Amaninamide

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Amaninamide
Amaninamide structure.png
Amaninamide with tube model.png
Names
Other names
4-(2-mercapto-L-tryptophan)-alpha-Amanitin
Identifiers
58311-65-2
ChemSpider 2299516 YesY
Jmol-3D images Image
Image
PubChem 3035225
Properties
C39H54N10O13S
Molar mass 902.97 g/mol
Appearance Colorless, crystalline solid
Soluble
Solubility in ethanol, methanol Soluble
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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Infobox references

Amaninamide is a cyclic nonribosomal peptide. It is one of the amatoxins, all of which are found in several members of the Amanita genus of mushrooms.

Toxicology[edit]

Like other amatoxins, amaninamide is an inhibitor of RNA polymerase II. Upon ingestion, it binds to the RNA polymerase II enzyme which completely prevents mRNA synthesis, effectively causing cytolysis of hepatocytes (liver cells) and kidney cells.[1]

See also[edit]

References[edit]

External links[edit]