Lomustine

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Lomustine
Lomustine Structural Formulae V.1.svg
Lomustine ball-and-stick.png
Systematic (IUPAC) name
N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea
Clinical data
Trade names CeeNU
AHFS/Drugs.com monograph
MedlinePlus a682207
Pregnancy
category
  • D
Legal status
  • (Prescription only)
Routes of
administration
Oral
Pharmacokinetic data
Bioavailability ~100%
Protein binding 50%
Metabolism hepatic
Biological half-life 16–48 hours
Identifiers
CAS Registry Number 13010-47-4 YesY
ATC code L01AD02
PubChem CID: 3950
IUPHAR/BPS 7214
DrugBank DB01206 YesY
ChemSpider 3813 YesY
UNII 7BRF0Z81KG YesY
KEGG D00363 YesY
ChEBI CHEBI:6520 N
ChEMBL CHEMBL514 YesY
Synonyms 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea
Chemical data
Formula C9H16ClN3O2
Molecular mass 233.695 g/mol
 N (what is this?)  (verify)

Lomustine (or CCNU; marketed under the name CeeNU in U.S.) is an alkylating nitrosourea compound used in chemotherapy. It is in the same family as streptozotocin. This is a highly lipid-soluble drug, and thus crosses the blood-brain barrier. This property makes it ideal for treating brain tumors, and is its primary use. Lomustine has a long time to nadir (the time when white blood cells reach their lowest number).


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