Chlorothiazide

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Chlorothiazide
Chlorothiazide.svg
Chlorothiazide-from-xtal-3D-balls.png
Systematic (IUPAC) name
6-chloro-1,1-dioxo-2H-1,2,4-benzothiadiazine-7-sulfonamide
Clinical data
Trade names Diuril
AHFS/Drugs.com monograph
MedlinePlus a682341
Pregnancy cat.
Legal status
Routes Oral, IV
Pharmacokinetic data
Bioavailability low
Metabolism Nil
Half-life 45 to 60 hours
Excretion Renal
Identifiers
CAS number 58-94-6 YesY
ATC code C03AA04
PubChem CID 2720
DrugBank DB00880
ChemSpider 2619 YesY
UNII 77W477J15H YesY
KEGG D00519 YesY
ChEBI CHEBI:3640 YesY
ChEMBL CHEMBL842 YesY
Chemical data
Formula C7H6ClN3O4S2 
Mol. mass 295.72 g/mol
 YesY (what is this?)  (verify)

Chlorothiazide sodium (Diuril) is a diuretic used within the hospital setting or for personal use to manage excess fluid associated with congestive heart failure. It is also used as an antihypertensive.

Most often taken in pill form, it is usually taken orally once or twice a day. In the ICU setting, chlorothiazide is given to diurese a patient in addition to furosemide (Lasix). Working in a separate mechanism than furosemide, and absorbed enterically as a reconstituted suspension administered through a nasogastric tube (NG tube), the two drugs potentiate one another.

Indications[edit]

Contraindications[edit]

Dose[edit]

  • 500 mg–1 g once or twice a day, by mouth or through NG tube (reconstituted suspension)
  • May also be given intravenously, and should be given first if given in combination with IV lasix since it potentiate's the diuretic effect of furosemide.

Side effects[edit]

History[edit]

The Research team of Merck Sharp and Dohme Research Laboratories: Karl H. Beyer, Jr., M.D., Ph.D.; James M. Sprague, Ph.D.; John E. Baer, Ph.D.; and Frederick C. Novello, Ph.D. created a new series of medications, the thiazide diuretics, which includes chlorothiazide. They won an Albert Lasker Special Award in 1975 for its creation. http://www.laskerfoundation.org/awards/formaward.htm

Chemical[edit]

Chlorothiazide.png

Novello, Frederick C.; Sprague, James M. (1957). Journal of the American Chemical Society 79 (8): 2028. doi:10.1021/ja01565a079.