Dichlorvos

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Dichlorvos
Dichlorvos Structural Formulae .V.1.svg
Dichlorvos3d.png
Systematic (IUPAC) name
2,2-dichlorovinyl dimethyl phosphate
Clinical data
AHFS/Drugs.com International Drug Names
Legal status
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Identifiers
CAS number 62-73-7 YesY
ATCvet code QP52AB03 QP53AF04
PubChem CID 3039
ChemSpider 2931 YesY
UNII 7U370BPS14 YesY
KEGG D03791 YesY
ChEBI CHEBI:34690 YesY
ChEMBL CHEMBL167911 YesY
Chemical data
Formula C4H7Cl2O4P 
Mol. mass 220.98 g/mol
 YesY (what is this?)  (verify)

Dichlorvos or 2,2-dichlorovinyl dimethyl phosphate (Trade Names: DDVP, Vapona, etc.) is a organophosphate, widely used as an insecticide to control household pests, in public health, and protecting stored product from insects. The compound has been commercially available since 1961 and has become controversial because of its prevalence in urban waterways and the fact that its toxicity extends well beyond insects.[1]

Use[edit]

It is effective against mushroom flies, aphids, spider mites, caterpillars, thrips, and whiteflies in greenhouse, outdoor fruit, and vegetable crops. It is also used in the milling and grain handling industries and to treat a variety of parasitic worm infections in dogs, livestock, and humans. It is fed to livestock to control bot fly larvae in the manure. It acts against insects as both a contact and a stomach poison. It is available as an aerosol and soluble concentrate. It is also used in pet collars and "no-pest strips" in the form of a pesticide-impregnated plastic; this material has been available to households since 1964 and has been the source of some concern, partly due to its misuse.[2]

Mechanism of action[edit]

Dichlorvos, like other organophosphate insecticides, acts on acetylcholinesterase, associated with the nervous systems of insects. Evidence for other modes of action, applicable to higher animals, have been presented.[3][4] It is claimed to damages DNA of insects.[5]

Regulation[edit]

The United States Environmental Protection Agency have reviewed the safety data of dichlovos several times.[6] In 1995 a voluntary agreement was reached with the supplier, Amvac Chemical Corporation which restricted the use of dichlovos in many, but not all, domestic uses, all aerial applications, and other uses.[7] Additional voluntary cancellations were implemented in 2006, 2008 and 2010. Major concerns focus on acute and chronic toxicity and the fact that his pesticide is prevalent in urban waterways.[8] Conclusive evidence of carcinogenicity exists.[citation needed] A 2010 study found that each 10-fold increase in urinary concentration of organophosphate metabolites was associated with a 55% to 72% increase in the odds of ADHD in children.[9][10][11]

Safety[edit]

Dichlorvos is absorbed through all routes of exposure. Since it is an acetylcholinesterase inhibitor, its overdose symptoms are weakness, headache, tightness in chest, blurred vision, salivation, sweating, nausea, vomiting, diarrhea, and abdominal cramps.[medical citation needed]

References[edit]

  1. ^ DAS, SUCHISMITA. "A review of Dichlorvos toxicity in fish". Current World Environment Journal 8 (1). doi:10.12944/CWE.8.1.08. 
  2. ^ W. Gillett, James; R. Harr, James; T. Lindstrom, Frederick; A. Mount, Darl; D. St. Clair, Akos; J. Weber, Lavern (1972). "Evaluation of human health hazards on use of dichlorvos (DDVP), especially in resin strips". Residue Reviews 44: 115–159. doi:10.1007/978-1-4615-8491-9_6. 
  3. ^ Pancetti, F., Olmos, C., Dagnino-Subiabre, A., Rozas, C., Morales, B., "Noncholinesterase Effects Induced by Organophosphate Pesticides and their Relationship to Cognitive Processes: Implication for the Action of Acylpeptide Hydrolase", J. Toxicol. Environ. Health, Part B 2007, 10, 623.
  4. ^ Booth, E. D., Jones, E., Elliott, B. M., "Review of the in vitro and in vivo genotoxicity of dichlorvos", Regul. Toxicol. Pharmacol. 2007, 49, 316. doi:10.1016/j.yrtph.2007.08.011
  5. ^ Espeland M., Irestedt M., Johanson K. A., Åkerlund M., Bergh J.-E. & Källersjö M. (2010). "Dichlorvos exposure impedes extraction and amplification of DNA from insects in museum collections". Frontiers in Zoology 2010, 7: 2. doi:10.1186/1742-9994-7-2
  6. ^ Mennear, John H. "Dichlorvos: A Regulatory Conundrum". Regulatory Toxicology and Pharmacology 27 (3): 265–272. doi:10.1006/rtph.1998.1217. 
  7. ^ "Dichlorvos (DDVP): Deletion of Certain Uses and Directions.". U.S. Environmental Protection Agency: Office of Pesticide Programs. April 19, 1995. pp. 19580–19581. Docket Control Number OPP-38511. 
  8. ^ http://www.nytimes.com/2014/09/12/us/pesticide-levels-in-waterways-have-dropped-reducing-the-risks-to-humans.html?hp&action=click&pgtype=Homepage&version=HpHeadline&module=second-column-region&region=top-news&WT.nav=top-news
  9. ^ Medscape: Medscape Access
  10. ^ http://pediatrics.aappublications.org/content/early/2010/05/17/peds.2009-3058.full.pdf
  11. ^ Slow-Acting: Scientific American

External links[edit]