|Jmol-3D images||Image 1|
|Molar mass||77.08 g mol−1|
|Appearance||White solid crystals, deliquescent|
|Density||1.17 g/cm3 (20 °C)
1.073 g/cm3 (25 °C)
|Melting point||110–114 °C (230–237 °F; 383–387 K) 
|Boiling point||117.1 °C (242.8 °F; 390.2 K)
at 760 mmHg, decomposes
|Solubility in water||102 g/100 mL (0 °C)
148 g/100 mL (4 °C)
143 g/100 mL (20 °C)
533 g/100 mL (80 °C)
|Solubility||Soluble in alcohol, SO2, acetone, liquid ammonia|
|Solubility in methanol||7.89 g/100 mL (15 °C)
131.24 g/100 g (94.2 °C)
|Solubility in dimethylformamide||0.1 g/100 g|
|Std enthalpy of
|GHS signal word||Warning|
|GHS hazard statements||H303, H316, H320, H333|
|GHS precautionary statements||P281, P335|
|Flash point||136 °C (277 °F; 409 K) |
|LD50||386 mg/kg (mice, intravenous)|
|Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)|
|(what is: / ?)|
Ammonium acetate is a chemical compound with the formula NH4C2H3O2 (or C2H4O2.NH3 or C2H7NO2). It is a white solid and can be derived from the reaction of ammonia and acetic acid. It is available commercially and, depending on grade, can be rather inexpensive.
Uses and distinctive properties
- NH4C2H3O2 is occasionally employed as a biodegradable de-icing agent.
- It is often used with acetic acid to create a buffer solution, one that can be thermally decomposed to non-ionic products
- Ammonium acetate is useful as a catalyst in the Knoevenagel condensation and as a source of ammonia in the Borch reaction in organic synthesis.
- It is a relatively unusual example of a salt that melts at low temperatures.
- Can be used with distilled water to make a protein precipitating reagent.
- Is often used as an aqueous buffer for ESI mass spectrometry of proteins and other molecules.
- Useful in dialysis as part of a protein purification step to remove contaminants via diffusion.
Ammonium acetate is volatile at low pressures. Because of this, it has been used to replace cell buffers with non-volatile salts in preparing samples for mass spectrometry. It is also popular as a buffer for mobile phases for HPLC with ELSD detection for this reason. Other volatile salts that have been used for this include ammonium formate.
- CH3COONH4 → CH3C(O)NH2 + H2O
In this reaction, a salt is converted to two molecular species, which is a relatively uncommon conversion at mild temperatures. Further dehydration leads to acetonitrile or methyl cyanide, an important and widely used solvent.
Ammonium acetate is produced by the neutralization of acetic acid with ammonium carbonate or by saturating glacial acetic acid with dry ammonia gas. Obtaining crystalline ammonium acetate is difficult on account of its aqueous solution giving off ammonia when evaporated.
- Pradyot, Patnaik (2003). Handbook of Inorganic Chemicals. The McGraw-Hill Companies, Inc. ISBN 0-07-049439-8.
- "Safety Data Sheet of Ammonium Acetate". http://www.tedia.com. Tedia Company Inc. 2011-08-12. Retrieved 2014-06-10.
- Berman et al., 2008. J Am Soc Mass Spectrom, 19:1230-1236.
- Australia New Zealand Food Standards Code "Standard 1.2.4 - Labelling of ingredients". Retrieved 2011-10-27.
- Brannt, William (1914). A practical treatise on the manufacture of vinegar. Lancaster, PA: Henry Carey Baird & Co. pp. 316–317.
- G. Jones, Organic Reactions, 1967, volume 15, 204ff (the Knoevenagel Reaction)
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