Hypogammaglobulinemia
| Hypogammaglobulinemia | |
|---|---|
| Specialty | Hematology  |
Hypogammaglobulinemia is a type of primary immune deficiency disease characterized by a reduction in all types of gamma globulins.[1]
Hypogammaglobulinemia is a characteristic of common variable immunodeficiency.[2]
Terminology
"Hypogammaglobulinemia" is largely synonymous with "agammaglobulinemia". When the latter term is used (as in "X-linked agammaglobulinemia") it implies that gamma globulins are not merely reduced, but completely absent. Modern assays have allowed most agammaglobulinemias to be more precisely defined as hypogammaglobulinemias,[3] but the distinction is not usually clinically relevant.
"Hypogammaglobulinemia" is distinguished from dysgammaglobulinemia, which is a reduction in some types of gamma globulins, but not others.[4][5]
Types
| Type | OMIM | Gene |
|---|---|---|
| AGM1 | Template:OMIM2 | IGHM |
| AGM2 | Template:OMIM2 | IGLL1 |
| AGM3 | Template:OMIM2 | CD79A |
| AGM4 | Template:OMIM2 | BLNK |
| AGM5 | Template:OMIM2 | LRRC8A |
| AGM6 | Template:OMIM2 | CD79B |
References
External links
- "Hypogammaglobulinemia" at Dorland's Medical Dictionary
- Mark E. Rose & David M. Lang: "Evaluating and managing hypogammaglobulinemia", Cleveland Clinic Journal of Medicine, Vol. 73, No. 2 (February 2006), pp. 133–144. Accessed 2009-07-17.
- Robert Y Li, et al.: "Hypogammaglobulinemia", Medscape. Accessed 2009-07-17.
- Saul Greenberg: "Hypogammaglobulinemia ". Accessed 2009-07-17.
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