Canrenone

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Canrenone
Skeletal formula of canrenone
Ball-and-stick model of the canrenone molecule
Systematic (IUPAC) name
10,13-dimethylspiro[2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthrene-17,5'-oxolane]-2',3-dione
Clinical data
Pharmacokinetic data
Protein binding 95%
Half-life 10-35 hours
Identifiers
976-71-6 N
C03DA03
PubChem CID 13789
ChemSpider 13192 YesY
UNII 78O20X9J0U YesY
ChEMBL CHEMBL1463345 N
Synonyms RP-11614, SC-9376
Chemical data
Formula C22H28O3
340.456 g/mol
 N (what is this?)  (verify)

Canrenone (INN, USAN) (brand names Contaren, Luvion, Phanurane, Spiroletan) is an aldosterone antagonist with additional antiandrogen properties which is used as a diuretic in Europe.[1][2]

Carenone is a major active metabolite of spironolactone, canrenoic acid, and potassium canrenoate, and is believed to be partially responsible for their effects.

See also[edit]

References[edit]

  1. ^ R.A. Hill; H.L.J. Makin; D.N. Kirk; G.M. Murphy (23 May 1991). Dictionary of Steroids. CRC Press. pp. 656–. ISBN 978-0-412-27060-4. 
  2. ^ Romanelli RG, Gentilini P (May 2004). "Cross reactivity due to positive canrenone interference". Gut 53 (5): 772–3. PMC 1774040. PMID 15082604.