Proamanullin

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Proamanullin
Proamanullin structure.png
Names
Other names
2-L-Proline-3-isoleucine-alpha-amanitin
Identifiers
CAS number 54532-46-6
Jmol-3D images Image
PubChem 171350
Properties
C39H54N10O11S
Molar mass 870.97 g/mol
Appearance Colorless, odorless
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 YesY verify (what isYesY/N?)
Infobox references

Promanullin is a cyclic nonribosomal peptide. It is an amatoxin, all of which are found in several members of the Amanita genus of mushrooms.

Toxicology[edit]

Like other amatoxins, proamanullin is an inhibitor of RNA polymerase II. Promanullin has a specific attraction to the enzyme RNA polymerase II. Upon ingestion, it binds to the RNA polymerase II enzyme, effectively causing cytolysis of hepatocytes (liver cells).[1]

See also[edit]

References[edit]

  1. ^ Cochet-Meilhac M, Chambon P (June 1974). "Animal DNA-dependent RNA polymerases. 11. Mechanism of the inhibition of RNA polymerases B by amatoxins". Biochim. Biophys. Acta 353 (2): 160–84. doi:10.1016/0005-2787(74)90182-8. PMID 4601749. 

External links[edit]