Distigmine
(Redirected from ATCvet code QN07AA03)
 Distigmine bromide | |
| Clinical data | |
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| Routes of administration | By mouth, i.m. |
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| Pharmacokinetic data | |
| Bioavailability | 4.65% [1] |
| Elimination half-life | 65 h [1] |
| Excretion | renal [1] |
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| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.036.360 |
| Chemical and physical data | |
| Formula | C22H32Br2N4O4 |
| Molar mass | 576.330 g·mol−1 |
| 3D model (JSmol) | |
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Distigmine (as distigmine bromide) is a parasympathomimetic. Distigmine is similar to pyridostigmine and neostigmine but has a longer duration of action. It is available as tablets on prescription only. It is commonly used to treat various conditions, including myasthenia gravis and underactive bladder.[2] Distigmine has a greater risk of causing cholinergic crisis because of accumulation of the drug being more likely than with neostigmine or pyridostigmine and so distigmine is rarely used as a treatment for myasthenia gravis, unlike pyridostigmine and neostigmine.
References
[edit]- ^ a b c "Distigmine" (PDF). The Japanese Pharmacopoeia. Official Monographs (14/I ed.). Tokyo: Yakuji Nippo. Ltd. 2001. p. 599. ISBN 978-4-8408-0672-5.
- ^ Moro C, Phelps C, Veer V, Clark J, Glasziou P, Tikkinen KA, Scott AM (November 2021). "The effectiveness of parasympathomimetics for treating underactive bladder: A systematic review and meta-analysis" (PDF). Neurourology and Urodynamics. 41 (1): 127–139. doi:10.1002/nau.24839. PMID 34816481. S2CID 244530010.
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