Lomustine

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Lomustine
Lomustine Structural Formulae V.1.svg
Lomustine ball-and-stick model.png
Systematic (IUPAC) name
N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea
Clinical data
Trade names CeeNU
AHFS/Drugs.com monograph
MedlinePlus a682207
Pregnancy
category
  • D
Legal status
  • (Prescription only)
Routes of
administration
Oral
Pharmacokinetic data
Bioavailability ~100%
Protein binding 50%
Metabolism hepatic
Biological half-life 16–48 hours
Identifiers
CAS Registry Number 13010-47-4 YesY
ATC code L01AD02
PubChem CID: 3950
IUPHAR/BPS 7214
DrugBank DB01206 YesY
ChemSpider 3813 YesY
UNII 7BRF0Z81KG YesY
KEGG D00363 YesY
ChEBI CHEBI:6520 N
ChEMBL CHEMBL514 YesY
Synonyms 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea
Chemical data
Formula C9H16ClN3O2
Molecular mass 233.695 g/mol
Physical data
Melting point 90 °C (194 °F)
 N (what is this?)  (verify)

Lomustine (CCNU), marketed under the name CeeNU in U.S.) is an alkylating nitrosourea compound used in chemotherapy. It is in the same family as streptozotocin. This is a highly lipid-soluble drug, and thus crosses the blood-brain barrier. This property makes it ideal for treating brain tumors, and is its primary use. Lomustine has a long time to nadir (the time when white blood cells reach their lowest number).


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