Bendroflumethiazide

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Bendroflumethiazide
Bendroflumethiazide.svg
Bendroflumethiazide-3D-vdW.png
Systematic (IUPAC) name
3-benzyl-1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4- benzothiadiazine-7-sulfonamide
Clinical data
AHFS/Drugs.com Consumer Drug Information
Pregnancy cat.
Legal status
Routes Oral
Pharmacokinetic data
Bioavailability 100%
Protein binding 96%
Metabolism extensive
Half-life 3-4 hours[2]
Identifiers
CAS number 73-48-3 YesY
ATC code C03AA01
PubChem CID 2315
DrugBank DB00436
ChemSpider 2225 YesY
UNII 5Q52X6ICJI YesY
KEGG D00650 YesY
ChEBI CHEBI:3013 YesY
ChEMBL CHEMBL1684 YesY
Chemical data
Formula C15H14F3N3O4S2 
Mol. mass 421.415 g/mol
 YesY (what is this?)  (verify)

Bendroflumethiazide (INN), formerly bendrofluazide (BAN), is a thiazide diuretic used to treat hypertension.

Bendroflumethiazide is a thiazide diuretic which works by inhibiting sodium reabsorption at the beginning of the distal convoluted tubule (DCT). Water is lost as a result of more sodium reaching the collecting ducts. Bendroflumethiazide has a role in the treatment of mild heart failure although loop diuretics are better for reducing overload. The main use of bendroflumethiazide currently is in hypertension (part of the effect is due to vasodilation).

Common adverse effects

Rare adverse effects


References[edit]

  1. ^ BNF 45 March 2003
  2. ^ Ed. Sean C. Sweetman (ed.). Martindale: The complete drug reference (33 ed.). Pharmaceutical Press. 

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