Thioesterase: Difference between revisions
m Added an additional reference for a recent manuscript which comprehensively describes the ACOT gene family. |
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[[Ubiquitin thiolesterase]] is a well-known example, whose structure has been analyzed. |
[[Ubiquitin thiolesterase]] is a well-known example, whose structure has been analyzed. |
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Humans genes which encode thiolesterases include:<ref>{{cite journal|last=Brocker|first=C|coauthors=Carpenter, C; Nebert, DW; Vasiliou, V|title=Evolutionary divergence and functions of the human acyl-CoA thioesterase gene ( ACOT ) family.|journal=Human Genomics|year=2010|month=Aug|volume=4|issue=6|pages=411-20|pmid=20846931|url=http://www.humgenomics.com/content/4/6/411}}</ref> |
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Humans genes which encode thiolesterases include: |
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[[ACOT1]], [[ACOT2]], [[ACOT4]], [[ACOT6]], [[ACOT7]], [[ACOT8]], [[ACOT9]], [[ACOT11]](STARD14), [[ACOT12]] (STARD15), [[OLAH]], [[palmitoyl-coA hydrolase|PPT1]], [[palmitoyl-coA hydrolase|PPT2]], [[THEM2]] (ACOT13), [[THEM4]], [[THEM4P1]], [[THEM5]] |
[[ACOT1]], [[ACOT2]], [[ACOT4]], [[ACOT6]], [[ACOT7]], [[ACOT8]], [[ACOT9]], [[ACOT11]](STARD14), [[ACOT12]] (STARD15), [[OLAH]], [[palmitoyl-coA hydrolase|PPT1]], [[palmitoyl-coA hydrolase|PPT2]], [[THEM2]] (ACOT13), [[THEM4]], [[THEM4P1]], [[THEM5]] |
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Revision as of 00:35, 3 October 2012
Thioesterases are enzymes which belong to the Esterase family. Esterases, in turn, are one type of the several hydrolases known.
Thioesterases exhibit Esterase activity (splitting of an ester into acid and alcohol, in the presence of water) specifically at a thiol group.
Thioesterases or thiolester hydrolases are identified as members of E.C.3.1.2.
Examples
Acetyl-coA hydrolase, palmitoyl-coA hydrolase, succinyl-coA hydrolase, formyl-coA hydrolase, acyl-coA hydrolase are a few examples of this group of enzymes.
Ubiquitin thiolesterase is a well-known example, whose structure has been analyzed.
Humans genes which encode thiolesterases include:[1]
ACOT1, ACOT2, ACOT4, ACOT6, ACOT7, ACOT8, ACOT9, ACOT11(STARD14), ACOT12 (STARD15), OLAH, PPT1, PPT2, THEM2 (ACOT13), THEM4, THEM4P1, THEM5
External links
- thioesterase+I at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- thioesterase+II at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
 | This enzyme-related article is a stub. You can help Wikipedia by expanding it. |
- ^ Brocker, C (2010). "Evolutionary divergence and functions of the human acyl-CoA thioesterase gene ( ACOT ) family". Human Genomics. 4 (6): 411–20. PMID 20846931.
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