, Iakovenko A, Kalinin A, ''et al.'' |title=Allosteric regulation of substrate binding and product release in geranylgeranyltransferase type II. |journal=Biochemistry |volume=40 |issue= 1 |pages= 268-74 |year= 2001 |pmid= 11141079 |doi= }}
*{{cite journal | author=Syed N, Smith JE, John SK, ''et al.'' |title=Evaluation of retinal photoreceptors and pigment epithelium in a female carrier of choroideremia. |journal=Ophthalmology |volume=108 |issue= 4 |pages= 711-20 |year= 2001 |pmid= 11297488 |doi= }}
*{{cite journal | author=Rak A, Reents R, Pylypenko O, ''et al.'' |title=Crystallization and preliminary X-ray diffraction analysis of the Rab escort protein-1 in complex with Rab geranylgeranyltransferase. |journal=J. Struct. Biol. |volume=136 |issue= 2 |pages= 158-61 |year= 2002 |pmid= 11886217 |doi= 10.1006/jsbi.2001.4433 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CLDN4... {November 19, 2007 12:34:40 AM PST}
- SEARCH REDIRECT: Control Box Found: CLDN4 {November 19, 2007 12:35:18 AM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 19, 2007 12:35:21 AM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 19, 2007 12:35:21 AM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 19, 2007 12:35:21 AM PST}
- UPDATED: Updated protein page: CLDN4 {November 19, 2007 12:35:27 AM PST}
- INFO: Beginning work on COIL... {November 19, 2007 12:39:43 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 19, 2007 12:40:12 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Coilin
| HGNCid = 2184
| Symbol = COIL
| AltSymbols =; CLN80; p80-coilin
| OMIM = 600272
| ECnumber =
| Homologene = 3413
| MGIid = 104842
| GeneAtlas_image1 = PBB_GE_COIL_203654_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_COIL_203653_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0001674 |text = female germ cell nucleus}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0015030 |text = Cajal body}}
| Process =
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8161
| Hs_Ensembl = ENSG00000121058
| Hs_RefseqProtein = NP_004636
| Hs_RefseqmRNA = NM_004645
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 52370562
| Hs_GenLoc_end = 52393410
| Hs_Uniprot = P38432
| Mm_EntrezGene = 12812
| Mm_Ensembl = ENSMUSG00000033983
| Mm_RefseqmRNA = NM_016706
| Mm_RefseqProtein = NP_057915
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 88790039
| Mm_GenLoc_end = 88807703
| Mm_Uniprot =
}}
}}
'''Coilin''', also known as '''COIL''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: COIL coilin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8161| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14.<ref name="entrez">{{cite web | title = Entrez Gene: COIL coilin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8161| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Andrade LE, Chan EK, Raska I, ''et al.'' |title=Human autoantibody to a novel protein of the nuclear coiled body: immunological characterization and cDNA cloning of p80-coilin. |journal=J. Exp. Med. |volume=173 |issue= 6 |pages= 1407-19 |year= 1991 |pmid= 2033369 |doi= }}
*{{cite journal | author=Bohmann K, Ferreira JA, Lamond AI |title=Mutational analysis of p80 coilin indicates a functional interaction between coiled bodies and the nucleolus. |journal=J. Cell Biol. |volume=131 |issue= 4 |pages= 817-31 |year= 1996 |pmid= 7490287 |doi= }}
*{{cite journal | author=Carmo-Fonseca M, Ferreira J, Lamond AI |title=Assembly of snRNP-containing coiled bodies is regulated in interphase and mitosis--evidence that the coiled body is a kinetic nuclear structure. |journal=J. Cell Biol. |volume=120 |issue= 4 |pages= 841-52 |year= 1993 |pmid= 7679389 |doi= }}
*{{cite journal | author=Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, ''et al.'' |title=Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening. |journal=Genomics |volume=23 |issue= 1 |pages= 42-50 |year= 1995 |pmid= 7829101 |doi= 10.1006/geno.1994.1457 }}
*{{cite journal | author=Kusuda J, Tanuma R, Gotoh E, ''et al.'' |title=Assignment of a human autoimmune antigen, p80-coilin gene to chromosome 17q21-q23 and of its possible pseudogene to chromosome 14. |journal=Hum. Genet. |volume=95 |issue= 2 |pages= 233-4 |year= 1995 |pmid= 7860074 |doi= }}
*{{cite journal | author=Chan EK, Takano S, Andrade LE, ''et al.'' |title=Structure, expression and chromosomal localization of human p80-coilin gene. |journal=Nucleic Acids Res. |volume=22 |issue= 21 |pages= 4462-9 |year= 1994 |pmid= 7971277 |doi= }}
*{{cite journal | author=Lyon CE, Bohmann K, Sleeman J, Lamond AI |title=Inhibition of protein dephosphorylation results in the accumulation of splicing snRNPs and coiled bodies within the nucleolus. |journal=Exp. Cell Res. |volume=230 |issue= 1 |pages= 84-93 |year= 1997 |pmid= 9013710 |doi= 10.1006/excr.1996.3380 }}
*{{cite journal | author=Parfenov VN, Davis DS, Pochukalina GN, ''et al.'' |title=Dynamics of distribution of splicing components relative to the transcriptional state of human oocytes from antral follicles. |journal=J. Cell. Biochem. |volume=69 |issue= 1 |pages= 72-80 |year= 1998 |pmid= 9513048 |doi= }}
*{{cite journal | author=Pochukalina GN, Davis DS, Kostiuchek DF, ''et al.'' |title=[Splicing factors in oocyte nuclei from human antral follicles] |journal=Tsitologiia |volume=40 |issue= 4 |pages= 239-47 |year= 1998 |pmid= 9644758 |doi= }}
*{{cite journal | author=Isaac C, Yang Y, Meier UT |title=Nopp140 functions as a molecular link between the nucleolus and the coiled bodies. |journal=J. Cell Biol. |volume=142 |issue= 2 |pages= 319-29 |year= 1998 |pmid= 9679133 |doi= }}
*{{cite journal | author=Liu J, Hebert MD, Ye Y, ''et al.'' |title=Cell cycle-dependent localization of the CDK2-cyclin E complex in Cajal (coiled) bodies. |journal=J. Cell. Sci. |volume=113 ( Pt 9) |issue= |pages= 1543-52 |year= 2000 |pmid= 10751146 |doi= }}
*{{cite journal | author=Hebert MD, Matera AG |title=Self-association of coilin reveals a common theme in nuclear body localization. |journal=Mol. Biol. Cell |volume=11 |issue= 12 |pages= 4159-71 |year= 2001 |pmid= 11102515 |doi= }}
*{{cite journal | author=Young PJ, Le TT, Dunckley M, ''et al.'' |title=Nuclear gems and Cajal (coiled) bodies in fetal tissues: nucleolar distribution of the spinal muscular atrophy protein, SMN. |journal=Exp. Cell Res. |volume=265 |issue= 2 |pages= 252-61 |year= 2001 |pmid= 11302690 |doi= 10.1006/excr.2001.5186 }}
*{{cite journal | author=Hebert MD, Szymczyk PW, Shpargel KB, Matera AG |title=Coilin forms the bridge between Cajal bodies and SMN, the spinal muscular atrophy protein. |journal=Genes Dev. |volume=15 |issue= 20 |pages= 2720-9 |year= 2001 |pmid= 11641277 |doi= 10.1101/gad.908401 }}
*{{cite journal | author=Andersen JS, Lyon CE, Fox AH, ''et al.'' |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1-11 |year= 2002 |pmid= 11790298 |doi= }}
*{{cite journal | author=Sleeman JE, Ajuh P, Lamond AI |title=snRNP protein expression enhances the formation of Cajal bodies containing p80-coilin and SMN. |journal=J. Cell. Sci. |volume=114 |issue= Pt 24 |pages= 4407-19 |year= 2002 |pmid= 11792806 |doi= }}
*{{cite journal | author=Hebert MD, Shpargel KB, Ospina JK, ''et al.'' |title=Coilin methylation regulates nuclear body formation. |journal=Dev. Cell |volume=3 |issue= 3 |pages= 329-37 |year= 2002 |pmid= 12361597 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Shpargel KB, Ospina JK, Tucker KE, ''et al.'' |title=Control of Cajal body number is mediated by the coilin C-terminus. |journal=J. Cell. Sci. |volume=116 |issue= Pt 2 |pages= 303-12 |year= 2003 |pmid= 12482916 |doi= }}
*{{cite journal | author=Sleeman JE, Trinkle-Mulcahy L, Prescott AR, ''et al.'' |title=Cajal body proteins SMN and Coilin show differential dynamic behaviour in vivo. |journal=J. Cell. Sci. |volume=116 |issue= Pt 10 |pages= 2039-50 |year= 2004 |pmid= 12679382 |doi= 10.1242/jcs.00400 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on COL4A6... {November 19, 2007 12:33:34 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 19, 2007 12:34:03 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Collagen, type IV, alpha 6
| HGNCid = 2208
| Symbol = COL4A6
| AltSymbols =; MGC88184
| OMIM = 303631
| ECnumber =
| Homologene = 48050
| MGIid = 2152695
| GeneAtlas_image1 = PBB_GE_COL4A6_211473_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_COL4A6_213992_at_tn.png
| GeneAtlas_image3 = PBB_GE_COL4A6_210945_at_tn.png
| Function = {{GNF_GO|id=GO:0005201 |text = extracellular matrix structural constituent}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005581 |text = collagen}} {{GNF_GO|id=GO:0005587 |text = collagen type IV}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006817 |text = phosphate transport}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0030198 |text = extracellular matrix organization and biogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1288
| Hs_Ensembl = ENSG00000197565
| Hs_RefseqProtein = NP_001838
| Hs_RefseqmRNA = NM_001847
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 107285493
| Hs_GenLoc_end = 107569383
| Hs_Uniprot = Q14031
| Mm_EntrezGene = 94216
| Mm_Ensembl = ENSMUSG00000031273
| Mm_RefseqmRNA = NM_053185
| Mm_RefseqProtein = NP_444415
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 136412396
| Mm_GenLoc_end = 136720444
| Mm_Uniprot =
}}
}}
'''Collagen, type IV, alpha 6''', also known as '''COL4A6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: COL4A6 collagen, type IV, alpha 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1288| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene, alpha 5 type IV collagen, so that the gene pair shares a common promoter. Deletions in the alpha 5 gene that extend into the alpha 6 gene result in diffuse leiomyomatosis accompanying the X-linked Alport syndrome caused by the deletion in the alpha 5 gene. Two splice variants have been identified for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: COL4A6 collagen, type IV, alpha 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1288| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Ständer M, Naumann U, Wick W, Weller M |title=Transforming growth factor-beta and p-21: multiple molecular targets of decorin-mediated suppression of neoplastic growth. |journal=Cell Tissue Res. |volume=296 |issue= 2 |pages= 221-7 |year= 1999 |pmid= 10382266 |doi= }}
*{{cite journal | author=Kurpakus Wheater M, Kernacki KA, Hazlett LD |title=Corneal cell proteins and ocular surface pathology. |journal=Biotechnic & histochemistry : official publication of the Biological Stain Commission |volume=74 |issue= 3 |pages= 146-59 |year= 1999 |pmid= 10416788 |doi= }}
*{{cite journal | author=Ghebrehiwet B, Peerschke EI, Hong Y, ''et al.'' |title=Short amino acid sequences derived from C1q receptor (C1q-R) show homology with the alpha chains of fibronectin and vitronectin receptors and collagen type IV. |journal=J. Leukoc. Biol. |volume=51 |issue= 6 |pages= 546-56 |year= 1992 |pmid= 1377218 |doi= }}
*{{cite journal | author=Gupta S, Batchu RB, Datta K |title=Purification, partial characterization of rat kidney hyaluronic acid binding protein and its localization on the cell surface. |journal=Eur. J. Cell Biol. |volume=56 |issue= 1 |pages= 58-67 |year= 1992 |pmid= 1724753 |doi= }}
*{{cite journal | author=Hernandez MR, Igoe F, Neufeld AH |title=Extracellular matrix of the human optic nerve head. |journal=Am. J. Ophthalmol. |volume=102 |issue= 2 |pages= 139-48 |year= 1986 |pmid= 2426947 |doi= }}
*{{cite journal | author=Glant TT, Hadházy C, Mikecz K, Sipos A |title=Appearance and persistence of fibronectin in cartilage. Specific interaction of fibronectin with collagen type II. |journal=Histochemistry |volume=82 |issue= 2 |pages= 149-58 |year= 1985 |pmid= 3997552 |doi= }}
*{{cite journal | author=Matsubara T, Trüeb B, Fehr K, ''et al.'' |title=The localization and secretion of type IV collagen in synovial capillaries by immunohistochemistry using a monoclonal antibody against human type IV collagen. |journal=Exp. Cell Biol. |volume=52 |issue= 3 |pages= 159-69 |year= 1984 |pmid= 6386565 |doi= }}
*{{cite journal | author=Uscanga L, Kennedy RH, Stocker S, ''et al.'' |title=Immunolocalization of collagen types, laminin and fibronectin in the normal human pancreas. |journal=Digestion |volume=30 |issue= 3 |pages= 158-64 |year= 1984 |pmid= 6389236 |doi= }}
*{{cite journal | author=Sundarraj N, Willson J |title=Monoclonal antibody to human basement membrane collagen type IV. |journal=Immunology |volume=47 |issue= 1 |pages= 133-40 |year= 1982 |pmid= 6811420 |doi= }}
*{{cite journal | author=Hahn E, Wick G, Pencev D, Timpl R |title=Distribution of basement membrane proteins in normal and fibrotic human liver: collagen type IV, laminin, and fibronectin. |journal=Gut |volume=21 |issue= 1 |pages= 63-71 |year= 1980 |pmid= 6988303 |doi= }}
*{{cite journal | author=Sasaki T, Göhring W, Pan TC, ''et al.'' |title=Binding of mouse and human fibulin-2 to extracellular matrix ligands. |journal=J. Mol. Biol. |volume=254 |issue= 5 |pages= 892-9 |year= 1996 |pmid= 7500359 |doi= 10.1006/jmbi.1995.0664 }}
*{{cite journal | author=Oohashi T, Ueki Y, Sugimoto M, Ninomiya Y |title=Isolation and structure of the COL4A6 gene encoding the human alpha 6(IV) collagen chain and comparison with other type IV collagen genes. |journal=J. Biol. Chem. |volume=270 |issue= 45 |pages= 26863-7 |year= 1995 |pmid= 7592929 |doi= }}
*{{cite journal | author=Sugimoto M, Oohashi T, Ninomiya Y |title=The genes COL4A5 and COL4A6, coding for basement membrane collagen chains alpha 5(IV) and alpha 6(IV), are located head-to-head in close proximity on human chromosome Xq22 and COL4A6 is transcribed from two alternative promoters. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 24 |pages= 11679-83 |year= 1994 |pmid= 7972123 |doi= }}
*{{cite journal | author=Donovan FM, Vaughan PJ, Cunningham DD |title=Regulation of protease nexin-1 target protease specificity by collagen type IV. |journal=J. Biol. Chem. |volume=269 |issue= 25 |pages= 17199-205 |year= 1994 |pmid= 8006028 |doi= }}
*{{cite journal | author=Oohashi T, Sugimoto M, Mattei MG, Ninomiya Y |title=Identification of a new collagen IV chain, alpha 6(IV), by cDNA isolation and assignment of the gene to chromosome Xq22, which is the same locus for COL4A5. |journal=J. Biol. Chem. |volume=269 |issue= 10 |pages= 7520-6 |year= 1994 |pmid= 8125972 |doi= }}
*{{cite journal | author=Zhou J, Ding M, Zhao Z, Reeders ST |title=Complete primary structure of the sixth chain of human basement membrane collagen, alpha 6(IV). Isolation of the cDNAs for alpha 6(IV) and comparison with five other type IV collagen chains. |journal=J. Biol. Chem. |volume=269 |issue= 18 |pages= 13193-9 |year= 1994 |pmid= 8175748 |doi= }}
*{{cite journal | author=Zhou J, Mochizuki T, Smeets H, ''et al.'' |title=Deletion of the paired alpha 5(IV) and alpha 6(IV) collagen genes in inherited smooth muscle tumors. |journal=Science |volume=261 |issue= 5125 |pages= 1167-9 |year= 1993 |pmid= 8356449 |doi= }}
*{{cite journal | author=Zhang X, Zhou J, Reeders ST, Tryggvason K |title=Structure of the human type IV collagen COL4A6 gene, which is mutated in Alport syndrome-associated leiomyomatosis. |journal=Genomics |volume=33 |issue= 3 |pages= 473-9 |year= 1996 |pmid= 8661006 |doi= 10.1006/geno.1996.0222 }}
*{{cite journal | author=Cáceres J, Brandan E |title=Interaction between Alzheimer's disease beta A4 precursor protein (APP) and the extracellular matrix: evidence for the participation of heparan sulfate proteoglycans. |journal=J. Cell. Biochem. |volume=65 |issue= 2 |pages= 145-58 |year= 1997 |pmid= 9136074 |doi= }}
*{{cite journal | author=Knott JC, Mahesparan R, Garcia-Cabrera I, ''et al.'' |title=Stimulation of extracellular matrix components in the normal brain by invading glioma cells. |journal=Int. J. Cancer |volume=75 |issue= 6 |pages= 864-72 |year= 1998 |pmid= 9506531 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on FRS2... {November 19, 2007 12:43:07 AM PST}
- SEARCH REDIRECT: Control Box Found: FRS2 {November 19, 2007 12:43:53 AM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 19, 2007 12:43:55 AM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 19, 2007 12:43:55 AM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 19, 2007 12:43:55 AM PST}
- UPDATED: Updated protein page: FRS2 {November 19, 2007 12:44:01 AM PST}
- INFO: Beginning work on GABARAP... {November 19, 2007 12:44:01 AM PST}
- SEARCH REDIRECT: Control Box Found: GABARAP {November 19, 2007 12:44:30 AM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 19, 2007 12:44:31 AM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 19, 2007 12:44:31 AM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 19, 2007 12:44:31 AM PST}
- UPDATED: Updated protein page: GABARAP {November 19, 2007 12:44:38 AM PST}
- INFO: Beginning work on MAP3K8... {November 19, 2007 12:34:03 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 19, 2007 12:34:40 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Mitogen-activated protein kinase kinase kinase 8
| HGNCid = 6860
| Symbol = MAP3K8
| AltSymbols =; COT; EST; ESTF; FLJ10486; TPL2; Tpl-2; c-COT
| OMIM = 191195
| ECnumber =
| Homologene = 3812
| MGIid = 1346878
| GeneAtlas_image1 = PBB_GE_MAP3K8_205027_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004672 |text = protein kinase activity}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1326
| Hs_Ensembl = ENSG00000107968
| Hs_RefseqProtein = NP_005195
| Hs_RefseqmRNA = NM_005204
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 10
| Hs_GenLoc_start = 30762872
| Hs_GenLoc_end = 30790768
| Hs_Uniprot = P41279
| Mm_EntrezGene = 26410
| Mm_Ensembl = ENSMUSG00000024235
| Mm_RefseqmRNA = NM_007746
| Mm_RefseqProtein = NP_031772
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 18
| Mm_GenLoc_start = 4331325
| Mm_GenLoc_end = 4352951
| Mm_Uniprot = Q3T9M0
}}
}}
'''Mitogen-activated protein kinase kinase kinase 8''', also known as '''MAP3K8''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MAP3K8 mitogen-activated protein kinase kinase kinase 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1326| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene was identified by its oncogenic transforming activity in cells. The encoded protein is a member of the serine/threonine protein kinase family. This kinase can activate both the MAP kinase and JNK kinase pathways. This kinase was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This kinase was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. Studies of a similar gene in rat suggested the direct involvement of this kinase in the proteolysis of NF-kappaB1,p105 (NFKB1). This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity.<ref name="entrez">{{cite web | title = Entrez Gene: MAP3K8 mitogen-activated protein kinase kinase kinase 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1326| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Aoki M, Akiyama T, Miyoshi J, Toyoshima K |title=Identification and characterization of protein products of the cot oncogene with serine kinase activity. |journal=Oncogene |volume=6 |issue= 9 |pages= 1515-9 |year= 1991 |pmid= 1833717 |doi= }}
*{{cite journal | author=Miyoshi J, Higashi T, Mukai H, ''et al.'' |title=Structure and transforming potential of the human cot oncogene encoding a putative protein kinase. |journal=Mol. Cell. Biol. |volume=11 |issue= 8 |pages= 4088-96 |year= 1991 |pmid= 2072910 |doi= }}
*{{cite journal | author=Aoki M, Hamada F, Sugimoto T, ''et al.'' |title=The human cot proto-oncogene encodes two protein serine/threonine kinases with different transforming activities by alternative initiation of translation. |journal=J. Biol. Chem. |volume=268 |issue= 30 |pages= 22723-32 |year= 1993 |pmid= 8226782 |doi= }}
*{{cite journal | author=Chan AM, Chedid M, McGovern ES, ''et al.'' |title=Expression cDNA cloning of a serine kinase transforming gene. |journal=Oncogene |volume=8 |issue= 5 |pages= 1329-33 |year= 1993 |pmid= 8479752 |doi= }}
*{{cite journal | author=Salmeron A, Ahmad TB, Carlile GW, ''et al.'' |title=Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase. |journal=EMBO J. |volume=15 |issue= 4 |pages= 817-26 |year= 1996 |pmid= 8631303 |doi= }}
*{{cite journal | author=Ballester A, Tobeña R, Lisbona C, ''et al.'' |title=Cot kinase regulation of IL-2 production in Jurkat T cells. |journal=J. Immunol. |volume=159 |issue= 4 |pages= 1613-8 |year= 1997 |pmid= 9257820 |doi= }}
*{{cite journal | author=Ballester A, Velasco A, Tobeña R, Alemany S |title=Cot kinase activates tumor necrosis factor-alpha gene expression in a cyclosporin A-resistant manner. |journal=J. Biol. Chem. |volume=273 |issue= 23 |pages= 14099-106 |year= 1998 |pmid= 9603908 |doi= }}
*{{cite journal | author=Lin X, Mu Y, Cunningham ET, ''et al.'' |title=Molecular determinants of NF-kappaB-inducing kinase action. |journal=Mol. Cell. Biol. |volume=18 |issue= 10 |pages= 5899-907 |year= 1998 |pmid= 9742107 |doi= }}
*{{cite journal | author=Belich MP, Salmerón A, Johnston LH, Ley SC |title=TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105. |journal=Nature |volume=397 |issue= 6717 |pages= 363-8 |year= 1999 |pmid= 9950430 |doi= 10.1038/16946 }}
*{{cite journal | author=Lin X, Cunningham ET, Mu Y, ''et al.'' |title=The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-kappaB acting through the NF-kappaB-inducing kinase and IkappaB kinases. |journal=Immunity |volume=10 |issue= 2 |pages= 271-80 |year= 1999 |pmid= 10072079 |doi= }}
*{{cite journal | author=Chiariello M, Marinissen MJ, Gutkind JS |title=Multiple mitogen-activated protein kinase signaling pathways connect the cot oncoprotein to the c-jun promoter and to cellular transformation. |journal=Mol. Cell. Biol. |volume=20 |issue= 5 |pages= 1747-58 |year= 2000 |pmid= 10669751 |doi= }}
*{{cite journal | author=Sánchez-Góngora E, Lisbona C, de Gregorio R, ''et al.'' |title=COT kinase proto-oncogene expression in T cells: implication of the JNK/SAPK signal transduction pathway in COT promoter activation. |journal=J. Biol. Chem. |volume=275 |issue= 40 |pages= 31379-86 |year= 2000 |pmid= 10896655 |doi= 10.1074/jbc.M000382200 }}
*{{cite journal | author=Luftig MA, Cahir-McFarland E, Mosialos G, Kieff E |title=Effects of the NIK aly mutation on NF-kappaB activation by the Epstein-Barr virus latent infection membrane protein, lymphotoxin beta receptor, and CD40. |journal=J. Biol. Chem. |volume=276 |issue= 18 |pages= 14602-6 |year= 2001 |pmid= 11278268 |doi= 10.1074/jbc.C100103200 }}
*{{cite journal | author=Eliopoulos AG, Davies C, Blake SS, ''et al.'' |title=The oncogenic protein kinase Tpl-2/Cot contributes to Epstein-Barr virus-encoded latent infection membrane protein 1-induced NF-kappaB signaling downstream of TRAF2. |journal=J. Virol. |volume=76 |issue= 9 |pages= 4567-79 |year= 2002 |pmid= 11932422 |doi= }}
*{{cite journal | author=Kane LP, Mollenauer MN, Xu Z, ''et al.'' |title=Akt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription. |journal=Mol. Cell. Biol. |volume=22 |issue= 16 |pages= 5962-74 |year= 2002 |pmid= 12138205 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Waterfield MR, Zhang M, Norman LP, Sun SC |title=NF-kappaB1/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the Tpl2 kinase. |journal=Mol. Cell |volume=11 |issue= 3 |pages= 685-94 |year= 2003 |pmid= 12667451 |doi= }}
*{{cite journal | author=Channavajhala PL, Wu L, Cuozzo JW, ''et al.'' |title=Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling. |journal=J. Biol. Chem. |volume=278 |issue= 47 |pages= 47089-97 |year= 2004 |pmid= 12975377 |doi= 10.1074/jbc.M306002200 }}
*{{cite journal | author=Gándara ML, López P, Hernando R, ''et al.'' |title=The COOH-terminal domain of wild-type Cot regulates its stability and kinase specific activity. |journal=Mol. Cell. Biol. |volume=23 |issue= 20 |pages= 7377-90 |year= 2003 |pmid= 14517305 |doi= }}
*{{cite journal | author=Bouwmeester T, Bauch A, Ruffner H, ''et al.'' |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97-105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on NCOA4... {November 19, 2007 12:39:03 AM PST}
- SEARCH REDIRECT: Control Box Found: NCOA4 {November 19, 2007 12:39:34 AM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 19, 2007 12:39:36 AM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 19, 2007 12:39:36 AM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 19, 2007 12:39:36 AM PST}
- UPDATED: Updated protein page: NCOA4 {November 19, 2007 12:39:43 AM PST}
- INFO: Beginning work on SLC4A4... {November 19, 2007 12:40:12 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 19, 2007 12:40:59 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Solute carrier family 4, sodium bicarbonate cotransporter, member 4
| HGNCid = 11030
| Symbol = SLC4A4
| AltSymbols =; DKFZp781H1314; HNBC1; KNBC; NBC1; NBC2; SLC4A5; hhNMC; pNBC
| OMIM = 603345
| ECnumber =
| Homologene = 55776
| MGIid = 1927555
| GeneAtlas_image1 = PBB_GE_SLC4A4_203908_at_tn.png
| GeneAtlas_image2 = PBB_GE_SLC4A4_210738_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_SLC4A4_210739_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005452 |text = inorganic anion exchanger activity}} {{GNF_GO|id=GO:0008510 |text = sodium:bicarbonate symporter activity}} {{GNF_GO|id=GO:0015293 |text = symporter activity}} {{GNF_GO|id=GO:0031402 |text = sodium ion binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006814 |text = sodium ion transport}} {{GNF_GO|id=GO:0006820 |text = anion transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8671
| Hs_Ensembl = ENSG00000080493
| Hs_RefseqProtein = NP_003750
| Hs_RefseqmRNA = NM_003759
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 72271867
| Hs_GenLoc_end = 72656663
| Hs_Uniprot = Q9Y6R1
| Mm_EntrezGene = 54403
| Mm_Ensembl = ENSMUSG00000060961
| Mm_RefseqmRNA = NM_018760
| Mm_RefseqProtein = NP_061230
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 90009311
| Mm_GenLoc_end = 90310338
| Mm_Uniprot = O88343
}}
}}
'''Solute carrier family 4, sodium bicarbonate cotransporter, member 4''', also known as '''SLC4A4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC4A4 solute carrier family 4, sodium bicarbonate cotransporter, member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8671| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Sodium bicarbonate cotransporters (NBCs) mediate the coupled movement of sodium and bicarbonate ions across the plasma membrane of many cells. This is an electrogenic process with an apparent stoichiometry of 3 bicarbonate ions per sodium ion. Sodium bicarbonate cotransport is involved in bicarbonate secretion/absorption and intracellular pH regulation. Romero and Boron (1999) reviewed NBCs. Soleimani and Burnham (2000) reviewed NBCs and their regulation in physiologic and pathophysiologic states.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: SLC4A4 solute carrier family 4, sodium bicarbonate cotransporter, member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8671| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Romero MF, Boron WF |title=Electrogenic Na+/HCO3- cotransporters: cloning and physiology. |journal=Annu. Rev. Physiol. |volume=61 |issue= |pages= 699-723 |year= 1999 |pmid= 10099707 |doi= 10.1146/annurev.physiol.61.1.699 }}
*{{cite journal | author=Soleimani M, Burnham CE |title=Physiologic and molecular aspects of the Na+:HCO3- cotransporter in health and disease processes. |journal=Kidney Int. |volume=57 |issue= 2 |pages= 371-84 |year= 2000 |pmid= 10652014 |doi= 10.1046/j.1523-1755.2000.00857.x }}
*{{cite journal | author=Burnham CE, Amlal H, Wang Z, ''et al.'' |title=Cloning and functional expression of a human kidney Na+:HCO3- cotransporter. |journal=J. Biol. Chem. |volume=272 |issue= 31 |pages= 19111-4 |year= 1997 |pmid= 9235899 |doi= }}
*{{cite journal | author=Abuladze N, Lee I, Newman D, ''et al.'' |title=Molecular cloning, chromosomal localization, tissue distribution, and functional expression of the human pancreatic sodium bicarbonate cotransporter. |journal=J. Biol. Chem. |volume=273 |issue= 28 |pages= 17689-95 |year= 1998 |pmid= 9651366 |doi= }}
*{{cite journal | author=Choi I, Romero MF, Khandoudi N, ''et al.'' |title=Cloning and characterization of a human electrogenic Na+-HCO-3 cotransporter isoform (hhNBC). |journal=Am. J. Physiol. |volume=276 |issue= 3 Pt 1 |pages= C576-84 |year= 1999 |pmid= 10069984 |doi= }}
*{{cite journal | author=Igarashi T, Inatomi J, Sekine T, ''et al.'' |title=Mutations in SLC4A4 cause permanent isolated proximal renal tubular acidosis with ocular abnormalities. |journal=Nat. Genet. |volume=23 |issue= 3 |pages= 264-6 |year= 1999 |pmid= 10545938 |doi= 10.1038/15440 }}
*{{cite journal | author=Pushkin A, Yip KP, Clark I, ''et al.'' |title=NBC3 expression in rabbit collecting duct: colocalization with vacuolar H+-ATPase. |journal=Am. J. Physiol. |volume=277 |issue= 6 Pt 2 |pages= F974-81 |year= 2000 |pmid= 10600945 |doi= }}
*{{cite journal | author=Park K, Hurley PT, Roussa E, ''et al.'' |title=Expression of a sodium bicarbonate cotransporter in human parotid salivary glands. |journal=Arch. Oral Biol. |volume=47 |issue= 1 |pages= 1-9 |year= 2002 |pmid= 11743927 |doi= }}
*{{cite journal | author=Gross E, Hawkins K, Pushkin A, ''et al.'' |title=Phosphorylation of Ser(982) in the sodium bicarbonate cotransporter kNBC1 shifts the HCO(3)(-) : Na(+) stoichiometry from 3 : 1 to 2 : 1 in murine proximal tubule cells. |journal=J. Physiol. (Lond.) |volume=537 |issue= Pt 3 |pages= 659-65 |year= 2002 |pmid= 11744745 |doi= }}
*{{cite journal | author=Gross E, Pushkin A, Abuladze N, ''et al.'' |title=Regulation of the sodium bicarbonate cotransporter kNBC1 function: role of Asp(986), Asp(988) and kNBC1-carbonic anhydrase II binding. |journal=J. Physiol. (Lond.) |volume=544 |issue= Pt 3 |pages= 679-85 |year= 2003 |pmid= 12411514 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Tatishchev S, Abuladze N, Pushkin A, ''et al.'' |title=Identification of membrane topography of the electrogenic sodium bicarbonate cotransporter pNBC1 by in vitro transcription/translation. |journal=Biochemistry |volume=42 |issue= 3 |pages= 755-65 |year= 2003 |pmid= 12534288 |doi= 10.1021/bi026826q }}
*{{cite journal | author=Gross E, Fedotoff O, Pushkin A, ''et al.'' |title=Phosphorylation-induced modulation of pNBC1 function: distinct roles for the amino- and carboxy-termini. |journal=J. Physiol. (Lond.) |volume=549 |issue= Pt 3 |pages= 673-82 |year= 2004 |pmid= 12730338 |doi= 10.1113/jphysiol.2003.042226 }}
*{{cite journal | author=Sun XC, Bonanno JA |title=Identification and cloning of the Na/HCO(3-) cotransporter (NBC) in human corneal endothelium. |journal=Exp. Eye Res. |volume=77 |issue= 3 |pages= 287-95 |year= 2003 |pmid= 12907161 |doi= }}
*{{cite journal | author=Yamada H, Yamazaki S, Moriyama N, ''et al.'' |title=Localization of NBC-1 variants in human kidney and renal cell carcinoma. |journal=Biochem. Biophys. Res. Commun. |volume=310 |issue= 4 |pages= 1213-8 |year= 2003 |pmid= 14559244 |doi= }}
*{{cite journal | author=Alvarez BV, Loiselle FB, Supuran CT, ''et al.'' |title=Direct extracellular interaction between carbonic anhydrase IV and the human NBC1 sodium/bicarbonate co-transporter. |journal=Biochemistry |volume=42 |issue= 42 |pages= 12321-9 |year= 2003 |pmid= 14567693 |doi= 10.1021/bi0353124 }}
*{{cite journal | author=Becker HM, Deitmer JW |title=Voltage dependence of H+ buffering mediated by sodium bicarbonate cotransport expressed in Xenopus oocytes. |journal=J. Biol. Chem. |volume=279 |issue= 27 |pages= 28057-62 |year= 2004 |pmid= 15123668 |doi= 10.1074/jbc.M402401200 }}
*{{cite journal | author=Pushkin A, Abuladze N, Gross E, ''et al.'' |title=Molecular mechanism of kNBC1-carbonic anhydrase II interaction in proximal tubule cells. |journal=J. Physiol. (Lond.) |volume=559 |issue= Pt 1 |pages= 55-65 |year= 2005 |pmid= 15218065 |doi= 10.1113/jphysiol.2004.065110 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SSTR5... {November 19, 2007 12:35:27 AM PST}
- SEARCH REDIRECT: Control Box Found: SSTR5 {November 19, 2007 12:35:46 AM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 19, 2007 12:35:49 AM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 19, 2007 12:35:49 AM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 19, 2007 12:35:49 AM PST}
- UPDATED: Updated protein page: SSTR5 {November 19, 2007 12:35:55 AM PST}
- INFO: Beginning work on TCOF1... {November 19, 2007 12:35:55 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 19, 2007 12:36:20 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Treacher Collins-Franceschetti syndrome 1
| HGNCid = 11654
| Symbol = TCOF1
| AltSymbols =; MFD1; treacle
| OMIM = 606847
| ECnumber =
| Homologene = 68049
| MGIid = 892003
| GeneAtlas_image1 = PBB_GE_TCOF1_202384_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_TCOF1_202385_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005730 |text = nucleolus}}
| Process = {{GNF_GO|id=GO:0001501 |text = skeletal development}} {{GNF_GO|id=GO:0006810 |text = transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6949
| Hs_Ensembl = ENSG00000070814
| Hs_RefseqProtein = NP_000347
| Hs_RefseqmRNA = NM_000356
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 149717410
| Hs_GenLoc_end = 149760063
| Hs_Uniprot =
| Mm_EntrezGene = 21453
| Mm_Ensembl = ENSMUSG00000024613
| Mm_RefseqmRNA = NM_011552
| Mm_RefseqProtein = NP_035682
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 18
| Mm_GenLoc_start = 60939133
| Mm_GenLoc_end = 60974286
| Mm_Uniprot = O08784
}}
}}
'''Treacher Collins-Franceschetti syndrome 1''', also known as '''TCOF1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TCOF1 Treacher Collins-Franceschetti syndrome 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6949| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a nucleolar protein with a LIS1 homology domain. The protein is involved in ribosomal DNA gene transcription through its interaction with upstream binding factor (UBF). Mutations in this gene have been associated with Treacher Collins syndrome, a disorder which includes abnormal craniofacial development. Alternate transcriptional splice variants encoding different isoforms have been found for this gene, but only three of them have been characterized to date.<ref name="entrez">{{cite web | title = Entrez Gene: TCOF1 Treacher Collins-Franceschetti syndrome 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6949| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Splendore A, Silva EO, Alonso LG, ''et al.'' |title=High mutation detection rate in TCOF1 among Treacher Collins syndrome patients reveals clustering of mutations and 16 novel pathogenic changes. |journal=Hum. Mutat. |volume=16 |issue= 4 |pages= 315-22 |year= 2000 |pmid= 11013442 |doi= 10.1002/1098-1004(200010)16:4<315::AID-HUMU4>3.0.CO;2-H }}
*{{cite journal | author=Dixon MJ, Dixon J, Raskova D, ''et al.'' |title=Genetic and physical mapping of the Treacher Collins syndrome locus: refinement of the localization to chromosome 5q32-33.2. |journal=Hum. Mol. Genet. |volume=1 |issue= 4 |pages= 249-53 |year= 1993 |pmid= 1303194 |doi= }}
*{{cite journal | author=Jabs EW, Li X, Coss CA, ''et al.'' |title=Mapping the Treacher Collins syndrome locus to 5q31.3----q33.3. |journal=Genomics |volume=11 |issue= 1 |pages= 193-8 |year= 1992 |pmid= 1765376 |doi= }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal | author=Dixon MJ, Dixon J, Houseal T, ''et al.'' |title=Narrowing the position of the Treacher Collins syndrome locus to a small interval between three new microsatellite markers at 5q32-33.1. |journal=Am. J. Hum. Genet. |volume=52 |issue= 5 |pages= 907-14 |year= 1993 |pmid= 8488840 |doi= }}
*{{cite journal | author= |title=Positional cloning of a gene involved in the pathogenesis of Treacher Collins syndrome. The Treacher Collins Syndrome Collaborative Group. |journal=Nat. Genet. |volume=12 |issue= 2 |pages= 130-6 |year= 1996 |pmid= 8563749 |doi= 10.1038/ng0296-130 }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
*{{cite journal | author=Edwards SJ, Gladwin AJ, Dixon MJ |title=The mutational spectrum in Treacher Collins syndrome reveals a predominance of mutations that create a premature-termination codon. |journal=Am. J. Hum. Genet. |volume=60 |issue= 3 |pages= 515-24 |year= 1997 |pmid= 9042910 |doi= }}
*{{cite journal | author=Dixon J, Edwards SJ, Anderson I, ''et al.'' |title=Identification of the complete coding sequence and genomic organization of the Treacher Collins syndrome gene. |journal=Genome Res. |volume=7 |issue= 3 |pages= 223-34 |year= 1997 |pmid= 9074926 |doi= }}
*{{cite journal | author=Wise CA, Chiang LC, Paznekas WA, ''et al.'' |title=TCOF1 gene encodes a putative nucleolar phosphoprotein that exhibits mutations in Treacher Collins Syndrome throughout its coding region. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 7 |pages= 3110-5 |year= 1997 |pmid= 9096354 |doi= }}
*{{cite journal | author=Paznekas WA, Zhang N, Gridley T, Jabs EW |title=Mouse TCOF1 is expressed widely, has motifs conserved in nucleolar phosphoproteins, and maps to chromosome 18. |journal=Biochem. Biophys. Res. Commun. |volume=238 |issue= 1 |pages= 1-6 |year= 1997 |pmid= 9299440 |doi= 10.1006/bbrc.1997.7229 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal | author=Marsh KL, Dixon J, Dixon MJ |title=Mutations in the Treacher Collins syndrome gene lead to mislocalization of the nucleolar protein treacle. |journal=Hum. Mol. Genet. |volume=7 |issue= 11 |pages= 1795-800 |year= 1998 |pmid= 9736782 |doi= }}
*{{cite journal | author=Winokur ST, Shiang R |title=The Treacher Collins syndrome (TCOF1) gene product, treacle, is targeted to the nucleolus by signals in its C-terminus. |journal=Hum. Mol. Genet. |volume=7 |issue= 12 |pages= 1947-52 |year= 1998 |pmid= 9811939 |doi= }}
*{{cite journal | author=Jones NC, Farlie PG, Minichiello J, Newgreen DF |title=Detection of an appropriate kinase activity in branchial arches I and II that coincides with peak expression of the Treacher Collins syndrome gene product, treacle. |journal=Hum. Mol. Genet. |volume=8 |issue= 12 |pages= 2239-45 |year= 1999 |pmid= 10545604 |doi= }}
*{{cite journal | author=Isaac C, Marsh KL, Paznekas WA, ''et al.'' |title=Characterization of the nucleolar gene product, treacle, in Treacher Collins syndrome. |journal=Mol. Biol. Cell |volume=11 |issue= 9 |pages= 3061-71 |year= 2000 |pmid= 10982400 |doi= }}
*{{cite journal | author=Emes RD, Ponting CP |title=A new sequence motif linking lissencephaly, Treacher Collins and oral-facial-digital type 1 syndromes, microtubule dynamics and cell migration. |journal=Hum. Mol. Genet. |volume=10 |issue= 24 |pages= 2813-20 |year= 2002 |pmid= 11734546 |doi= }}
*{{cite journal | author=Splendore A, Jabs EW, Passos-Bueno MR |title=Screening of TCOF1 in patients from different populations: confirmation of mutational hot spots and identification of a novel missense mutation that suggests an important functional domain in the protein treacle. |journal=J. Med. Genet. |volume=39 |issue= 7 |pages= 493-5 |year= 2002 |pmid= 12114482 |doi= }}
*{{cite journal | author=Ohta S, Shiomi Y, Sugimoto K, ''et al.'' |title=A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein. |journal=J. Biol. Chem. |volume=277 |issue= 43 |pages= 40362-7 |year= 2002 |pmid= 12171929 |doi= 10.1074/jbc.M206194200 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TNK2... {November 19, 2007 12:42:05 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 19, 2007 12:42:38 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TNK2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1cf4.
| PDB = {{PDB2|1cf4}}, {{PDB2|1u46}}, {{PDB2|1u4d}}, {{PDB2|1u54}}
| Name = Tyrosine kinase, non-receptor, 2
| HGNCid = 19297
| Symbol = TNK2
| AltSymbols =; ACK; ACK1; FLJ44758; FLJ45547; p21cdc42Hs
| OMIM = 606994
| ECnumber =
| Homologene = 4224
| MGIid = 1858308
| GeneAtlas_image1 = PBB_GE_TNK2_203838_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_TNK2_203839_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004713 |text = protein-tyrosine kinase activity}} {{GNF_GO|id=GO:0004715 |text = non-membrane spanning protein tyrosine kinase activity}} {{GNF_GO|id=GO:0005095 |text = GTPase inhibitor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007010 |text = cytoskeleton organization and biogenesis}} {{GNF_GO|id=GO:0007264 |text = small GTPase mediated signal transduction}} {{GNF_GO|id=GO:0050731 |text = positive regulation of peptidyl-tyrosine phosphorylation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 10188
| Hs_Ensembl = ENSG00000061938
| Hs_RefseqProtein = NP_001010938
| Hs_RefseqmRNA = NM_001010938
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 197074633
| Hs_GenLoc_end = 197120352
| Hs_Uniprot = Q07912
| Mm_EntrezGene = 51789
| Mm_Ensembl = ENSMUSG00000022791
| Mm_RefseqmRNA = NM_016788
| Mm_RefseqProtein = NP_058068
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 16
| Mm_GenLoc_start = 32583504
| Mm_GenLoc_end = 32601030
| Mm_Uniprot = Q0Z844
}}
}}
'''Tyrosine kinase, non-receptor, 2''', also known as '''TNK2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TNK2 tyrosine kinase, non-receptor, 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10188| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.<ref name="entrez">{{cite web | title = Entrez Gene: TNK2 tyrosine kinase, non-receptor, 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10188| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal | author=Manser E, Leung T, Salihuddin H, ''et al.'' |title=A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42. |journal=Nature |volume=363 |issue= 6427 |pages= 364-7 |year= 1993 |pmid= 8497321 |doi= 10.1038/363364a0 }}
*{{cite journal | author=Satoh T, Kato J, Nishida K, Kaziro Y |title=Tyrosine phosphorylation of ACK in response to temperature shift-down, hyperosmotic shock, and epidermal growth factor stimulation. |journal=FEBS Lett. |volume=386 |issue= 2-3 |pages= 230-4 |year= 1996 |pmid= 8647288 |doi= }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal | author=Mott HR, Owen D, Nietlispach D, ''et al.'' |title=Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK. |journal=Nature |volume=399 |issue= 6734 |pages= 384-8 |year= 1999 |pmid= 10360579 |doi= 10.1038/20732 }}
*{{cite journal | author=Eisenmann KM, McCarthy JB, Simpson MA, ''et al.'' |title=Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas. |journal=Nat. Cell Biol. |volume=1 |issue= 8 |pages= 507-13 |year= 2000 |pmid= 10587647 |doi= 10.1038/70302 }}
*{{cite journal | author=Kato J, Kaziro Y, Satoh T |title=Activation of the guanine nucleotide exchange factor Dbl following ACK1-dependent tyrosine phosphorylation. |journal=Biochem. Biophys. Res. Commun. |volume=268 |issue= 1 |pages= 141-7 |year= 2000 |pmid= 10652228 |doi= 10.1006/bbrc.2000.2106 }}
*{{cite journal | author=Owen D, Mott HR, Laue ED, Lowe PN |title=Residues in Cdc42 that specify binding to individual CRIB effector proteins. |journal=Biochemistry |volume=39 |issue= 6 |pages= 1243-50 |year= 2000 |pmid= 10684602 |doi= }}
*{{cite journal | author=Kiyono M, Kato J, Kataoka T, ''et al.'' |title=Stimulation of Ras guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm) upon tyrosine phosphorylation by the Cdc42-regulated kinase ACK1. |journal=J. Biol. Chem. |volume=275 |issue= 38 |pages= 29788-93 |year= 2000 |pmid= 10882715 |doi= 10.1074/jbc.M001378200 }}
*{{cite journal | author=Linseman DA, Heidenreich KA, Fisher SK |title=Stimulation of M3 muscarinic receptors induces phosphorylation of the Cdc42 effector activated Cdc42Hs-associated kinase-1 via a Fyn tyrosine kinase signaling pathway. |journal=J. Biol. Chem. |volume=276 |issue= 8 |pages= 5622-8 |year= 2001 |pmid= 11087735 |doi= 10.1074/jbc.M006812200 }}
*{{cite journal | author=Teo M, Tan L, Lim L, Manser E |title=The tyrosine kinase ACK1 associates with clathrin-coated vesicles through a binding motif shared by arrestin and other adaptors. |journal=J. Biol. Chem. |volume=276 |issue= 21 |pages= 18392-8 |year= 2001 |pmid= 11278436 |doi= 10.1074/jbc.M008795200 }}
*{{cite journal | author=Kato-Stankiewicz J, Ueda S, Kataoka T, ''et al.'' |title=Epidermal growth factor stimulation of the ACK1/Dbl pathway in a Cdc42 and Grb2-dependent manner. |journal=Biochem. Biophys. Res. Commun. |volume=284 |issue= 2 |pages= 470-7 |year= 2001 |pmid= 11394904 |doi= 10.1006/bbrc.2001.5004 }}
*{{cite journal | author=Oda T, Muramatsu MA, Isogai T, ''et al.'' |title=HSH2: a novel SH2 domain-containing adapter protein involved in tyrosine kinase signaling in hematopoietic cells. |journal=Biochem. Biophys. Res. Commun. |volume=288 |issue= 5 |pages= 1078-86 |year= 2001 |pmid= 11700021 |doi= 10.1006/bbrc.2001.5890 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Salomon AR, Ficarro SB, Brill LM, ''et al.'' |title=Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 2 |pages= 443-8 |year= 2003 |pmid= 12522270 |doi= 10.1073/pnas.2436191100 }}
*{{cite journal | author=Yokoyama N, Miller WT |title=Biochemical properties of the Cdc42-associated tyrosine kinase ACK1. Substrate specificity, authphosphorylation, and interaction with Hck. |journal=J. Biol. Chem. |volume=278 |issue= 48 |pages= 47713-23 |year= 2004 |pmid= 14506255 |doi= 10.1074/jbc.M306716200 }}
*{{cite journal | author=Ahmed I, Calle Y, Sayed MA, ''et al.'' |title=Cdc42-dependent nuclear translocation of non-receptor tyrosine kinase, ACK. |journal=Biochem. Biophys. Res. Commun. |volume=314 |issue= 2 |pages= 571-9 |year= 2004 |pmid= 14733946 |doi= }}
*{{cite journal | author=Gu Y, Lin Q, Childress C, Yang W |title=Identification of the region in Cdc42 that confers the binding specificity to activated Cdc42-associated kinase. |journal=J. Biol. Chem. |volume=279 |issue= 29 |pages= 30507-13 |year= 2004 |pmid= 15123659 |doi= 10.1074/jbc.M313518200 }}
*{{cite journal | author=Brandenberger R, Wei H, Zhang S, ''et al.'' |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707-16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
*{{cite journal | author=Lougheed JC, Chen RH, Mak P, Stout TJ |title=Crystal structures of the phosphorylated and unphosphorylated kinase domains of the Cdc42-associated tyrosine kinase ACK1. |journal=J. Biol. Chem. |volume=279 |issue= 42 |pages= 44039-45 |year= 2004 |pmid= 15308621 |doi= 10.1074/jbc.M406703200 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TUBA1A... {November 19, 2007 12:38:25 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 19, 2007 12:39:03 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TUBA1A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ffx.
| PDB = {{PDB2|1ffx}}, {{PDB2|1ia0}}, {{PDB2|1jff}}, {{PDB2|1sa0}}, {{PDB2|1sa1}}, {{PDB2|1tub}}, {{PDB2|1tvk}}, {{PDB2|1z2b}}, {{PDB2|2hxf}}, {{PDB2|2hxh}}
| Name = Tubulin, alpha 1a
| HGNCid = 20766
| Symbol = TUBA1A
| AltSymbols =; B-ALPHA-1; FLJ25113; TUBA3
| OMIM = 602529
| ECnumber =
| Homologene = 68498
| MGIid = 98869
| GeneAtlas_image1 = PBB_GE_TUBA1A_209118_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_TUBA1A_201090_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_TUBA1A_209251_x_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005874 |text = microtubule}} {{GNF_GO|id=GO:0043234 |text = protein complex}}
| Process = {{GNF_GO|id=GO:0007018 |text = microtubule-based movement}} {{GNF_GO|id=GO:0051258 |text = protein polymerization}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7846
| Hs_Ensembl = ENSG00000167552
| Hs_RefseqProtein = NP_006000
| Hs_RefseqmRNA = NM_006009
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 47864847
| Hs_GenLoc_end = 47869153
| Hs_Uniprot = Q71U36
| Mm_EntrezGene = 22142
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_011653
| Mm_RefseqProtein = NP_035783
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Tubulin, alpha 1a''', also known as '''TUBA1A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TUBA1A tubulin, alpha 1a| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7846| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to mouse and rat Tuba1 gene. Northern blotting studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q.<ref name="entrez">{{cite web | title = Entrez Gene: TUBA1A tubulin, alpha 1a| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7846| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Desai A, Mitchison TJ |title=Tubulin and FtsZ structures: functional and therapeutic implications. |journal=Bioessays |volume=20 |issue= 7 |pages= 523-7 |year= 1998 |pmid= 9722999 |doi= 10.1002/(SICI)1521-1878(199807)20:7<523::AID-BIES1>3.0.CO;2-L }}
*{{cite journal | author=Oakley BR |title=An abundance of tubulins. |journal=Trends Cell Biol. |volume=10 |issue= 12 |pages= 537-42 |year= 2001 |pmid= 11121746 |doi= }}
*{{cite journal | author=Dutcher SK |title=The tubulin fraternity: alpha to eta. |journal=Curr. Opin. Cell Biol. |volume=13 |issue= 1 |pages= 49-54 |year= 2001 |pmid= 11163133 |doi= }}
*{{cite journal | author=Miller FD, Naus CC, Durand M, ''et al.'' |title=Isotypes of alpha-tubulin are differentially regulated during neuronal maturation. |journal=J. Cell Biol. |volume=105 |issue= 6 Pt 2 |pages= 3065-73 |year= 1988 |pmid= 3693406 |doi= }}
*{{cite journal | author=Hall JL, Cowan NJ |title=Structural features and restricted expression of a human alpha-tubulin gene. |journal=Nucleic Acids Res. |volume=13 |issue= 1 |pages= 207-23 |year= 1985 |pmid= 3839072 |doi= }}
*{{cite journal | author=Cowan NJ, Dobner PR, Fuchs EV, Cleveland DW |title=Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions. |journal=Mol. Cell. Biol. |volume=3 |issue= 10 |pages= 1738-45 |year= 1984 |pmid= 6646120 |doi= }}
*{{cite journal | author=Alexandrova N, Niklinski J, Bliskovsky V, ''et al.'' |title=The N-terminal domain of c-Myc associates with alpha-tubulin and microtubules in vivo and in vitro. |journal=Mol. Cell. Biol. |volume=15 |issue= 9 |pages= 5188-95 |year= 1995 |pmid= 7651436 |doi= }}
*{{cite journal | author=Sapir T, Elbaum M, Reiner O |title=Reduction of microtubule catastrophe events by LIS1, platelet-activating factor acetylhydrolase subunit. |journal=EMBO J. |volume=16 |issue= 23 |pages= 6977-84 |year= 1998 |pmid= 9384577 |doi= 10.1093/emboj/16.23.6977 }}
*{{cite journal | author=Kinnunen T, Kaksonen M, Saarinen J, ''et al.'' |title=Cortactin-Src kinase signaling pathway is involved in N-syndecan-dependent neurite outgrowth. |journal=J. Biol. Chem. |volume=273 |issue= 17 |pages= 10702-8 |year= 1998 |pmid= 9553134 |doi= }}
*{{cite journal | author=Faruki S, Geahlen RL, Asai DJ |title=Syk-dependent phosphorylation of microtubules in activated B-lymphocytes. |journal=J. Cell. Sci. |volume=113 ( Pt 14) |issue= |pages= 2557-65 |year= 2000 |pmid= 10862713 |doi= }}
*{{cite journal | author=Watts NR, Sackett DL, Ward RD, ''et al.'' |title=HIV-1 rev depolymerizes microtubules to form stable bilayered rings. |journal=J. Cell Biol. |volume=150 |issue= 2 |pages= 349-60 |year= 2000 |pmid= 10908577 |doi= }}
*{{cite journal | author=Germani A, Bruzzoni-Giovanelli H, Fellous A, ''et al.'' |title=SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis. |journal=Oncogene |volume=19 |issue= 52 |pages= 5997-6006 |year= 2001 |pmid= 11146551 |doi= 10.1038/sj.onc.1204002 }}
*{{cite journal | author=Crabtree DV, Ojima I, Geng X, Adler AJ |title=Tubulins in the primate retina: evidence that xanthophylls may be endogenous ligands for the paclitaxel-binding site. |journal=Bioorg. Med. Chem. |volume=9 |issue= 8 |pages= 1967-76 |year= 2001 |pmid= 11504633 |doi= }}
*{{cite journal | author=Payton JE, Perrin RJ, Clayton DF, George JM |title=Protein-protein interactions of alpha-synuclein in brain homogenates and transfected cells. |journal=Brain Res. Mol. Brain Res. |volume=95 |issue= 1-2 |pages= 138-45 |year= 2002 |pmid= 11687285 |doi= }}
*{{cite journal | author=Bifulco M, Laezza C, Stingo S, Wolff J |title=2',3'-Cyclic nucleotide 3'-phosphodiesterase: a membrane-bound, microtubule-associated protein and membrane anchor for tubulin. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 4 |pages= 1807-12 |year= 2002 |pmid= 11842207 |doi= 10.1073/pnas.042678799 }}
*{{cite journal | author=Saugstad JA, Yang S, Pohl J, ''et al.'' |title=Interaction between metabotropic glutamate receptor 7 and alpha tubulin. |journal=J. Neurochem. |volume=80 |issue= 6 |pages= 980-8 |year= 2002 |pmid= 11953448 |doi= }}
*{{cite journal | author=Ivings L, Pennington SR, Jenkins R, ''et al.'' |title=Identification of Ca2+-dependent binding partners for the neuronal calcium sensor protein neurocalcin delta: interaction with actin, clathrin and tubulin. |journal=Biochem. J. |volume=363 |issue= Pt 3 |pages= 599-608 |year= 2002 |pmid= 11964161 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TYROBP... {November 19, 2007 12:36:21 AM PST}
- SEARCH REDIRECT: Control Box Found: TYROBP {November 19, 2007 12:36:45 AM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 19, 2007 12:36:48 AM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 19, 2007 12:36:48 AM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 19, 2007 12:36:48 AM PST}
- UPDATED: Updated protein page: TYROBP {November 19, 2007 12:36:54 AM PST}
- INFO: Beginning work on TYRP1... {November 19, 2007 12:36:54 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 19, 2007 12:37:32 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Tyrosinase-related protein 1
| HGNCid = 12450
| Symbol = TYRP1
| AltSymbols =; CAS2; CATB; GP75; TRP; TYRP; b-PROTEIN
| OMIM = 115501
| ECnumber =
| Homologene = 464
| MGIid = 98881
| GeneAtlas_image1 = PBB_GE_TYRP1_205694_at_tn.png
| Function = {{GNF_GO|id=GO:0004497 |text = monooxygenase activity}} {{GNF_GO|id=GO:0005507 |text = copper ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0046982 |text = protein heterodimerization activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0042470 |text = melanosome}}
| Process = {{GNF_GO|id=GO:0006583 |text = melanin biosynthetic process from tyrosine}} {{GNF_GO|id=GO:0008152 |text = metabolic process}} {{GNF_GO|id=GO:0043473 |text = pigmentation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7306
| Hs_Ensembl = ENSG00000107165
| Hs_RefseqProtein = NP_000541
| Hs_RefseqmRNA = NM_000550
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 12683435
| Hs_GenLoc_end = 12700290
| Hs_Uniprot = P17643
| Mm_EntrezGene = 22178
| Mm_Ensembl = ENSMUSG00000005994
| Mm_RefseqmRNA = NM_031202
| Mm_RefseqProtein = NP_112479
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 80305461
| Mm_GenLoc_end = 80322950
| Mm_Uniprot = Q3UFK6
}}
}}
'''Tyrosinase-related protein 1''', also known as '''TYRP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TYRP1 tyrosinase-related protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7306| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Sarangarajan R, Boissy RE |title=Tyrp1 and oculocutaneous albinism type 3. |journal=Pigment Cell Res. |volume=14 |issue= 6 |pages= 437-44 |year= 2002 |pmid= 11775055 |doi= }}
*{{cite journal | author=Lowings P, Yavuzer U, Goding CR |title=Positive and negative elements regulate a melanocyte-specific promoter. |journal=Mol. Cell. Biol. |volume=12 |issue= 8 |pages= 3653-62 |year= 1992 |pmid= 1321344 |doi= }}
*{{cite journal | author=Shibata K, Takeda K, Tomita Y, ''et al.'' |title=Downstream region of the human tyrosinase-related protein gene enhances its promoter activity. |journal=Biochem. Biophys. Res. Commun. |volume=184 |issue= 2 |pages= 568-75 |year= 1992 |pmid= 1575733 |doi= }}
*{{cite journal | author=Murty VV, Bouchard B, Mathew S, ''et al.'' |title=Assignment of the human TYRP (brown) locus to chromosome region 9p23 by nonradioactive in situ hybridization. |journal=Genomics |volume=13 |issue= 1 |pages= 227-9 |year= 1992 |pmid= 1577487 |doi= }}
*{{cite journal | author=Colman MA, Shibahara S, Kwon B, ''et al.'' |title=A two allele XbaI RFLP at the catalase 2 locus. |journal=Nucleic Acids Res. |volume=19 |issue= 4 |pages= 960 |year= 1991 |pmid= 1673236 |doi= }}
*{{cite journal | author=Halaban R, Moellmann G |title=Murine and human b locus pigmentation genes encode a glycoprotein (gp75) with catalase activity. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 12 |pages= 4809-13 |year= 1990 |pmid= 1693779 |doi= }}
*{{cite journal | author=Abbott C, Jackson IJ, Carritt B, Povey S |title=The human homolog of the mouse brown gene maps to the short arm of chromosome 9 and extends the known region of homology with mouse chromosome 4. |journal=Genomics |volume=11 |issue= 2 |pages= 471-3 |year= 1992 |pmid= 1769662 |doi= }}
*{{cite journal | author=Chintamaneni CD, Ramsay M, Colman MA, ''et al.'' |title=Mapping the human CAS2 gene, the homologue of the mouse brown (b) locus, to human chromosome 9p22-pter. |journal=Biochem. Biophys. Res. Commun. |volume=178 |issue= 1 |pages= 227-35 |year= 1991 |pmid= 1906272 |doi= }}
*{{cite journal | author=Urquhart A |title=Human tyrosinase-like protein (TYRL) carboxy terminus: closer homology with the mouse protein than previously reported. |journal=Nucleic Acids Res. |volume=19 |issue= 20 |pages= 5803 |year= 1991 |pmid= 1945866 |doi= }}
*{{cite journal | author=Cohen T, Muller RM, Tomita Y, Shibahara S |title=Nucleotide sequence of the cDNA encoding human tyrosinase-related protein. |journal=Nucleic Acids Res. |volume=18 |issue= 9 |pages= 2807-8 |year= 1990 |pmid= 2111010 |doi= }}
*{{cite journal | author=Vijayasaradhi S, Bouchard B, Houghton AN |title=The melanoma antigen gp75 is the human homologue of the mouse b (brown) locus gene product. |journal=J. Exp. Med. |volume=171 |issue= 4 |pages= 1375-80 |year= 1990 |pmid= 2324688 |doi= }}
*{{cite journal | author=Box NF, Sturm RA |title=Dinucleotide repeat polymorphism at the human TYRP1 locus. |journal=Hum. Mol. Genet. |volume=3 |issue= 12 |pages= 2270 |year= 1995 |pmid= 7881448 |doi= }}
*{{cite journal | author=Orlow SJ, Zhou BK, Chakraborty AK, ''et al.'' |title=High-molecular-weight forms of tyrosinase and the tyrosinase-related proteins: evidence for a melanogenic complex. |journal=J. Invest. Dermatol. |volume=103 |issue= 2 |pages= 196-201 |year= 1994 |pmid= 8040609 |doi= }}
*{{cite journal | author=Sturm RA, O'Sullivan BJ, Box NF, ''et al.'' |title=Chromosomal structure of the human TYRP1 and TYRP2 loci and comparison of the tyrosinase-related protein gene family. |journal=Genomics |volume=29 |issue= 1 |pages= 24-34 |year= 1996 |pmid= 8530077 |doi= 10.1006/geno.1995.1211 }}
*{{cite journal | author=Boissy RE, Zhao H, Oetting WS, ''et al.'' |title=Mutation in and lack of expression of tyrosinase-related protein-1 (TRP-1) in melanocytes from an individual with brown oculocutaneous albinism: a new subtype of albinism classified as "OCA3". |journal=Am. J. Hum. Genet. |volume=58 |issue= 6 |pages= 1145-56 |year= 1996 |pmid= 8651291 |doi= }}
*{{cite journal | author=Manga P, Kromberg JG, Box NF, ''et al.'' |title=Rufous oculocutaneous albinism in southern African Blacks is caused by mutations in the TYRP1 gene. |journal=Am. J. Hum. Genet. |volume=61 |issue= 5 |pages= 1095-101 |year= 1997 |pmid= 9345097 |doi= }}
*{{cite journal | author=Box NF, Wyeth JR, Mayne CJ, ''et al.'' |title=Complete sequence and polymorphism study of the human TYRP1 gene encoding tyrosinase-related protein 1. |journal=Mamm. Genome |volume=9 |issue= 1 |pages= 50-3 |year= 1998 |pmid= 9434945 |doi= }}
*{{cite journal | author=Bertolotto C, Buscà R, Abbe P, ''et al.'' |title=Different cis-acting elements are involved in the regulation of TRP1 and TRP2 promoter activities by cyclic AMP: pivotal role of M boxes (GTCATGTGCT) and of microphthalmia. |journal=Mol. Cell. Biol. |volume=18 |issue= 2 |pages= 694-702 |year= 1998 |pmid= 9447965 |doi= }}
*{{cite journal | author=Abe T, Sato M, Tamai M |title=Dedifferentiation of the retinal pigment epithelium compared to the proliferative membranes of proliferative vitreoretinopathy. |journal=Curr. Eye Res. |volume=17 |issue= 12 |pages= 1103-9 |year= 1999 |pmid= 9872531 |doi= }}
*{{cite journal | author=Commo S, Bernard BA |title=Melanocyte subpopulation turnover during the human hair cycle: an immunohistochemical study. |journal=Pigment Cell Res. |volume=13 |issue= 4 |pages= 253-9 |year= 2000 |pmid= 10952393 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on UCN... {November 19, 2007 12:37:32 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 19, 2007 12:38:02 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Urocortin
| HGNCid = 12516
| Symbol = UCN
| AltSymbols =; MGC129974; MGC129975; UI; UROC
| OMIM = 600945
| ECnumber =
| Homologene = 2515
| MGIid = 1276123
| GeneAtlas_image1 = PBB_GE_UCN_206072_at_tn.png
| Function = {{GNF_GO|id=GO:0005184 |text = neuropeptide hormone activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7349
| Hs_Ensembl = ENSG00000163794
| Hs_RefseqProtein = NP_003344
| Hs_RefseqmRNA = NM_003353
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 27383769
| Hs_GenLoc_end = 27384634
| Hs_Uniprot = P55089
| Mm_EntrezGene = 22226
| Mm_Ensembl = ENSMUSG00000038676
| Mm_RefseqmRNA = NM_021290
| Mm_RefseqProtein = NP_067265
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 31414570
| Mm_GenLoc_end = 31415476
| Mm_Uniprot = Q14A76
}}
}}
'''Urocortin''', also known as '''UCN''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: UCN urocortin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7349| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II.<ref name="entrez">{{cite web | title = Entrez Gene: UCN urocortin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7349| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Tsarev OB |title=[Dynamics of matrix synthesis in molecular biophysics. II. Principle of insertability and the single-valued solution of feedback tasks] |journal=Biofizika |volume=22 |issue= 2 |pages= 197-200 |year= 1977 |pmid= 861256 |doi= }}
*{{cite journal | author=Donaldson CJ, Sutton SW, Perrin MH, ''et al.'' |title=Cloning and characterization of human urocortin. |journal=Endocrinology |volume=137 |issue= 5 |pages= 2167-70 |year= 1996 |pmid= 8612563 |doi= }}
*{{cite journal | author=Adachi T, Schamel WW, Kim KM, ''et al.'' |title=The specificity of association of the IgD molecule with the accessory proteins BAP31/BAP29 lies in the IgD transmembrane sequence. |journal=EMBO J. |volume=15 |issue= 7 |pages= 1534-41 |year= 1996 |pmid= 8612576 |doi= }}
*{{cite journal | author=Iino K, Sasano H, Oki Y, ''et al.'' |title=Urocortin expression in human pituitary gland and pituitary adenoma. |journal=J. Clin. Endocrinol. Metab. |volume=82 |issue= 11 |pages= 3842-50 |year= 1997 |pmid= 9360550 |doi= }}
*{{cite journal | author=Gottowik J, Goetschy V, Henriot S, ''et al.'' |title=Labelling of CRF1 and CRF2 receptors using the novel radioligand, [3H]-urocortin. |journal=Neuropharmacology |volume=36 |issue= 10 |pages= 1439-46 |year= 1998 |pmid= 9423932 |doi= }}
*{{cite journal | author=Bamberger CM, Wald M, Bamberger AM, ''et al.'' |title=Human lymphocytes produce urocortin, but not corticotropin-releasing hormone. |journal=J. Clin. Endocrinol. Metab. |volume=83 |issue= 2 |pages= 708-11 |year= 1998 |pmid= 9467598 |doi= }}
*{{cite journal | author=Takahashi K, Totsune K, Sone M, ''et al.'' |title=Regional distribution of urocortin-like immunoreactivity and expression of urocortin mRNA in the human brain. |journal=Peptides |volume=19 |issue= 4 |pages= 643-7 |year= 1998 |pmid= 9622018 |doi= }}
*{{cite journal | author=Zhao L, Donaldson CJ, Smith GW, Vale WW |title=The structures of the mouse and human urocortin genes (Ucn and UCN). |journal=Genomics |volume=50 |issue= 1 |pages= 23-33 |year= 1999 |pmid= 9628819 |doi= 10.1006/geno.1998.5292 }}
*{{cite journal | author=Iino K, Sasano H, Oki Y, ''et al.'' |title=Urocortin expression in the human central nervous system. |journal=Clin. Endocrinol. (Oxf) |volume=50 |issue= 1 |pages= 107-14 |year= 1999 |pmid= 10341863 |doi= }}
*{{cite journal | author=Watanabe F, Oki Y, Ozawa M, ''et al.'' |title=Urocortin in human placenta and maternal plasma. |journal=Peptides |volume=20 |issue= 2 |pages= 205-9 |year= 1999 |pmid= 10422876 |doi= }}
*{{cite journal | author=Slominski A, Roloff B, Curry J, ''et al.'' |title=The skin produces urocortin. |journal=J. Clin. Endocrinol. Metab. |volume=85 |issue= 2 |pages= 815-23 |year= 2000 |pmid= 10690896 |doi= }}
*{{cite journal | author=Muramatsu Y, Fukushima K, Iino K, ''et al.'' |title=Urocortin and corticotropin-releasing factor receptor expression in the human colonic mucosa. |journal=Peptides |volume=21 |issue= 12 |pages= 1799-809 |year= 2001 |pmid= 11150640 |doi= }}
*{{cite journal | author=Muramatsu Y, Sugino N, Suzuki T, ''et al.'' |title=Urocortin and corticotropin-releasing factor receptor expression in normal cycling human ovaries. |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 3 |pages= 1362-9 |year= 2001 |pmid= 11238533 |doi= }}
*{{cite journal | author=Hsu SY, Hsueh AJ |title=Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor. |journal=Nat. Med. |volume=7 |issue= 5 |pages= 605-11 |year= 2001 |pmid= 11329063 |doi= 10.1038/87936 }}
*{{cite journal | author=Lewis K, Li C, Perrin MH, ''et al.'' |title=Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 13 |pages= 7570-5 |year= 2001 |pmid= 11416224 |doi= 10.1073/pnas.121165198 }}
*{{cite journal | author=Kimura Y, Takahashi K, Totsune K, ''et al.'' |title=Expression of urocortin and corticotropin-releasing factor receptor subtypes in the human heart. |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 1 |pages= 340-6 |year= 2002 |pmid= 11788672 |doi= }}
*{{cite journal | author=Florio P, Arcuri F, Ciarmela P, ''et al.'' |title=Identification of urocortin mRNA and peptide in the human endometrium. |journal=J. Endocrinol. |volume=173 |issue= 2 |pages= R9-14 |year= 2002 |pmid= 12010647 |doi= }}
*{{cite journal | author=Arcuri F, Cintorino M, Florio P, ''et al.'' |title=Expression of urocortin mRNA and peptide in the human prostate and in prostatic adenocarcinoma. |journal=Prostate |volume=52 |issue= 3 |pages= 167-72 |year= 2002 |pmid= 12111693 |doi= 10.1002/pros.10094 }}
*{{cite journal | author=Ikeda K, Tojo K, Oki Y, Nakao K |title=Urocortin has cell-proliferative effects on cardiac non-myocytes. |journal=Life Sci. |volume=71 |issue= 16 |pages= 1929-38 |year= 2002 |pmid= 12175707 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ZYX... {November 19, 2007 12:38:02 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 19, 2007 12:38:25 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Zyxin
| HGNCid = 13200
| Symbol = ZYX
| AltSymbols =; ESP-2; HED-2
| OMIM = 602002
| ECnumber =
| Homologene = 31164
| MGIid = 103072
| GeneAtlas_image1 = PBB_GE_ZYX_200808_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ZYX_215706_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0005913 |text = cell-cell adherens junction}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7791
| Hs_Ensembl = ENSG00000159840
| Hs_RefseqProtein = NP_001010972
| Hs_RefseqmRNA = NM_001010972
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 142788482
| Hs_GenLoc_end = 142798322
| Hs_Uniprot = Q15942
| Mm_EntrezGene = 22793
| Mm_Ensembl = ENSMUSG00000029860
| Mm_RefseqmRNA = NM_011777
| Mm_RefseqProtein = NP_035907
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 42279476
| Mm_GenLoc_end = 42289753
| Mm_Uniprot = Q62523
}}
}}
'''Zyxin''', also known as '''ZYX''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ZYX zyxin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7791| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform.<ref name="entrez">{{cite web | title = Entrez Gene: ZYX zyxin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7791| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Reinhard M, Jouvenal K, Tripier D, Walter U |title=Identification, purification, and characterization of a zyxin-related protein that binds the focal adhesion and microfilament protein VASP (vasodilator-stimulated phosphoprotein). |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 17 |pages= 7956-60 |year= 1995 |pmid= 7644520 |doi= }}
*{{cite journal | author=Wang LF, Miao SY, Zong SD, ''et al.'' |title=Gene encoding a mammalian epididymal protein. |journal=Biochem. Mol. Biol. Int. |volume=34 |issue= 6 |pages= 1131-6 |year= 1995 |pmid= 7696985 |doi= }}
*{{cite journal | author=Hobert O, Schilling JW, Beckerle MC, ''et al.'' |title=SH3 domain-dependent interaction of the proto-oncogene product Vav with the focal contact protein zyxin. |journal=Oncogene |volume=12 |issue= 7 |pages= 1577-81 |year= 1996 |pmid= 8622875 |doi= }}
*{{cite journal | author=Zumbrunn J, Trueb B |title=A zyxin-related protein whose synthesis is reduced in virally transformed fibroblasts. |journal=Eur. J. Biochem. |volume=241 |issue= 2 |pages= 657-63 |year= 1997 |pmid= 8917469 |doi= }}
*{{cite journal | author=Macalma T, Otte J, Hensler ME, ''et al.'' |title=Molecular characterization of human zyxin. |journal=J. Biol. Chem. |volume=271 |issue= 49 |pages= 31470-8 |year= 1997 |pmid= 8940160 |doi= }}
*{{cite journal | author=Kotake K, Ozaki N, Mizuta M, ''et al.'' |title=Noc2, a putative zinc finger protein involved in exocytosis in endocrine cells. |journal=J. Biol. Chem. |volume=272 |issue= 47 |pages= 29407-10 |year= 1997 |pmid= 9367993 |doi= }}
*{{cite journal | author=Zumbrunn J, Trueb B |title=Assignment of the ZYX gene for the LIM protein zyxin to human chromosome bands 7q34-->q35 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=81 |issue= 3-4 |pages= 283-4 |year= 1998 |pmid= 9730620 |doi= }}
*{{cite journal | author=Yang JX, Miao SY, Wu YW, ''et al.'' |title=Gene encoding a human testis Sertoli cell component related to LIM domain protein. |journal=Biochem. Mol. Biol. Int. |volume=46 |issue= 1 |pages= 11-9 |year= 1998 |pmid= 9784834 |doi= }}
*{{cite journal | author=Reinhard M, Zumbrunn J, Jaquemar D, ''et al.'' |title=An alpha-actinin binding site of zyxin is essential for subcellular zyxin localization and alpha-actinin recruitment. |journal=J. Biol. Chem. |volume=274 |issue= 19 |pages= 13410-8 |year= 1999 |pmid= 10224105 |doi= }}
*{{cite journal | author=Drees B, Friederich E, Fradelizi J, ''et al.'' |title=Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins. |journal=J. Biol. Chem. |volume=275 |issue= 29 |pages= 22503-11 |year= 2000 |pmid= 10801818 |doi= 10.1074/jbc.M001698200 }}
*{{cite journal | author=Hirota T, Morisaki T, Nishiyama Y, ''et al.'' |title=Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor. |journal=J. Cell Biol. |volume=149 |issue= 5 |pages= 1073-86 |year= 2000 |pmid= 10831611 |doi= }}
*{{cite journal | author=Smolenski A, Poller W, Walter U, Lohmann SM |title=Regulation of human endothelial cell focal adhesion sites and migration by cGMP-dependent protein kinase I. |journal=J. Biol. Chem. |volume=275 |issue= 33 |pages= 25723-32 |year= 2000 |pmid= 10851246 |doi= 10.1074/jbc.M909632199 }}
*{{cite journal | author=Harbeck B, Hüttelmaier S, Schluter K, ''et al.'' |title=Phosphorylation of the vasodilator-stimulated phosphoprotein regulates its interaction with actin. |journal=J. Biol. Chem. |volume=275 |issue= 40 |pages= 30817-25 |year= 2000 |pmid= 10882740 |doi= 10.1074/jbc.M005066200 }}
*{{cite journal | author=Schenker T, Trueb B |title=BSPRY, a novel protein of the Ro-Ret family. |journal=Biochim. Biophys. Acta |volume=1493 |issue= 1-2 |pages= 255-8 |year= 2000 |pmid= 10978534 |doi= }}
*{{cite journal | author=Li B, Trueb B |title=Analysis of the alpha-actinin/zyxin interaction. |journal=J. Biol. Chem. |volume=276 |issue= 36 |pages= 33328-35 |year= 2001 |pmid= 11423549 |doi= 10.1074/jbc.M100789200 }}
*{{cite journal | author=Degenhardt YY, Silverstein S |title=Interaction of zyxin, a focal adhesion protein, with the e6 protein from human papillomavirus type 6 results in its nuclear translocation. |journal=J. Virol. |volume=75 |issue= 23 |pages= 11791-802 |year= 2001 |pmid= 11689660 |doi= 10.1128/JVI.75.23.11791-11802.2001 }}
*{{cite journal | author=Yi J, Kloeker S, Jensen CC, ''et al.'' |title=Members of the Zyxin family of LIM proteins interact with members of the p130Cas family of signal transducers. |journal=J. Biol. Chem. |volume=277 |issue= 11 |pages= 9580-9 |year= 2002 |pmid= 11782456 |doi= 10.1074/jbc.M106922200 }}
*{{cite journal | author=van der Gaag EJ, Leccia MT, Dekker SK, ''et al.'' |title=Role of zyxin in differential cell spreading and proliferation of melanoma cells and melanocytes. |journal=J. Invest. Dermatol. |volume=118 |issue= 2 |pages= 246-54 |year= 2002 |pmid= 11841540 |doi= 10.1046/j.0022-202x.2001.01657.x }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Scherer SW, Cheung J, MacDonald JR, ''et al.'' |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767-72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 }}
}}
{{refend}}
{{protein-stub}}
end log.
